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Chemical Structure| 2304-96-3 Chemical Structure| 2304-96-3
Chemical Structure| 2304-96-3
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Product Details of Cbz-Asn-OH

CAS No. :2304-96-3
Formula : C12H14N2O5
M.W : 266.25
SMILES Code : O=C(N)C[C@@H](C(O)=O)NC(OCC1=CC=CC=C1)=O
Synonyms :
Z-Asn-OH
MDL No. :MFCD00008035
InChI Key :FUCKRCGERFLLHP-VIFPVBQESA-N
Pubchem ID :75314

Safety of Cbz-Asn-OH

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Cbz-Asn-OH

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2304-96-3 ]

[ 2304-96-3 ] Synthesis Path-Downstream   1~5

  • 2
  • [ 2304-96-3 ]
  • [ 60846-91-5 ]
YieldReaction ConditionsOperation in experiment
With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In DMF (N,N-dimethyl-formamide); at 80℃; for 6h; Intermediate 6; (3S)-3-(N-Cbz-Amino)azolane-2,5-dione. To a stirred solution of N(alpha)-Cbz-L-asparagine (10 g, 37.5 mmol) dissolved in DMF (50 ml) was added DCC (7.8 g, 37.5 mmol) and N-hydroxysuccinimide (4.4 g, 37.5 mmol) and the mixture was heated at 80 C for 6 h. DMF was evaporated under reduced pressure and the residue was dissolved in ethyl acetate (100 ml) and filtered to remove DCU. The filterate was washed with water (2 x 100 ml), brine (100 ml) and dried (Na2SO4). The product obtained after evaporation of the solvent was purified by silica gel column chromatography using 50 % ethyl acetate in petroleum ether to give 4.2 g of the product as white solid, mp 66-69 C; IR (KBr) 3395, 3177, 2936, 2749, 1723, 1689, 1519, 1260, 1177 cm-1; 1H NMR (300 MHz, CDC13) 5 2.81-2.89 (m, 1 H), 3.04-3.13 (m, 1 H), 4.33-4.40 (m, 1 H), 5.11 (s, 2 H), 4.63 (brs, 1 H), 7.34 (s, 5 H), 8.54 (brs, 1 H).
  • 3
  • [ 29880-22-6 ]
  • [ 4474-86-6 ]
  • [ 2304-96-3 ]
  • 4
  • [ 2304-96-3 ]
  • [ 4089-07-0 ]
  • [ 16152-92-4 ]
 

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