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Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Structure of 10340-91-7
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 10340-91-7 |
Formula : | C8H7N |
M.W : | 117.15 |
SMILES Code : | [C-]#[N+]CC1=CC=CC=C1 |
MDL No. : | MFCD00000004 |
InChI Key : | RIWNFZUWWRVGEU-UHFFFAOYSA-N |
Pubchem ID : | 82558 |
GHS Pictogram: |
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Signal Word: | Danger |
Hazard Statements: | H301-H311-H315-H319-H331-H335 |
Precautionary Statements: | P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P330-P332+P313-P337+P313-P361-P403+P233-P405-P501 |
Class: | 6.1 |
UN#: | 2810 |
Packing Group: | Ⅲ |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | In methanol; at 50℃; for 24h; | To a stirred solution of 2-aminoethanol (44, 0.049 mL, 0.82 mmol) in MeOH (2.3 mL) at r.t. were added 2-furfural (8, 0.120 mL, 1.23 mmol), <strong>[6214-35-3](Z)-3-iodoacrylic acid</strong> [(Z)-6, 162 mg, 0.82 mmol],28 and benzyl isocyanide (7, 0.923 mL, 7.58 mmol). After stirring at 50 C for 24 h, the mixture was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, 15 g, hexane-EtOAc, 7:3) to give 45 (279 mg, 77%) as a brown foam. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
50% | With copper diacetate; palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,2-bis-(diphenylphosphino)ethane; In acetonitrile; at 100℃; for 0.24h;Sealed tube; | General procedure: General procedure for the palladium-catalyzed intermolecularoxidative cyclization of 2-vinylanilines with isocyanides to thesynthesis of 2-aminoquinolines: A mixture of 2-vinylaniline 1(0.2 mmol) and isocyanide 2 (0.4 mmol, 2.0 equiv), Pd(OAc)2(10 mol %), dppe (20 mol %), Cu(OAc)2 (0.4 mmol, 2.0 equiv), DBU(0.4 mmol, 2.0 equiv), and CH3CN (2 mL) were added into a sealedtube. The mixture was stirred at 100 C or about 24 h (monitored byTLC). After being cooling to room temperature, evaporation of thesolvent under reduced pressure followed purication by silica gel chromatography using petroleum ether/ethyl acetate (20:1 to 10:1)as eluent to provide the desired products 3. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
56% | In methanol; dichloromethane; at 0℃; for 24h;Inert atmosphere; | In a dry two-necked reaction flask33 mg (0.2 mmol) of N-indolecarboxylic acid and 46 mg (0.24 mmol) of 6,7-dimethoxy-3,4-dihydroisoquinoline were weighed in, and 2 mL of a solvent (dichloromethane: (Methanol = 1: 2), followed by injection of 28 mg of benzyl isonitrile, and the reaction was stirred in an ice water bath for 24 hours. The reaction conversion was detected by TLC.After adding silica gel for sample stirring, column chromatography (eluent: petroleum ether: ethyl acetate = 5: 1) yielded 53 mg of the product with a yield of 56%. The reaction is as follows: |