Alternatived Products of [ 804567-14-4 ]
Product Details of [ 804567-14-4 ]
CAS No. : | 804567-14-4 |
MDL No. : | N/A |
Formula : |
C25H30NO2P
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | QVDNEBLZNKUPFA-UHFFFAOYSA-N |
M.W : |
407.49
|
Pubchem ID : | 11315768 |
Synonyms : |
|
Safety of [ 804567-14-4 ]
Application In Synthesis of [ 804567-14-4 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 804567-14-4 ]
- 1
-
[ CAS Unavailable ]
-
[ 159496-93-2 ]
-
[ 1221902-03-9 ]
Yield | Reaction Conditions | Operation in experiment |
|
With triethylamine In toluene at 20℃; for 2h; |
|
|
With triethylamine In toluene at 20℃; for 2h; |
|
|
With phosphoryl oxychloride on N,N-dimethylformamide; triethylamine In toluene at 90℃; for 3h; |
General procedure: A 25 mL round-bottom flask was charged with 2 mmol of corresponding amine, 3 mmol of Et3N and 10 ml toluene. The above made chlorophosphite was dissolved in 5 mL toluene and was transfered to the reaction flask. The mixture was stirred for 3 h. The solid was removed by filtration. The filtrate was concentrated and purified by flash column chromatography (EtOAc/Hex) to yield desired ligand (yield: 75-95%). |
Reference:
[1]Duursma, Ate; Boiteau, Jean-Guy; Lefort, Laurent; Boogers, Jeroen A. F.; De Vries, Andre H. M.; De Vries, Johannes G.; Minnaard, Adriaan J.; Feringa, Ben L.
[Journal of Organic Chemistry, 2004, vol. 69, # 23, p. 8045 - 8052]
[2]Duursma, Ate; Lefort, Laurent; Boogers, Jeroen A.F.; De Vries, Andre H.M.; De Vries, Johannes G.; Minnaard, Adriaan J.; Feringa, Ben L.
[Organic and Biomolecular Chemistry, 2004, vol. 2, # 12, p. 1682 - 1684]
[3]Gao, Guorui; Du, Shaozhi; Yang, Yang; Lei, Xue; Huang, Haizhou; Chang, Mingxin
[Molecules, 2018, vol. 23, # 9]
- 2
-
[ 65355-14-8 ]
-
[ 1221902-03-9 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: PCl3 / 6 h / Heating
2: triethylamine / toluene / 2 h / 20 °C |
|
|
Multi-step reaction with 2 steps
1: phosphorus trichloride / 1-methyl-pyrrolidin-2-one / 0.25 h / 90 °C / Schlenk technique; Inert atmosphere
2: triethylamine; phosphoryl oxychloride on N,N-dimethylformamide / toluene / 3 h / 90 °C |
|
Reference:
[1]Duursma, Ate; Boiteau, Jean-Guy; Lefort, Laurent; Boogers, Jeroen A. F.; De Vries, Andre H. M.; De Vries, Johannes G.; Minnaard, Adriaan J.; Feringa, Ben L.
[Journal of Organic Chemistry, 2004, vol. 69, # 23, p. 8045 - 8052]
[2]Gao, Guorui; Du, Shaozhi; Yang, Yang; Lei, Xue; Huang, Haizhou; Chang, Mingxin
[Molecules, 2018, vol. 23, # 9]
- 3
-
[ 18531-94-7 ]
-
[ 1221902-03-9 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 3 steps
1: hydrogen; Pd/C / ethanol / 16 h / 70 °C / 37503.8 Torr / Autoclave
2: phosphorus trichloride / 1-methyl-pyrrolidin-2-one / 0.25 h / 90 °C / Schlenk technique; Inert atmosphere
3: triethylamine; Phosphoryl oxychloride / toluene / 3 h / 90 °C |
|