Home Cart Sign in  
Chemical Structure| 6563-11-7 Chemical Structure| 6563-11-7

Structure of 6563-11-7

Chemical Structure| 6563-11-7

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 6563-11-7 ]

CAS No. :6563-11-7
Formula : C9H6BrNO
M.W : 224.05
SMILES Code : [O-][N+]1=C2C=CC(Br)=CC2=CC=C1
MDL No. :MFCD08062621

Safety of [ 6563-11-7 ]

Application In Synthesis of [ 6563-11-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6563-11-7 ]

[ 6563-11-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 6563-11-7 ]
  • [ 791626-58-9 ]
YieldReaction ConditionsOperation in experiment
78.3% To a round bottom flask was charged 2 (2.24g, 10.0mmol, 1.0equiv), 40mL trifluorotoluene and 20mL chloroform under N2. After compound 2 was dissolved, the mixture was cooled to 0-10C with an ice-bath. T-butylamine (5.3mL, 50.0mmol, 5.0equiv) was added followed by Ts2O (6.50g, 20.0mmol, 2.0equiv) while the temperature was kept at 5-12C. If the reaction were not completed within 30min, portions of t-butylamine (0.6equiv. to 4.0equiv.) and Ts2O (0.3equiv. to 2.3equiv.) would be charged until the reaction completed. The reaction was then treated with TFA 25mL at 70C for 10h. Most of the solvents could be removed under vacuum. The oil residue was diluted with CH2Cl2 and quenched with 50% aq solution NaOH to pH 9-10. The aqueous layer was extracted with CH2Cl2 (50mL) three times. The combined organic layers were dried with MgSO4. The solvent was removed by reduced pressure and the crude product was then purified by silica gel column chromatography (2% MeOH/CH2Cl2) to give the desired 4 as a gray solid (1.75g, 78.3% yield), m.p. 139-145C (lit [16]. 141-146C). 1H NMR (400MHz, CDCl3) δ (ppm): 7.79 (d, J=8.8Hz, 1H), 7.76 (d, J=2.2Hz, 1H), 7.61 (dd, J1=8.9Hz, J2=2.2Hz, 1H), 7.52 (d, J=8.9Hz, 1H), 6.73 (d, J=8.8Hz, 1H), 4.83 (s, 2H).
  • 2
  • [ 6563-11-7 ]
  • [ 3894-25-5 ]
  • [ 861872-54-0 ]
 

Historical Records