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Chemical Structure| 2456-81-7 Chemical Structure| 2456-81-7
Chemical Structure| 2456-81-7

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Product Details of 4-(Pyrrolidin-1-yl)pyridine

CAS No. :2456-81-7
Formula : C9H12N2
M.W : 148.21
SMILES Code : C1(N2CCCC2)=CC=NC=C1
MDL No. :MFCD00006415
InChI Key :RGUKYNXWOWSRET-UHFFFAOYSA-N
Pubchem ID :75567

Safety of 4-(Pyrrolidin-1-yl)pyridine

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H314
Precautionary Statements:P280-P305+P351+P338-P310-P304+P340-P301+P330+P331-P303+P361+P353
Class:8(6.1)
UN#:2923
Packing Group:

Application In Synthesis of 4-(Pyrrolidin-1-yl)pyridine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2456-81-7 ]

[ 2456-81-7 ] Synthesis Path-Downstream   1~35

  • 1
  • [ 123-75-1 ]
  • [ 626-55-1 ]
  • [ 69698-09-5 ]
  • [ 2456-81-7 ]
  • 2
  • [ 123-75-1 ]
  • [ 27248-04-0 ]
  • [ 15097-49-1 ]
  • [ 2456-81-7 ]
  • 3
  • [ 108-96-3 ]
  • [ 15097-49-1 ]
  • [ 2456-81-7 ]
  • 4
  • [ 51757-15-4 ]
  • [ 2456-81-7 ]
  • [ 128826-96-0 ]
  • 5
  • [ 6262-42-6 ]
  • [ 2456-81-7 ]
  • [ 114692-37-4 ]
  • 6
  • [ 6262-42-6 ]
  • [ 2456-81-7 ]
  • 1,1,2,3,3-pentakis(4-pyrrolidinopyridinium-1-yl)allylid tetrachloride [ No CAS ]
  • 7
  • 4-pyrrolidinopyridine hydrochloride [ No CAS ]
  • [ 2456-81-7 ]
  • 1-Prop-2-ynyl-4-pyrrolidin-1-yl-pyridinium; perchlorate [ No CAS ]
  • C21H28N4(2+)*2ClO4(1-) [ No CAS ]
  • 8
  • [ 90432-32-9 ]
  • [ 2456-81-7 ]
  • 1,2,3,3-tetrakis(4-(dimethylamino)pyridinium-1-yl)-1-(4-pyrrolidinopyridinium-1-yl)allylid tetrachloride [ No CAS ]
  • 9
  • [ 2456-81-7 ]
  • [ 139574-87-1 ]
  • [ 133226-72-9 ]
  • 10
  • [ 2456-81-7 ]
  • [ 624-65-7 ]
  • 1-Prop-2-ynyl-4-pyrrolidin-1-yl-pyridinium; perchlorate [ No CAS ]
  • 12
  • [ 2456-81-7 ]
  • [ 121697-81-2 ]
YieldReaction ConditionsOperation in experiment
96% With water-d2; at 190℃; for 2h;Microwave irradiation; General procedure: A solution of the substrate in D2O (5 mL) was irradiated in a sealed Pyrex tube at 190 °C for 2 h (hold-time) using a CEM Explorer microwave synthesizer (maximum pressure 150 psi) by moderation of the initial microwave power (300 W). The mixture was cooled in a stream of compressed air and extracted with CH2Cl2 (3 × 10 mL). The organic extracts were combined, dried (MgSO4), filtered and evaporated in vacuo to give the title compound.
  • 13
  • [ 121409-81-2 ]
  • [ 2456-81-7 ]
  • 14
  • [ 2456-81-7 ]
  • [ 106-89-8 ]
  • [ 94843-15-9 ]
  • 15
  • [ 2456-81-7 ]
  • [ 3132-64-7 ]
  • [ 94821-46-2 ]
  • 16
  • [ 75-84-3 ]
  • [ 375-72-4 ]
  • [ 2456-81-7 ]
  • N-neopentyl-4-pyrrolidinopyridinium nonaflate [ No CAS ]
  • 17
  • [ 3764-01-0 ]
  • [ 143-66-8 ]
  • [ 2456-81-7 ]
  • 1,1',1''-(pyrimidin-2,4,6-triyl)-tris-4-(pyrrolidin-1-yl)pyridinium tris(tetraphenylborate) [ No CAS ]
  • 18
  • [ 3764-01-0 ]
  • [ 2456-81-7 ]
  • 1,1',1''-(pyrimidin-2,4,6-triyl)-tris-4-(pyrrolidin-1-yl)pyridinium tri-iodide [ No CAS ]
  • 19
  • [ 3764-01-0 ]
  • [ 2456-81-7 ]
  • (pyrimidine-2,4,6-triyl)-1,1',1''-tris[4-(pyrrolidin-1-yl)pyridinium] trichloride [ No CAS ]
  • 20
  • [ 1780-40-1 ]
  • [ 2456-81-7 ]
  • 5-chloro-2,6-bis[4-(pyrrolidin-1-yl)pyridino]pyrimidin-4-olate chloride [ No CAS ]
  • 21
  • [ 1780-40-1 ]
  • [ 2456-81-7 ]
  • C22H24ClN6O(1+)*HI*I(1-) [ No CAS ]
  • 22
  • [ 143-66-8 ]
  • [ 2456-81-7 ]
  • [ 90845-52-6 ]
  • 5-chloro-2,6-bis-[4-(pyrrolidin-1-yl)pyridinio]-pyrimidine-4-(4-nitrophenyl)aminide tetraphenylborate [ No CAS ]
  • 23
  • [ 2456-81-7 ]
  • [ 90845-52-6 ]
  • 5-chloro-2,6-bis-[4-(pyrrolidin-1-yl)pyridinio]-pyrimidine-4-(4-nitrophenyl)aminide chloride [ No CAS ]
  • 24
  • [ 143-66-8 ]
  • [ 2456-81-7 ]
  • [ 74894-28-3 ]
  • 1,1'-(6-anilino-5-chloropyrimidine-2,4-diyl)-bis-[4-(pyrrolidin-1-yl)pyridinium] bis(tetraphenylborate) [ No CAS ]
  • 25
  • [ 2456-81-7 ]
  • [ 74894-28-3 ]
  • 1,1'-(6-anilino-5-chloropyrimidine-2,4-diyl)-bis-[4-(pyrrolidin-1-yl)pyridinium] dichloride [ No CAS ]
  • 26
  • [ 594-19-4 ]
  • [ 2456-81-7 ]
  • 2-tert-butyl-4-(pyrrolidin-1-yl)pyridine [ No CAS ]
  • 27
  • [ 2456-81-7 ]
  • [ 74-88-4 ]
  • 2-methyl-4-(pyrrolidin-1-yl)pyridine [ No CAS ]
  • 30
  • [ 4270-27-3 ]
  • [ 2456-81-7 ]
  • 4-(pyrrolidin-1-yl)-1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-6-yl)pyridinium chloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
66% EXAMPLE 7 4-pyrrolidinopyridine To a 250 ml, 3-neck round bottom flask equipped with a thermometer, pressure equalizing addition funnel and magnetic stir bar, was charged 10.6 ml of pyrrolidine (0.125 mole) and 13.5 ml of deionized water. The flask was cooled in an ice water bath and 10 g (0.125 mole) of a 50percent (w/w) sodium hydroxide solution was added slowly with stirring. Upon complete addition, the solution was cooled below 5° C. A solution of 1-(2-carbamoylethyl)-4-cyanopyridinium chloride (21.2 g; 0.1 mole) dissolved in 15 ml of deionized water was prepared and charged to the dropping funnel. This solution was then added to the pyrrolidine/sodium hydroxide solution at a rate which permitted maintenance of the reaction temperature with stirring at below 5° C. It was held there for an additional hour, after which 14 g (0.175 mole) of a 50percent (w/w) sodium hydroxide solution was added dropwise with continued maintenance of the reaction temperature below 5° C. (approximately 45 minutes). The mixture was then heated to reflux and maintained for two hours and then allowed to cool. The aqueous mixture was extracted four times with half its volume of toluene and the combined extracts were concentrated to a residue of 14.7 g which solidified. This crude material was crystallized from ethylacetate to give 4.04 g of the title compound as product, mp. 58°-59° C. (66percent yield).
  • 33
  • [ 558-37-2 ]
  • [ 201230-82-2 ]
  • [ 2456-81-7 ]
  • 4,4-dimethyl-1-(4-pyrrolidin-1-yl-pyridin-2-yl)-pentan-1-one [ No CAS ]
  • 34
  • [ 6522-21-0 ]
  • [ 2456-81-7 ]
  • 2,6-dipyrrolidinopyridinium-9-thiabicyclo[3.3.1]nonane dichloride [ No CAS ]
  • 35
  • [ 6337-67-3 ]
  • [ 2456-81-7 ]
  • 1,1'-[1,2-ethylenebis(benzene-1,4-diylmethylene)]bis[4-(pyrrolidino)pyridinium] dibromide [ No CAS ]
 

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