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Chemical Structure| 4403-71-8 Chemical Structure| 4403-71-8
Chemical Structure| 4403-71-8

4-(Aminomethyl)aniline

CAS No.: 4403-71-8

4.5 *For Research Use Only !

Cat. No.: A525887 Purity: 98%

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Product Details of [ 4403-71-8 ]

CAS No. :4403-71-8
Formula : C7H10N2
M.W : 122.17
SMILES Code : NC1=CC=C(CN)C=C1
MDL No. :MFCD00075513
InChI Key :BFWYZZPDZZGSLJ-UHFFFAOYSA-N
Pubchem ID :427814

Safety of [ 4403-71-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338+P310-P363-P405-P501
Class:8
UN#:3259
Packing Group:

Application In Synthesis [ 4403-71-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4403-71-8 ]

[ 4403-71-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 6492-86-0 ]
  • [ 4403-71-8 ]
  • [ 1070270-93-7 ]
  • 2
  • [ 21279-62-9 ]
  • [ 4403-71-8 ]
  • 3-[(4-aminobenzyl)amino]pyrazine-2-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
46% With pyridine; In methanol; at 140℃; for 0.5h;Sealed tube; Microwave irradiation; General procedure: Compounds 1-6 were prepared according to conventional organic synthesis methods. 3-Chloropyrazine-2-carboxamide (1.27 mmol) was dissolved in THF (20 mL) in a round bottom flask and after that treated with two equivalents of the corresponding benzylamine and an equimolar amount of triethylamine. The reaction was conducted with continuous stirring and heating (70 C) under reflux in an oil bath for 15 h. Compounds 7-15 were synthesised using a microwave reactor with a focused field. 3-Chloropyrazine-2-carboxamide (1.27 mmol) was put into a thick-walled tube together with the corresponding benzylamine (2.54 mmol), pyridine (1.27 mmol), methanol (approx. 5 mL) and a magnetic stir bar and then sealed with a special cap. The reaction parameters were set according to the previously published paper as follows-140 C, 30 min, 200 W [29]. Reaction progress was checked by TLC (hexane:ethyl acetate-1:1). Regardless of the synthesis method used,all reaction mixtures were adsorbed on silica and subjected to preparative flash chromatography (hexane and ethyl acetate, gradient elution, detection wavelengths 260 nm and 280 nm). Products were recrystallized from ethanol or ethanol and water if necessary. All final substances were chemically characterized (1H-NMR, 13C-NMR, IR, melting point and elemental analysis).
 

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