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Chemical Structure| 100-09-4 Chemical Structure| 100-09-4
Chemical Structure| 100-09-4

p-Anisic acid

CAS No.: 100-09-4

p-Anisic acid (4-Methoxybenzoic acid) is one of the isomers of anisic acid, with anti-bacterial and antiseptic properties.

Synonyms: 4-Methoxybenzoic acid; Draconic acid; NSC 32742

4.5 *For Research Use Only !

Cat. No.: A143500 Purity: 98%

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Product Citations

Product Citations

Siriboe, Mary G ; Vargas, David A ; Fasan, Rudi ;

Abstract: Chiral cyclopropanols are highly desirable building blocks for medicinal chemistry, but the stereoselective synthesis of these molecules remains challenging. Here, a novel strategy is reported for the diastereo- and enantioselective synthesis of cyclopropanol derivatives via the biocatalytic asymmetric cyclopropanation of vinyl esters with ethyl diazoacetate (EDA). A dehaloperoxidase enzyme from Amphitrite ornata was repurposed to catalyze this challenging cyclopropanation reaction, and its activity and stereoselectivity were optimized via protein engineering. Using this system, a broad range of electron-deficient vinyl esters were efficiently converted to the desired cyclopropanation products with up to 99.5:0.5 diastereomeric and enantiomeric ratios. In addition, the engineered dehaloperoxidase-based biocatalyst is able to catalyze a variety of other abiological carbene transfer reactions, including N−H/S−H carbene insertion with EDA as well as cyclopropanation with diazoacetonitrile, thus adding to the multifunctionality of this enzyme and defining it as a valuable new scaffold for the development of novel carbene transferases.

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Product Details of p-Anisic acid

CAS No. :100-09-4
Formula : C8H8O3
M.W : 152.15
SMILES Code : O=C(O)C1=CC=C(OC)C=C1
Synonyms :
4-Methoxybenzoic acid; Draconic acid; NSC 32742
MDL No. :MFCD00002542
InChI Key :ZEYHEAKUIGZSGI-UHFFFAOYSA-N
Pubchem ID :7478

Safety of p-Anisic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of p-Anisic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 100-09-4 ]
  • Downstream synthetic route of [ 100-09-4 ]

[ 100-09-4 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 100-09-4 ]
  • [ 133865-89-1 ]
References: [1] Patent: CN107915657, 2018, A, .
 

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