35979-69-2|4-Bromo-2-methyl-2-butanol| Ambeed

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Quality Control of [ 35979-69-2 ] Purity: 98% SDS Specification

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Product Details of [ 35979-69-2 ]

CAS No. :	35979-69-2
Formula :	C₅H₁₁BrO
M.W :	167.04
SMILES Code :	CC(O)(C)CCBr
MDL No. :	MFCD20483824
InChI Key :	RBFVGQWGOARJRU-UHFFFAOYSA-N
Pubchem ID :	10607172

Safety of [ 35979-69-2 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 35979-69-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 35979-69-2 ]

[ 35979-69-2 ] Synthesis Path-Downstream 1~35

1
[ 917-64-6 ]
[ 539-74-2 ]
[ 35979-69-2 ]

References: [1]Helvetica Chimica Acta,1979,vol. 62,p. 1854 - 1865.
[2]Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases,1984,vol. 80,p. 3391 - 3398.
[3]Tetrahedron Letters,2000,vol. 41,p. 7337 - 7340.

2
[ 539-74-2 ]
[ 75-16-1 ]
[ 35979-69-2 ]

Yield	Reaction Conditions	Operation in experiment
75.1%	In tetrahydrofuran; at 0℃;	Intermediate 45 4-bromo-2-methylbutan-2-ol To a solution of methyl 3-bromopropanoate (0.2 g, 1.2 mmol,) in THF (5 mL) was added methyl magnesium bromide (2.4 mL, 2.4 mmol) at 0 C. The mixture was stirred at this temperature until the substrate was consumed based on tic [petroleum ether/ethyl acetate (3: 1); product Rf 0.3]. The reaction was quenched with ammonium chloride (2 mL) at 0 C. The mixture was partitioned between ethyl acetate and water. The combined organic layer was dried over sodium sulfate, filtered and concentrated, to give a crude product which was purified by a column chromatography eluting with petroleum ether/ ethyl acetate (3: 1 ) to give 4-bromo-2- methylbutan-2-ol (0.15 g, 75.1 % yield) as a yellow oil.
	In diethyl ether; at 0℃;	a) 4-Bromo-2-methylbutan-2-olTo a cooled solution of ethyl 3-bromopropanoate (0.5 g, 2.8 mmol) in diethyl ether (50 ml) at 0 C was added methyl magnesium bromide (0.98 g, 8.3 mmol, 3 eq.) dropwise over 5 min and the mixture was allowed to stir until TLC showed complete absence of the starting material. The mixture was quenched and extracted as in Inter- mediate Example 5(c). The solvent was distilled off to give the crude product (0.4 g).
	In diethyl ether; at 0℃; for 0.0833333h;	To a cooled solution of ethyl 3-bromopropanoate (0.5 g, 2.8 mmol) in diethyl ether (50 ml) at 0 C. was added methyl magnesium bromide (0.98 g, 8.3 mmol, 3 eq.) dropwise over 5 min and the mixture was allowed to stir until TLC showed complete absence of the starting material. The mixture was quenched and extracted as in Intermediate Example 5(c). The solvent was distilled off to give the crude product (0.4 g).

In diethyl ether; at -20 - 20℃; for 2h;

Methyl magnesium bromide (11.04 mL, 33.14 mmol) was added drop wise over 10 min to a well-stirred mixture of ethyl 3-bromopropanoate (compound 24; 2.0 g, 11.04 mmol) in diethyl ether (25 mL) at -20 C. The reaction mixture was stirred at rt for over 2 h. On completion the reaction mixture was poured into aq. NH4Cl (25 mL) and extracted with EtOAc (2*25 mL). The combined organic layers were washed with H2O (100 mL) and brine (100 mL), separated and then dried over anhydrous Na2SO4. Evaporated under reduced pressure yielded 2.1 g of crude compound 25 which was used directly in the next step without any further purification.

References: [1]Patent: WO2014/143799,2014,A2 .Location in patent: Page/Page column 403.
[2]Bioorganic and Medicinal Chemistry,2001,vol. 9,p. 525 - 535.
[3]Journal of Medicinal Chemistry,2022,vol. 65,p. 4767 - 4782.
[4]Journal of Medicinal Chemistry,2021,vol. 64,p. 629 - 643.
[5]Journal of Organometallic Chemistry,1973,vol. 47,p. 337 - 350.
[6]Tetrahedron Letters,1992,vol. 33,p. 105 - 108.
[7]ACS Medicinal Chemistry Letters,2012,vol. 3,p. 828 - 833.
[8]Patent: WO2013/53983,2013,A1 .Location in patent: Page/Page column 32.
[9]Patent: US2015/11548,2015,A1 .Location in patent: Paragraph 0138.
[10]Patent: US2019/263792,2019,A1 .Location in patent: Paragraph 0444; 0445.

3
[ 35979-69-2 ]
[ 603-35-0 ]
[ 67883-18-5 ]

References: [1]Tetrahedron Letters,2000,vol. 41,p. 7337 - 7340.
[2]Journal of general chemistry of the USSR,1978,vol. 48,p. 818 - 822.
Zhurnal Obshchei Khimii,1978,vol. 48,p. 897 - 902.

4
[ 107-82-4 ]
[ 35979-69-2 ]

References: [1]Synthesis,1976,p. 523 - 524.

5
[ 3395-91-3 ]
[ 75-16-1 ]
[ 35979-69-2 ]

Yield	Reaction Conditions	Operation in experiment
71.7%	In diethyl ether; at -20℃; for 1h;Inert atmosphere;	In a 250 mL round bottom flask, methyl 3-bromopropanoate (5.0 mL, 45.8 mmol, 1.0 eq.) was taken up in dry ether (55.2 mL, 0.83 M) under nitrogen and cooled to -20 C. To this, 3.0 M methylmagnesium bromide (45.8 ml, 137 mmol, 3.0 eq) was added in dropwise fashion and the resulting mixture was stirred for an hour. The reaction was quenched with aqueous ammonium chloride. The resulting white suspension was extracted with ether multiple times. The combined organics were washed with brine, dried over MgSO4, and concentrated to yield 4-bromo-2-methylbutan-2-ol as an oil (5.49 g, 71.7%)
65%	In diethyl ether; at 0 - 20℃; for 2h;	To a stirred solution of 4-bromo-butyric acid methyl ester (2 g, 12.27 mmol) in diethyl ether (20 mL) is added methyl magnesium bromide (16.4 mL, 49.08 mmol) at 0 C. and the mixture is stirred at room temperature for 2 hours. The reaction mixture is quenched with 1 N HCl and extracted with diethyl ether (2*20 mL). The combined organic extracts are washed with saturated brine solution (20 mL), dried over sodium sulphate, filtered, and concentrated. The crude material is purified with silica gel column chromatography (combiflash) eluting in 20% EtOAc/hexanes to give the title compound (1.3 g, 65%). 1H NMR (400 MHz, CDCl3): δ 3.48 (t, J=8.0 Hz, 2H), 2.16 (t, J=7.4 Hz, 2H), 1.89 (s, 6H), 1.76 (s, 3H), 1.27 (s, 6H).
60%	In diethyl ether; at 0 - 20℃; for 1h;	To a stirred solution of 4-bromo-butyric acid methyl ester (1 g, 5.9 mmol) in diethyl ether (20 mL) is added methyl magnesium bromide (19.9 mL, 23.9 mmol) at 0 C and the mixture is stirred at room temperature for 1 hour. The reaction mixture is quenched with aqueous ammonium chloride (40 mL) and extracted with diethyl ether (2x20 mL). The combined organic extracts are washed with saturated brine solution (20 mL), dried over sodium sulphate, filtered, and concentrated. The crude material is purified by silica gel column chromatography (combiflash) eluting with 20%EtOAc/hexanes to obtain title compound as pale pink liquid (0.6 g, 60%). ^NMR (400 MHz, DMSO) δ 4.38 (s, 1H), 3.52-3.48 (m, 2H), 1.97-1.91 (m, 2H), 1.08 (s, 6H).

48.9%	In tetrahydrofuran; at 0 - 20℃; for 16h;	a) 4-Bromo-2-methylbutan-2-olTo a solution of methyl 3-bromopropanoate (5.0 g, 29.94 mmol, and 1.0 eq) in dry THF was added methyl magnesium bromide at 0C. The mixture was stirred at RT for 16 h and quenched and extracted as in Intermediate Example 5(c). The solvent was distilled off to afford the crude residue which was purified by column chromatography (60-120 silica gel, 50 % ethyl acetate in hexane). Yield 48.9 % (2.4 g). LC-MS (ESI): Calculated mass: 167.0; Observed massl67.1 [M+H]+ (it: 0.8-1.0 min).
48.9%	In tetrahydrofuran; at 0 - 20℃; for 16h;	To a solution of methyl 3-bromopropanoate (5.0 g,29.94 mmol, and 1.0 eq) in dry THF was added methyl mag21 nesium bromide at 0 C. The mixture was stirred at RT for 16 h and quenched and extracted as in Intermediate Example 5(c). The solvent was distilled off to afford the crude residue which was purified by column chromatography (60-120 silica gel, 50% ethyl acetate in hexane). Yield 48.9% (2.4 g). LCMS (ESI): Calculatedmass: 167.0; Observedmass 167.1[M+ H] (it: 0.8-1.0mm).

References: [1]Patent: US2011/105509,2011,A1 .Location in patent: Page/Page column 51.
[2]Patent: US2016/333005,2016,A1 .Location in patent: Paragraph 0074-0075.
[3]Steroids,1991,vol. 56,p. 311 - 315.
[4]Patent: WO2015/105786,2015,A1 .Location in patent: Page/Page column 13; 14.
[5]Patent: WO2013/53983,2013,A1 .Location in patent: Page/Page column 45; 46.
[6]Patent: US2015/11548,2015,A1 .Location in patent: Paragraph 0180.

6
[ 35979-69-2 ]
[ 69739-34-0 ]
[ 116585-11-6 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1988,p. 1417 - 1424.
[2]ACS Medicinal Chemistry Letters,2012,vol. 3,p. 828 - 833.

7
[ 35979-69-2 ]
[ 143-33-9 ]
[ 6789-52-2 ]

References: [1]Tetrahedron,1997,vol. 53,p. 10851 - 10870.
[2]Tetrahedron Letters,1992,vol. 33,p. 105 - 108.

8
[ 35979-69-2 ]
[ 108-98-5 ]
[ 91967-95-2 ]

References: [1]Steroids,1991,vol. 56,p. 311 - 315.

9
[ 110-87-2 ]
[ 35979-69-2 ]
4-bromo-2-methyl-2-butyltetrahydropyranylether [ No CAS ]

References: [1]European Journal of Medicinal Chemistry,1995,vol. 30,p. 769 - 778.

10
[ 35979-69-2 ]
[ 107-30-2 ]
[ 305371-69-1 ]

References: [1]Bioorganic and Medicinal Chemistry,2001,vol. 9,p. 525 - 535.

11
[ 863408-15-5 ]
[ 35979-69-2 ]
4-(4-{1-ethyl-1-[4-(3-hydroxy-3-methyl-butylamino)-3-methyl-phenyl]-propyl}-2-methyl-phenylamino)-2-methyl-butan-2-ol [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 4327 - 4331.

12
[ 35979-69-2 ]
[ 305371-76-0 ]

References: [1]Bioorganic and Medicinal Chemistry,2001,vol. 9,p. 525 - 535.

13
[ 35979-69-2 ]
[ 305371-75-9 ]

References: [1]Bioorganic and Medicinal Chemistry,2001,vol. 9,p. 525 - 535.

14
[ 35979-69-2 ]
[ 66774-84-3 ]

References: [1]Tetrahedron Letters,2000,vol. 41,p. 7337 - 7340.

15
[ 35979-69-2 ]
[ 70550-73-1 ]

References: [1]Tetrahedron Letters,2000,vol. 41,p. 7337 - 7340.

16
[ 35979-69-2 ]
[ 307953-25-9 ]

References: [1]Tetrahedron Letters,2000,vol. 41,p. 7337 - 7340.

17
[ 35979-69-2 ]
[ 139619-77-5 ]

References: [1]Tetrahedron,1997,vol. 53,p. 10851 - 10870.
[2]Tetrahedron Letters,1992,vol. 33,p. 105 - 108.

18
[ 35979-69-2 ]
[ 139619-79-7 ]

References: [1]Tetrahedron,1997,vol. 53,p. 10851 - 10870.
[2]Tetrahedron Letters,1992,vol. 33,p. 105 - 108.

19
[ 35979-69-2 ]
[ 139619-76-4 ]

References: [1]Tetrahedron,1997,vol. 53,p. 10851 - 10870.
[2]Tetrahedron Letters,1992,vol. 33,p. 105 - 108.

20
[ 35979-69-2 ]
[ 139619-80-0 ]

References: [1]Tetrahedron,1997,vol. 53,p. 10851 - 10870.
[2]Tetrahedron Letters,1992,vol. 33,p. 105 - 108.

21
[ 35979-69-2 ]
[ 194414-15-8 ]

References: [1]Tetrahedron,1997,vol. 53,p. 10851 - 10870.
[2]Tetrahedron Letters,1992,vol. 33,p. 105 - 108.

22
[ 35979-69-2 ]
[ 139619-81-1 ]

References: [1]Tetrahedron,1997,vol. 53,p. 10851 - 10870.
[2]Tetrahedron Letters,1992,vol. 33,p. 105 - 108.

23
[ 35979-69-2 ]
[ 139619-75-3 ]

References: [1]Tetrahedron,1997,vol. 53,p. 10851 - 10870.
[2]Tetrahedron Letters,1992,vol. 33,p. 105 - 108.

24
[ 35979-69-2 ]
[ 139619-73-1 ]

References: [1]Tetrahedron,1997,vol. 53,p. 10851 - 10870.
[2]Tetrahedron Letters,1992,vol. 33,p. 105 - 108.

25
[ 35979-69-2 ]
[ 139619-84-4 ]

References: [1]Tetrahedron,1997,vol. 53,p. 10851 - 10870.
[2]Tetrahedron Letters,1992,vol. 33,p. 105 - 108.

26
[ 35979-69-2 ]
[ 194208-59-8 ]

References: [1]Tetrahedron,1997,vol. 53,p. 10851 - 10870.
[2]Tetrahedron Letters,1992,vol. 33,p. 105 - 108.

27
[ 35979-69-2 ]
[ 139619-83-3 ]

References: [1]Tetrahedron,1997,vol. 53,p. 10851 - 10870.
[2]Tetrahedron Letters,1992,vol. 33,p. 105 - 108.

28
[ 35979-69-2 ]
5-ethyl-5-(3-hydroxy-3-methylbutyl)-2-thiobarbituric acid [ No CAS ]

References: [1]European Journal of Medicinal Chemistry,1995,vol. 30,p. 769 - 778.

29
[ 35979-69-2 ]
[ 172797-72-7 ]

References: [1]European Journal of Medicinal Chemistry,1995,vol. 30,p. 769 - 778.

30
[ 35979-69-2 ]
[ 139619-82-2 ]

References: [1]Tetrahedron Letters,1992,vol. 33,p. 105 - 108.

31
methanol potassium hydroxide [ No CAS ]
[ 368878-17-5 ]
[ 35979-69-2 ]
ammonium chloride [ No CAS ]
[ 368878-18-6 ]

Yield	Reaction Conditions	Operation in experiment
90%	In tetrahydrofuran;	(5) 1α,3β-bis(tert-butyldimethylsilyloxy)-17β-(3-hydroxy-3-methylbutylthiomethyl)androsta-5,7-diene To a solution of 1α,3β-bis(tert-butyldimethylsilyloxy)-17β-(acetylthiomethyl)androsta-5,7-diene (135 mg, 0.223 mmol) and <strong>[35979-69-2]4-bromo-2-methylbutan-2-ol</strong> (186 mg, 1.12 mmol) in tetrahydrofuran (1.5 ml), was added a 1M potassium hydroxide methanol solution (1.5 ml), followed by stirring at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure, followed by the addition of a saturated aqueous ammonium chloride solution and the extraction with ethyl acetate. The extract was washed with water and saturated brine, dried over anhydrous magnesium sulfate and evaporated under reduced pressure to remove the solvent. The thus obtained residue was purified by preparative thin layer chromatography (4 sheets (each 0.5 mm thickness), dichloromethane:ethyl acetate=9:1, developed once) to give the titled compound (131 mg, 90%) as a colorless oil. IR(neat): 3388, 2954, 2929, 2897, 2856, 1462, 1377, 1254, 1099, 1082 cm-1. 1H NMR δ: 0.05 (s, 3H), 0.06 (s, 6H), 0.11 (s, 3H), 0.58 (s, 3H), 0.88 (s, 18H), 0.91 (s, 3H), 1.23 (s, 6H), 2.71 (dd, J=11.8, 5.1 Hz, 1H), 2.75-2.87 (m, 1H), 3.67-3.74 (m, 1H), 3.96-4.12 (m, 1H), 5.28-5.35 (m, 1H), 5.54-5.61 (m, 1H). MS m/z: 648 (M+), 459 (100%). UV λmax nm: 271, 282, 294.

References: [1]Patent: US2003/195176,2003,A1 .

32
methanol potassium hydroxide [ No CAS ]
[ 368877-33-2 ]
[ 35979-69-2 ]
[ 368877-93-4 ]

Yield	Reaction Conditions	Operation in experiment
93%	In tetrahydrofuran;	(1) Synthesis of 1α,3β-bis(tert-butyldimethylsilyloxy)-17-(3-hydroxy-3-methylbutylthiomethyl)androsta-5,7,16-triene 17-Acetylthiomethyl-1α,3β-bis(tert-butyldimethylsilyloxy)androsta-5,7,16-triene (67.7 mg, 0.112 mmol), 1-bromo-3-hydroxy-3-methylbutane (93.5 mg, 0.560 mmol), 1M potassium hydroxide methanol solution (1 ml) and tetrahydrofuran (1 ml) were subjected to reaction using a procedure similar to that of Example 31(1) (at room temperature for 30 min.), worked up and purified by preparative thin layer chromatography (2 sheets (each 0.5 mm thickness), hexane:ethyl acetate=3:1, developed once) to give the titled compound (67.4 mg, 93%) as a colorless oil. IR(neat): 3417, 2956, 2929, 2856, 1471, 1462, 1371, 1254, 1099, 1074 cm-1. 1H NMR δ: 0.05 (s, 3H), 0.07 (s, 3H), 0.07 (s, 3H), 0.11 (s, 3H), 0.85 (s, 3H), 0.88 (s, 9H), 0.89 (s, 9H), 0.95 (s, 3H), 1.24 (s, 6H), 2.59 (m, 2H), 2.85 (m, 1H), 3.23 (m, 2H), 3.71 (brs, 1H), 3.98-4.12 (m, 1H), 5.36-5.42 (m, 1H), 5.56-5.64 (m, 2H). MS m/z: 646 (M+), 457 (100%). UV λmax nm: 271, 281, 294.

References: [1]Patent: US2003/195176,2003,A1 .

33
[ 67883-17-4 ]
[ 35979-69-2 ]

Yield	Reaction Conditions	Operation in experiment
	In methanol; chloroform;	Preparation 2 3-Hydroxy-3-methylbutyl phenyl sulphone (Compound 21) To a solution of 4-bromo-2-methyl-2-trimethylsilyloxybutane (9) (12 g) in methanol (55 ml) at room temperature was added ethanolic hydrogen chloride (ca. 1M, 0.2 ml). After 10 minutes the solution was concentrated in vacuo (at room temperature) to constant weight. The residue was taken up in chloroform and reconcentrated to constant weight to give 4-bromo-2-methyl-2-butanol (H, y=1, R1 =R2 =Me) as a chromatographically homogenous oil.

References: [1]Patent: US5401731,1995,A .

34
[ 288-32-4 ]
[ 994-30-9 ]
[ 35979-69-2 ]
[ 617-86-7 ]

Yield	Reaction Conditions	Operation in experiment
4.02 g (93%)	In N,N-dimethyl-formamide; pentane;	EXAMPLE 23 Preparation of 3-bromo-1,1-dimethylpropoxy)triethylsilane To a solution of 2.56 g (15.3 mmol) of <strong>[35979-69-2]4-bromo-2-methyl-2-butanol</strong> and 4.86 g (71.4 mmol) of imidazole in 15 ml of dry N,N-dimethylformamide at 0 C. was added dropwise 6.48 g (43.0 mmol) of chlorotriethylsilane. The mixture was stirred at room temperature for 3 hours and 20 minutes, then quenched by adding ice chips. The mixture was diluted with water and extracted with pentane. The organic phase was washed with water, saturated brine, dried (Na2 SO4) and evaporated to dryness. The residue was chromatographed on silica gel (40-63μ) using pentane to give 4.02 g (93%) of 3-bromo-1,1-dimethylpropoxy)triethylsilane as an oil: IR (CHCl3) 838 cm-1; 1 H NMR (CDCl3) δ 0.58 (q, J=8 Hz, 6 H), 0.94 (t, J=8 Hz, 9 H), 2.03 (m, 2 H), 3.48 (m, 2 H); MS m/e 265 (M+ --CH3).

References: [1]Patent: US5087619,1992,A .

35
ethyl acetate n-hexane [ No CAS ]
[ 539-74-2 ]
[ 35979-69-2 ]

Yield	Reaction Conditions	Operation in experiment
2.57 g (45%)	With hydrogenchloride; methylmagnesium bromide; In tetrahydrofuran;	EXAMPLE 22 Preparation of 4-bromo-2-methyl-2-butanol To a solution of 6.25 g (34.5 mmol) of ethyl 3-bromopropionate in 28 ml of dry tetrahydrofuran at -20 C. was added dropwise 28.8 ml (80.6 mmol) of 2.8M methylmagnesium bromide in ether. The mixture was stirred at room temperature for 2 hours and 50 minutes then quenched by addition of 15 ml of saturated aqueous ammonium chloride. After addition of 42 ml of 1N aqueous HCl, the organic phase was separated and the aqueous phase extracted with ether. The combined organic extracts were washed with saturated brine, dried (Na2 SO4) and evaporated to dryness. The residue was chromatographed on silica gel (40-63μ) using 30% ethyl acetate-hexane to give 2.57 g (45%) of 4-bromo-2-methyl-2-butanol as an oil: IR (CHCl3) 3605 cm-1; 1 H NMR (CDCl3) δ1.27 (s, 6 H), 1.33 (s, 1 H), 2.11 (m, 2 H), 3.51 (m, 2 H); MS m/e 151 (M+ --CH3).

References: [1]Patent: US5087619,1992,A .

Historical Records

Technical Information

• Alkyl Halide Occurrence • Appel Reaction • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chugaev Reaction • Corey-Kim Oxidation • Dess-Martin Oxidation • General Reactivity • Grignard Reaction • Heat of Combustion • Hiyama Cross-Coupling Reaction • Hydride Reductions • Jones Oxidation • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Martin's Sulfurane Dehydrating Reagent • Mitsunobu Reaction • Moffatt Oxidation • Oxidation of Alcohols by DMSO • Preparation of Alcohols • Preparation of Amines • Reactions of Alcohols • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Dihalides • Reactions with Organometallic Reagents • Ritter Reaction • Sharpless Olefin Synthesis • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Swern Oxidation

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P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 35979-69-2

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CAS No.: 35979-69-2

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[ 35979-69-2 ] Synthesis Path-Downstream 1~35

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