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Chemical Structure| 34702-96-0 Chemical Structure| 34702-96-0

Structure of 34702-96-0

Chemical Structure| 34702-96-0

Ethyl (1S,2S)-2-phenylcyclopropane-1-carboxylate

CAS No.: 34702-96-0

4.5 *For Research Use Only !

Cat. No.: A549222 Purity: 97%

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Product Citations

Product Citations

Siriboe, Mary G ; Vargas, David A ; Fasan, Rudi ;

Abstract: Chiral cyclopropanols are highly desirable building blocks for medicinal chemistry, but the stereoselective synthesis of these molecules remains challenging. Here, a novel strategy is reported for the diastereo- and enantioselective synthesis of cyclopropanol derivatives via the biocatalytic asymmetric cyclopropanation of vinyl esters with ethyl diazoacetate (EDA). A dehaloperoxidase enzyme from Amphitrite ornata was repurposed to catalyze this challenging cyclopropanation reaction, and its activity and stereoselectivity were optimized via protein engineering. Using this system, a broad range of electron-deficient vinyl esters were efficiently converted to the desired cyclopropanation products with up to 99.5:0.5 diastereomeric and enantiomeric ratios. In addition, the engineered dehaloperoxidase-based biocatalyst is able to catalyze a variety of other abiological carbene transfer reactions, including N−H/S−H carbene insertion with EDA as well as cyclopropanation with diazoacetonitrile, thus adding to the multifunctionality of this enzyme and defining it as a valuable new scaffold for the development of novel carbene transferases.

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Product Details of [ 34702-96-0 ]

CAS No. :34702-96-0
Formula : C12H14O2
M.W : 190.24
SMILES Code : O=C([C@@H]1[C@@H](C2=CC=CC=C2)C1)OCC
MDL No. :MFCD01877627
InChI Key :SRGUIJLJERBBCM-MNOVXSKESA-N
Pubchem ID :816742

Safety of [ 34702-96-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
 

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