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Chemical Structure| 3680-69-1 Chemical Structure| 3680-69-1
Chemical Structure| 3680-69-1

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Synonyms: 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

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Product Citations

Product Citations

Pieterse, Lianie ; Beteck, Richard M. ; Baratte, Blandine ; Jesumoroti, Omobolanle J. ; Robert, Thomas ; Ruchaud, Sandrine , et al.

Abstract: Protein kinases, including CDK9/CyclinT and Haspin, are regarded as potential drug targets in cancer therapy. Findings from a previous study suggested 7-azaindole as a privileged scaffold for producing inhibitors of CDK9/CyclinT and Haspin. Inspired by these findings, the current study synthesized and evaluated thirteen (13) C6-substituted 7-azaindole and twenty (20) C4-substituted structurally related 7H-pyrrolo[2,3-d]pyrimidine derivatives against a panel of protein kinases, including CDK9/CyclinT and Haspin. Eleven of the 7H-pyrrolo[2,3-d]pyrimidine derivatives exhibited activity toward CDK9/CyclinT, while 4 of compounds had activity against Haspin. The best CDK9/CyclinT (IC50 of 0.38 μM) and Haspin (IC50 of 0.11 μM) activities were achieved by compounds 7d and 7f, resp. Hence, these compounds may be valuable starting points for development of new anti-cancer drugs.

Keywords: 7-Deazapurine ; Anticancer ; CDK9/CylinT ; Haspin ; Protein kinase

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Product Details of 6-Chloro-7-deazapurine

CAS No. :3680-69-1
Formula : C6H4ClN3
M.W : 153.57
SMILES Code : ClC1=C2C(NC=C2)=NC=N1
Synonyms :
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
MDL No. :MFCD01686865
InChI Key :BPTCCCTWWAUJRK-UHFFFAOYSA-N
Pubchem ID :5356682

Safety of 6-Chloro-7-deazapurine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of 6-Chloro-7-deazapurine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 3680-69-1 ]
  • Downstream synthetic route of [ 3680-69-1 ]

[ 3680-69-1 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 100-44-7 ]
  • [ 3680-69-1 ]
  • [ 16019-34-4 ]
References: [1] Journal of Medicinal Chemistry, 1995, vol. 38, # 19, p. 3884 - 3888.
[2] Patent: US2002/19526, 2002, A1, .
  • 2
  • [ 100-39-0 ]
  • [ 3680-69-1 ]
  • [ 16019-34-4 ]
References: [1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 18, p. 5473 - 5482.
  • 3
  • [ 3680-69-1 ]
  • [ 16019-34-4 ]
References: [1] Tetrahedron Letters, 1998, vol. 39, # 32, p. 5685 - 5688.
 

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