66-39-7|4-(Phenylsulfonyl)benzaldehyde| Ambeed

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Quality Control of [ 66-39-7 ] Purity: 97% SDS Specification

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Product Details of [ 66-39-7 ]

CAS No. :	66-39-7
Formula :	C₁₃H₁₀O₃S
M.W :	246.28
SMILES Code :	O=CC1=CC=C(S(=O)(C2=CC=CC=C2)=O)C=C1
MDL No. :	MFCD00444612
InChI Key :	OFZOVFCBBFJMNV-UHFFFAOYSA-N
Pubchem ID :	14417477

Safety of [ 66-39-7 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

Application In Synthesis of [ 66-39-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 66-39-7 ]

[ 66-39-7 ] Synthesis Path-Downstream 1~35

1
[ 54-85-3 ]
[ 66-39-7 ]
[ 3506-95-4 ]

References: [1]Journal of the American Pharmaceutical Association (1912),1954,vol. 43,p. 513,514.

2
[ 141-82-2 ]
[ 66-39-7 ]
[ 30568-18-4 ]

References: [1]Journal of the Chemical Society,1949,p. 178,179.

3
[ 28525-13-5 ]
[ 66-39-7 ]

References: [1]Journal of the Chemical Society,1948,p. 601.

4
[ 37991-83-6 ]
[ 66-39-7 ]

References: [1]Patent: DE939325,1954,C .

5
[ 114194-15-9 ]
[ 66-39-7 ]

References: [1]Journal of the Chemical Society,1948,p. 601.

6
[ 66-39-7 ]
[ 96-22-0 ]
2r,6c-bis-(4-benzenesulfonyl-phenyl)-3t,5t-dimethyl-piperidin-4-one [ No CAS ]

References: [1]Journal Of Scientific and Industrial Research,1953,vol. 12B,p. 644.

7
[ 66-39-7 ]
[ 100-46-9 ]
[ 102078-99-9 ]

References: [1]Patent: US2744895,1954,A .

8
[ 110-91-8 ]
[ 66-39-7 ]
[ 3506-99-8 ]

References: [1]Bollettino Chimico Farmaceutico,1965,vol. 104,p. 155 - 169.

9
[ 640-57-3 ]
[ 66-39-7 ]
[ 13333-14-7 ]

References: [1]Journal of the American Chemical Society,1963,vol. 85,p. 3406 - 3410.

10
[ 66-39-7 ]
[ 876-58-4 ]
[ 3507-03-7 ]

References: [1]Bollettino Chimico Farmaceutico,1965,vol. 104,p. 155 - 169.

11
[ 66-39-7 ]
[ 5953-06-0 ]
[ 69600-23-3 ]

References: [1]Helvetica Chimica Acta,1978,vol. 61,p. 2904 - 2940.

12
[ 7705-64-8 ]
[ 66-39-7 ]

References: [1]Journal of Organic Chemistry,1980,vol. 45,p. 1596 - 1600.

13
[ 66-39-7 ]
[ 7705-64-8 ]

Yield	Reaction Conditions	Operation in experiment
61%		Sodium borohydhde (777 mg, 20.5 mmol) was added slowly in portions to a 0 C solution of 4-(benzenesulfonyl)-benzaldehyde (4.29 g, 18.6 mmol) and tetrahydrofuran (60 ml_). The reaction mixture was allowed to warm to room temperature, then stirred at room temperature for 4 hours. The reaction mixture was then cooled over an ice-water bath, diluted with ethyl acetate (80 ml_), then carefully quenched with a saturated aqueous solution of ammonium chloride (10 ml_). The mixture was washed with water (80 ml_), then the organic phase was dried over MgSO4, filtered, and concentrated to afford 2.83 g (61 %) of (4-benzenesulfonyl- phenyl)-methanol as a white solid. This product was used in subsequent steps without further purification.
	With sodium tetrahydroborate; In tetrahydrofuran; methanol; for 1h;	4-(Phenylsulfonyl)benzaldehyde (prepared according to the method of Ulman et al., J. Org. Chem. (1989), 54(19), 4691-2; 12.3 g, 50 mmol) was dissolved in tetrahydrofuran and methanol was added, followed by careful addition of sodium borohydride (2.0 g, 52.9 mmol). The reaction was stirred for 1 hour before pouring into water and extracting with ethyl acetate. The organic layer was dried over MgSO4 and evaporated in vacuo to give [4-(phenylsulfonyl)phenyl]methanol. This was treated with phosphorus tribromide and heated to reflux for 16 hours. The cooled reaction mixture was poured onto ice and extracted with ethyl acetate. The organic layer was dried over MgSO4 and evaporated in vacuo. The residue was purified by flash column chromatography on silica, eluting with dichloromethane, to give 1-(bromomethyl)-4(phenylsulfonyl)benzene (10.1 g, 65%). δH (500 MHz, CDCl3): 7.96-7.90 (4 H, m), 7.59-7.56 (1 H, m), 7.52-7.49 (4 H, m).
		Example 1 l-fluoro-2-[4-(phcnylsulfonyl)bcnzyl]oxy}bcnzcncStep 1: l-(bromomethyl)-4-(phenylsulfonyl)benzene; 4-(Phenylsulfonyl)benzaldehyde (prepared according to the method of Ulman et ah, J. Org. Chent. (1989), 54(19), 4691-2; 12.3 g, 50 mmol) was dissolved in THF and MeOH was added, followed by careful addition of sodium borohydride (2.0 g, 52.9 mmol). The reaction was stirred for 1 h before pouring into water and extracting with EtOAc. The organic layer was dried over MgSO4 and evaporated in vacuo to give [4-(phenylsulfonyl)phenyl]methanol. This was treated with phosphorus tribromide and heated to reflux for 16 h. The cooled reaction mixture was poured onto ice and extracted with EtOAc. The organic layer was dried over MgSO4 and evaporated in vacuo. The residue was purified by flash column chromatography on silica, eluting with dichloromethane, to give to give the title compound as a solid (10.1 g, 65%). 1H NMR (500 MHz, CDCl3): δ 7.96-7.90 (4 H, m), 7.59-7.56 (1 H, m), 7.52-7.49 (4 H, m).

References: [1]Patent: WO2010/55005,2010,A1 .Location in patent: Page/Page column 91.
[2]Journal of Organic Chemistry,1980,vol. 45,p. 1596 - 1600.
[3]Patent: WO2006/21805,2006,A1 .Location in patent: Page/Page column 46.
[4]Patent: WO2006/97766,2006,A1 .Location in patent: Page/Page column 14.

14
[ 873-55-2 ]
[ 459-57-4 ]
[ 66-39-7 ]

Yield	Reaction Conditions	Operation in experiment
80%	In dimethyl sulfoxide; at 120℃; for 96h;	Sodium phenylsulfinate (16.4 g, 0.1 mol) and 4-fluorobenzaldehyde (12.4 g, 0.1 mol) were combined in dimethylsulfoxide (100 mL) and heated at 120C for 4 days. The cooled reaction was poured into water. The resulting crystals were filtered off and washed with water, then dissolved in ethyl acetate/dichloromethane, dried and concentrated in vacuo until crystallisation ensued. The mixture was diluted with isohexane and the crystals filtered off and washed with further isohexane to yield 4(phenylsulfonyl)benzaldehyde (19.6 g, 80%). δH (500 MHz, d6 DMSO): 10.06 (1 H, s), 8.16 (2 H, d, J = 8.3 Hz), 8.09 (2 H, d, J = 8.3 Hz), 7.99 (2 H, d, J = 7.7 Hz), 7.71 (1 H, t, J = 6.9 Hz), 7.63 (2 H, t, J = 7.7 Hz).
80%	In dimethyl sulfoxide; at 120℃; for 96h;	In the first step, 60 ml of DMSO was added to a 100 ml round bottom flask equipped with a condenser tube with stirring,Then, 8.2 g (0.05 mol) of sodium benzenesulfinate was added to the flask, 6.2 g (0.05 mol) of p-fluorobenzaldehyde,The reaction was then stirred at 120 4 days.After completion of the reaction, the mixture was cooled to room temperature,The reaction mixture was poured into a large amount of water,Precipitate the precipitate and wash it several times with water,The precipitate was then recrystallized three times with a mixed solvent of ethyl acetate / dichloromethane,To give 9.8 g of 4-benzenesulfonylbenzaldehyde in 80% yield;
41%	In dimethyl sulfoxide; at 100℃; for 20h;	A mixture of 4-fluorobenzaldehyde (6 g, 48 mmol), sodium benzenesulfinate (7.5 g, 4.6 mmol), and dimethylsulfoxide (30 ml_) was heated at 100 C for 20 hours. The reaction mixture was cooled to room temperature, then partitioned between ethyl acetate and water. The organic phase was dried over MgSO4, filtered, and concentrated to give a white solid. A solution of this crude product and dichloromethane was evaporated over silica gel, and the resulting silica gel supported crude product was purified using flash chromatography (Analogix SuperFlash column, 15% - 40% ethyl acetate in hexanes) to give 4.29 g (41 %) of 4-(benzenesulfonyl)-benzaldehyde as a white solid.

References: [1]Journal of Organic Chemistry,1989,vol. 54,p. 4691 - 4692.
[2]Patent: WO2006/21805,2006,A1 .Location in patent: Page/Page column 58.
[3]Patent: CN106588935,2017,A .Location in patent: Paragraph 0039; 0040.
[4]Patent: WO2010/55005,2010,A1 .Location in patent: Page/Page column 90-91.
[5]Journal of Medicinal Chemistry,1996,vol. 39,p. 3984 - 3997.

15
[ 873-55-2 ]
[ 104-88-1 ]
[ 66-39-7 ]

Yield	Reaction Conditions	Operation in experiment
76%	In dimethyl sulfoxide; at 180℃; for 1.5h;Microwave irradiation;	Example 35: (S)-4-(4-Benzenesulfonyl-benzyl)-2-phenyl-morpholine4-Benzenesulfonyl-benzaldehyde; A microwave vessel was charged with Ig of 4-chlorobenzaldehyde in 6mL of DMSO and 1.75g of sodium benzenesulfinate. The vessel was sealed and heated in a microwave reactor at 1800C for 1.5 hours. The mixture was cooled and poured into 12mL of ice water. Filtered and the solid was purified by flash chromatography using ethyl acetate/hexane as eluent mixtures to afford 1.34g of the title compound. 76 % yield.
76%	In dimethyl sulfoxide; at 180℃; for 1.5h;Microwave irradiation;	A microwave vessel was charged with Ig of 4-chlorobenzaldehyde in 6mL of DMSO and 1.75g of sodium benzenesulfmate. The vessel was sealed and heated in a microwave reactor at 180 oC for 1.5 hours. The mixture was cooled and poured into 12mL of ice water. Filtered and the solid was purified by flash chromatography using ethyl acetate/hexane as eluent mixtures to afford 1.34g of product. 76 % yield.
12%	With copper(l) iodide; potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 150℃; for 1h;Microwave irradiation;	4-(phenylsulfonyl)benzaldehyde. The mixture of 4-chlorobenzaldehyde (1.4 g, 10 mmol) and sodium benzenesulfinate (1.7 g, 10 mmol) and CuT (190 mg, 1 mmol) and K2C03 (138 mg, 1 mmol) in NIVIP (10 mL) was stirred at 1 50C for 1 hr with the microwave. The mixture was quenched with H20 and extracted with EtOAc. The combined organic layer was washed with brine, dried over Mg504 and concentrated in vacuo. The residue was purified by columnchromatography (Petroleum ether:EtOAc =10:1) to give 4-(phenylsulfonyl)benzaldehyde (300 mg, yield 12%).

References: [1]Synlett,2011,p. 2750 - 2756.
[2]Patent: WO2008/48914,2008,A1 .Location in patent: Page/Page column 22.
[3]Patent: WO2007/118041,2007,A1 .Location in patent: Page/Page column 12-13.
[4]Journal of Organic Chemistry,1989,vol. 54,p. 4691 - 4692.
[5]Patent: WO2016/19588,2016,A1 .Location in patent: Page/Page column 110.

16
[ 640-57-3 ]
[ 66-39-7 ]

References: [1]Journal of Organic Chemistry,1967,vol. 32,p. 1274 - 1277.

17
[ 66-39-7 ]
[ 920-39-8 ]
1-(4-Benzenesulfonyl-phenyl)-2-methyl-propan-1-ol [ No CAS ]

References: [1]Journal of Organic Chemistry,1995,vol. 60,p. 4688 - 4689.

18
[ 66-39-7 ]
[ 1937-19-5 ]
[ 102451-50-3 ]

References: [1]Journal of medicinal and pharmaceutical chemistry,1961,vol. 4,p. 177 - 182.

19
[ 66-39-7 ]
[ 123-30-8 ]
[ 3525-48-2 ]

References: [1]Bollettino Chimico Farmaceutico,1965,vol. 104,p. 155 - 169.

20
[ 66-39-7 ]
[ 108-91-8 ]
[ 3525-70-0 ]

References: [1]Bollettino Chimico Farmaceutico,1965,vol. 104,p. 155 - 169.

21
[ 66-39-7 ]
[ 104-94-9 ]
[ 3525-59-5 ]

References: [1]Bollettino Chimico Farmaceutico,1965,vol. 104,p. 155 - 169.

22
[ 66-39-7 ]
[ 150-13-0 ]
[ 3782-76-1 ]

References: [1]Bollettino Chimico Farmaceutico,1965,vol. 104,p. 155 - 169.

23
[ 66-39-7 ]
[ 94-09-7 ]
[ 3782-59-0 ]

References: [1]Bollettino Chimico Farmaceutico,1965,vol. 104,p. 155 - 169.

24
[ 66-39-7 ]
[ 4136-97-4 ]
[ 3731-81-5 ]

References: [1]Bollettino Chimico Farmaceutico,1965,vol. 104,p. 155 - 169.

25
[ 66-39-7 ]
[ 563-41-7 ]
C₁₄H₁₃N₃O₃S [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1996,vol. 39,p. 3984 - 3997.

27
α.α-diacetoxy-4-benzenesulfonyl-toluene [ No CAS ]
[ 66-39-7 ]

References: [1]Journal of the Chemical Society,1948,p. 601.

28
[ 56613-81-1 ]
[ 66-39-7 ]
(S)-2-(4-benzenesulfonyl-benzylamino)-1-phenyl-ethanol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
68%		To a solution of 11 lmg of (S)-(+)-2-amino-l-phenylethanol in 1OmL of THF was added116μL of acetic acid and 200mg of 4-benzenesulfonyl-benzaldehyde. The mixture was stirred at room temperature for 20 minutes and then added 344mg of sodium triacetoxyborohydride. The reaction mixture was stirred at room temperature overnight. The mixture was quenched with saturated sodium carbonate aqueous solution and extracted with ethyl acetate three times. The organic layer was washed with brine and dried with magnesium sulfate. The filtrate was concentrated and purified by flash chromatography using methanol/dichloromethane as eluent mixtures to afford 202mg of product. 68 % yield. ES MS (+) m/z 368

References: [1]Patent: WO2007/118041,2007,A1 .Location in patent: Page/Page column 13.

29
[ 66-39-7 ]
p-(Phenylsulfonyl)isobutyrophenone [ No CAS ]

References: [1]Journal of Organic Chemistry,1995,vol. 60,p. 4688 - 4689.

30
[ 66-39-7 ]
2r,6c-bis-(4-benzenesulfonyl-phenyl)-1,3t,5t-trimethyl-piperidin-4-one [ No CAS ]

References: [1]Journal Of Scientific and Industrial Research,1953,vol. 12B,p. 644.

31
[ 66-39-7 ]
[ 123-54-6 ]
3-[(4-Phenylsulfonylphenyl)methylene]-2,4-pentanedione [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With thionyl chloride; In isopropyl alcohol;	EXAMPLE 1 3-[(4-Phenylsulfonylphenyl)methylene]-2,4-pentanedione To a solution containing 2.1 g of 4-phenylsulfonylbenzaldehyde and 1.5 g of 2,4-pentanedione in 10 ml of 2-propanol was added 1 ml of thionyl chloride with stirring at 20 C. The solution was stirred for 1 h at 20 C. and evaporated to dryness in vacuo. The residue was crystallized from toluene, mp 102-105 C.
	With thionyl chloride; In isopropyl alcohol;	Example 1 3-[(4-Phenylsulfonylphenyl)methylene]-2,4-pentanedione To a solution containing 2.1 g of 4-phenylsulfonylbenzaldehyde and 1.5 g of 2,4-pentanedione in 10 ml of 2-propanol was added 1 ml of thionyl chloride with stirring at 20C. The solution was stirred for 1h at 20C and evaporated to dryness in vacuo. The residue was crystallized from toluene, mp 102-105C.

References: [1]Patent: US5185370,1993,A .
[2]Patent: EP440324,1991,A2 .

32
[ 66-39-7 ]
[ 21047-57-4 ]
[ 97442-87-0 ]

Yield	Reaction Conditions	Operation in experiment
42%	With potassium carbonate; In methanol; at 20℃; for 72h;	To a mixture of <strong>[66-39-7]4-(phenylsulfonyl)benzaldehyde</strong> (8 g, 32.5 mmol) and potassium carbonate (8.97 g, 65 retool) in methanol (400 mL) was added diethyl (1-diazo-2oxopropyl)phosphonate (8.6 g, 39 mmol). The reaction was stirred at room temperature for 3 days then poured into water (600 mL) and extracted with ethyl acetate (x3). The combined organic layers were dried and evaporated. The residue was purified by flash column chromatography on silica, eluting with 5% ethyl acetate/isohexane, to give 1-ethynyl-4-(phenylsulfonyl)benzene (3.3 g, 42%). δH (500 MHz, CDCl3): 7.94-7.88 (4 H, m), 7.60-7.50 (5 H, m), 3.23 (1 H, s).

References: [1]Patent: WO2006/21805,2006,A1 .Location in patent: Page/Page column 58.

33
[ 66-39-7 ]
2-(4-fluorophenyl)-1-[4-(phenylsulfonyl)phenyl]ethanol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
90%		Lithium chloride (0.57 g, 13.5 mmol, dried at 140C under vacuum) and copper(I) cyanide (0.605 g, 6.8 mmol) were dissolved in tetrahydrofuran (5 mL) and cooled to 40C under nitrogen. 4-Fluorobenzylzinc chloride (0.5M in tetrahydrofuran, 15 mL) was added dropwise and the solution cooled to -20C for 5 minutes then to -78C. Boron trifiuoride diethyl etherate (1.7 mL, 13.5 mmol) and 4(phenylsulfonyl)benzaldehyde (Example 113 Step 1,300 mg, 1.2 mmol) in tetrahydrofuran (5 mL) were added and the reaction stirred at -78C for 30 minutes then warmed to 25C and quenched with saturated ammonium chloride solution. Ethyl acetate was added and the mixture stirred for 10 minutes then the layers separated. The organic layer was washed with brine, dried over MgSO4 and evaporated. The residue was purified by flash column chromatography on silica, eluting with 40% ethyl acetate/isohexane, to give the title compound as a whim solid (0.386 g, 90%). δH (360 MHz, CDCl3): 7.94-7.88 (4 H, m), 7.58-7.43 (5 H, m), 7.107.02 (2 H, m), 6.99-6.93 (2 H, m), 4.92-4.88 (1 H, m), 2.99-2.85 (2 H, m), 2.01 (1 H, d, J = 3.2 Hz).

References: [1]Patent: WO2006/21805,2006,A1 .Location in patent: Page/Page column 60.

34
(3S)-1-butyl-2,5-dioxo-3-cyclohexylmethyl-1,4,9-triazaspiro[5.5]undecane · hydrochloride [ No CAS ]
[ 66-39-7 ]
(3S)-1-butyl-3-(cyclohexylmethyl)-9-[4-(phenylsulfonyl)-benzyl]-1,4,9-triazaspiro[5.5]undecane-2,5-dione hydrochloride [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 763 - 766.

35
[ 66-39-7 ]
2,4-difluoro benzylphosphonate de diethyle [ No CAS ]
C₂₀H₁₄F₂O₂S [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 3708 - 3712.

Historical Records

Technical Information

• Barbier Coupling Reaction • Baylis-Hillman Reaction • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Bucherer-Bergs Reaction • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Chaykovsky Reaction • Corey-Fuchs Reaction • Fischer Indole Synthesis • Friedel-Crafts Reaction • Grignard Reaction • Hantzsch Dihydropyridine Synthesis • Henry Nitroaldol Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Hydrogenolysis of Benzyl Ether • Julia-Kocienski Olefination • Knoevenagel Condensation • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Mukaiyama Aldol Reaction • Nozaki-Hiyama-Kishi Reaction • Nucleophilicity of Sulfur Compounds • Oxidation States of Sulfur Compounds • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Alkylbenzene • Preparation of Amines • Preparation of Phosphorus and Sulfur Ylides • Prins Reaction • Ramberg-Bäcklund Reaction • Reactions of Aldehydes and Ketones • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reformatsky Reaction • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Stetter Reaction • Stobbe Condensation • Tebbe Olefination • Ugi Reaction • Vilsmeier-Haack Reaction • Wittig Reaction • Wolff-Kishner Reduction

Related Functional Groups of
[ 66-39-7 ]

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P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 66-39-7

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