As the most studied and widely used chiral ligands, chiral phosphoramidite ligands have been rapidly developed in recent decades due to their simple synthesis, easy modification, and the ability to achieve excellent results in multiple reactions.

Phosphoramidites belong to phosphite derived amides, is an important class of trivalent phosphine ligands. Phosphoramidites differ from other trivalent phosphine ligands in that the structure of phosphoramidites contains a P-N bond and two P-O bonds with a pair of lone pair electrons on the phosphorus atom, which also becomes a possible coordination site when they are coordinated with metals. Phosphoramidite ligands can be divided into phosphanylidene groups and amine groups, and four typical phosphanylidene backbone structures are listed below: specifically, binaphthylenediphenol (BINOL) backbone, octahydrobinaphthylenediphenol (H8-BINOL) backbone, biphenol (BIPOL) backbone, and TADDOL backbone, as detailed in below:

BINOL Backbone General Structure
A1375407	A495505	A1006117
A1005842	A1002597	A1188217
A796324	A385864	A1006200
BINOL Backbone General Structure
A413238	A264873	A1220018
A1220021	A1220038	A103673
A1220035	A1220017	A1220036
BIPOL Backbone	General Structure	A1371112
TADDOL Backbone General Structure
A1274634 A1220049 A651597 A146234

Phosphoramidite ligands can be involved in many different asymmetric catalyses and can achieve better reaction results. In the following, the application of phosphoramidite ligands in many different asymmetric catalyses will be briefly described in terms of different reaction types.