Structure of Adapalene
CAS No.: 106685-40-9
Adapalene is an agonist of RAR-β (Kd = 34 nM), RAR-γ (Kd = 130 nM) and RXR which is used in the treatment of acne.
Synonyms: CD271
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Josephine Bicknell ; Sidhaesh A. Agarwal ; Kyle J. Petersen ; Jesus Daniel Loya ; Nicholas Lutz ; Paulina M. Sittinger , et al.
Abstract: Lipophilic aggregation using adamantanes is a widely exploited molecular property in medicinal and materials chemistry. Adamantanes are traditionally installed to molecular units via covalent bonds. However, the noncovalent installation of adamantanes has been relatively underexplored and presents the potential to bring properties associated with adamantanes to molecules without affecting their intrinsic properties (e.g., pharmacophores). Here, we systematically study a series of adamantanecarboxylic acids with varying substitution levels of methyl groups and their cocrystals with bipyridines. Specifically, single-crystal X-ray diffraction shows that while the directionality of single-component adamantanes is notably sensitive to changes in methyl substitution, hydrogen-bonded cocrystals with bipyridines show consistent and robust packing due to π-stacking predominance. Our observations are supported by Hirshfeld surface and energy framework analyses. The applicability of cocrystal formation of adamantanes bearing carboxylic acids was used to generate the first cocrystals of adapalene, an adamantane-bearing retinoid used for treating acne vulgaris. We envisage our study to inspire noncovalent (i.e., cocrystal) installation of adamantanes to generate lipophilic aggregation in multicomponent systems.
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Purchased from AmBeed: 106685-40-9 ; 828-51-3 ; 14670-94-1 ; 2632-99-7 ; 4916-57-8 ; 15291-66-4
CAS No. : | 106685-40-9 |
Formula : | C28H28O3 |
M.W : | 412.52 |
SMILES Code : | C4=C(C12CC3CC(C1)CC(C2)C3)C(=CC=C4C6=CC5=CC=C(C=C5C=C6)C(O)=O)OC |
Synonyms : |
CD271
|
MDL No. : | MFCD03106112 |
InChI Key : | LZCDAPDGXCYOEH-UHFFFAOYSA-N |
Pubchem ID : | 60164 |
GHS Pictogram: | ![]() |
Signal Word: | Warning |
Hazard Statements: | H302 |
Precautionary Statements: | P280-P305+P351+P338 |
In Vitro:
Concentration | Treated Time | Description | References |
DLD1 human colon cancer cells | 1, 3, 10, 30 µM | 6, 12, 24, 48, 72 hours | Evaluate the effect of Adapalene on the viability of DLD1 cells, results showed Adapalene significantly inhibited cell proliferation with IC50 of 4.43 µM | PMC4626183 |
LoVo human colon cancer cells | 1, 3, 10, 30 µM | 6, 12, 24, 48, 72 hours | Evaluate the effect of Adapalene on the viability of LoVo cells, results showed Adapalene significantly inhibited cell proliferation with IC50 of 7.135 µM | PMC4626183 |
In Vivo:
Administration | Dosage | Frequency | Description | References |
Mice | HCC tumor model | Oral | 10 mg/kg | Twice administration | ADA treatment significantly reduced tumor formation and tumor growth, and increased the survival rate of snord88b KO mice | PMC11306581 |
BALB/C nude mice | DLD1 human colon cancer xenograft model | Oral | 15, 20, 65, 100 mg/kg | Once daily for 21 days | Evaluate the effect of Adapalene on DLD1 xenograft tumor growth, results showed Adapalene significantly inhibited tumor growth, with 20 mg/kg dose comparable to oxaliplatin 40 mg/kg | PMC4626183 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT02731105 | Acne Vulgaris | Phase 4 | Completed | - | Germany ... More >> Universitätsklinikum Carl Gustav Carus; Klinik und Poliklinik für Dermatologie Dresden, Saxony, Germany, 01307 Less << |
NCT02620813 | Acne Vulgaris | Phase 4 | Recruiting | May 2019 | United States, California ... More >> Dermatology Research Area Recruiting Davis, California, United States, 95616 Contact: Negar Foolad, MAS 916-734-1509 nfoolad@ucdavis.edu Contact: Lauren A Hassoun, BS 916-734-6550 lahassoun@ucdavis.edu Principal Investigator: Raja K Sivamani, MD UC Davis Department of Dermatology Recruiting Sacramento, California, United States, 95816 Contact: Raja Sivamani, MD rajasivamani@gmail.com Less << |
NCT02442817 | Schizophrenia | Phase 4 | Unknown | May 2017 | United States, Nevada ... More >> University of Nevada School of Medicine Recruiting Reno, Nevada, United States, 89503 Contact: Brian Kirkpatrick, MD 775-682-8449 bkirkpatrick@medicine.nevada.edu Principal Investigator: Brian Kirkpatrick, MD Less << |
NCT02192632 | Facial Acne L... More >>ocal Adverse Effects Less << | Not Applicable | Completed | - | Korea, Republic of ... More >> Dermatology, Seoul National University Seoul, Joungro, Korea, Republic of, 110-744 Less << |
NCT00887484 | Acne Vulgaris | Phase 4 | Completed | - | Argentina ... More >> Centro de Investigación y Prevencion de Enfermidades Cardiovasculares Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, 1119 Hospital Italiano de Buenos Aires Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, 1181 ACH LUMIPIEL - Centro Dermatológico Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, 1181 ACH Buenos Aires Skin Ciudad de Buenos Aires, Buenos Aires, Argentina, C1055AAO Less << |
NCT02180425 | - | Completed | - | United States, California ... More >> Dermatology Research Area Davis, California, United States, 95616 UC Davis Department of Dermatology Sacramento, California, United States, 95816 Less << | |
NCT00887484 | - | Completed | - | - | |
NCT01106807 | Acne | Phase 2 | Completed | - | United States, Arkansas ... More >> Burke Pharmaceuticals Hot Springs, Arkansas, United States United States, Kentucky Dermatology Specialist PSC Louisville, Kentucky, United States, 40202 United States, Michigan Grekin Skin Institute Warren, Michigan, United States, 48088 United States, New Jersey TKL Research Rochelle Park, New Jersey, United States, 07662 United States, North Carolina Piedmont Medical Research Winston-Salem, North Carolina, United States, 27103 United States, North Dakota Cetero Fargo, North Dakota, United States, 58104 United States, Texas Derm Research, Inc Austin, Texas, United States, 78759 J & S Studies Bryan, Texas, United States, 77845 United States, Virginia Education and Research Foundation, Inc Lynchburg, Virginia, United States, 24501 Less << |
NCT01474590 | Acne | Phase 3 | Completed | - | Canada ... More >> Galderma investigational site Ajax, Canada Galderma investigational site Barrie, Canada Galderma investigational site Calgary, Canada Galderma investigational site Edmonton, Canada Galderma investigational site Halifax, Canada Galderma investigational site Hamilton, Canada Galderma investigational site Markham, Canada Galderma investigational site Montreal, Canada Galderma investigational site Newmarket, Canada Galderma investigational site Oakville, Canada Galderma investigational site Oshawa, Canada Galderma investigational site Peterborough, Canada Galderma investigational site Quebec city, Canada Galderma investigational site Richmond Hill, Canada Galderma investigational site Saint-Hyacinthe, Canada Galderma investigational site Saint-John's, Canada Galderma investigational site Saskatoon, Canada Galderma investigational site St John's, Canada Galderma investigational site Sudbury, Canada Galderma investigational site Surrey, Canada Galderma investigational site Toronto, Canada Galderma investigational site Vancouver, Canada Galderma investigational site Waterloo, Canada Galderma investigational site Windsor, Canada Galderma investigational site Winnipeg, Canada Galderma investigational site Woodbridge, Canada Less << |
NCT01474590 | - | Completed | - | - | |
NCT01188538 | Acne Vulgaris | Phase 4 | Completed | - | Poland ... More >> Dermatologiczna Klinika Uzdrowiskowa Iwonicz Zdrój, Poland, 38-440 Less << |
NCT02073448 | Acne Vulgaris | Phase 3 | Completed | - | Japan ... More >> Galderma investigational site Chitose, Hokkaido, Japan Galderma investigational site Kitami, Hokkaido, Japan Galderma investigational site Sapporo, Hokkaido, Japan Galderma investigational site Yokohama, Kanagawa, Japan Galderma investigational site Kurashiki, Okayama, Japan Galderma investigational site Daito, Osaka, Japan Galderma investigational site Neyagawa, Osaka, Japan Galderma investigational site Sakai, Osaka, Japan Galderma investigational site Adachi, Tokyo, Japan Galderma investigational site Setagaya, Tokyo, Japan Galderma investigational site Kagoshima, Japan Galderma investigational site Osaka, Japan Galderma investigational site Saitama, Japan Less << |
NCT02557399 | Acne Vulgaris | Phase 4 | Completed | - | Japan ... More >> GSK Investigational Site Aichi, Japan, 453-0054 GSK Investigational Site Aichi, Japan, 464-0821 GSK Investigational Site Aichi, Japan, 468-0011 GSK Investigational Site Chiba, Japan, 272-0143 GSK Investigational Site Chiba, Japan, 273-0046 GSK Investigational Site Kanagawa, Japan, 221-0825 GSK Investigational Site Kanagawa, Japan, 242-0007 GSK Investigational Site Osaka, Japan, 560-0824 GSK Investigational Site Osaka, Japan, 572-0838 GSK Investigational Site Osaka, Japan, 580-0032 GSK Investigational Site Osaka, Japan, 593-8324 GSK Investigational Site Saitama, Japan, 333-0055 GSK Investigational Site Tokyo, Japan, 133-0057 GSK Investigational Site Tokyo, Japan, 143-0023 GSK Investigational Site Tokyo, Japan, 169-0075 Less << |
NCT02557399 | - | Completed | - | - | |
NCT01188538 | - | Completed | - | - | |
NCT02073448 | - | Completed | - | - | |
NCT03626298 | Acne Vulgaris | Phase 4 | Completed | - | - |
NCT02525549 | Acne | Phase 3 | Completed | - | - |
NCT02709876 | Retinitis Pigmentosa | Phase 1 Phase 2 | Active, not recruiting | March 2021 | Jordan ... More >> Stem Cells Arabia Amman, Jordan, 11953 Less << |
NCT00757523 | Acne Vulgaris | Phase 4 | Completed | - | Germany ... More >> GSK Investigational Site Berlin,, Germany, 14169 GSK Investigational Site Berlin, Germany, 14052 GSK Investigational Site Bonn, Germany, 53105 GSK Investigational Site Dessau, Germany, 06847 GSK Investigational Site Duelmen, Germany, 48249 GSK Investigational Site Essen, Germany, 45122 GSK Investigational Site Frankfurt, Germany, 60590 GSK Investigational Site Giessen, Germany, 35392 GSK Investigational Site Halle, Germany, 06097 GSK Investigational Site Hamburg, Germany, 20246 GSK Investigational Site Kiel, Germany, 24148 GSK Investigational Site Landau, Germany, 76829 GSK Investigational Site Magdeburg, Germany, 39120 GSK Investigational Site München, Germany, 80337 GSK Investigational Site München, Germany, 80802 GSK Investigational Site Münster, Germany, 48149 GSK Investigational Site Potsdam, Germany, 14469 Less << |
NCT01910064 | - | Completed | - | - | |
NCT02755545 | Acne | Phase 4 | Completed | - | United States, Texas ... More >> Stephens & Associates, Inc. Texas Research Center Richardson, Texas, United States Less << |
NCT01618773 | - | Completed | - | - | |
NCT00437151 | Acne | Phase 4 | Completed | - | United States, North Carolina ... More >> Wake Forest School of Medicine Winston-Salem, North Carolina, United States, 27157 Less << |
NCT01220102 | - | Completed | - | - | |
NCT00919191 | Acne Vulgaris | Phase 4 | Completed | - | United States, Pennsylvania ... More >> Skin Study Center Broomall, Pennsylvania, United States, 19008 Less << |
NCT03393494 | Acne Vulgaris | Phase 3 | Recruiting | November 2018 | United States, North Carolina ... More >> Dermatology Consultants Recruiting High Point, North Carolina, United States, 27262 Contact: Vicki Ellis 336-841-2044 Less << |
NCT02338544 | - | Completed | - | - | |
NCT00971282 | Healthy Skin | Phase 4 | Completed | - | Singapore ... More >> national Skin Center Singapore, Singapore Less << |
NCT00719121 | Cutaneous Inflammation | Phase 1 | Completed | - | Belgium ... More >> Department of DermatopathologyCentre Hospitalier Universitaire du Sart Tilman Liege, Belgium, B-4000 Less << |
NCT00971282 | - | Completed | - | - | |
NCT03573115 | Acne Vulgaris ... More >> Microparticles Less << | Not Applicable | Active, not recruiting | August 1, 2020 | Denmark ... More >> Bispebjerg Hospital, Department of Dermatology Copenhagen, Denmark, 2400 Less << |
NCT00237978 | Acne Papulopustulosa | Phase 4 | Unknown | September 2009 | Germany ... More >> Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden Recruiting Dresden, Sachsen, Germany, 01307 Contact: Roland Aschoff, MD 0049-351-458 ext 2007 Roland.Aschoff@mailbox.tu-dresden.de Less << |
NCT03457636 | Acne | Phase 4 | Active, not recruiting | January 2019 | United States, Kentucky ... More >> Skin Sciences, PLLC Louisville, Kentucky, United States, 40014 Less << |
NCT00952523 | - | Completed | - | - | |
NCT03076320 | Acne Vulgaris Superficial Mixe... More >>d Comedonal and Inflammatory Less << | Phase 1 Phase 2 | Recruiting | March 31, 2019 | Mexico ... More >> Hospital Civil de Guadalajara Fray Antonio Alcalde Recruiting Guadalajara, Jalisco, Mexico, 44280 Contact: Yocasta Martínez Alvarado, MD +52 (33) 14794863 yocastadermatologia@gmail.com Contact: Marisol Ramirez Padilla, MD +52 (33) 31563006 yeuxenor@hotmail.com Principal Investigator: Yocasta Martínez-Alvarado, MD Sub-Investigator: Marisol Ramirez-Padilla, MD Less << |
NCT00952523 | Acne Vulgaris | Phase 4 | Completed | - | United States, Pennsylvania ... More >> Skin Study Center Broomall, Pennsylvania, United States, 19008 Less << |
NCT01504204 | - | Completed | - | - | |
NCT03585140 | Acne Vulgaris ... More >> Diet Modification Less << | Not Applicable | Completed | - | - |
NCT01504204 | Acne Vulgaris | Phase 4 | Completed | - | United States, North Carolina ... More >> Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27104 Less << |
NCT02249104 | - | Completed | - | - | |
NCT02249104 | Acne Vulgaris | Phase 4 | Completed | - | United States, Texas ... More >> Pflugerville Dermatology Clinical Research Pflugerville, Texas, United States, 78660 Less << |
NCT01910064 | Acne Vulgaris | Phase 3 | Completed | - | Japan ... More >> Galderma investigational site Urayasu, Chiba, Japan Galderma investigational site Kawasaki, Kanagawa, Japan Galderma investigational site Yamato, Kanagawa, Japan Galderma investigational site Yokohama, Kanagawa, Japan Galderma investigational site Kumagaya, Saitama, Japan Galderma investigational site Chiyoda, Tokyo, Japan Galderma investigational site Koto, Tokyo, Japan Galderma investigational site Machida, Tokyo, Japan Galderma investigational site Musashino, Tokyo, Japan Galderma investigational site Ota, Tokyo, Japan Galderma investigational site Shibuya, Tokyo, Japan Galderma investigational site Shinjuku, Tokyo, Japan Galderma investigational site Suginami, Tokyo, Japan Galderma investigational site Tachikawa, Tokyo, Japan Galderma investigational site Koto, Tpkyo, Japan Galderma investigational site Fukuoka, Japan Less << |
NCT00964223 | Acne Vulgaris | Phase 4 | Completed | - | United States, Maryland ... More >> Aesthetics, Skin Care & Dermasurgery Rockville, Maryland, United States, 20850 United States, Michigan Grekin Skin Institute Warren, Michigan, United States, 48088 Less << |
NCT00907101 | - | Completed | - | - | |
NCT00964223 | - | Completed | - | - | |
NCT00160394 | Acne Vulgaris | Phase 4 | Completed | - | Poland ... More >> Prof A Langner Warsaw, Poland, 00710 United Kingdom Dr V Goulden Leeds, United Kingdom, LS1 3EX Dr A Chu London, United Kingdom, W12 0NN Less << |
NCT00714714 | Acne Vulgaris | Phase 4 | Completed | - | United States, Pennsylvania ... More >> A J&J CPPW Investigational Site Broomall, Pennsylvania, United States, 19008 Less << |
NCT02899000 | Acne Vulgaris | Phase 4 | Completed | - | United States, Texas ... More >> Galderma Laboratories, LP Fort Worth, Texas, United States, 76177 Less << |
NCT00919191 | - | Completed | - | - | |
NCT01014689 | Acne Vulgaris | Phase 3 | Completed | - | Australia ... More >> Galderma Investigator site Camberra, Australia Galderma Investigator site Kogarah, Australia Galderma Investigator site Melbourne, Australia Galderma Investigator site Sydney, Australia Belgium Galderma Investigator site Bruxelles, Belgium Galderma Investigator site Gent, Belgium Galderma Investigator site Leuven, Belgium Brazil Galderma Investigator site Belo Horizonte, Brazil Galderma Investigator site Sao Paulo, Brazil France Galderma Investigator site Bordeaux, France Galderma Investigator site Cannes, France Galderma Investigator site Martigues, France Galderma Investigator site Nantes, France Galderma Investigator site Pantin, France Galderma Investigator site Pierre Benite, France Germany Galderma Investigator site Cuxhaven, Germany Galderma Investigator site Darmstadt, Germany Galderma Investigator site Frankfurt, Germany Italy Galderma Investigator site Catania, Italy Galderma Investigator site Ferrara, Italy Mexico Galderma Investigator site Mexico city, Mexico Galderma Investigator site Monterrey, Mexico Galderma Investigator site Tlalnepantla, Mexico Galderma Investigator site Zapopan, Mexico Poland Galderma Investigator site Lodz, Poland Sweden Galderma Investigator site Eskilstuna, Sweden Galderma Investigator site Farsta, Sweden Galderma Investigator site Hagersten, Sweden Less << |
NCT00907101 | P Acnes Colonization | Phase 4 | Completed | - | United States, Pennsylvania ... More >> Skin Study Center Broomall, Pennsylvania, United States, 19008 Less << |
NCT00696449 | Acne Vulgaris | Phase 4 | Completed | - | United States, North Carolina ... More >> Wake Forest University Health Sciences Dermatology Winston-Salem, North Carolina, United States, 27157 Less << |
NCT01014689 | - | Completed | - | - | |
NCT00714714 | - | Completed | - | - | |
NCT02651220 | Acne | Phase 3 | Completed | - | United States, Arizona ... More >> Site 103 Mesa, Arizona, United States, 85202 Site 109 Tucson, Arizona, United States, 85712 United States, California Site 112 Anaheim, California, United States, 92804 Site 110 Long Beach, California, United States, 90813 Site 111 Los Angeles, California, United States, 92210 Site 104 San Diego, California, United States, 92108 Site 113 West Covina, California, United States, 91790 United States, Florida Site 101 Brandon, Florida, United States, 33511 Site 119 Jacksonville, Florida, United States, 32256 Site 114 Miami, Florida, United States, 33015 Site 115 Miami, Florida, United States, 33175 Site 116 Miramar, Florida, United States, 33027 United States, Illinois Site 102 Arlington Heights, Illinois, United States, 60005 United States, Indiana Site 105 Carmel, Indiana, United States, 46032 Site 120 New Albany, Indiana, United States, 47150 United States, Nevada Site 107 Henderson, Nevada, United States, 89052 United States, North Carolina Site 106 High Point, North Carolina, United States, 27262 United States, Wisconsin Site 108 Rhinelander, Wisconsin, United States, 54501 Belize Site 117 Belize City, Belize Site 118 Belize City, Belize Less << |
NCT00151541 | Acne Vulgaris | Phase 3 | Completed | - | - |
NCT01387048 | Acne Vulgaris | Phase 4 | Completed | - | Germany ... More >> Clinic for Dermatology and Vereology, Central Hospital Magdeburg Magdeburg, Saxony-Anhalt, Germany, 39120 Less << |
NCT03563365 | Acne Vulgaris | Phase 4 | Recruiting | June 4, 2019 | United States, Pennsylvania ... More >> Yardley Dermatology Associates, PC Recruiting Yardley, Pennsylvania, United States, 19067 Contact: Michelle Clinical Trial Site Manager 215-579-6155 ext 27 msibona@yardleyderm.com Principal Investigator: Richard G Fried, MD, PhD Sub-Investigator: Lauren Sternberg, MD Sub-Investigator: Judith Cenci, MD Sub-Investigator: Priya Dhanaraj, MD Less << |
NCT01245946 | Acne | Phase 2 | Completed | - | Chile ... More >> Departamento de dermatología, Centro Médico San Joaquín, Pontificia Universidad Católica de Chile Santiago, San Joaquín, Chile, 1234 Less << |
NCT01522456 | Acne Vulgaris | Phase 4 | Completed | - | United States, Texas ... More >> Stephens and Associates Dallas, Texas, United States, 75006 Less << |
NCT00696449 | - | Completed | - | - | |
NCT00671749 | Acne Vulgaris | Phase 4 | Completed | - | United States, California ... More >> Center for Dermatology and Laser Surgery Sacramento, California, United States, 95819 United States, Kentucky Derm Research, P.L.L.C. Louisville, Kentucky, United States, 40217 United States, Ohio Brodell Medical Warren, Ohio, United States, 44483 United States, Oregon Northwest Cutaneous Research Specialists Portland, Oregon, United States, 97210 Less << |
NCT00829049 | - | Terminated(Study enrollment wa... More >>s terminated due to company decision before the target enrollment of 220 patients was reached.) Less << | - | - | |
NCT00829049 | Acne Vulgaris | Phase 4 | Terminated(Study enrollment wa... More >>s terminated due to company decision before the target enrollment of 220 patients was reached.) Less << | - | United States, California ... More >> Fremont, California, United States Less << |
NCT02716090 | Acne Vulgaris | Phase 3 | Withdrawn(Due to budget limita... More >>tions, the company decided to withdraw this study.) Less << | - | - |
NCT01425320 | Acne Vulgaris | Phase 1 | Withdrawn(Study was never init... More >>iated due to company decision. No study subjects were ever enrolled or dosed.) Less << | June 2013 | - |
NCT01522456 | - | Completed | - | - | |
NCT00469755 | Acne Vulgaris | Phase 4 | Completed | - | United States, California ... More >> Therapeutics Clinical Research San Diego, California, United States, 92123 United States, Michigan Henry Ford Medical Center-Dept. of Dermatology Detroit, Michigan, United States, 48202 United States, Minnesota Minnesota Clinical Study Center Fridley, Minnesota, United States, 55432 United States, New York State University of New York Downstate Medical Center-Dept. of Dermatology Brooklyn, New York, United States, 11203 United States, Ohio Dermatology Research Associates Cincinnati, Ohio, United States, 45230 United States, Oregon Phoebe Rich, MD & Associates Portland, Oregon, United States, 97210 United States, Pennsylvania Milton S. Hershey Medical Center Center-Div. of Dermatology Hershey, Pennsylvania, United States, 17033-0850 United States, Texas DermResearch, Inc. Austin, Texas, United States, 78759 J & S Studies, Inc. Bryan, Texas, United States, 77802 Stephens & Associates Carrollton, Texas, United States, 75006 United States, Utah Dermatology Research Center Salt Lake City, Utah, United States, 84124 United States, Virginia Virginia Clinical Research, Inc. Norfolk, Virginia, United States, 23507 Less << |
NCT00421993 | Acne Vulgaris | Phase 3 | Completed | - | - |
NCT00441415 | Acne Vulgaris | Phase 3 | Completed | - | United States, California ... More >> Paul YAMAUCHI Santa Monica, California, United States, 90404 United States, Minnesota Steven E. KEMPERS Fridley, Minnesota, United States, 55432 United States, New Mexico Dr Alicia BUCKO Albuquerque, New Mexico, United States, 87106 United States, New York Elisabeth ARTHUR Rochester, New York, United States, 14609 Less << |
NCT01231334 | Acne Vulgaris | Phase 4 | Completed | - | United States, Florida ... More >> Miramar, Florida, United States Less << |
NCT02593383 | Acne | Phase 1 Phase 2 | Unknown | March 2016 | China, Jiangsu ... More >> Institute of Dermatology, Chinese Academy of Medical Sciences Recruiting Nanjing, Jiangsu, China, 210042 Contact: Heng GU, MD Less << |
NCT00421993 | - | Completed | - | - | |
NCT00422240 | Acne Vulgaris | Phase 3 | Completed | - | United States, Texas ... More >> Miller MD San Antonio, Texas, United States, 78229 Less << |
NCT00926367 | - | Completed | - | - | |
NCT01231334 | - | Completed | - | - | |
NCT00446043 | Acne Vulgaris | Phase 3 | Completed | - | United States, Oregon ... More >> Phoebe Rich, MD Portland, Oregon, United States, 97210 Less << |
NCT02709902 | Acne Vulgaris | Phase 1 | Completed | - | - |
NCT00926367 | Acne Vulgaris | Phase 4 | Completed | - | United States, Pennsylvania ... More >> cyberDERM Broomall, Pennsylvania, United States, 19008 Less << |
NCT00883233 | - | Completed | - | - | |
NCT01138735 | Acne | Phase 4 | Completed | - | - |
NCT00671749 | - | Completed | - | - | |
NCT00807014 | Acne Vulgaris | Phase 4 | Completed | - | Spain ... More >> Hospital Germans Trias I Pujol Badalona, Spain, 08916 Hospital del Mar Barcelona, Spain, 08003 Hospital Abente y Lago in La Coruna La Coruna, Spain Hospital Universitario Ramón and Cajal Madrid, Spain, 28034 Hospital Universitario 12 de Octubre Madrid, Spain, 28041 Hospital Clínico Universitario Ntra. Sra. de the Victoria Málaga, Spain, 29010 Clínica Universitaria de Navarra Pamplona, Spain, 31008 Hospital Clínico de Salamanca Salamanca, Spain, 37007 Less << |
NCT00883233 | Acne | Phase 3 | Completed | - | Canada, Ontario ... More >> Galderma Investigational Site Windsor, Ontario, Canada Canada, Quebec Galderma Investigational Site Montreal, Quebec, Canada Less << |
NCT03650361 | Acne Vulgaris | Phase 3 | Recruiting | August 15, 2019 | United States, California ... More >> Unison Center for Clinical Trials Recruiting Sherman Oaks, California, United States, 91403 United States, Florida Moore Clinical Research Institute, Inc. Recruiting Brandon, Florida, United States, 33511 FXM Research Corp. Recruiting Miami, Florida, United States, 33175 FXM Research Miramar Not yet recruiting Miramar, Florida, United States, 33027 Moore Clinical Research Institute, Inc. Recruiting Tampa, Florida, United States, 33609 Moore Clinical Research Institute, Inc. Recruiting Tampa, Florida, United States, 33618 United States, North Carolina Dermatology Consulting Services, PLLC Recruiting High Point, North Carolina, United States, 27262 United States, Texas 3A Research, LLC Recruiting El Paso, Texas, United States, 79902 3A Research, LLC Recruiting El Paso, Texas, United States, 79925 Belize FXM Research International Not yet recruiting Belize City, Belize FXM Research International Recruiting Belize City, Belize Less << |
NCT01138735 | - | Completed | - | - | |
NCT00660985 | Acne Vulgaris | Phase 4 | Completed | - | United States, Texas ... More >> DermResearch, Inc. Austin,, Texas, United States, 78759 J&S Studies, Inc. College Station,, Texas, United States, 77845 Less << |
NCT00807014 | - | Completed | - | - | |
NCT00688064 | Severe Acne Vulgaris | Phase 3 | Completed | - | - |
NCT00688064 | - | Completed | - | - | |
NCT00660985 | - | Completed | - | - | |
NCT00687908 | Acne | Phase 3 | Completed | - | - |
NCT00687908 | - | Completed | - | - | |
NCT03650881 | Acne | Not Applicable | Not yet recruiting | December 2020 | - |
NCT00647556 | Photoaging | Phase 3 | Completed | - | United States, Michigan ... More >> University of Michigan Department of Dermatology Ann Arbor, Michigan, United States, 48109 Less << |
NCT00647556 | - | Completed | - | - | |
NCT01095640 | Acne Vulgaris | Not Applicable | Completed | - | India ... More >> L.T.M. Medical College & General Hospital Mumbai, India Less << |
NCT01149330 | Acne Vulgaris | Phase 4 | Completed | - | Brazil ... More >> Serviço de Dermatologia do Ambulatório Magalhães Neto do Complexo HUPES - Universidade Federal da Bahia Salvador, Bahia, Brazil, 40110-160 Instituo da Pele Goiania, Goias, Brazil, 74125-010 Hospital De Clínicas - Universidade Federal do Paraná Curitiba, Paraná, Brazil, 80060-900 KOLderma Instituto de Pesquisa Clínica Ltda Campinas, Sao Paulo, Brazil, 13020-100 Instituto de Dermatologia e Estética do Brasil Ltda. Rio de Janeiro, Brazil, 22470-220 Instituto de Assistência Médica ao Servidor Público Estadual Sao Paulo, Brazil, 02404-020 Less << |
NCT01209949 | - | Completed | - | - | |
NCT01742637 | Acne Vulgaris | Phase 1 | Completed | - | - |
NCT02735421 | Acne Vulgaris ... More >> Atrophic Acne Scars Less << | Phase 4 | Completed | - | Canada, Ontario ... More >> Markham, Ontario, Canada Oakville, Ontario, Canada Toronto, Ontario, Canada Windsor, Ontario, Canada Canada, Quebec Montreal, Quebec, Canada Saint Jérôme, Quebec, Canada France Nantes, France Less << |
NCT01182636 | Acne Vulgaris | Phase 1 | Completed | - | - |
NCT01209949 | Acne Vulgaris | Phase 4 | Completed | - | United States, Texas ... More >> Thomas J. Stephens and Associates Carrollton, Texas, United States, 75006 Less << |
NCT00599521 | - | Completed | - | - | |
NCT00598832 | Acne Vulgaris | Phase 3 | Completed | - | - |
NCT00599521 | Acne Vulgaris | Phase 3 | Completed | - | - |
NCT01046396 | Skin Manifestations | Phase 1 | Completed | - | United States, Colorado ... More >> Thomas J. Stephens & Associates, Inc. Colorado Springs, Colorado, United States, 80915 Less << |
NCT02721173 | Acne Vulgaris | Phase 4 | Completed | - | India ... More >> AIIMS, Bhubaneswar Bhubaneswar, Odisha, India, 751019 Less << |
NCT01046396 | - | Completed | - | - | |
NCT01046565 | - | Completed | - | - | |
NCT02932267 | Acne Vulgaris | Phase 3 | Completed | - | United States, Texas ... More >> Dermresearch Austin, Texas, United States, 78759 Mauritius CIDP Phoenix, Mauritius Singapore CIDP Singapore, Singapore Less << |
NCT01046565 | Skin Manifestations | Phase 1 | Completed | - | United States, Texas ... More >> Thomas J. Stephens & Associates, Inc. Carrollton, Texas, United States, 75006 Less << |
NCT01951417 | Acne | Phase 4 | Completed | - | United States, Florida ... More >> Study Protocol, Inc. Boynton Beach, Florida, United States, 33437 United States, Tennessee Tennessee Clinical Research Center Nashville, Tennessee, United States, 37215 United States, Texas Stephens & Associates Carrolton, Texas, United States, 75006 J&S Studies, Inc. College Station, Texas, United States, 77845 The Dermatology Clinical Research Center of San Antonio San Antoinio, Texas, United States, 78229 Less << |
NCT03615768 | Acne Vulgaris | Phase 3 | Recruiting | June 2020 | China, Jiangsu ... More >> Institute of Dermatology and Hospital for Skin Diseases, Chinese Academy of Medical Sciences Recruiting Nanjing, Jiangsu, China, 210042 Contact: Yu Zhu zhuyu@leespharm.com Less << |
NCT01951417 | - | Completed | - | - | |
NCT02411942 | Acne Vulgaris | Phase 1 | Completed | - | - |
NCT01406080 | Photoaging Ph... More >>otodamage Less << | Phase 3 | Completed | - | Brazil ... More >> Centro de Dermatologia Dona Libania Fortaleza, Ceará, Brazil, 60035-101 Santa Casa de Belo Horizonte Belo Horizonte, Minas Gerais, Brazil, 30150-221 Hospital de Clínicas da Universidade Federal do Paraná Curitiba, Paraná, Brazil, 80060-900 Universidade Federal de São Paulo - UNIFESP - UNICCO São Paulo, Brazil, 04022-000 Less << |
NCT02173054 | Acne | Phase 3 | Completed | - | Thailand ... More >> Siriraj Hospital Mahidol Univeristy Bangkok, Thailand, 10700 Less << |
NCT01213199 | Acne Scars | PHASE2 | COMPLETED | 2025-09-12 | Manisha PATEL, Baltimore, Mary... More >>land, 21231, United States Less << |
NCT01213199 | Acne Scars | PHASE2 | COMPLETED | 2025-09-12 | Manisha PATEL, Baltimore, Mary... More >>land, 21231, United States Less << |
NCT02173054 | - | Completed | - | - | |
NCT01485367 | Senile Purpura | Phase 2 | Unknown | December 2012 | United States, California ... More >> Multispecialty Aesthetic Clinical Research Organization Recruiting Woodland Hills, California, United States, 91367 Contact: Ronnie Zocks, BS 310-963-5001 macroclinicaltrials@gmail.com Principal Investigator: Douglas Hamilton, MD Multispecialty Aesthetic Clinical Research Organization Recruiting Woodland Hills, California, United States, 91367 Contact: Ronnie Zocks, BS 310-963-5001 macroclinicaltrials@gmail.com Less << |
NCT01501799 | Acne Vulgaris | Not Applicable | Completed | - | United States, California ... More >> Center for Dermatology Clinical Research Inc. Fremont, California, United States, 94538 United States, Florida FXM Research Corp. Miami, Florida, United States, 33175 FXM Research Miramar Miramar, Florida, United States, 33027 United States, Indiana The Indiana Clinical Trials Center Plainfield, Indiana, United States, 46168 United States, Kansas Adult & Pediatric Dermatology Overland Park, Kansas, United States, 66211 United States, New York Skin Search of Rochester Inc. Rochester, New York, United States, 14623 United States, North Carolina Dermatology Consulting Services High Point, North Carolina, United States, 27262 United States, Ohio Haber Dermatology and Cosmetic Surgery Inc. South Euclid, Ohio, United States, 44118 Belize FXM Research International - Belize Belize City, Belize India Chamarajpet Skin and Laser Centre Chamarajpet, Bangalore, India, 560 018 Rajbal Polyclinic & Research Center Kalyan Nagar, Bangalore, India, 560043 Department of Skin & STD, Kempegowda Institute of Medical Sciences, V.V. Puram, Bangalore, India, 560-004 Bhagwan Mahaveer Jain Hospital Vasanthnagar, Bangalore, India, 560-052 Skin & Cosmetology Clinic Banjara Hills, Hyderabad, India, 500034 Department of Dermatology, Durga Bai Deshmukh Hospital Vidya Nagar, Hyderabad, India, 500044 Bhatia Skin, Laser & Cosmetic Center Anand Bazar, Indore, India, 452 001 Swarnakar Super Specialty Centre Anand Bazar, Indore, India, 452 018 Skin Clinic RNT Marg, Indore, India, 452 001 Agrawal Skin & Laser Centre Vijaya Nagar, Indore, India, 452 010 Sri Gayathri Skin Care & Hair Transplant Centre Dwarakanagar, Visakhapatnam, India, 530016 Raga's Skin Care Bangalore, India, 560 061 MS Clinical Research Pvt. Ltd. Bangalore, India, 560025 Dayal Clinic Visakhapatnam, India, 530 016 B.V. Department of Dermatology King George Hospital Visakhapatnam, India, 530002 Skin & Cosmetology Visakhapatnam, India, 530002 Less << |
NCT00598832 | - | Completed | - | - |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() | 1mg | 5mg | 10mg |
1 mM 5 mM 10 mM | 2.42mL 0.48mL 0.24mL | 12.12mL 2.42mL 1.21mL | 24.24mL 4.85mL 2.42mL |