[ CAS No. 791626-58-9 ] 6-Bromoquinolin-2-amine

Cat. No.: A700981

2D 3D

Structure of 791626-58-9 * Storage: Keep in dark place,Sealed in dry,2-8°C

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Quality Control of [ 791626-58-9 ]

COA NMR CNMR HPLC LC-MS

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Specification

Alternatived Products of [ 791626-58-9 ]

Product Details of [ 791626-58-9 ]

CAS No. :	791626-58-9	MDL No. :	MFCD06738670
Formula :	C₉H₇BrN₂	Boiling Point :	No data available
Linear Structure Formula :	-	InChI Key :	GSKICCPQEZRQEC-UHFFFAOYSA-N
M.W :	223.07	Pubchem ID :	11183666
Synonyms :

Safety of [ 791626-58-9 ]

Signal Word:	Warning	Class:
Precautionary Statements:	P261-P305+P351+P338	UN#:
Hazard Statements:	H302-H315-H319-H335	Packing Group:
GHS Pictogram:

Application In Synthesis of [ 791626-58-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 791626-58-9 ]

[ 791626-58-9 ] Synthesis Path-Downstream 1~21

1
[ 1810-71-5 ]
[ 791626-58-9 ]

Yield	Reaction Conditions	Operation in experiment
58%	With acetamide; potassium carbonate; at 200℃; for 2h;	Part D. Preparation of 6-bromo-2-aminoquinoline.; [00797] The product from Part C (173mg, 0.713mmol), acetamide (843mg, 14.27mmol) and potassium carbonate (493mg, 3.57mmol) were combined and heated at 200 0C for 2h. Cooled to room temperature, whereupon it solidified. Dissolved in a mixture of CHCl3 and water. Aqueous layer was extracted twice more with CHCI3, extracts were combined, washed with brine, dried over Na2SOφ filtered and concentrated under vacuum. Purification by silica gel column chromatography eluting with MeOH/CHCl3 gave title compound (92mg, 58 %).
58%		[00539] Part D. Preparation of 6-bromo-2-aminoquinoline.; [00540] The product from Part C (173mg, 0.713mmol), acetamide (843mg, 14.27mmol) and potassium carbonate (493mg, 3.57mmol) were combined and heated at 200 0C for 2h. Cooled to room temperature, whereupon it solidified. Dissolved in a mixture of CHCI3 and water. Aqueous layer was extracted twice more with CHCI3, extracts were combined, washed with brine, dried over Na2SOφ filtered and concentrated under vacuum. Purification by silica gel column chromatography eluting with MeOH/CHCl3 gave title compound (92mg, 58 %).
34%	With acetamide; potassium carbonate; at 200℃; for 2h;	A mixture of 6-bromo-2-chloro-quinoline (2.0 g, 8.3 mmol), acetamide (9.74 g, 165 mmol) and potassium carbonate (3.4 g, 25 mmol) was heated at 200 C for 2 h. The reaction mixture was allowed to cool to rt whereupon the mixture solidified. The residue was taken up in DCM (15 ml_) and water (10 ml_), and the layers separated. The aqueous layer was extracted with DCM (2 x 15 ml_), the combined organic extracts were washed with brine, dried (MgSCU) and concentrated under vacuum to yield the title compound as a beige solid (780 mg, 34 %).1H NMR dH(400 MHz, Chloroform-d) 8.01 (d, J = 8.6 Hz, 1 H), 7.83 - 7.78 (m, 1 H), 7.78 - 7.73 (m, 1 H), 7.61 (dd, J = 8.9, 2.2 Hz, 1 H), 7.51 (d, J = 8.9 Hz, 1 H), 4.94 (s, 2H); LCMS (Method B): 1.10 min, (222.9/224.9, MH+).

Reference： [1]Patent: WO2009/39127,2009,A1 .Location in patent: Page/Page column 181
[2]Patent: WO2009/39134,2009,A1 .Location in patent: Page/Page column 110
[3]Patent: WO2021/13910,2021,A1 .Location in patent: Page/Page column 46
[4]Journal of Medicinal Chemistry,2004,vol. 47,p. 5405 - 5417
[5]Journal of Medicinal Chemistry,2011,vol. 54,p. 5836 - 5857
[6]Patent: WO2018/237370,2018,A1

2
[ 4637-24-5 ]
[ 791626-58-9 ]
[ 1056616-23-9 ]

Yield	Reaction Conditions	Operation in experiment
		Step 2: 7-Bromo-[1,2,4]triazolo[1,5-a]quinoline (8b) 8a (497 mg, 2.46 mmol) and dimethoxymethyldimethylamine (1 mL) were combined in DMF (5 mL) and heated to 130 C. for 1 hour. The reaction was concentrated and redissolved in MeOH (5 mL) and pyridine (400 mg). Hydroxylamine-O-sulfonic acid (282 mg, 2.49 mmol) was added, and the mixture was stirred at room temperature for 3 days. The solution was concentrated and poured into water, and the resulting solid was filtered and dried to give the desired product, 8b.

Reference： [1]Patent: US2007/173508,2007,A1 .Location in patent: Page/Page column 111; 112

3
6-bromo-N-(4-methoxybenzyl)quinolin-2-amine [ No CAS ]
[ 791626-58-9 ]

Yield	Reaction Conditions	Operation in experiment
78%	With trifluoroacetic acid; at 80℃;	A mixture of B80-1 (100 mg, 0.29 mmol) in TFA (4 mL) was stirred at 80 C overnight. After cooling to room temperature, the mixture was evaporated. The residue was dissolved in iN HC1 (10 mL) and washed with ethyl acetate (10 mL * 3). It was adjusted pH to 9 by iN NaOH and extracted with dichloromethane (20 mL * 3). The organic layer was dried over Na2504, filtered and concentrated to give the title compound as a yellow oil (50 mg, 78 %).
	With trifluoroacetic acid; for 1h;Heating / reflux;	Step 1: 6-Bromo-quinolin-2-ylamine (8a) 6-Bromo-2-chloro-quinoline (3.34 g, 13.8 mmol) was dissolved in p-methoxybenzylamine (5 mL) and heated to 140 C. for 1 hour. The mixture was cooled to room temperature, filtered, and concentrated. The residue was purified by silica gel chromatography, and the isolated material was refluxed in TFA (6 mL) for 1 hour. The mixture was concentrated and purified by silica gel chromatography to give the desired product, 8a.

Reference： [1]Patent: WO2018/237370,2018,A1 .Location in patent: Paragraph 00271; 00274; 00275
[2]Patent: US2007/173508,2007,A1 .Location in patent: Page/Page column 82; 111; 112
[3]Journal of Medicinal Chemistry,2011,vol. 54,p. 5836 - 5857

4
[ 124-63-0 ]
[ 791626-58-9 ]
[ 1132940-94-3 ]

Yield	Reaction Conditions	Operation in experiment
61%	With triethylamine; In dichloromethane; at 20℃; for 17h;	Part E. Preparation of N-(6-bromoquinolin-2-yl)-N-(methylsulfonyl)methanesulfonamide.; [00799] Combined the product from Part D (90mg, 0.403 mmol) and CH2Cl2 (2.0ml) and added triethylamine (0.062ml, 0.444mmol) and methanesulfonyl chloride (0.035ml, 0.444mmol). Stirred at room temperature 16h. Added triethylamine (0.062ml, 0.444mmol) and methanesulfonyl chloride (0.035ml, 0.444mmol) and stirred at room temperature for Ih. Diluted with EtOAc, washed with 10% citric acid, 10% NaHCO3 and brine. Dried over Na2SO4, filtered and concentrated under vacuum. Dissolved in EtOAc and poured into excess hexane. Solid collected by filtration to give the title compound (94mg, 61%).
61%	With triethylamine; In dichloromethane; at 20℃; for 17h;	[00541] Part E. Preparation of N-(6-bromoquinolin-2-yl)-N-(methylsulfonyl)methanesulfonamide.; [00542] Combined the product from Part D (90mg, 0.403mmol) and CH2Cl2 (2.0ml) and added triethylamine (0.062ml, 0.444mmol) and methanesulfonyl chloride (0.035ml, 0.444mmol). Stirred at room temperature 16h. Added triethylamine (0.062ml, 0.444mmol) and methanesulfonyl chloride (0.035ml, 0.444mmol) and stirred at room temperature for Ih. Diluted with EtOAc, washed with 10% citric acid, 10% NaHCO3 and brine. Dried over Na2SO4, filtered and concentrated under vacuum. Dissolved in EtOAc and poured into excess hexane. Solid collected by filtration to give the title compound (94mg, 61%).

Reference： [1]Patent: WO2009/39127,2009,A1 .Location in patent: Page/Page column 181
[2]Patent: WO2009/39134,2009,A1 .Location in patent: Page/Page column 110

5
[ 108-24-7 ]
[ 791626-58-9 ]
[ 1201845-09-1 ]

Yield	Reaction Conditions	Operation in experiment
63.1%	dmap; at 45 - 100℃;	(3) N-(6-bromoquinolin-2-yl)acetamide.; A pyrex reaction tube was charged with <strong>[791626-58-9]6-bromoquinolin-2-amine</strong> (200 mg, 897 μmol) and acetic anhydride (1692 μl, 17932 μmol). The tube was sealed and the mixture was heated at 45 0C. After 3 h, LCMS showed no conversion. Catalytic DMAP was added, and heating was continued for 2 h. Trace conversion was observed. The temperature was increased to 100 0C and the reaction was stirred overnight. LCMS showed complete conversion in the morning. The mixture was cooled to 0 0C and the solids were filtered and rinsed with ether to provide N-(6-bromoquinolin-2-yl)acetamide (150 mg, 63.1% yield) as a brown solid. MS (ESI pos. ion) m/z calc'd for CnH9BrN2O: 265.1/267.1; found 264.9/267.0.

Reference： [1]Patent: WO2009/155121,2009,A2 .Location in patent: Page/Page column 109

6
[ 1112983-23-9 ]
[ 791626-58-9 ]
[ 1201842-62-7 ]

Yield	Reaction Conditions	Operation in experiment
12%	With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In ethanol; at 90℃; for 2h;	EXAMPLE 46; N-(5-(2-amino-6-quinolinyl)-2-chloro-3-pyridinyl)-4- methoxybenzenesulfonamide; A reaction tube was charged with sodium carbonate (353 μl, 706 μmol), Pd(Ph3P)4 (16 mg, 14 μmol), N-(2-chloro-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)pyridin-3-yl)-4-methoxybenzenesulfonamide (100 mg, 235 μmol), <strong>[791626-58-9]6-bromoquinolin-2-amine</strong> (53 mg, 235 μmol) and 1.2 mL EtOH. The tube was sealed and the mixture was heated at 90 0C for 2 h. The mixture was diluted with CH2Cl2 and washed with water. The organic portion was dried with MgSO4, filtered and concentrated. The crude material was dissolved in MeOH/DMSO and purified by reverse phase chromatography, 10-90% ACN/0.1% TFA in water over 15 min. The aqueous portion was brought to ~pH 7 and extracted. The organic portion was dried, filtered and concentrated to provide N-(5-(2-aminoquinolin-6-yl)-2-chloropyridin-3-yl)-4- methoxybenzenesulfonamide (12 mg, 12% yield) as a light yellow solid. MS (ESI pos. ion) m/z calc'd for C2IH17ClN4O3S: 440.9/442.9; found 441.0/443.0. 1H NMR (400 MHz, DMSO-d6) δ ppm 3.88 (s, 3 H), 6.88 (br s, 2 H), 6.89 (d, 1 H, J = 8), 7.15-7.18 (m, 2 H), 7.61 (d, 1 H, J = 8), 7.75-7.80 (m, 3 H), 7.97-8.00 (m, 2 H), 8.03-8.06 (m, 1 H), 8.62-8.63 (m, 1 H), 10.46 (br, s, 1 H).

Reference： [1]Patent: WO2009/155121,2009,A2 .Location in patent: Page/Page column 110

7
[ 16419-60-6 ]
[ 791626-58-9 ]
[ 1308869-78-4 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium carbonate;bis-triphenylphosphine-palladium(II) chloride; In butan-1-ol; at 55℃;Inert atmosphere;	Step 1 : To a solution of <strong>[791626-58-9]6-bromoquinolin-2-amine</strong> (5.0 g, 22 mmol), o-tolylboronic acid (4.3 g, 31 mmol), saturated sodium carbonate (2.5 ml, 22 mmol) and «BuOH (50 ml, 546 mmol) under N2 was added dichlorobis (triphenyl-phosphine)palladium (II) (1.6 g, 2.2 mmol). The reaction mixture was heated to 55 C and allowed to stir overnight. The reaction mixture was allowed to cool to RT then was extracted with EtOAc and washed with water and brine (3 x) then dried over MgS0 and concentrated in vacuo to remove solvent. The crude orange solid was dissolved in DCM and loaded onto achromatography column and eluted with 0-75% EtOAc/Hexane then 100% EtOAc to give 6-o-tolylquinolin-2-amine as light yellow solid.

Reference： [1]Patent: WO2011/63272,2011,A1 .Location in patent: Page/Page column 37
[2]Journal of Medicinal Chemistry,2011,vol. 54,p. 5836 - 5857

8
[ 791626-58-9 ]
[ 1308869-79-5 ]

Reference： [1]Patent: WO2011/63272,2011,A1

9
[ 791626-58-9 ]
N-(3-(2-(6-cyclopentenylpyrimidin-4-yl)cyclopent-2-enyl)-6-o-tolylquinolin-2-yl)pivalamide [ No CAS ]

Reference： [1]Patent: WO2011/63272,2011,A1

10
[ 791626-58-9 ]
[ 1308869-86-4 ]

Reference： [1]Patent: WO2011/63272,2011,A1

11
[ 791626-58-9 ]
[ 1308869-06-8 ]

Reference： [1]Patent: WO2011/63272,2011,A1

12
[ 791626-58-9 ]
[ 1308869-64-8 ]

Reference： [1]Patent: WO2011/63272,2011,A1

13
[ 147621-18-9 ]
[ 791626-58-9 ]
[ 1309365-60-3 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate;PS-PPh3-Pd; In 1,2-dimethoxyethane; ethanol; at 140℃; for 0.166667h;microwave irradiation;	Step 1; A mixture of l//-indol-6-ylboronic acid (43 mg, 0.27 mmol), 6-bromoquinolin-2 -amine (40 mg, 0.22 mmol), K2C03 (3M, 100 uL), PS-PPh3-Pd (20 mg, 0.11 mmol/g), andDME/EtOH (50%, 1 mL) was heated in a microwave at 140 C for 10 min. The resulting slurry was filtered and purified by HPLC (10-60% CH3CN/water modified with 0.1% TFA) to give 6-(l//-indol-6-yl)quinolin-2-amine (31 mg). MS (ESI, pos. ion) m/z: 260 (M+l).

Reference： [1]Patent: WO2011/63233,2011,A1 .Location in patent: Page/Page column 54

14
[ 269409-99-6 ]
[ 791626-58-9 ]
[ 1309365-78-3 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium acetate;bis[di-t-butyl(p-dimethylaminophenyl)phosphino]palladium (II) Dichloride; In ethanol; water; at 85℃; for 8h;microwave irradiation;	Step 1; To a microwave reaction vessel was added ethyl-2-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)benzoate (3.7 g, 13 mmol), <strong>[791626-58-9]6-bromoquinolin-2-amine</strong> (2.0 g, 9.0 mmol), PdCl2(PPh(t-Bu)2)2 (0.084 g, 0.13 mmol), potassium acetate (1.8 g, 18 mmol), EtOH (9.9 ml, 170 mmol) and water (2.4 ml, 134 mmol). The reaction mixture was heated at 85 C for 8 h, and was then partitioned between EtOAc and water. The organic layer was washed with water and brine and allowed to stand for 72 h. The supernatant was decanted from the resulting precipitate and the precipitate was dried in vacuo to give ethyl 2-(2-aminoquinolin-6-yl)benzoate.

Reference： [1]Patent: WO2011/63233,2011,A1 .Location in patent: Page/Page column 55

15
[ 791626-58-9 ]
[ 1309365-68-1 ]

Reference： [1]Patent: WO2011/63233,2011,A1

16
[ 791626-58-9 ]
[ 1309365-61-4 ]

Reference： [1]Patent: WO2011/63233,2011,A1

17
[ 5332-25-2 ]
[ 791626-58-9 ]

Reference： [1]Patent: US2011/152246,2011,A1
[2]Dyes and Pigments,2013,vol. 99,p. 240 - 249
[3]Journal of Materials Chemistry C,2015,vol. 3,p. 3774 - 3782
[4]Advanced Synthesis and Catalysis,2020,vol. 362,p. 5777 - 5782

18
[ 15761-39-4 ]
[ 791626-58-9 ]
[ 1312611-19-0 ]

Yield	Reaction Conditions	Operation in experiment
64%		General Procedure VII-AETo a solution of compound I-If (0.3 g 1.34 mmol) and HATU (0.56 g 1.34 mmol) in dry DMF (15 mL) was added DMA (0.35 g, 2.68 mmol). The mixture was stirred for 1 h at room temperature. Then <strong>[791626-58-9]6-bromoquinolin-2-amine</strong> (VII-VIIIf, 0.288 g, 1.34 mmol) was added into the mixture. The reaction mixture was stirred overnight at room temperature, and quenched with saturate NH4Cl solution then extracted with EA (4×30 mL). Combined organic layer extracts was dried over Na2SO4 and concentrated under reduced pressure to give the crude product which was purified by chromatography on silica gel column to give compound VII-VIIIg (200 mg, yield: 64%). 1H NMR (300 MHz, DMSO-d6): δ8.45-8.45 (d, 1H), 8.44-8.44 (d, 1H), 8.33-8.29 (q, 1H), 7.32-7.28 (q, 2H), 4.06-4.04 (t, 1H), 3.34-3.30 (t, 2H), 1.83-1.69 (m, 4H), 1.43-1.28 (s, 9H), MS (ESI) m/z (M+Na)+ 443.9.

Reference： [1]Patent: US2011/152246,2011,A1 .Location in patent: Page/Page column 270-271

19
[ 6563-11-7 ]
[ 791626-58-9 ]

Yield	Reaction Conditions	Operation in experiment
78.3%		To a round bottom flask was charged 2 (2.24g, 10.0mmol, 1.0equiv), 40mL trifluorotoluene and 20mL chloroform under N2. After compound 2 was dissolved, the mixture was cooled to 0-10C with an ice-bath. T-butylamine (5.3mL, 50.0mmol, 5.0equiv) was added followed by Ts2O (6.50g, 20.0mmol, 2.0equiv) while the temperature was kept at 5-12C. If the reaction were not completed within 30min, portions of t-butylamine (0.6equiv. to 4.0equiv.) and Ts2O (0.3equiv. to 2.3equiv.) would be charged until the reaction completed. The reaction was then treated with TFA 25mL at 70C for 10h. Most of the solvents could be removed under vacuum. The oil residue was diluted with CH2Cl2 and quenched with 50% aq solution NaOH to pH 9-10. The aqueous layer was extracted with CH2Cl2 (50mL) three times. The combined organic layers were dried with MgSO4. The solvent was removed by reduced pressure and the crude product was then purified by silica gel column chromatography (2% MeOH/CH2Cl2) to give the desired 4 as a gray solid (1.75g, 78.3% yield), m.p. 139-145C (lit [16]. 141-146C). 1H NMR (400MHz, CDCl3) δ (ppm): 7.79 (d, J=8.8Hz, 1H), 7.76 (d, J=2.2Hz, 1H), 7.61 (dd, J1=8.9Hz, J2=2.2Hz, 1H), 7.52 (d, J=8.9Hz, 1H), 6.73 (d, J=8.8Hz, 1H), 4.83 (s, 2H).

Reference： [1]Dyes and Pigments,2013,vol. 99,p. 240 - 249
[2]Patent: US2011/152246,2011,A1
[3]Journal of Materials Chemistry C,2015,vol. 3,p. 3774 - 3782
[4]Advanced Synthesis and Catalysis,2020,vol. 362,p. 5777 - 5782

20
[ 65148-10-9 ]
[ 791626-58-9 ]

Reference： [1]Patent: US2011/152246,2011,A1

21
[ 65185-41-3 ]
[ 791626-58-9 ]

Reference： [1]Patent: US2011/152246,2011,A1

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P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 791626-58-9 ] 6-Bromoquinolin-2-amine

Quality Control of [ 791626-58-9 ]

Related Doc. of [ 791626-58-9 ]

Product Details of [ 791626-58-9 ]

Safety of [ 791626-58-9 ]

Application In Synthesis of [ 791626-58-9 ]

[ 791626-58-9 ] Synthesis Path-Downstream 1~21

Technical Information

Related Functional Groups of [ 791626-58-9 ]

Bromides

Amines

Related Parent Nucleus of [ 791626-58-9 ]

Quinolines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 791626-58-9 ]

Related Parent Nucleus of
[ 791626-58-9 ]