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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
2-(Aminomethyl)pyridine is an amino-containing pyridine derivative widely used in medicinal chemistry and catalyst development. It serves as an important intermediate and reagent in organic synthesis.
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Ingraham, Charles H. IV ; Stalinska, Joanna ; Carson, Sean C. ; Colley, Susan B. ; Rak, Monika ; Lassak, Adam , et al.
Abstract: Glioblastomas are highly aggressive brain tumors for which therapeutic options are very limited. In a quest for new anti-glioblastoma drugs, we focused on specific structural modifications to the benzoyl-phenoxy-acetamide (BPA) structure present in a common lipid-lowering drug, fenofibrate, and in our first prototype glioblastoma drug, PP1. Here, we propose extensive computational analyses to improve the selection of the most effective glioblastoma drug candidates. Initially, over 100 structural BPA variations were analyzed and their physicochemical properties, such as water solubility (- logS), calculated partition coefficient (ClogP), probability for BBB crossing (BBB_SCORE), probability for CNS penetration (CNS-MPO) and calculated cardiotoxicity (hERG), were evaluated. This integrated approach allowed us to select pyridine variants of BPA that show improved BBB penetration, water solubility, and low cardiotoxicity. Herein the top 24 compounds were synthesized and analyzed in cell culture. Six of them demonstrated glioblastoma toxicity with IC50 ranging from 0.59 to 3.24 µM. Importantly, one of the compounds, HR68, accumulated in the brain tumor tissue at 3.7 ± 0.5 µM, which exceeds its glioblastoma IC50 (1.17 µM) by over threefold.
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Purchased from AmBeed: 20173-04-0 ; 1539-42-0 ; 16867-03-1 ; 85622-93-1 ; 13207-66-4 ; 591-54-8 ; 6971-44-4 ; 18364-47-1 ; 45695-03-2 ; 2706-56-1 ; 21035-59-6 ; 90-45-9 ; 40154-75-4 ; 38767-72-5 ; 33630-99-8 ; 3731-52-0 ; 27854-90-6 ; 20173-24-4 ; 3731-53-1 ; 42017-89-0 ; 13010-47-4 ; 154-93-8 ; 3731-51-9 ; 56129-55-6 ; 671-16-9 ; 42017-89-0 ; 90-45-9
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Synthesis of N-Sulfenylimines from Disulfides and Primary Methanamines
Robert Kawȩcki ;
Abstract: N-Sulfenylimines (sulfenimines, thiooximes, N-alkylidenesulfenamides) were efficiently synthesized through the reaction of primary amines and disulfides with NBS or bromine. This reaction can be carried out in an open flask at room temperature without the need for any transition-metal-containing additives. The use of thiols instead of disulfides gave similar results. A wide range of amines were reacted with aryl and alkyldisulfides, resulting in the formation of sulfenimines in a yield of 44–99%.
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Synthesis of 2-oxoquinoline derivatives as dual pim and mTORC protein kinase inhibitors
Giri R. Gnawali ; Koichi Okumura ; Karolina Perez ; Rosa Gallagher ; Julia Wulfkuhle ; Emanuel F. Petricoin , et al.
Abstract: Compound VBT-5445 was identified as an inhibitor to block the association of Pim and the protein Enhancer of Decapping 3 (EDC3), a Pim substrate, which normally functions to enhance the decapping of messenger RNA (mRNA). It was also shown to inhibit both the Pim and mTORC protein kinases. The activity of this compound class can be fine-tuned by structural modification. A series of VBT analogs were designed, synthesized, and evaluated. These compounds decrease the growth of multiple cancer types, including pancreas, prostate, breast, lung, and leukemia. Notably, 6-methyl (GRG-1-31, 6d), 4-chloro (GRG-1-34, 6e), 4-Bromo (GRG-1-35, 6f), and phenylthio substituted (GRG-1-104, 6n) derivatives are highly potent at inhibiting tumor growth. The ability of these compounds to block cancer growth in vitro is highly correlated with their activity as mTORC inhibitors. The toxicity of GRG 1–34 is low in mice treated with twice-daily gavage for 30 days and did not induce weight loss. Pharmacokinetics of a single oral dose demonstrated a peak concentration at 0.5 h after gavage. In summary, further development of this compound class has the potential to inhibit important signaling pathways and impact cancer treatment.
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Keywords: Quinoline derivatives ; Pim kinase ; Antitumor activity ; mTORC
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Purchased from AmBeed: 180748-30-5 ; 4837-01-8 ; 589-10-6 ; 6627-60-7 ; 31106-82-8 ; 1260903-05-6 ; 872577-05-4 ; 865156-50-9 ; 188637-63-0 ; 103-67-3 ; 3731-51-9 ; 164341-39-3 ; 67938-76-5 ; 22921-76-2 ; 1241725-81-4 ; 131052-62-5 ; 184637-50-1
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CAS No. : | 3731-51-9 |
Formula : | C6H8N2 |
M.W : | 108.14 |
SMILES Code : | NCC1=NC=CC=C1 |
MDL No. : | MFCD00006360 |
InChI Key : | WOXFMYVTSLAQMO-UHFFFAOYSA-N |
Pubchem ID : | 19509 |
GHS Pictogram: |
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Signal Word: | Danger |
Hazard Statements: | H314 |
Precautionary Statements: | P280-P305+P351+P338-P310 |
Class: | 8 |
UN#: | 2735 |
Packing Group: | Ⅱ |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In tetrahydrofuran; | Preparation 146 A mixture of <strong>[99368-67-9]2-chloro-5-nitro-3-(trifluoromethyl)pyridine</strong> (226mg) and 2-pyridylmethanamine (0.2ml) in tetrahydrofuran (2.0ml) was stirred for 18 hours. The mixture was poured into water and stirred for 1 hour. The precipitated solid was collected by filtration, washed with water, and dried to give 5-nitro-N-(2-pyridylmethyl)-3-(trifluoromethyl)-2-pyridinamine (277mg). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91% | With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 80℃; | The amine (1.1 equivalents) and 1.5 equivalents of diisopropylethylamine in isopropanol at a total concentration of 1M were heated overnight at 80 0C. The reaction mixture was concentrated, washed with water, filtered, and the resulting solid partitioned between ethyl acetate or dichloromethane and water. After a further water wash, and a citirc acid wash with amines possessing no additional basic functionality, the organic layer was dried then concentrated to give the crude 7-substituted amino-3- bromopyrazolo[1 ,5a]pyrimidine in good yield. The purity of this material was sufficient for use in the next stage cross-couipling reaction. As Example 1, the use of 2- aminomethylpyidine gave 7- aminomethyl-3-bromopyrazolo[1 ,5a]pyrimidine in 91% yield and 99% purity (MS: m/z 306/304 [M+H]+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
93% | With sodium hydrogencarbonate; In water; ethyl acetate; at 0 - 20℃; for 18h; | Example 1; 3-(5-Methyl-3-phenyl-isoxazol-4-yl)-imidazo[l,5-a]pyridinea) S-Methyl-S-phenyl-isoxazole-φcarboxyric acid (pyridin-2-ylmethyl)-amide A mixture of 5-methyl-3-phenyl-isoxazole-4-carboxylic acid (4.06 g, 20 mmol, commercially available) and thionyl chloride (5 mL) was heated under reflux for 3 h. Evaporation of all volatiles afforded 5-methyl-3-phenyl-isoxazole-4-carboxylic acid chloride (4.4 g, 93%) as yellow oil, which was used without further purification in the next reaction. To a mixture of an aqueous solution of 2-picolylamine (0.182 g, 1.68 mmol) in water (2 mL) and ethyl acetate (4 mL) were added sodium hydrogen carbonate (362 mg, 4.2 mmol) in one portion. Then 5-methyl-3-phenyl-isoxazole-4-carboxylic acid chloride (0.31 g, 1.4 mmol) in ethyl acetate (2 mL) was added dropwise with vigorous stirring under ice-bath cooling keeping the temperature at 0 0C. After addition, the reaction mixture was stirred at room temperature for 18 h. The resulting solution was then diluted with ethyl acetate. The organic layer was separated, and the aqueous layer was extracted with ethyl acetate. The combined extracts were then washed with brine, dried over sodium sulphate, and concentrated to afford the title compound (0.38 g, 93%) as a white solid. MS: m/e: 294.1 [M+H]+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Synthesis Example 14-2: Synthesis of 5-(N-Boc-N-2-picolylamino methyl) thiophene-2-carboxylic acid (Compound VII-7) 513 mg of the compound obtained in Synthesis Example 14-1 was dissolved in 10 ml of DMF, and then 603 mg of potassium carbonate and 0.45 ml of 2-picolylamine were added to the solution. After 17 hours, the reaction solution was concentrated and then water was added thereto, followed by extraction with chloroform. An organic layer was washed with a saturated salt solution and was then dried with anhydrous sodium sulfate. The residue obtained by concentrating the layer was dissolved in 6 ml of dioxane, and then 0.55 ml of di-t-butyldicarbonate and 6 ml of a 1 mol/l sodium hydroxide aqueous solution were added to the solution. After 6 hours, about 2 ml of a 1 mol/l sodium hydroxide aqueous solution was added to the reaction solution. Then, the solution was further stirred for 4 hours. The reaction solution was concentrated and water and 1 mol/l hydrochloric acid were added to the solution to be slightly acidic. Then, the solution was extracted with chloroform. An organic layer was dried with anhydrous sodium hydroxide and concentrated. The resulting residue was dissolved in 12 ml of methanol, to which 12 ml of a 1 mol/l sodium hydroxide aqueous solution was added. After 16 hours, the reaction solution was concentrated and dissolved in water, followed by gradually adding 1 mol/l hydrochloric acid to adjust to pH 4 to 5. After the solution was left to stand for overnight, a precipitated solid was filtrated and dried under reduced pressure. Consequently, 523.3 mg of the above-mentioned material was obtained as a white solid product. MS(FAB,Pos.):m/z=349[M+1]+ 1H-NMR(500MHz,CDCl3): delta=1.50 and 1.55 (9H,2s), 4.52, 4.60, 4.64 and 4.69 (4H,4s),6.93 and 6.97 (1H,2d,J=3.7Hz), 7.33 (1H,dd,J=5.6, 7.1Hz), 7.37 and 7.50 (1H,2d,J=7.6Hz), 7.67 (1H,d,J=3.7Hz), 7.80 (1H,t,J=7.3Hz), 8.69 (1H,brs). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Synthesis Example 13-3: Synthesis of 5-(N-Boc-N-2-picolylamino methyl)pyrazine-2-carboxylic acid (Compound VII-6) 320 mg of the compound obtained in Synthesis Example 13-2 was dissolved in 6.4 ml of DMF, and then 383 mg of potassium carbonate and 286 mul of 2-picolylamine were added to the solution. After the 17-hour reaction, the reaction solution was concentrated and then water was added thereto, followed by extracting with chloroform. An organic layer was washed with a saturated salt solution. Subsequently, the organic layer was dried with anhydrous sodium sulfate and concentrated, and 444.1 mg of a crude product of the above-mentioned compound was obtained as brown syrup. The crude product was dissolved in 4 ml of dioxane, and then 0.35 ml of di-t-butyldicarbonate and 4 ml of a 1 mol/l sodium hydroxide aqueous solution were added to the solution. After 2 hours, the reaction solution was concentrated and diluted hydrochloric acid was added to the reaction solution, followed by extraction with chloroform. An organic layer was washed with a saturated salt solution and then dried with anhydroussodiumsulfate,followed by concentration, and 158.8 g of the above-mentioned compound was obtained as a light-brown solid product. MS(FAB,Pos.):m/z=345[M+1]+ |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84% | In methanol; at 30℃; for 0.5h; | The ligand (L) was prepared by a slow addition of 2-picolyamine(0.1446 g, 1 mmol) in methanol to 3,5-diiodosalicyaldehyde (0.5 g,1 mmol). The mixture was stirred for 30 min at 30 C and the progressof reaction was monitored by TLC. The obtained yellow precipitatewas filtered off, washed thoroughly with methanol anddried in vacuo: Yield: 84%; M.P: 110 C; Color: yellow. IR (KBr,cm1): 3448 (AOH), 1633 (CHN), 1573(m), 1462(w) (CC),1437 (CN), 1429, 1356(m), 1276(m) (CAO).1H NMR (300 MHz, CDCl3) d:14.70 (s, 1H, OH), 8.56 (d, J = 4.8 Hz,1H, ArH), 8.32 (s, 1H, ACN), 8.04 (d, J = 2.1 Hz, 1H, ArH), 7.69 (td, J= 7.7, 1.8 Hz, 1H, ArH), 7.55 (d, J = 2.1 Hz, 1H, ArH), 7.33 (d, J= 7.8 Hz, 1H, ArH), 7.24-7.16 (m, 1H, ArH), 4.93 (s, 2H, ACH2).UV-vis (MeOH, nm) 235, 344, 406; ESI-MS (MeOH) Foundm/z = 464.75 [M + H] (calculated m/z = 463.89 for M+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
83% | In isopropyl alcohol; at 80℃; for 1h;Inert atmosphere; | General procedure: Compound 1 (1.00 g, 4.01 mmol) was mixed with the benzylamine (2-3 eq.) and i-PrOH (2-10 mL) and agitated at 80 C for 1-50 h, under nitrogen atmosphere. Then the mixture was cooled to rt, concentrated in vacuo, diluted with water (50 mL) and diethyl ether (100 mL) or EtOAc (100 mL). After phase separation, the water phase was extracted with more diethyl ether (2×50 mL) or EtOAc (2×50 mL). The combined organic phases were washed with saturated aq NaCl solution (25-50 mL), dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The crude oil was purified by drying under reduced pressure to constant weight, by silica-gel column chromatography or crystallized as specified for each individual compound. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
69% | With montmorillonite K-10; In ethanol; at 80℃; for 0.5h;Sealed tube; Microwave irradiation; | General procedure: To a solution of 1 (2.0 mmol) in absolute EtOH (8.0 mL)in a glass tube was added dropwise the appropriate amine(3.6 mmol) and K-10 (0.3 g mmol-1); the quartz tubewas sealed with reaction mixture and introduced intoa microwave oven. The flask was irradiated for 30 min(150 W) the temperature of 80 C. After completion of thereaction the mixture was filtered, the organic phase wasdried with Na2SO4, filtered and the solvent was evaporatedunder reduced pressure to give the crude products. All thecompounds were purified by column chromatographyon silica gel using 2-5% EtOH-CH2Cl2 as eluent to giveanalytically pure products 3a-m. The products werecharacterized by corresponding spectroscopic data (1H and13C NMR, and HRMS). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
63% | With teflon; In methanol; at 140℃; for 72h; | Will be 1.00 mmolN-methyl-benzimidazole-2-carbaldehyde (0.1700 g)Add to 15 mLCapacity of polytetrafluoroethylene reactor,After adding 10 mL of methanol to dissolve,Add 0.5 mmol of zinc chloride (0.0685 g),0.25 mmol of 2-aminomethylpyridine (26 μL) was added under stirring.Stirring was continued for 3 minutes, sealed, placed in an oven at 140 C for 72 h, and then slowly cooled to obtain orange block crystals (about 10 h to room temperature) in a yield of 63% (based on 2-aminomethylpyridine). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
61% | With teflon; In methanol; at 160℃; for 72h; | Add 1.00 mmol of N-methyl-benzimidazole-2-carbaldehyde (0.1700 g) to a 15 mL capacity of polytetrafluoroethyleneIn the reaction kettle, add 10 mL of methanol to dissolve, then add 0.5 mmol.Of manganese chloride tetrahydrate (0.099 g),Under stirring, 0.25 mmol of 2-aminomethylpyridine (26 μL) was added, stirring was continued for 3 minutes, sealed, placed in an oven at 160 C for 72 h, and then slowly cooled to obtain yellow lump crystals (approximately 10 h lower) To room temperature),The yield was 61% (based on 2-aminomethylpyridine). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
58% | With teflon; In methanol; at 160℃; for 72h; | Add 1.00 mmol of N-methyl-benzimidazole-2-carbaldehyde (0.1700 g) to 15 mLCapacity of polytetrafluoroethylene reactor,After adding 10 mL of methanol to dissolve,Add 0.5 mmol of manganese bromide (0.1074 g),0.25 mmol of 2-aminomethylpyridine (26 μL) was added under stirring.Stirring was continued for 3 minutes, sealed, and placed in an oven at 160 C for 72 h.Then slowly cool down to get yellow block crystals (about 10 h down to room temperature),The yield was 58% (based on 2-aminomethylpyridine). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
46% | With teflon; In methanol; at 160℃; for 48h; | Add 1.00 mmol of N-methyl-benzimidazole-2-carbaldehyde (0.1700 g) to a 15 mL capacity of polytetrafluoroethyleneIn the reaction kettle, after adding 10 mL of methanol to dissolve,Add 0.5 mmol of cobalt chloride tetrahydrate (0.119 g),Add 0.25 mmol under stirring2-Aminomethylpyridine (26 μL), stirring for 3 minutes, sealed, placed in an oven at 160 C for 48 h, then slowly cooled to obtain yellow block crystals (about 10 h down to room temperature), yield 46 % (based on 2-aminomethylpyridine). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
71% | With teflon; In methanol; at 140℃; for 48h; | 1.00 Mmol of n-methyl benzimidazole-2-formaldehyde (a,0.1700g) adding into a reaction kettle of 15 ml of polytetrafluoroethylene, adding 10 ml of methanol to dissolve, and then adding 0.5 mmol of ferrous chloride (0.0811g), wherein 0.25 mmol of 2-aminomethyl pyridine (b and 26 mu l) is added under the condition of stirring), continuously stirring for 3 minutes, sealing, and putting into a baking oven at the temperature of 140 DEG c for heat preservation for 48 hours, and then slowly cooling to obtain a red blocky crystal (about 10 hours to be reduced to the room temperature)), wherein the yield is 71% (based on b). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
25% | With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; for 49h;Reflux; | In the flask,Add ethyl acetate (100 mL),2-aminomethylpyridine (22 g, 200 mmol),5-bromo-dibenzoic acid (24.3 g, 100 mmol),T3P (50mL,50percent in ethyl acetate).After stirring at room temperature for 1 hour, the temperature was raised to reflux.After 48 hours of reaction,Adjust to neutral with aqueous sodium hydroxide solution,Separating the organic layer,Dried over anhydrous sodium sulfate and concentrated.The crude product was purified by column chromatography to give the product 9.7g,The yield was 25percent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | Pyrazine-2-carbaldehyde (1 g, 9.25 mmol) was dissolved in methanol(90 mL) and yridine-2-methylanamine (0.96 mL, 9.25 mmol) was added by a syringe. This mixture wasstirred at 25 C for 30 min followed by rapid addition of NaBH4 (1.06 g, 27.76 mmol), and then stirredat 25 C for an additional 2 h. The solvent was evaporated under reduced pressure, water (20 mL)was added to the residue and the solution pH was adjusted to approximately 10 by adding Na2CO3solution. The mixture was extracted with CH2Cl2 (330 mL) and purified by column chromatographywith CH2Cl2/MeOH (30:1, v/v) to give the product 7, Scheme 2, as a pale-yellow oil (1.6 g, 90% yield). |
Tags: 2-(Aminomethyl)pyridine | Pyridines | Amines | Heterocyclic Building Blocks | Organic Building Blocks | 3731-51-9
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P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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