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Chemical Structure| 2075-45-8 Chemical Structure| 2075-45-8
Chemical Structure| 2075-45-8

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Product Details of 4-Bromopyrazole

CAS No. :2075-45-8
Formula : C3H3BrN2
M.W : 146.97
SMILES Code : C1=N[NH]C=C1Br
MDL No. :MFCD00075602
InChI Key :WVGCPEDBFHEHEZ-UHFFFAOYSA-N
Pubchem ID :16375

Safety of 4-Bromopyrazole

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P305+P351+P338

Application In Synthesis of 4-Bromopyrazole

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 2075-45-8 ]
  • Downstream synthetic route of [ 2075-45-8 ]

[ 2075-45-8 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 2075-45-8 ]
  • [ 50901-46-7 ]
References: [1] Journal of Organic Chemistry USSR (English Translation), 1982, vol. 18, p. 6 - 10[2] Zhurnal Organicheskoi Khimii, 1982, vol. 18, # 1, p. 9 - 14.
  • 2
  • [ 2075-45-8 ]
  • [ 4333-56-6 ]
  • [ 1151802-23-1 ]
YieldReaction ConditionsOperation in experiment
68% With caesium carbonate In N,N-dimethyl-formamide at 180℃; for 1.5 h; Microwave irradiation Step 1 : 4-Bromo- 1 -cyc A mixture of 4-bromo-lH-pyrrazole (1.0 g, 6.8 mmol), bromo cyclopropane (1.3 g, 10.7 mmol), cesium carbonate (3.5 g. 10.7 mmol), and DMF (6 mL) in a 30 mL microwave vial is heated to 180 °C under radiation for 1.5 hr. After cooled to room temperature, the reaction mixture is filtered. The filtrate is concentrated and the residue is purified on a silica gel flash chromatography with ethyl acetate/petroleum ether (1 :5) to get a brown liquid (0.87 g, 68percent yield). (MS: [M+l] 259)
References: [1] Patent: WO2014/32498, 2014, A1, . Location in patent: Page/Page column 14.
[2] Patent: US2015/31673, 2015, A1, . Location in patent: Paragraph 0334.
 

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