Home Cart Sign in  
Chemical Structure| 585544-30-5 Chemical Structure| 585544-30-5

Structure of 585544-30-5

Chemical Structure| 585544-30-5

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 585544-30-5 ]

CAS No. :585544-30-5
Formula : C11H13BFNO3
M.W : 237.04
SMILES Code : CC1=C(F)C=C(C(NC2CC2)=O)C=C1B(O)O

Safety of [ 585544-30-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 585544-30-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 585544-30-5 ]

[ 585544-30-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 115309-58-5 ]
  • [ 585544-30-5 ]
  • 6-{5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl}-N-(1,1-dimethylethyl)-3-pyridinecarboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate; In water; isopropyl alcohol; at 90℃; for 18h; Intermediate 9: 6- 5-R (CVCLOPROPYLAMINO) CARBONVLL-3-FLUORO-2-METHVLPHENVL-N- (1, 1- DIMETHVLETHVL)-3-PVRIDINECARBOXAMIDE; N-TERTBUTYL-6-CHLORONICOTINAMIDE (100MG), {5- [ (CYCLOPROPYLAMINO) CARBONYL]-3-FLUORO-2- METHYLPHENYL} BORONIC acid (Intermediate 6,100mg), tetrakis (triphenylphosphine) palladium (10mg) and aqueous sodiumhydrogen carbonate (4ML) were mixed in propan-2-ol (8ML) and heated at 90C under nitrogen for 18hrs. The solvents were evaporated from the cooled reaction under vacuum and the residue dissolved as far as possible in ethylacetate. The solution was applied to an SPE (SCX, 10g) and washed with ethyl acetate. The product was eluted from the column with methanol/. 880 ammonia, and the solvents evaporated in vacuo. The residue was redissolved in ethyl acetate and filtered through an SPE (silica, 0.5g). The filtrate was reduced to dryness under vacuum and triturated with ether to give 6-{5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl}-N- (1, 1-dimethylethyl)-3-pyridinecarboxamide. LCMS: MH+ 370, retention time 2.86mins.
 

Historical Records

Technical Information

Categories