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Chemical Structure| 540-72-7 Chemical Structure| 540-72-7
Chemical Structure| 540-72-7

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Sodium thiocyanate can reduce pro-inflammatory cytokine IL-6 levels, increase anti-inflammatory cytokine IL-10 levels, and significantly decrease ROS formation, playing an important role in anti-inflammatory research.

Synonyms: Thiocyanate sodium; Sodium rhodanide; Sodium sulfocyanate

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Product Details of Sodium thiocyanate

CAS No. :540-72-7
Formula : CNNaS
M.W : 81.07
SMILES Code : [S-]C#N.[Na+]
Synonyms :
Thiocyanate sodium; Sodium rhodanide; Sodium sulfocyanate
MDL No. :MFCD00011123
InChI Key :VGTPCRGMBIAPIM-UHFFFAOYSA-M
Pubchem ID :516871

Safety of Sodium thiocyanate

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302+H312+H332-H318-H412
Precautionary Statements:P261-P264-P270-P271-P273-P280-P301+P312+P330-P302+P352+P312-P304+P340+P312-P305+P351+P338+P310-P501

Application In Synthesis of Sodium thiocyanate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 540-72-7 ]
  • Downstream synthetic route of [ 540-72-7 ]

[ 540-72-7 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 540-72-7 ]
  • [ 540-37-4 ]
  • [ 16582-58-4 ]
References: [1] Die Pharmazie, 1967, vol. 22, # 6, p. 229 - 233.
  • 2
  • [ 540-72-7 ]
  • [ 150-13-0 ]
  • [ 93-85-6 ]
YieldReaction ConditionsOperation in experiment
42% With bromine In methanol at -10 - -5℃; for 2 h; Synthesis of 2-aminobenzothiazole-6-carbolic Acid(2)NaSCN (65 g, 0.8 mol) was added to a suspension of commercially available 4-amino-benzoic acid (1, 100 g, 0.73 mol) in MeOH followed by the addition of Br2 (38 ml, 0.73 mol) in portions. The above solution was allowed to cool to -10° C. and stirred for 2 h while keeping the inner temperature below -5° C. The precipitate was then filtered and suspended in 350 ml of 1 M HCl. The suspension was heated to reflux for 30 min. After immediate filtration, 150 ml concd HCl was added to the hot filtrate to give 70 g (yield 42percent) of 2-amino-benzothiazole-6-carboxylic acid (2) (as a white solid), which was dried and used without further purification.
References: [1] Patent: US2009/123373, 2009, A1, . Location in patent: Page/Page column 14-15.
 

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