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Chemical Structure| 4089-07-0 Chemical Structure| 4089-07-0
Chemical Structure| 4089-07-0

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H-Tyr-OEt·HCl is a tyrosine derivative with hydroxyl ethyl esterification, in hydrochloride form, commonly used in peptide chemistry and other modification reactions.

Synonyms: H-Tyr-OEt.HCl

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Product Details of H-Tyr-OEt·HCl

CAS No. :4089-07-0
Formula : C11H16ClNO3
M.W : 245.70
SMILES Code : N[C@@H](CC1=CC=C(C=C1)O)C(OCC)=O.[H]Cl
Synonyms :
H-Tyr-OEt.HCl
MDL No. :MFCD00063047
InChI Key :BQULAXAVRFIAHN-PPHPATTJSA-N
Pubchem ID :2724939

Safety of H-Tyr-OEt·HCl

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of H-Tyr-OEt·HCl

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4089-07-0 ]

[ 4089-07-0 ] Synthesis Path-Downstream   1~35

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  • <i>O</i>-benzoyl-<i>N</i>-(<i>S</i>-benzyl-<i>N</i>-benzyloxycarbonyl-L-cysteinyl)-L-tyrosine ethyl ester [ No CAS ]
  • 5
  • [ 42918-86-5 ]
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  • <i>N</i>-((<i>S</i>)-2-benzyloxycarbonylamino-butyryl)-L-tyrosine amide [ No CAS ]
  • 6
  • [ 42918-86-5 ]
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  • [ 26607-51-2 ]
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  • 9
  • [ 39608-30-5 ]
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  • <i>N</i>-(<i>N</i>-benzyloxycarbonyl-L-norleucyl)-L-tyrosine amide [ No CAS ]
  • 10
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  • [ 21820-51-9 ]
  • 11
  • [ 4089-07-0 ]
  • <i>N</i>-(3-carboxy-propionyl)-L-tyrosine ethyl ester [ No CAS ]
  • 13
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  • 17
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  • [ 4515-23-5 ]
  • <i>N</i>-(<i>N</i>-benzyloxycarbonyl-L-β-aspartyl)-L-tyrosine ethyl ester [ No CAS ]
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  • [ 21957-65-3 ]
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  • 19
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  • [ 108541-02-2 ]
  • <i>N</i>-[<i>N</i>-(toluene-4-sulfonyl)-L-pyroglutamyl]-L-tyrosin-ethyl ester [ No CAS ]
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  • (S)-N-Acryloyl-tyrosin-ethylester [ No CAS ]
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  • N-Trifluoracetyl-L-asparagyl-α-L-tyrosin-ethylester [ No CAS ]
  • 23
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  • 25
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  • (2S,3S)-2-Benzyloxycarbonylamino-3-hydroxy-succinic acid 4-benzyl ester; compound with dibenzyl-amine [ No CAS ]
  • N-Benzyloxycarbonyl-threo-β-hydroxy-(β-benzyl-α-L-asparagyl)-L-tyrosin-ethylester [ No CAS ]
  • 26
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  • [ 5034-68-4 ]
YieldReaction ConditionsOperation in experiment
54% To 3 gr, 12 mM, L-tyrosine ethyl ester HCl in 50 ml dry ether was added 1.2 gr 32 mM LiAlH4. After stirring 3 hours at room temperature, water and KOH were added and the reaction was extracted with ethyl acetate. Evaporation gave 1.1 gr of a light yellow oil, 54percent yield, which on standing crystallized. mp-85.NMR CDCl3 7.20 (4H, AB q, J=8.6 Hz), 3.50 (2H, m) 3.20 (1H, m), 2.81 (2H, m). NMR tyrosine ethyl ester free base CDCl3 7.0, 6.56 (4H, AB q, J=8.8 Hz), 4.20 (2H, q, J=7, 0 Hz), 3.70, 3.0, 2.80 (3H, 12 line ABXm), 1.28 (3H, t, J=7.0 Hz). JACS 71, 305 (1949). Biels. -E3, Vol. 13, p 2263.
54% With lithium aluminium tetrahydride; In diethyl ether; at 20℃; for 3h; To 3 g, 12 mM, L-tyrosine ethyl ester HCl in 50 ml dry ether was added 1.2 g 32 mM LiAlH4. After stirring 3 hours at room temperature, water and KOH were added and the reaction was extracted with ethyl acetate. Evaporation gave 1.1 g of a light yellow oil, 54percent yield, which on standing crystallized. mp-85. (0093) NMR CDCl3 7.20 (4H, AB q, J=8.6 Hz), 3.50 (2H, m) 3.20 (1H, m), 2.81 (2H, m). (0094) NMR tyrosine ethyl ester free base CDCl3 7.0, 6.56 (4H, AB q, J=8.8 Hz), 4.20 (2H, q, J=7, 0 Hz), 3.70, 3.0, 2.80 (3H, 12 line ABXm), 1.28. (3H, t, J=7.0 Hz). JACS 71, 305(1949). Biels.?E3, Vol. 13, p 2263.
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  • 3-[(S)-1-Ethoxycarbonyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2,2-dimethyl-but-3-enoic acid tert-butyl ester [ No CAS ]
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  • [ 149522-86-1 ]
 

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