Home Cart Sign in  
Chemical Structure| 90-45-9 Chemical Structure| 90-45-9
Chemical Structure| 90-45-9

*Storage: Keep in dark place,Inert atmosphere,Room temperature.

*Shipping: Normal

9-Aminoacridine

CAS No.: 90-45-9

,99%

9-Aminoacridine is a highly fluorescent dye used as a preservative, mutagen, and pH indicator. It also acts as an HIV inhibitor, blocking virus replication, and is used in combination with rifampin for resistant bacterial studies.

Synonyms: Aminacrine

4.5 *For Research Use Only !

99%98%
Cat. No.: A2670780 Purity: 99%

Change View

Size Price

USA Stock *0-1 Day

Global Stock *5-7 Days

In Stock

Please Login or Create an Account to: See VIP prices and availability

    In Stock

    - +

    Please Login or Create an Account to: See VIP prices and availability

    • 1-2 Day Shipping
    • High Quality
    • Technical Support Online Technical Q&A
    Product Citations

    Product Citations

    Ingraham, Charles H. IV ; Stalinska, Joanna ; Carson, Sean C. , et al.

    Abstract: Glioblastomas are highly aggressive brain tumors for which therapeutic options are very limited. In a quest for new anti-glioblastoma drugs, we focused on specific structural modifications to the benzoyl-phenoxy-acetamide (BPA) structure present in a common lipid-lowering drug, fenofibrate, and in our first prototype glioblastoma drug, PP1. Here, we propose extensive computational analyses to improve the selection of the most effective glioblastoma drug candidates. Initially, over 100 structural BPA variations were analyzed and their physicochemical properties, such as water solubility (- logS), calculated partition coefficient (ClogP), probability for BBB crossing (BBB_SCORE), probability for CNS penetration (CNS-MPO) and calculated cardiotoxicity (hERG), were evaluated. This integrated approach allowed us to select pyridine variants of BPA that show improved BBB penetration, water solubility, and low cardiotoxicity. Herein the top 24 compounds were synthesized and analyzed in cell culture. Six of them demonstrated glioblastoma toxicity with IC50 ranging from 0.59 to 3.24 µM. Importantly, one of the compounds, HR68, accumulated in the brain tumor tissue at 3.7 ± 0.5 µM, which exceeds its glioblastoma IC50 (1.17 µM) by over threefold.

    Product Details of [ 90-45-9 ]

    CAS No. :90-45-9
    Formula : C13H10N2
    M.W : 194.23
    SMILES Code : NC1=C(C=CC=C2)C2=NC3=CC=CC=C31
    Synonyms :
    Aminacrine
    MDL No. :MFCD00037839
    InChI Key :XJGFWWJLMVZSIG-UHFFFAOYSA-N
    Pubchem ID :7019

    Safety of [ 90-45-9 ]

    GHS Pictogram:
    Signal Word:Warning
    Hazard Statements:H315-H319-H335
    Precautionary Statements:P261-P305+P351+P338
     

    Related Products

    Historical Records

    Technical Information

    Categories

    Related Functional Groups of
    [ 90-45-9 ]

    Amines

    Chemical Structure| 581-28-2

    A145789 [581-28-2]

    Acridin-2-amine

    Similarity: 0.95

    Chemical Structure| 578-68-7

    A224551 [578-68-7]

    4-Aminoquinoline

    Similarity: 0.79

    Chemical Structure| 18978-78-4

    A238027 [18978-78-4]

    2-Methylquinolin-8-amine

    Similarity: 0.79

    Chemical Structure| 21352-22-7

    A277892 [21352-22-7]

    2-Methylquinolin-3-amine

    Similarity: 0.77

    Chemical Structure| 178265-65-1

    A494540 [178265-65-1]

    4-([2,2':6',2''-Terpyridin]-4'-yl)aniline

    Similarity: 0.77

    Related Parent Nucleus of
    [ 90-45-9 ]

    Other Aromatic Heterocycles

    Chemical Structure| 581-28-2

    A145789 [581-28-2]

    Acridin-2-amine

    Similarity: 0.95

    Chemical Structure| 611-64-3

    A194914 [611-64-3]

    9-Methylacridine

    Similarity: 0.92

    Chemical Structure| 602-56-2

    A137990 [602-56-2]

    9-Phenylacridine

    Similarity: 0.90

    Chemical Structure| 904886-12-0

    A146630 [904886-12-0]

    Benzo[h]quinoline-2-carbaldehyde

    Similarity: 0.83

    Chemical Structure| 18123-20-1

    A122355 [18123-20-1]

    Acridin-4-ol

    Similarity: 0.75

    Acridines

    Chemical Structure| 581-28-2

    A145789 [581-28-2]

    Acridin-2-amine

    Similarity: 0.95

    Chemical Structure| 611-64-3

    A194914 [611-64-3]

    9-Methylacridine

    Similarity: 0.92

    Chemical Structure| 602-56-2

    A137990 [602-56-2]

    9-Phenylacridine

    Similarity: 0.90

    Chemical Structure| 18123-20-1

    A122355 [18123-20-1]

    Acridin-4-ol

    Similarity: 0.75

    Chemical Structure| 1207-69-8

    A123325 [1207-69-8]

    9-Chloroacridine

    Similarity: 0.74