215178-45-3|(R)-(9H-Fluoren-9-yl)methyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate| Ambeed

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

{[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

Quality Control of [ 215178-45-3 ] Purity: 95% SDS Specification

COA

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

NMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

CNMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

HPLC

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

LC-MS

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

1-2 Day Shipping
High Quality
Technical Support

Product Details of [ 215178-45-3 ]

CAS No. :	215178-45-3
Formula :	C₂₀H₂₁NO₃
M.W :	323.39
SMILES Code :	O=C(N1[C@@H](CO)CCC1)OCC2C3=C(C4=C2C=CC=C4)C=CC=C3
MDL No. :	MFCD00270370
InChI Key :	HJUXXCOVGMCKQL-CQSZACIVSA-N
Pubchem ID :	688636

Safety of [ 215178-45-3 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 215178-45-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 215178-45-3 ]

[ 215178-45-3 ] Synthesis Path-Downstream 1~10

1
C₂₅H₂₂N₂O₃S [ No CAS ]
[ 215178-45-3 ]

References: [1]Journal of Medicinal Chemistry,2009,vol. 52,p. 6126 - 6141.

2
[ 215178-45-3 ]
[ 269072-00-6 ]

Yield	Reaction Conditions	Operation in experiment
		General procedure: A solution of 0.3mL (0.32g, 4.1mmol) of anhydrous dimethyl sulfoxide in anhyd. CH2Cl2 (15mL) was placed in a round-bottom flask with magnetic stirrer and under inert atmosphere (N2). The mixture was cooled at-78C, 0.32mL (0.48g, 3.7mmol) of oxalyl chloride was added drop-wise and the reaction mixture was stirred during thirty additional minutes at-78C. (S)- or (R)-Fmoc prolinol (0.56g, 1.7mmol) of 2 dissolved in anhydrous CH2Cl2 (10mL) was added dropwise and the resulting mixture was stirred for 60min at-78C. Triethylamine (1.44mL, 1.04g, 10.28mmol) was added drop-wise and the resulting reaction mixture was stirred during 60min at-78C and 30min at 0C. The organic layer was washed with brine (3×25mL), dried over anhydrous Na2SO4, filtered and concentrated in vacuo to obtain the crude product as an oil. The crude was used immediately in the next step without further purification.

References: [1]Journal of Medicinal Chemistry,2009,vol. 52,p. 6126 - 6141.
[2]Tetrahedron,2017,vol. 73,p. 4707 - 4718.

3
[ 215178-45-3 ]
[ 124482-92-4 ]
[ 1361107-60-9 ]

References: [1]Chemistry - A European Journal,2011,vol. 17,p. 11813 - 11827.

4
[ 71989-31-6 ]
[ 215178-45-3 ]