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Chemical Structure| 269072-00-6 Chemical Structure| 269072-00-6

Structure of 269072-00-6

Chemical Structure| 269072-00-6

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Product Details of [ 269072-00-6 ]

CAS No. :269072-00-6
Formula : C20H19NO3
M.W : 321.37
SMILES Code : O=C(N1[C@@H](C=O)CCC1)OCC2C3=C(C4=C2C=CC=C4)C=CC=C3
MDL No. :N/A

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Application In Synthesis of [ 269072-00-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 269072-00-6 ]

[ 269072-00-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 215178-45-3 ]
  • [ 269072-00-6 ]
YieldReaction ConditionsOperation in experiment
General procedure: A solution of 0.3mL (0.32g, 4.1mmol) of anhydrous dimethyl sulfoxide in anhyd. CH2Cl2 (15mL) was placed in a round-bottom flask with magnetic stirrer and under inert atmosphere (N2). The mixture was cooled at-78C, 0.32mL (0.48g, 3.7mmol) of oxalyl chloride was added drop-wise and the reaction mixture was stirred during thirty additional minutes at-78C. (S)- or (R)-Fmoc prolinol (0.56g, 1.7mmol) of 2 dissolved in anhydrous CH2Cl2 (10mL) was added dropwise and the resulting mixture was stirred for 60min at-78C. Triethylamine (1.44mL, 1.04g, 10.28mmol) was added drop-wise and the resulting reaction mixture was stirred during 60min at-78C and 30min at 0C. The organic layer was washed with brine (3×25mL), dried over anhydrous Na2SO4, filtered and concentrated in vacuo to obtain the crude product as an oil. The crude was used immediately in the next step without further purification.
 

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