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Chemical Structure| 115443-55-5 Chemical Structure| 115443-55-5

Structure of 115443-55-5

Chemical Structure| 115443-55-5

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Product Details of [ 115443-55-5 ]

CAS No. :115443-55-5
Formula : C4H7N3OS
M.W : 145.18
SMILES Code : NC1=NC(COC)=NS1
MDL No. :MFCD14690991

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Application In Synthesis of [ 115443-55-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 115443-55-5 ]

[ 115443-55-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 333-20-0 ]
  • [ 1903-91-9 ]
  • [ 115443-55-5 ]
YieldReaction ConditionsOperation in experiment
60% To a solution of <strong>[1903-91-9]2-methoxy-acetamidine hydrochloride</strong> (4.66 g, 0.037 mol) in methanol (20 mL) at 0 C. under vigorous stirring was added dropwise bromine (1.90 mL, 0.037 mol) and a 5.4M sodium methylate solution in methanol (13.7 mL, 0.037 mol) simultaneously over 30 min maintaining a slight bromine excess by color. To the resulting nearly colorless suspension was added dropwise a solution of potassium thiocyanate (3.64 g, 0.037 mol) in methanol (20 mL) over 10 min at 0-10 C. The resulting mixture was stirred for 2 h at 0-10 C. and filtered. The isolated material was washed with methanol and dried which afforded a brown solid which was purified by flash chromatography (silica gel 60, 5% methanol/diethyl ether) and crystallized from diethyl ether/hexanes which afforded 3-methoxymethyl-[1,2,4]thiadiazol-5-ylamine (3.25 g, 60%) as a light yellow solid.
 

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