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CAS No. : | 17159-79-4 |
Formula : | C9H14O3 |
M.W : | 170.21 |
SMILES Code : | C1(C(OCC)=O)CCC(=O)CC1 |
MDL No. : | MFCD00013285 |
InChI Key : | ZXYAWONOWHSQRU-UHFFFAOYSA-N |
Pubchem ID : | 317638 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
67% | Potassium tert-butoxide (24 gm, 0.22 moles) and triphenylphosphine methyl iodide (78 gm, 28.22 moles) were dissolved in dry tetrahydrofuran (150 ml). The mixture was cooled to -780C and stirred at the same temperature for about 15 minutes. Ethyl 4- oxocyclohexane carboxylate (25 gm, 0.147 moles) in tetrahydrofuran was added drop wise and the mixture was stirred at the same temperature for about 30 minutes and then it was warmed to room temperature and stirred overnight, extraction was done with ethyl acetate and water. The organic layer was dried over sodium sulfate and concentrated. Purification was done by column chromatography using 5% ethyl acetate in hexane. Yield: 19 gm (67%); m/z: (M++l) 169.26NMR: (delta, CDCl3) : 4.64 (2H, s), 4.09- 4.15 (2H, q), 2.42- 2.47 (IH, m), 2.31- 2.39 (2H, m), 1.96- 2.09 (4H, m), 1.43- 1.62 (2H, m), 1.23- 1.26 (3H, t) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95.7% | Triphenylmethylphosphonium bromide (53.7g, 0.15mol) was dissolved in 500mL of THF, and potassium tert-butoxide (16.8g, 0.15mol) was added at -20C. Reacted for 0.5h after the temperature was raised to 0 C. Subsequently, ethyl 4-oxo-cyclohexylcarboxylate (Compound 8-1) (17g, 0.1mol) was dissolved in 100mL of THF and added dropwise to the flask under nitrogen, reacted at room temperature for 3 hours, then a small amount of water was added to dissolve the solid, and rotary evaporated to remove THF, extracted with anhydrous diethyl ether, dried, and concentrated, the concentrate was dissolved in n-hexane, and filtered by silica gel, then concentrated to give Compound 8-2 as a colorless liquid (16.1g, 95.7% yield). | |
95.7% | With potassium tert-butylate; In tetrahydrofuran; hexane; water; | 1) Ethyl 4-methylenecyclohexylcarboxylate (Compound 8-2) Triphenylmethylphosphonium bromide (53.7 g, 0.15 mol) was dissolved in 500 mL of THF, and potassium tert-butoxide (16.8 g, 0.15 mol) was added at -20 C. Reacted for 0.5 h after the temperature was raised to 0 C. Subsequently, ethyl 4-oxo-cyclohexylcarboxylate (Compound 8-1) (17 g, 0.1 mol) was dissolved in 100 mL of THF and added dropwise to the flask under nitrogen, reacted at room temperature for 3 hours, then a small amount of water was added to dissolve the solid, and rotary evaporated to remove THF, extracted with anhydrous diethyl ether, dried, and concentrated, the concentrate was dissolved in n-hexane, and filtered by silica gel, then concentrated to give Compound 8-2 as a colorless liquid (16.1 g, 95.7% yield). |
85% | Example 6 Ethyl 4-meth lenecyclohexanecarboxylate19[0141] To a suspension of methyltriphenylphosphonium bromide (1.57 g, 4.41 mmol) in THF (9 mL) at -10 C was added w-BuLi (2.5 M in hexanes, 1.65 mL, 4.11 mmol) dropwise and the solution was allowed to stir for lh. Ethyl 4-oxocyclohexanecarboxylate (0.47 mL, 2.94 mmol) was added and the reaction was allowed to warm to room temperature over 3 h. Acetone (3 mL) was added and the solvent was removed under reduced pressure. The residue was suspended in dichloromethane and ethyl ether (1 : 1), filtered and concentrated. The crude was purified by flash column chromatography to afford 19 as clear oil (419 mg, 85%). H NMR: 1.25 (t, 3H), 1.50-1.70 (m, 2H), 1.90-2.16 (m, 4H), 2.30-2.50 (m, 3H), 4.12 (q, 2H), 4.65 (s, 2H). |
84% | 30A. Ethyl 4-methylenecyclohexanecarboxylate To a solution of (methyl)triphenylphosphonium bromide (5.18 g, 14.51 mmol) in THF (50 mL) at 0 C. was added n-butyllithium (9.07 mL, 14.51 mmol). The reaction mixture was stirred at 0 C. for 30 min. Ethyl 4-oxocyclohexanecarboxylate (1.9 g, 11.16 mmol) in THF (8 mL) was then added at 0 C. and the reaction was warmed to rt and stirred for 2 h. The reaction was quenched with sat'd aq. NH4Cl and diluted with EtOAc. The organic layer was washed with water and brine, dried over MgSO4, filtered, and concentrated in vacuo. The residue was purified by flash chromatography on SiO2 (0 to 50% EtOAc:hexanes) to afford the title compound (1.58 g, 84% yield) as a colorless oil. 1H NMR (500 MHz, CDCl3) delta 4.65 (s, 2H), 4.17-4.11 (m, 2H), 2.44 (tt, J=11.1, 3.8 Hz, 1H), 2.35 (dt, J=13.7, 4.0 Hz, 2H), 2.11-1.96 (m, 4H), 1.64-1.54 (m, 2H), 1.28-1.23 (m, 3H). | |
81% | Preparation of 4-Methylenecyclohexanecarboxylic acid ethyl ester; A suspension of methyl phosphonium bromide (3.15 g, 8.82 mmol) in dry THF (20 mL) was cooled to 00C, a solution of KtBuO (1.185 g, 10.58 mmol) in dry THF (15 mL) was added. The reaction mixture was allowed to rt and maintained for 1 h. The resulting mixture was cooled to 5-100C, 4-Oxo-cyclohexanecarboxylic acid ethyl ester (1.0 g, 5.88 mmol) (Chem. Abstr. Reg. No. 17159-79-4) was added over a period of 5 min, then was warmed to rt, maintained for 2h, then was heated to 50C and maintained over night additionally. The resulted reaction mass was diluted with water (200 mL) and extracted with EtOAc (200 mL). The organic layer was washed with water (50 mL), brine solution (100 mL), dried over anhydrous sodium sulfate and concentrated to obtain the crude product. The crude was purified by column chromatography over silica gel column using 3-4% EtOAc in pet ether as eluting solvent to obtain the pure product (1) as liquid (800 mg, 81%). 1HNMR(CDCI3): delta 4.65(s, 2H), 4.12(q, 2H), 2.3-2.5(m, 3H), 1.9-2.16(m, 4H), 1.5-1.7(m, 2H) and 1.25(t, 3H). Mass: (M+1) 169 calculated for Ci0H16O2. | |
76% | To a suspension of MePh3PBr (37.1 g, 104 mmol) in THF (500 mL) at 0C was added slowly LDA (1.2 eq) over 1 h. The resulting orange solution was stirred for 30 min before ethyl 4-oxocyclohexanecarboxyIate (16.1 g, 94.4 mmol) was added dropwise. The resulting suspension was warmed to rt and stirred overnight (may not necessary). A saturated NH4CI (aq) was added and THF was removed. The aqueous residue was extracted with EtOAc (100*3). The combined organic layers were washed with brine, dried over Na2S04 and concentrated. The residue was purified by passing through a short silica gel plug(hexanes/EtOAc 7:1). After being concentrated, ethyl 4-methylenecyclohexanecarboxylate was obtained as pale yellow oil (12.1 g, 76%). | |
73% | Lithium bis(trimethylsilyl)amide (1.0 M in THF, 15 mL, 15 mmol) was added dropwisely to a stirred solution of methyltriphenylphosphonium bromide (5.36 g, 15 mmol) in THF (50 mL) at 0 C and stirred for 40 min at the same temperature. A solution of ethyl 4-oxocyclohexanecarboxylate (2.04 g, 12 mmol) in THF (20 mL) was added slowly at 0 C and stirred for 2 h from 0 C to room temperature. The reaction was quenched with saturated NH4C1 aq. and extracted with hexane. The collected organic layer was dried over MgS04 and concentrated under reduced pressure. The solvent ( 100 mL, hexane/Et20 = 5/1) was added to the residue and stirred for 30 min. The suspension was filtrated. The filtrate was concentrated under reduced pressure. The residue was purified by silicagel chromatography (5% EtOAc/hexane as eluent) to provide compound A122-1 (1.478 g, 73%) as a colorless oil. | |
68.8% | N-butyllithium (21 mL, 52.5 mmol) was added dropwise to a solution of diisopropylamine (7.54 mL, 52.9 mmol) in THF (40 mL) at -78 C. over a period of 10 min. The resulted solution was stirred in an ice bath for 20 min. The above LDA solution was canulated into a suspension of methyltriphenylphosphonium bromide (19 g, 53.2 mmol) in THF (100 mL) in ice bath and the resulted mixture was stirred in the ice bath for 40 min. A solution of ethyl 4-oxocyclohexanecarboxylate (7.5 g, 44.1 mmol) in THF (20 mL) was added dropwise to this mixture. The reaction mixture was stirred for 18 h and diluted with hexane. The solid was filtered off and the filtrate was concentrated to afford a liquid. This crude product was plugged through silica gel pad (?2", EtOAc/hexane: 0 to 10%) to yield the title compound as a clear liquid (5.0 g, 68.8% yield). 1H NMR (400 MHz, CHLOROFORM-d) delta 4.76-4.60 (m, 2H), 4.20-4.08 (m, 2H), 2.45 (tt, J=11.1, 3.6 Hz, 1H), 2.35 (dt, J=13.5, 3.5 Hz, 2H), 2.14-1.96 (m, 4H), 1.67-1.52 (m, 2H), 1.30-1.22 (m, 3H) | |
54% | Methyltriphenylphosphonium bromide (4.20 g, 11.75 mmol) and potassium 2-methylpropan-2-olate (1.32 g, 11.75 mmol) were dissolved in 1,4-dioxane (20 mL) under nitrogen. The solution was stirred for 30 min then cooled to 0 C. Separately, ethyl 4-methylenecyclohexane-1-carboxylate (1.06 g, 11.75 mmol) was dissolved in 1,4-dioxane (5 mL) and added dropwise over 15 min. The reaction mixture was stirred at 20 C for 1.5 h. The volatiles were removed under reduced pressure. The crude product was dissolved in DCM (30 mL) and filtered. The filtrate was purified via silica gel chromatography eluting with 0-40% EtOAc in heptane to afford ethyl 4-methylenecyclohexane-1-carboxylate 26 (1.06 g, 54%) as a clear oil. 1H NMR (400 MHz, CDCl3) 1.25 (t, J = 7.1, 3H), 1.50 - 1.66 (m, 2H), 1.93 - 2.13 (m, 4H), 2.34 (dt, J = 12.9, 3.7, 2H), 2.43 (tt, J = 10.9, 3.6, 1H), 4.13 (q, J = 7.1, 2H), 4.64 (t, J = 1.4, 2H). 1H NMR consistent with reported literature data4 | |
To a suspension of MePh3PBr (37.1 g, 104 mmol) in THF (500 mL) at 0C was added slowly LDA (1.2 eq) over 1 h. The resulting orange solution was stirred for 30 min before ethyl 4-oxocyclohexanecarboxylate (16.1 g, 94.4 mmol) was added dropwise. The resulting suspension was warmed to rt and stirred overnight. A saturated NH4CI (aq) was added and THF was removed. The aqueous residue was extracted with EtOAc (100mlx3). The combined organic layers were washed with brine, dried over Na2S04 and concentrated. The residue was purified by passing through a short silica gel plug (hexanes/EtOAc 7:1). After being concentrated, ethyl 4-methylenecyclohexanecarboxylate was obtained as a pale yellow oil (12.1 g). | ||
To a suspension of MePh3PBr (37.1 g, 104 mmol) in THF (500 mL) at 0 C was added slowly LDA (1.2 eq) over 1 h. The resulting orange solution was stirred for 30 min before ethyl 4-oxocyclohexanecarboxylate (16.1 g, 94.4 mmol) was added dropwise. The resulting suspension was warmed to rt and stirred overnight. A saturated NH4CI (aq) was added and THF was removed. The aqueous residue was extracted with EtOAc (100ml x 3). The combined organic layers were washed with brine, dried over Na2SC and concentrated. The residue was purified by passing through a short silica gel plug (hexanes/EtOAc 7:1). After being concentrated, ethyl 4-methylenecyclohexanecarboxyIate was obtained as a pale yellow oil (12.1 g). | ||
3.5 g | Brief procedure: KO-tBu was added to a solution of methyltriphenylphosponium bromide at 0 C under nitrogen atmosphere and stirred for 30 min. To the above yellow colored reaction, a solution of ethyl 4-oxocyclohexane carboxylate in THF was added dropwise and the resulting mixture was stirred at the same temperature for 16 h. Work up: The reaction mixture was quenched with water and extracted with diethyl ether. The combined ethereal extract was dried and concentrated under reduced pressure. Purification: The crude residue was purified by silica gel (100-200 mesh) column chromatography by gradual elution from 5% to 10% EtOAc-petroleum ether. TLC system: 20% Ethyl acetate-petroleum ether, Rf value: 0.6 Nature of the compound: Colorless liquid, Yield: 3.5 g |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With trifluorormethanesulfonic acid; In dichloromethane; at 25℃; | (1) To a solution of 4-oxocyclohexanecarboxylic acid ethyl ester (8.0 g) and 2,6-di(tert-butyl)-4-methylpyridine (14.4 g) in dichloromethane (200 ml) is added trifluoromethanesulfonic anhydride (8.73 ml) at -78°C, and the mixture is gradually warmed to 25°C, and the mixture is stirred at the same temperature overnight.. The reaction solution is poured into aqueous sodium hydrogen carbonate solution, and the mixture is extracted with ethyl acetate.. The organic layer is washed with saturated brine, and the solvent is evaporated under reduced pressure to give 4-trifluoromethanesulfonyloxy-3-cyclohexenecarboxylic acid ethyl ester. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With 2,8,9-tris(2-methylpropyl)-2,5,8,9-tetraaza-1-phosphabicyclo[3.3.3]undecane; In acetonitrile; at 0 - 20℃; for 1.5h;Product distribution / selectivity; | Procedure 9b; A mixture of 2,8,9-triisobutyl-2,5,8,9-tetraaza-1-phosphabicyclo[3.3.3]undecane (1.14 ml, 3.94 mmol) and acetonitrile (15 ml) was added to a stirred suspension of trimethylsulphonium iodide (0.81 g, 3.97 mmol) and ethyl 4-oxocyclohexanecarboxylate (0.563 g, 3.31 mmol) at 0 0C. The mixture was stirred at 0 0C for 30 minutes then allowed to warm to room temperature and stirred for a further 1 hour. The reaction mixture was concentrated under reduced pressure then diluted with diethyl ether. The resulting suspension was stirred for 30 minutes then filtered and the filter cake was washed with more diethyl ether. The combined ethereal phases were concentrated under reduced pressure and the residue was chromatographed on SiO2 (Biotage 25M column) eluting with a gradient of 5%-15% EtOAc/cyclohexane to give a -60:40, trans:cis mixture of the title compound as a colourless oil (250 mg); <n="30"/>1 H NMR (400 MHz, CDCI3): delta 4.16 (2H both isomers, q), 2.65 (2H trans isomer, s), 2.62 (2H cis isomer, s), 2.35-2.48 (1 H both isomers, m), 1.68-2.14 (6H both isomers, m), 1.37- 1.52 (2H both isomers, m), 1.27 (3H both isomers, t). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
65% | With potassium tert-butylate; In dimethyl sulfoxide; at 20℃;Product distribution / selectivity; | Intermediate 9; Ethyl 1 -oxaspiror2.51octane-6-carboxylate; Procedure 9a; To a mixture of trimethylsulfoxonium iodide and potassium tert-butoxide (as reported in Synthetic Communications, 33(12), 2135-2143; 3.9 g, 11.76 mmol) was added a solution of ethyl 4-oxocyclohexanecarboxylate (1 g, 5.87 mmol, Aldrich) in DMSO (20ml). The mixture was left to stir overnight at room temperature. The mixture was poured into water and extracted with diethyl ether; the organic phase was dried on Na2SO4, filtered and evaporated in vacuo to afford the title compound (704.5 mg, 65%), which was used without purification.Another batch of the same compound prepared using an analogous method showed the following NMR spectra:1H NMR (400 MHz, CDCI3): delta 4.06 (2H, q), 2.49-2.59 (2H, m), 2.26-2.28 (1 H, m), 1.63- 2.04 (6H, m), 1.27-1.49 (2H, m), 1.20 (3H, t) cis/trans 65:35 |
With potassium tert-butylate; In dimethyl sulfoxide; at 20℃;Product distribution / selectivity; | Intermediate delta: Ethyl 1-oxaspiror2.5loctane-6-carboxylate; To a mixture of trimethylsulfoxonium iodide and potassium tert-butoxide (as reported in Synthetic Communications, 33(12), 2135-2143; 3.9 g, 11.76 mmol) was added a solution of ethyl 4-oxocyclohexanecarboxylate (1 g, 5.87 mmole, Aldrich) in DMSO (20 ml). The mixture was left to stir overnight at room temperature. The mixture was poured into water and extracted with diethyl ether; the organic phase was dried on Na2SO4, filtered and evaporated in vacuo to afford ethyl 1-oxaspiro[2.5]octane-6-carboxylate (704.5 mg, 65%), which was used without purification. Another batch of the same compound prepared using an analogous method gave 1 H-NMR (400 MHz, CDCI3): delta 1.20 (t, 3 H), 1.27-1.49 (m, 2 H), 1.63-2.04 (m, 6 H), 2.26-2.28 (m, 1 H), 2.49-2.59 (m, 2 H), 4.06 (q, 2 H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
The ISONICOTINAMIDE 1-1 (100 g, 0.50 mol, Kingchem), THF (0.5 L) and a 1 M LiBr solution (prepared by dissolving 1.50 mol of LiBr in 1.5 L of THF) were mixed in a flask. The resulting solution was degassed with nitrogen and cooled TO-65 C. n-BuLi (1.56 M in hexane; 666 ML, 1.04 mol) was then added while maintaining the batch temperature BELOW-55 C. The resulting solution was then aged at a temperature less THAN-55 C for a period between 1 to 7 hours to give a metalated anilide mixture. A solution of ethyl 4-oxocyclohexanecarboxylate 1-2 (100 mL, 0.63 mol, EMS Dottikon AG) in THF (1 L) was cooled in a separate flask to a temperature BELOW-60 C. To the solution was added the above metalated anilide mixture, while maintaining the batch temperature below-55 C. The resulting solution was aged at a temperature BELOW-55 C for 1 hour and then carefully quenched into H20 (1 L). The resulting mixture was warmed to 40 C and aged at 40 C for a period between 1 to 4 hours. After cooling to room temperature, the organic layer was removed and the aqueous layer (1.3 L; pH - 11) was washed with THF (1 L) to give an aqueous solution of the diacid 1-3. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With ammonia; hydrogen;palladium 10% on activated carbon; In methanol; at 0 - 20℃; under 760.051 Torr; for 36h; | Example 4.48a. Synthesis of ethyl 4-aminocvclohexanecarboxylateEthyl 4-oxocyclohexanecarboxylate (3.0 g, 17.65 mmol) was dissolved in 150 mL methanol saturated with ammonia at 0 C, and to the solution was added wet 10% Pd/C catalyst (4.0 g). The mixture was stirred at room temperature under hydrogen (1 atm) for about 36 h. Then the catalyst was then removed by filtration and the filtrate was concentrated to give the crude product, which was purified by chromatography on silica gel to give 2.0 g of the desired product. MS (ESI): 172 (MH+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | With 2,6-dimethylpyridine; sodium periodate; ruthenium(III) chloride trihydrate; In dichloromethane; water; acetonitrile; at 20℃; for 1h;Inert atmosphere; | General procedure: The alkene (1.16 mmol, 1 equivalent) was dissolved in a vigorously stirred mixture of DCM (7 mL) and acetonitrile (7 mL) under nitrogen. 2,6-Lutidine (0.27 mL, 2.32 mmol, 2 equivalents), water (10.5 mL) and sodium periodate (993 mg, 4.64 mmol, 4 equivalents) were then added sequentially. The reaction concentration with respect to the alkene was 0.047 M in a mixture of 1: 1: 1.5 - DCM: acetonitrile: water. To the resulting mixture a stock solution of ruthenium(III) chloride trihydrate (0.035 M in water) (1.16 mL, 0.04 mmol, 3.5 mol %) was added dropwise via a syringe forming a brown suspension. The reaction was stirred vigorously at 20 C for 1 h (or for the time indicated in the Tables 2 and 3). The reaction was diluted with water (20 mL) then extracted with DCM (3 x 20 mL). The organic extracts were combined then washed with brine (20 mL), passed through a phase separating cartridge and the volatiles were removed under reduced pressure. The resulting residue was purified by flash silica chromatography (EtOAc / heptane) to afford the ketone. |
Tags: 4-(Ethoxycarbonyl)-1-cyclohexanone | Aliphatic Cyclic Hydrocarbons | Ketones | Esters | Organic Building Blocks | 17159-79-4
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P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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