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CAS No. : | 24544-04-5 |
Formula : | C12H19N |
M.W : | 177.29 |
SMILES Code : | NC1=C(C(C)C)C=CC=C1C(C)C |
MDL No. : | MFCD00008887 |
InChI Key : | WKBALTUBRZPIPZ-UHFFFAOYSA-N |
Pubchem ID : | 32484 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H319-H412 |
Precautionary Statements: | P264-P273-P280-P305+P351+P338-P312-P337+P313-P501 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 0 - 5℃; for 0.333333h;Inert atmosphere; | A solution of NBS (24.59 g, 137 mmol) in DMF (160 mL) was added slowly to a solution of 2,6-diisopropylaniline (25 g, 137 mmol) in DMF (300 mL) at 0-5C under a nitrogen atmosphere over a period of 20 minutes. The reaction mixture was stirred at 0-5C. After the reaction was complete, water was added and the oil suspension was stirred at rt. The aqueous layer was decanted out and the remaining oil was dissolved in ethyl acetate. The organic layer was separated, washed water and brine.Evaporation gave light brown oil (35.1 g, 100% yield). |
99% | With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 0℃; for 2h; | To a stirred solution of 2,6-diisopropylaniline (14 g, 78.97 mmol, 1.00 equiv) in N,N-dimethylformamide (200 mL) at 0 C. was added a solution of NBS (14 g, 78.65 mmol, 1.00 equiv) in N,N-dimethylformamide (100 mL) dropwise in 60 min. The reaction was stirred for another hour at 0 C. then water (900 mL) was added. The resulting mixture was extracted with 300 mL of ethyl acetate. The combined organic layers was washed with 3*100 mL of saturated NH4Cl solution and 1*100 mL of water then dried over anhydrous sodium sulfate and concentrated under vacuum to give 20.05 g (99%) of 4-bromo-2,6-diisopropylaniline as a red oil. 1H NMR (400 MHz, DMSO-d6): delta 6.95 (s, 2H), 4.77 (s, 2H), 5.47-5.39 (m, 1H), 3.04-2.98 (m, 1H), 1.13 (d, J=6.8 Hz, 12H) ppm. |
97% | With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 0 - 20℃; for 48h; | Synthesis of 4-bromo-2,6-diisopropylaniline (0199) A three neck round bottom flask was charged with 2,6-diisopropylaniline (22.96 g, 130 mmol) and DMF (Volume: 250 ml). A solution of 1-bromopyrrolidine-2,5-dione (23.05 g, 130 mmol) in 100 ml DMF was added into reaction mixture drop wise at 0 C. After addition was over; reaction mixture was stirred for 2 days at room temperature. The reaction mixture was poured into 500 ml deionized water and extracted with 3×150 ml ether. The combined extracts were washed with 150 ml deionized water, 150 ml 10% lithium chloride, dried over MgSO4 and evaporated to dryness. The residue was purified by vacuum distillation to yield 4-bromo-2,6-diisopropylaniline (32.3 g; 97%). |
95% | With tetra-N-butylammonium tribromide; In tetrahydrofuran; at 0℃; | 40.8 g (85 mmol) of tetra-n-butylammonium tribromide are added, at 0 C. and portionwise, to a solution of 15 g (85 mmol) of 2,6-diisopropylphenyl-amine in 200 ml of tetrahydrofuran. The medium is stirred for 2 h. It is then poured into a saturated aqueous solution of sodium thiosulphate and extracted with ethyl acetate. The organic phases are combined and washed with water. They are dried over sodium sulphate. The residue is purified by silica gel chromatography (80/20 heptane/ethyl acetate). 20.6 g of 4-bromo-2,6-diisopropylphenylamine are obtained in the form of a yellow oil (yield=95%). |
88% | With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 0℃; for 1h; | To a stirred solution of 2,6-diisopropylaniline (5.05 g, 28.4 mmol, 1.00 equiv) inN,Ndimethylformamide (70 mL) at 00 C was added a solution of NBS (5.05 g, 28.4 mmol, 1.00 equiv) in N,N-dimethylformamide (30 mL) dropwise over 60 mm. The reaction was stirred foranother hour at 0 C, at which time water (300 mL) was added. The resulting mixture was extracted with ethyl acetate (2 x 300 mL), and the combined organic layers were washed with saturated NH4C1 solution (3 x 100 mL) followed by water (100 mL) and dried over anhydrous sodium sulfate. Concentration of the solution under vacuum afforded 4-bromo-2,6- diisopropylaniline (6.5 g, 88% yield). LCMS (Method A): 256.1 [M+H], retention time 2.97mm. |
82% | With tetra-N-butylammonium tribromide; In tetrahydrofuran; at 20℃; | Preparative Example P16Step 1 : 4-Bromo-2,6-diisopropylaniline (PI 6a)To a solution of 2,6-diisopropylaniline (12.5 g, 70.6 mmol) in THF was added (C4H9)4NBr3 (47 g, 85 mmol) at rt and stirred overnight. Then sat. NaHS03 solution (30 mL) was added and the mixture was extracted with Et20 (3 x 250 mL). The organic layer was washed with brine, dried over Na2S04 and concentrated to give compound P16a (19 g, 82%). |
79% | With bromine; In methanol; at 20℃; | A solution of 2, [6-DIISOPROPYLANILINE] (2.0 mL, 11 mmol) in methanol (80 mL) was treated dropwise with bromine (543 muL, 10.6 mmol). The solution was stirred at room temperature for 15 min. Chloroform and 0.1 N [NAOH] were added and the organic layer was dried (Na2SO4), filtered and concentrated to an orange liquid. Kugelrohr distillation [(110 C @ ] 0.06 Torr) afforded a colorless liquid (2.22 g 79%): 1H NMR (400 MHz) 8 1.25 (d, J= 6.4 Hz, 12H), 2. 88 (m, 2H), 3.70 (brs, 2H), 7.11 (s, 2H) [; 13C NMR 8] 22.1, 27.9, 111.0, 125.6, 134.5, 139.3 ; Anal calcd for [C12HIGBRN] : C, 56.26 ; H, 7. 08 ; Br, 31.19 ; Found, C, 56.24 ; H, 7.07 ; Br, 30.98 |
72% | With bromine; In methanol; dichloromethane; at 20℃; for 24h; | A solution of Br2(2.1 ml, 41.0 mmol, 1.05 eq.) in CH2Cl2/MeOH (100 ml, 1:1 v/v)was added to a stirring solution of 2,6-diisopropylaniline (7.4 ml,39.0 mmol, 1.0 eq.) in CH2Cl2/MeOH (200 ml, 1:1 v/v) at r.t. over2 h. The orange-red solution was stirred for 1 day. The solvents were evaporated and the resultant pink solid was washed with PE and further recristallized from CH2Cl2/PE to give the title compound as light orange-red solid (7.8 g, 28.1 mmol, 72%).1H-NMR (300 MHz,CDCl3) [ppm]: 10.08 (s, 2H), 7.36 (s, 2H), 3.80-3.62 (m, 2H), 1.29(d, J = 6.7 Hz, 12H). The analytical data are in accordance with theliterature. |
65.7% | With N-Bromosuccinimide; In acetonitrile; at 20℃; | Into a 500-mL round-bottom flask, was placed 2,6-bis(propan-2-yl)aniline (10 g, 56.4 mmol) in ACN (200 mL), to the stirred solution was added NBS (11.0 g, 62.0 mmol). The resulting solution was stirred overnight at RT. The resulting mixture was concentrated undervacuum. The residue was eluted from silica gel with petroleum ether. This resulted in 9.5 g (65.7%) of the title compound as brown oil. MS-ESI: 256/258 [M+1]. |
48.8 g (42%) | With potassium hydroxide; bromine; In water; acetic acid; | 4-Bromo-2,6-diisopropylaniline To a solution of 80.0 g (0.452 mol) of 2,6-diisopropylaniline in 2000 cm3 of glacial acetic acid, 23.3 ml (72.3 g, 0.452 mol) of bromine were added dropwise, while vigorously stirring, over 20 minutes. This mixture was stirred additionally for 2 hours at 40 C. The white precipitate that formed was filtered off, washed with 100 ml of acetic acid, and dried in air. The resulting white solid was added to a solution of 150 g of potassium hydroxide in 600 ml of water. This mixture was stirred for 30 minutes. The product was extracted with 3*100 ml of methyl-tert-butyl ether. The combined organic fractions were washed with Na2SO4 and evaporated to dryness. Fractional distillation gave a yellowish oil, b.p. 112-115 C./1 mm Hg. Yield 48.8 g (42%). Anal. calc. for Cl2H18BrN: C, 56.26; H, 7.08. Found: C, 56.11; H, 7.13. 1H NMR (CDCl3): delta 7.10 (s, 2H, 3,5-H), 3.69 (br.s, 2H, NH2), 2.86 (sept, J=6.8 Hz, 2H, CHMe2), 1.23 (d, J=6.8 Hz, 12H, CHMe2). 13C{1H}NMR (CDCl3): delta 139.3, 134.5, 125.6, 111.0, 27.9, 22.1. |
Reference Example 4 4-bromo-2,6-diisopropyl-N,N-dimethylaniline To a solution of 2,6-diisopropylaniline (25 g, 0.141 moL) in toluene (25 mL) was added dimethyl sulfoxide (12.1 g, 1.1 equivalents), and the mixture was heated to 90C. 48% Aqueous hydrobromic acid solution (26.1 g, 1.1 equivalents) was added dropwise to the mixture at the same temperature over 30 min. Then, the mixture was stirred at 86C for 3 hr and at 100C for 2 hr. Water (20 mL) was added to the mixture at 0C, and 1M aqueous sodium hydroxide solution (30 mL) was added dropwise to the mixture. The mixture was partitioned, and the organic layer was washed with 1M aqueous sodium hydroxide solution (50 mL). The organic layer was dried over anhydrous magnesium sulfate and filtered naturally, and the filtrate was concentrated under reduced pressure. The residue was distilled under reduced pressure to give 4-bromo-2,6-diisopropylaniline (29.4 g, pale-yellow liquid). | ||
540 g | With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 0 - 20℃; for 18h; | Apparatus set-up:A 10 L 3-necked round-bottomed flask, equipped with a mechanical overhead stirrer, nitrogen inlet and exhaust.Experimental Procedure:1. 2, 6-Diisopropyl aniline (500 g, 2.8202 mol) was dissolved in dry N, N-dimethyl formamide.It was cooled to 0 C using an ice bath.2. N-Bromosuccinimide (501.9 g, 2.8202 mol) was added slowly portion wise.3. The reaction mixture was stirred at the room temperature for 18 h.4. After 18 h, TLC showed complete conversion of starting material.5. To the mixture, 10% NaHCO3 solution (4 L) was added and extracted with ethyl acetate (3 x2L).6. The combined organic phase was washed with water (1 L), brine (1 L), dried over sodium sulphate and concentrated.7. The crude product was purified by silica column chromatography using 8 % ethyl acetate in hexane as an eluent to get 540 g with 95.75 % HPLC purity. 1H-NMR (300 MHz, CDCl3): delta[ppm] 1.26 (d, J = 6.78 Hz, 12H), 2.84 - 2.93 (m, 2H), 3.72 (br, s, 2H), 7.12 (s, 2H). |
With bromine; In methanol; at 20℃; | 49 ml (152 g, 954 mmol) ofbromine was slowly (for 2 h) added to a stirred solutionof 169.7 g (957 mmol) of2,6-diisopropylaniline in 1500 ml of methanol. Theresulting dark-red solution was stirred overnight at room temperature, then most ofmethanol was removed under reduced pressure, and 1000 ml of dichloromethane was added to the residue. This solution was shaken with a cold solution of 140 g (2.5mol) of potassium hydroxide in 1100 ml of water. The organic layer was separated,and the aqueous one was extracted with 200 ml of dichloromethane. The combinedorganic extract was dried over K2C03, passed through a short layer of silica gel 60( 40-63 )liD), and evaporated in vacuum to give crude 4-bromo-2,6-diisopropylaniline (purity ca. 90%) as dark-red oil which was further used without an additionalpurification.1H NMR (CDCh): b 7.15 (s, 2H), 3.82 (br.s, 2H), 2.90 (sept, J = 6.9 Hz, 2H), 1.28(d, J = 6.9 Hz, 12H). 13CeH} NMR (CDCh,): b 139.15, 134.55, 125.65, 111.08,27.92, 22.16. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol; at 20℃; for 24h; | EXAMPLE 2; This example describes synthesis of another mid-transition metal complex of the invention, with ligand synthesis as illustrated in Scheme 3 and described in part (a), and metallation as illustrated in Scheme 4 and described in part (b). [00163] (a) The imine-containing ligand 3 may be synthesized by reaction of 2,6-pyrazine carboxaldehyde with 2,6-diisopropylanine as illustrated in Scheme 3: [C00023] [00164] A 250-mL flask is charged with 2,6-pyrazine carboxaldehyde and methanol. A slight excess of 2,6-diisopropylaniline (1.1 eq) is added by pipet. The mixture is stirred at room temperature in methanol for 1 d. The solvent and unreacted aniline are removed in vacuo to give the desired product. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In hexane; dichloromethane; ethyl acetate; | Synthesis Example 10 Synthesis of N-(2,6-diisopropylphenyl)-5-tert-butyl phthalimide (Compound No.173 as Described Hereinafter) 0.605 g of <strong>[32703-79-0]4-tert-butylphthalic anhydride</strong> and 0.630 g of 2,6-diisopropylaniline were mixed, and the mixture was reacted at a temperature of 200 C. for 1 hour. After the reaction was finished, the reaction mixture was dissolved in ethyl acetate, washed with sodium hydrogen carbonate aqueous solution, washed with water, and washed with saturated aqueous sodium chloride. Then, it was dried over anhydrous magnesium sulfate and subjected to filtration. The filtrate was concentrated and dried and solidified. Then, it was recrystallized by using a mixture of hexane and dichloromethane, to obtain 0.7055 g of the specified substance having a melting point of 234.0-234.8 C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | In acetic acid; at 20 - 114℃; for 6h;Heating / reflux; | 22 g of tetrafluorine-phtalic acid anhydride (100 mmol, 97%, Aldrich) was dissolved in glacial acetic acid (40 ml, 99,99%, Aldrich) and 2,6- diisopropylanilin was added (18,6 g, 105 mmol; 97%, Aldrich) to the solution. The reaction was refluxed for 2 hours (114 0C). Formation of crystals started at room temperature (4 hours), which was followed by incubation at 4 0C for 16 hours. Crystals were filtered from the solution, washed with 70% ethanol, then dried. 34 g of compound 2 was yielded as white crystals (85%) . The purity of the product was checked by Thin Layer Chromatography (6:4 chloroform :tetrahydrofurane), and with HPLC. |
85% | With acetic acid; at 120℃; for 4h; | General procedure: To a 10 mL round-bottomed flask equipped with a stirring bar and refluxcondenser was charged the appropriate mono-, di-, or tetrafluorophthalicanhydride 1 (0.5-4 mmol, 1 equiv). Glacial AcOH (0.5-4mL) was then added, and to the stirred solution was added the appropriateamine 2 (0.55-4.4 mmol, 1.1 equiv). The solution was heated at120 C and allowed to stir at this temperature for 4-12 h, then theflask was allowed to cool to rt. The reaction mixture was taken in aseparatory funnel, treated with sat. aq Na2CO3 (4-30 mL), and extractedwith EtOAc (2 × 2.5-15 mL). The combined organic phases weredried (anhyd MgSO4) and concentrated. The crude product was purifiedby recrystallization or flash chromatography using silica gel withhexanes/EtOAc as eluents. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
59% | To a250 mL 3-neck round bottom flask was added 2,6-diisopropylaniline (2.365 g, 13.34 mmol) and 70 mL toluene. The solution was cooled in an ice bath under nitrogen and trimethylaluminum (2.0 M in toluene, 9.34 mL, 18.68 mmol) was added dropwise via dropping funnel. The reaction mixture was stirred at room temperature for 2 hours. Next, <strong>[124289-21-0]3-bromo-5-methylbenzonitrile</strong> (3.4 g, 17.34 mmol) in 30 mL toluene was added and the reaction mixture was heated to 70 C overnight under nitrogen. The reaction mixture was cooled in an ice bath and was poured onto a stirring slurry of silica gel in 2: 1 dichloromethane/methanol (v/v). The silica gel was filtered off and washed with dichloromethane and methanol. The filtrate was evaporated leaving a solid.Hexane was added to the solvent and the solid was filtered off and washed with hexane (2.92 g, 59%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
67% | With potassium carbonate; potassium iodide; potassium bromide; In N,N-dimethyl-formamide; at 80℃; for 12h;Inert atmosphere; | Under an argon atmosphere, into a reaction vessel of 2-chloro-N- (2- (trifluoromethyl) phenyl) acetamide 2.85 g (12.0 mmol), potassium iodide 1.66 g (10.0 mmol), potassium bromide 580 mg ( 4.87 mmol), potassium carbonate 1.88g (13.6mmol), N, N- dimethylformamide 10mL and 2,6-diisopropyl aniline 7.52g of (42.7 mmol) was added.The reaction vessel was heated to 80 , and the mixture was stirred for 12 hours.The reaction vessel was cooled to room temperature, ethyl acetate 150mL was added, the organic layer was washed with water 50 mL, saturated brine 50 mL, dried over sodium sulfate.Distilling off the sodium sulfate and the solvent, the residue was purified by silica gel column chromatography (hexane: ethyl acetate = 100: 0 to 85: 150) to give 2 - ((2,6-diisopropylphenyl) amino) -N - (2-(trifluoromethyl) phenyl) acetamide 3.02 g (white solid, 7.98mmol, 67% yield). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | General procedure: Add 1.1 molar equivalent of crotonaldehyde to the hydrochloric acid solution of 2-bromoaniline, reflux overnight at 100C, add 1 molar equivalent of zinc chloride to the aqueous phase obtained after adding ether at room temperature, and use isopropanol and isopropanol to obtain the yellow solid. Wash with hydrochloric acid once, add water and ammonia water in a volume ratio of 3:1, stir, add ether, and remove the organic phase to obtain 8-bromo-2-methylquinoline. Under a nitrogen atmosphere, 8-bromo-2-methylquinoline and 1 molar equivalent of selenium dioxide were refluxed overnight in dioxane, and the reaction solution was suction filtered at room temperature. The filtrate was concentrated to obtain 8-bromo-2 quinolinecarboxaldehyde. Under a nitrogen atmosphere, dissolve the substituted aniline in toluene, add 1-1.5 molar equivalents of trimethylaluminum at room temperature, reflux for 4-6 hours, add the toluene solution of 8-bromo-2quinolinecarboxaldehyde, and reflux for 8- 12 hours; adding 5% NaOH aqueous solution, drying the organic phase, removing the organic solvent under reduced pressure, adding a small amount of methanol solvent to obtain a yellow solid, that is, the imine intermediate. Under a nitrogen atmosphere, differently substituted imine intermediates and 1 molar equivalent of differently substituted mercaptans were coupled to synthesize ligands under palladium catalysis. Under a nitrogen atmosphere, weigh the ligand (0.429g, 1.1mmol), add 20mL of dry dichloromethane to dissolve, weigh [CrCl3(THF)3] (0.371g, 1mmol), add 20mL of dry dichloromethane, and mix The body solution was introduced into the latter and stirred for 12 hours to obtain a green suspension. Concentrate to 5-10 mL, add 5 mL of dry ether, filter, and then add 5 mL of dry ether to wash once, filter to obtain 0.46 g of green powder Cr1 compound, with a yield of 85%. |
Tags: 24544-04-5 synthesis path| 24544-04-5 SDS| 24544-04-5 COA| 24544-04-5 purity| 24544-04-5 application| 24544-04-5 NMR| 24544-04-5 COA| 24544-04-5 structure
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P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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