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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
H-Tyr-OEt·HCl is a tyrosine derivative with hydroxyl ethyl esterification, in hydrochloride form, commonly used in peptide chemistry and other modification reactions.
Synonyms: H-Tyr-OEt.HCl
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 4089-07-0 |
Formula : | C11H16ClNO3 |
M.W : | 245.70 |
SMILES Code : | N[C@@H](CC1=CC=C(C=C1)O)C(OCC)=O.[H]Cl |
Synonyms : |
H-Tyr-OEt.HCl
|
MDL No. : | MFCD00063047 |
InChI Key : | BQULAXAVRFIAHN-PPHPATTJSA-N |
Pubchem ID : | 2724939 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
54% | To 3 gr, 12 mM, L-tyrosine ethyl ester HCl in 50 ml dry ether was added 1.2 gr 32 mM LiAlH4. After stirring 3 hours at room temperature, water and KOH were added and the reaction was extracted with ethyl acetate. Evaporation gave 1.1 gr of a light yellow oil, 54percent yield, which on standing crystallized. mp-85.NMR CDCl3 7.20 (4H, AB q, J=8.6 Hz), 3.50 (2H, m) 3.20 (1H, m), 2.81 (2H, m). NMR tyrosine ethyl ester free base CDCl3 7.0, 6.56 (4H, AB q, J=8.8 Hz), 4.20 (2H, q, J=7, 0 Hz), 3.70, 3.0, 2.80 (3H, 12 line ABXm), 1.28 (3H, t, J=7.0 Hz). JACS 71, 305 (1949). Biels. -E3, Vol. 13, p 2263. | |
54% | With lithium aluminium tetrahydride; In diethyl ether; at 20℃; for 3h; | To 3 g, 12 mM, L-tyrosine ethyl ester HCl in 50 ml dry ether was added 1.2 g 32 mM LiAlH4. After stirring 3 hours at room temperature, water and KOH were added and the reaction was extracted with ethyl acetate. Evaporation gave 1.1 g of a light yellow oil, 54percent yield, which on standing crystallized. mp-85. (0093) NMR CDCl3 7.20 (4H, AB q, J=8.6 Hz), 3.50 (2H, m) 3.20 (1H, m), 2.81 (2H, m). (0094) NMR tyrosine ethyl ester free base CDCl3 7.0, 6.56 (4H, AB q, J=8.8 Hz), 4.20 (2H, q, J=7, 0 Hz), 3.70, 3.0, 2.80 (3H, 12 line ABXm), 1.28. (3H, t, J=7.0 Hz). JACS 71, 305(1949). Biels.?E3, Vol. 13, p 2263. |