Structure of 115309-58-5
*Storage: {[sel_prStorage]}
*Shipping: {[sel_prShipping]}
The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
4.5
*For Research Use Only !
Change View
Size | Price | VIP Price | US Stock |
Global Stock |
In Stock | ||
{[ item.pr_size ]} |
Inquiry
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.discount_usd) ]} {[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} |
Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]} | Inquiry {[ item.pr_usastock ]} In Stock Inquiry - | {[ item.pr_chinastock ]} {[ item.pr_remark ]} In Stock 1-2 weeks - Inquiry - | Login | - + | Inquiry |
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days
1-2weeks
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price, item.pr_usd) ]}
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
In Stock
- +
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 115309-58-5 |
Formula : | C10H13ClN2O |
M.W : | 212.68 |
SMILES Code : | O=C(NC(C)(C)C)C1=CN=C(Cl)C=C1 |
MDL No. : | MFCD08460992 |
InChI Key : | OJIUMMXADBUVFN-UHFFFAOYSA-N |
Pubchem ID : | 11816697 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302 |
Precautionary Statements: | P280-P305+P351+P338 |
Num. heavy atoms | 14 |
Num. arom. heavy atoms | 6 |
Fraction Csp3 | 0.4 |
Num. rotatable bonds | 3 |
Num. H-bond acceptors | 2.0 |
Num. H-bond donors | 1.0 |
Molar Refractivity | 56.7 |
TPSA ? Topological Polar Surface Area: Calculated from |
41.99 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
2.18 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
2.07 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
2.26 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
1.43 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
2.22 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
2.03 |
Log S (ESOL):? ESOL: Topological method implemented from |
-2.58 |
Solubility | 0.557 mg/ml ; 0.00262 mol/l |
Class? Solubility class: Log S scale |
Soluble |
Log S (Ali)? Ali: Topological method implemented from |
-2.58 |
Solubility | 0.558 mg/ml ; 0.00262 mol/l |
Class? Solubility class: Log S scale |
Soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
-3.86 |
Solubility | 0.0295 mg/ml ; 0.000139 mol/l |
Class? Solubility class: Log S scale |
Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
Yes |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
Yes |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-6.13 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from |
0.0 |
Ghose? Ghose filter: implemented from |
None |
Veber? Veber (GSK) filter: implemented from |
0.0 |
Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
Muegge? Muegge (Bayer) filter: implemented from |
0.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
Brenk? Structural Alert: implemented from |
1.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
1.7 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20℃; for 6h; | The starting material 5-carboxy-2-chloropyridine (1 eq)Dissolved in 10 ml of thionyl chloride and refluxed for 2 h. After cooling to room temperature, the solvent was dried and dissolved in an appropriate amount of dry dichloromethane to give a yellow solution.Then the tert-butylamine (1.1 eq) and DIEA (N,N-diisopropylethylamine) (1.5 eq) were dissolved in dichloromethane, and the prepared acid chloride was slowly added dropwise to the reaction solution at 0 C, and added dropwise. After the completion, slowly rise to room temperature and continue to react for 6 h.Subsequent extraction with ethyl acetate (3 x 30 mL).The crude product was purified by silica gel chromatography to afford Intermediate A-1 (yield: 86%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | 3.4 g Magnesium (137.5 mmol) was suspended under argon in 12.0 ml tetrahydrofitrane and treated under reflux with a solution of 17.6 ml (137,3 mmol) 2-bromo-5- fluorotoluene in 20 ml TETRAHYDROFURANE. After the addition of the first 3 ml of this solution, the mixture was warmed to start the Grignard reaction. The reaction mixture was stirred for 30 minutes under reflux, cooled to 50 C and added within 10 minutes to a solution of 10. 0 G (97 %, 45 mmol) N-TERT-BUTYL-6-CHLORONICOTINAMIDE in 50 ml TETRAHYDROFURANE (exothermic reaction). The mixture was stirred at 70 C for 2 hours, cooled to room temperature and a solution of 17.4 G (68, 6 mmol, 1.5 eq. ) iodine in 100 ml TETRAHYDROFURANE was added slowly (exothermic reaction). The resulting suspension was stirred for 1.7 hours at 50 C, treated at room temperature with 50 ml water, poured onto 150 ml 2 N aqueous sulfuric acid and treated with 150 ml tert-butyl-methyl-ether. After vigorous stirring, the phases were separated and the organic phase was washed with half-saturated aqueous sodium bicarbonate and with half-saturated aqueous sodium chloride. The aqueous phases were extracted with tert-butyl-methyl-ether. The combined organic extracts were dried, concentrated in a rotary evaporator and dried under high vacuum at room temperature to provide 17.3 g of a yellow oil. This oil was dissolved in dichloromethane and filtered through silica gel eluting with hexane and then with dichloromethane. The fractions with the product were collected and concentrated under reduced pressure to a volume of ca. 200 ml to which 400 ml hexane was added. The solution was concentrated in a rotary evaporator to a volume of ca. 150 ml, the suspension obtained was treated with 200 ml hexane and stirred for 2 hours at 4 C. The precipitate was filtered off, washed with cold hexane/ethyl acetate 19/1 (-20C) and dried under high vacuum to yield 8.0 g (55 %) N-FERT-BUTYL-6-CHLORO-4- (4-NUORO-2-METHYL- phenyl) -nicotinamide as a light beige powder. The mother liquors were concentrated in a rotary evaporator PROVIDING 8. 5 G of an orange solid, which was purified by chromatography on silica gel eluting with hexane and then with hexane/ethyl acetate 9/1. The fractions with the product were collected, concentrated and dried under high vacuum to yield 3. 8 G (25'M)) N-TERT-BUTYL-6-CHLORO-4-(4-FLUORO-2-METHYL-PHENYL)- nicotinamide as a light beige powder. MS (ISP) : m/e = 321 (M+H-', 36), 273 (M-TBU, 100). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
88% | The intermediate A-1 (1.0 g, 4.7 mmol) was dissolved in 15 ml of tetrahydrofuran and the reaction mixture was cooled to 0 C. O-methylphenylmagnesium chloride (1M in tetrahydrofuran solution, 14.1 mL, 14.1 mmol) was slowly added, and the reaction was kept for 3 hours, then heated to 30 C for 18 h, and then cooled to 0 C. Glacial acetic acid (24 mmol) was slowly added dropwise, and then DDQ (dichlorodicyanobenzoquinone or manganese acetate) (1.6 g, 7.1 mmol) was added to react at room temperature for 1 h.The reaction solution was poured into a 2M sodium carbonate solution, extracted with ethyl acetate, washed with water and brine, and dried over anhydrous sodium sulfate.After concentration under reduced pressure, it was purified by silica gel column chromatography.Ethyl acetate/petroleum ether (1:1) was used as the mobile phase to give intermediate A-2.The yield of pale yellow solid was 88%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate; In water; isopropyl alcohol; at 90℃; for 18h; | Intermediate 9: 6- 5-R (CVCLOPROPYLAMINO) CARBONVLL-3-FLUORO-2-METHVLPHENVL-N- (1, 1- DIMETHVLETHVL)-3-PVRIDINECARBOXAMIDE; N-TERTBUTYL-6-CHLORONICOTINAMIDE (100MG), {5- [ (CYCLOPROPYLAMINO) CARBONYL]-3-FLUORO-2- METHYLPHENYL} BORONIC acid (Intermediate 6,100mg), tetrakis (triphenylphosphine) palladium (10mg) and aqueous sodiumhydrogen carbonate (4ML) were mixed in propan-2-ol (8ML) and heated at 90C under nitrogen for 18hrs. The solvents were evaporated from the cooled reaction under vacuum and the residue dissolved as far as possible in ethylacetate. The solution was applied to an SPE (SCX, 10g) and washed with ethyl acetate. The product was eluted from the column with methanol/. 880 ammonia, and the solvents evaporated in vacuo. The residue was redissolved in ethyl acetate and filtered through an SPE (silica, 0.5g). The filtrate was reduced to dryness under vacuum and triturated with ether to give 6-{5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl}-N- (1, 1-dimethylethyl)-3-pyridinecarboxamide. LCMS: MH+ 370, retention time 2.86mins. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Example 46 N-t-Butyl-6-chloro-3-pyridinecarboxamide The title compound was prepared by the same method as that described in Example 26, using 6-chloronicotinic acid and t-butylamine. 1H-NMR(270 MHz, CDCl3) 8.67 (d, J=2.6 Hz, 1H), 8.03 (dd, J=8.3, 2.6 Hz, 1H), 7.39 (dd, J=8.3, 0.7 Hz, 1H), 5.88 (br, 1H), 1.48 (s, 9H) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
63.3 g (94%) | a) N-tert.-Butyl-6-chloro-nicotinamide 25.7 ml (349 mMol) Thionylchloride and 0.5 ml (6.35 mMol) DMF were added to a suspension of 50.0 g (317 mMol) 6-chloro-nicotinic acid in 250 ml toluene and the reaction mixture was heated to 80 C. for 2 hours. After cooling to 10 C., 100.5 ml (952 mMol) tert.-butylamine were added over 40 minutes and stirring was pursued for 30 minutes at the same temperature. 250 ml Aqueous sodium hydroxide 2N were added and the mixture was stirred 30 minutes at room temperature. Dilution with 300 ml water and extraction with ethyl acetate yielded 63.3 g (94%) N-tert.-butyl-6-chloro-nicotinamide as a beige powder of m.p.=108-110 C. MS (ISP): 235 (M+Na+, 36), 213 (M+H+, 100), 157 (M-C4H8, 25). | |
63.3 g (94%) | a N-tert.-Butyl-6-chloro-nicotinamide 25.7 ml (349 mMol) Thionylchloride and 0.5 ml (6.35 mMol) DMF were added to a suspension of 50.0 g (317 mMol) 6-chloro-nicotinic acid in 250 ml toluene and the reaction mixture was heated to 80 C. for 2 hours. After cooling to 10 C., 100.5 ml (952 mMol) tert.-butylamine were added over 40 minutes and stirring was pursued for 30 minutes at the same temperature. 250 ml Aqueous sodium hydroxide 2N were added and the mixture was stirred 30 minutes at room temperature. Dilution with 300 ml water and extraction with ethyl acetate yielded 63.3 g (94%) N-tert.-butyl-6-chloro-nicotinamide as a beige powder of m.p. =108-110 C. MS (ISP): 235 (M+Na+, 36), 213 (M+H+, 100), 157 (M-C4H8, 25). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
6.3 g (90%) | In tetrahydrofuran; methanol; | b) N-tert.-Butyl-6-chloro-4-o-tolyl-nicotinamide 92 ml (92 mMol) o-Tolylmagnesium chloride solution (1M in THF) were added over 15 minutes to a solution of 5.0 g (23 mMol) <strong>[115309-58-5]N-tert.-butyl-6-chloro-nicotinamide</strong> in 25 ml THF cooled to 0 C. The reaction mixture was stirred 18 hours at 30 C. and cooled again to 0 C. 5.6 ml (138 mMol) Methanol were added over 30 minutes, stirring was pursued for 10 minutes and 6.3 g (27 mMol) 2,3-dichloro-5,6-dicyano-1,4-benzoquinone were added. After 1 hour at room temperature, the reaction mixture was concentrated to 50 g under reduced pressure, heated to 50 C. and 100 ml tert.-butyl-methylether were added. The resulting suspension was refluxed for 30 minutes, cooled to room temperature and, after 1 hour, filtered off. The filtrate was concentrated and dried under high vacuum to yield 6.3 g (90%) of N-tert.-butyl-6-chloro-4-o-tolyl-nicotinamide as an orange foam. MS (ISP): 303 (M+H+, 100), 247 (M-C4H8, 10). |
6.3 g (90%) | In tetrahydrofuran; methanol; | b N-tert.-Butyl-6-chloro-4-o-tolyl-nicotinamide 92 ml (92 mMol) o-Tolylmagnesium chloride solution (1M in THF) were added over 15 minutes to a solution of 5.0 g (23 mMol) <strong>[115309-58-5]N-tert.-butyl-6-chloro-nicotinamide</strong> in 25 ml THF cooled to 0 C. The reaction mixture was stirred 18 hours at 30 C. and cooled again to 0 C. 5.6 ml (138 mMol) Methanol were added over 30 minutes, stirring was pursued for 10 minutes and 6.3 g (27 mMol) 2,3-dichloro-5,6-dicyano-1,4-benzoquinone were added. After 1 hour at room temperature, the reaction mixture was concentrated to 50 g under reduced pressure, heated to 50 C. and 100 ml tert.-butyl-methylether were added. The resulting suspension was refluxed for 30 minutes, cooled to room temperature and, after 1 hour, filtered off. The filtrate was concentrated and dried under high vacuum to yield 6.3 g (90%) of N-tert.-butyl-6-chloro-4-o-tolyl-nicotinamide as an orange foam. MS (ISP): 303 (M+H+, 100), 247 (M-C4H8, 10). |
Tags: 115309-58-5 synthesis path| 115309-58-5 SDS| 115309-58-5 COA| 115309-58-5 purity| 115309-58-5 application| 115309-58-5 NMR| 115309-58-5 COA| 115309-58-5 structure
A132866 [342417-04-3]
N-(tert-Butyl)-6-chloro-4-(o-tolyl)nicotinamide
Similarity: 0.90
A140133 [54864-83-4]
6-Chloro-N,N-dimethylnicotinamide
Similarity: 0.90
A409955 [724726-05-0]
2-(2-Chloropyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one
Similarity: 0.79
A136174 [182224-71-1]
N-Benzyl-2,6-dichloroisonicotinamide
Similarity: 0.76
A132866 [342417-04-3]
N-(tert-Butyl)-6-chloro-4-(o-tolyl)nicotinamide
Similarity: 0.90
A140133 [54864-83-4]
6-Chloro-N,N-dimethylnicotinamide
Similarity: 0.90
A409955 [724726-05-0]
2-(2-Chloropyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one
Similarity: 0.79
A307951 [6265-73-2]
N-(2-Hydroxyethyl)nicotinamide
Similarity: 0.77
A132866 [342417-04-3]
N-(tert-Butyl)-6-chloro-4-(o-tolyl)nicotinamide
Similarity: 0.90
A140133 [54864-83-4]
6-Chloro-N,N-dimethylnicotinamide
Similarity: 0.90
A307951 [6265-73-2]
N-(2-Hydroxyethyl)nicotinamide
Similarity: 0.77
A136174 [182224-71-1]
N-Benzyl-2,6-dichloroisonicotinamide
Similarity: 0.76
A132866 [342417-04-3]
N-(tert-Butyl)-6-chloro-4-(o-tolyl)nicotinamide
Similarity: 0.90
A140133 [54864-83-4]
6-Chloro-N,N-dimethylnicotinamide
Similarity: 0.90
A409955 [724726-05-0]
2-(2-Chloropyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one
Similarity: 0.79
A307951 [6265-73-2]
N-(2-Hydroxyethyl)nicotinamide
Similarity: 0.77
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :
Total Compounds: mg
The concentration of the dissolution solution you need to prepare is mg/mL