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Structure of 3-Amino-1-propanol
CAS No.: 156-87-6
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
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CAS No. : | 156-87-6 |
Formula : | C3H9NO |
M.W : | 75.11 |
SMILES Code : | OCCCN |
MDL No. : | MFCD00008223 |
InChI Key : | WUGQZFFCHPXWKQ-UHFFFAOYSA-N |
Pubchem ID : | 9086 |
GHS Pictogram: |
![]() ![]() |
Signal Word: | Danger |
Hazard Statements: | H302-H314 |
Precautionary Statements: | P264-P270-P280-P301+P312+P330-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338+P310-P363-P405-P501 |
Class: | 8 |
UN#: | 2735 |
Packing Group: | Ⅱ |
Num. heavy atoms | 5 |
Num. arom. heavy atoms | 0 |
Fraction Csp3 | 1.0 |
Num. rotatable bonds | 2 |
Num. H-bond acceptors | 2.0 |
Num. H-bond donors | 2.0 |
Molar Refractivity | 20.4 |
TPSA ? Topological Polar Surface Area: Calculated from |
46.25 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
0.92 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
-1.12 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
-0.67 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
-0.63 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
-0.61 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
-0.42 |
Log S (ESOL):? ESOL: Topological method implemented from |
0.53 |
Solubility | 256.0 mg/ml ; 3.4 mol/l |
Class? Solubility class: Log S scale |
Highly soluble |
Log S (Ali)? Ali: Topological method implemented from |
0.64 |
Solubility | 328.0 mg/ml ; 4.36 mol/l |
Class? Solubility class: Log S scale |
Highly soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
-0.03 |
Solubility | 70.3 mg/ml ; 0.935 mol/l |
Class? Solubility class: Log S scale |
Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
No |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
No |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-7.55 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from |
0.0 |
Ghose? Ghose filter: implemented from |
None |
Veber? Veber (GSK) filter: implemented from |
0.0 |
Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
Muegge? Muegge (Bayer) filter: implemented from |
2.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
Brenk? Structural Alert: implemented from |
0.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
1.0 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | With triethylamine; In ethanol; at 160℃; for 3.0h;Microwave irradiation; | Step 1 : (R)-2, 4-Dihydroxy-N-(3-hydroxy-propyl)-3, 3-dimethyl-butyramideTo a solution of D-pantolactone (0.5 g, 1 eq) in dry EtOH (5 mL) in a microwave vial were added 3-amino-propan-1-ol (0.53 mL, 1.5 eq), Et3N (0.54 mL, 1 eq) and irradiated with MW radiation at 160C for 3 h. After this time, the reaction mixture wasconcentrated and purified by silica gel column chromatography to afford the product as a white solid (800 mg, 95%).1H NMR (400 MHz, DMSO d6): delta 7.70 (t, J = 4.0 Hz, 1 H), 5.32 (d, J = 4.0 Hz, H), 4.48-4.42 (m, 2H), 3.68 (d, J = 8.0 Hz, 1 H), 3.40 (dd, J = 4.0, 8.0 Hz, 2H), 3.31-3.26 (m, 1 H), 3.19-3.07 (m, 3H), 2.56-2.52 (m, 2H), 0.78 (s, 3H), 0.76 (s, 3H). |
at 60℃; for 5.0h; | Preparation of Panthenol:A 1 l four-neck flask was initially charged with 150 g of 3-aminopropanol. While stirring, 260 g of D-pantolactone were added slowly at room temperature. After the addition had ended, the reaction mixture was heated to 60 C. and stirred for a further 5 hours. The D-pantolactone used was washed twice beforehand with methyl tert-butyl ether (MTBE) and then dried.The crude panthenol obtained by the reaction of 3-aminopropanol and D-pantolactone was subsequently degassed and distilled.The degassing was performed in a thin-film evaporator at a pressure of 0.027 mbar, a bottom temperature of 80 C. and a lamellar speed of 280 rpm. After the degassing, the apparatus was cleaned by repeatedly purging with demineralized water and 2-propanol with subsequent drying under reduced pressure.Subsequently, the degassed panthenol was distilled. The distillation was performed in the same apparatus in which the degassing had already been undertaken. The bottom temperature was 120 C., the pressure 0.027 mbar and the lamellar speed 800 rpm.In the internal condenser, at a cooling coil temperature of 60 C., panthenol was obtained. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99.5% | (Step 1) <strong>[5147-80-8][Bis(methylthio)methylene]malononitrile</strong> (2.01 g, 11.8 8 mmol) was dissolved in THF (60 mL) and the solution was added with 4-amino-1-benzylpiperidine (2.41ml,11.8 mmol) dissolved in THF (2 mL), followed by stirring at room temperature for 2.5 hours. Then the mixture was added with 3-aminopropanol (0.96 mL, 12.4 mmol) and stirred at 60C for 8 hours. Further, the mixture was added with 3-aminopropanol (0.45 mL, 5.9 mmol) and stirred at 60C for 8 hours. After the mixture was cooled to room temperature, the solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (chloroform/methanol (100:1)) to obtain [1-(1-benzylpiperidin-4-ylamino)-2-(3-hydroxypropylamino) methylene]malononitrile (3.98 g, 99.5 %). 1H NMR (CDCl3, δppm): 1.50-1.65 (m, 2H), 1.72-1.87 (m, 2H), 1.96-2.02 (m, 2H), 2.10-2.17 (m, 2H), 2.81-2.86 (m, 2H), 3.46-3.53 (m, 4H), 3.62-3.74 (m, 1H), 3.83 (t, J = 5.5 Hz, 2H), 5.69 (brd, J = 11.1 Hz, 1H), 5.98 (s, 1H), 7.27-7.35 (m, 5H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
57% | In water; N,N-dimethyl-formamide; | Example 3 Preparation of N-(3-hydroxypropyl)-2-anthraquinonecarboxamide (2) To a stirred suspension of <strong>[117-78-2]anthraquinone-2-carboxylic acid</strong> (Aldrich, 10.00 g, 39.64 mmol) in DMF (130 ml), was added (benzotriazol-1-yloxy)tris(dimethylamino)-phosphonium hexafluorophosphate (17.54 g, 39.66 mmol) and trethylamine (11.05 ml, 79.28 mmol). The resulting mixture (initially a clear green solution) was stirred at room temperature for 10 min. before dropwise addition of 3-amino-1-propanol (3.34 ml, 43.67 mmol). The reaction mixture (clear brown solution) was stirred at room temperature in the dark for 17 hours. The solution was poured in a thin stream into water (300 ml) containing some ice. The precipitated material was isolated by filtration and recrystallized from boiling 96percent ethanol (ca. 200 ml) and gave the title compound 2 as a bright yew solid (6.93 g, 57percent yield). 1H NMR (250 MHz, DMSO-d6) delta: 1.74 (2H, quintet, J=6.52 Hz, CH2), 3.25-3.44 (2H, m, CH2), 3.50 (2H, broad t, J=5.80 Hz, CH2), 4.53 (1H, broad s, OH), 7.76-8.00 (2H, m, Ar), 8.04-8.36 (4H, m, Ar), 8.56 (1H, d, J=1.55 Hz, Ar), 8.89 (1H, t, J=5.42 Hz, NH). 13C NMR (250 MHz, DMSO-d6) delta: 32.32, 36.96, 58.68, 125.50, 126.83, 126.85, 127.05, 132.79, 133.04, 133.08, 134.45, 134.66, 139.49, 164.62, 182.11. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With camphor-10-sulfonic acid; trifluoroacetic acid; In water; | C. Preparation of Aminoethyl Ether The propanolamine compound prepared above (1.0 eq), ethanolamine hydrochloride (200 eq) and camphorsulfonic acid (1.0 eq) are dissolved in a small amount of DMF and stirred at room. temperature for 1 to 4 days until the starting propanolamine is consumed. The mixture is diluted with water and purified by preparative HPLC (C18 "ZORBAX", step gradient starting at 70/30:H2O/CH3CN/0.1% TFA) and the appropriate fractions are combined, frozen and lyophilized to give a solid. The material is dissolved in water and passed down an anion exchange column (C1-form) and the elude lyophilized to obtain the desired product as a hydrochloride salt (MW=1271.27). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | With potassium carbonate; In acetone; at 20℃; | General procedure: A mixture of the corresponding benzyl chloride/bromide (2.1 eq.), 3-aminopropanol (1.0 eq.) and K2CO3 (5.0 eq.) in acetone, dichloromethane or dimethylformamide was stirred at room temperature. After completion of the reaction (12-16h) monitored by TLC, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography to afford the corresponding aminoalcohol. 4.1.1 2a: 3-(dibenzylamino)propan-1-ol Conditions: Benzylbromide in acetone. Yellow oil, (70%). Rf (Cyclohexane/EtOAc 8:2)?=?0.26. 1H NMR (300?MHz, MeOD): delta?=?7.35-7.21 (m, 10H), 3.56-3.53 (m, 6H), 2.55 (t, J?=?6.5?Hz, 2H), 1.76 (m, 2H) ppm. 13C NMR (75?MHz, D2O): delta = 138.1, 128.9, 128.2, 63.4, 58.3, 52.7, 27.9 ppm. HRMS-ESI(+): calcd for C17H21NO: 255.1623, found: 256.1629 [M+H]+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine; In dichloromethane; at 0 - 20℃; | Part E To a solution of <strong>[723280-98-6]7-bromo-4-chloro-3-nitroquinoline</strong> (10.00 g, 34.78 mmol) in dichloromethane (140 mL) was added triethylamine (10.2 mL, 73.1 mmol). The solution was cooled to 0 C, and 3-amino-1-butanol (2.80 mL, 36.5 mmol) was added. The solution was stirred overnight at ambient temperature and then filtered to collect a precipitate. The precipitate was washed with dichloromethane and water. The filtrate was washed with saturated aqueous sodium bicarbonate and then added to the precipitate. The mixture was concentrated under reduced pressure. Methanol and toluene were added several times and removed under reduced pressure. The resulting solid was dried under high vacuum to provide 11.34 g of 3- [ (7-BROMO-3-NITROQUINOLIN-4-YL) amino] PROPAN-1-OL as a yellow solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
30% | With acetic acid; In tetrahydrofuran; at 20℃; for 48h;Inert atmosphere; | 3-Aminopropanol (174 μl, 2.3 mmol) and acetic acid (260 μl, 4.6 mmol) are added to a solution of methyl-2-formyl benzimidazole (730 mg, 4.6 mmol) in THF anhydride (25 ml). The reaction mixture is then stirred for 48 h at ambient temperature under N2 atmosphere. After concentration of the reaction crude under vacuum, the residue is taken up with CH2Cl2 and then washed with a saturated sodium bicarbonate solution. The aqueous phase is extracted twice with dichloromethane and then the organic phases are pooled, dried over MgSO4 and concentrated. Finally, the reaction crude is purified by silica column flash chromatography (9/1 EtOAc/MeOH) to give the expected product in the form of a colorless oil (245 mg, 0.68 mmol, 30% yield). (0090) 1H NMR (400 MHz, Chloroform-d) δ=7.70 (m, 2H), 7.24-7.19 (m, 6H), 3.96 (s, 4H), 3.82 (t, J=5.8 Hz, 2H), 3.67 (s, 6H), 2.92 (t, J=5.8 Hz, 2H), 1.84 (quin, J=5.8 Hz, 2H) ppm; (0091) 13C NMR (101 MHz, Chloroform-d) δ=151.5 (2C), 141.7 (2C), 135.9 (2C), 122.9 (2C), 122.3 (2C), 119.4 (2C), 109.3 (2C), 60.8, 53.5, 51.4 (2C), 30.1 (2C), 29.5 ppm; (0092) IR (NaCl pellets): 3287, 2938, 1478, 1402, 1333, 174 cm-1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium sulfate; In methanol;Reflux; | General procedure: General procedure: To a solution of the aldehyde (1 g) inmethanol (70 mL) was added Na2SO4(8 eq.) and 3-amino-1-propanol (1 eq.), the reaction was heated to reflux and stirredovernight. The mixture was then cooled to room temperature, fil-tered and concentrated in vacuo to afford the product. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84% | With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 90℃; for 5h; | A solution of <strong>[349-02-0]4-fluoro-3-nitrobenzamide</strong> (50 mg, 1.3 mmol) ini-PrOH (5 ml) was treated with DIPEA (0.14 ml, 3.8 mmol) and 3-aminopropan-1-ol(0.05 ml, 3.8 mmol). After stirring at 90oC for 5 h, solvent was removed under reduced pressure to give a crude product which was purified by column chromatography (SiO2, CH2Cl2:MeOH:NH4OH:H2O = 80:20:1:1) to give5bas a yellow powder (54 mg, 0.23 mmol, 84% yield);1H NMR (400 MHz, (CD3)2SO) delta (ppm) 8.69 (s, 1H), 8.58 (br s, 1H), 8.04 (d,J= 8.2 Hz, 1H), 8.03 (s, 1H), 7.31 (br s, 1H), 7.11 (d,J= 8.9 Hz, 1H), 4.76 (br s, 1H), 3.58-3.57 (m, 2H), 3.50-3.49 (m, 2H), 1.83-1.80 (m, 2H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
47% | In tetrahydrofuran; for 8h;Reflux; | 1.54 g of ethylene glycol monomethyl ether protected with Ms 24-2 (0.01 mol) and 7.5 g of amino-n-propanol 24-3 (0.1 mol) was dissolved in 30 mL of anhydrous tetrahydrofuran, and the mixture was reacted under refluxing for 8 hours. The reaction solution was washed with water and concentrated to obtain the crude target product 24-4. The crude product was dissolved in dichloromethane (30 mL), an appropriate amount of silica gel was added and the sample was stirred, spin-dried under reduced pressure and directly placed on a silica gel column for column chromatographic purification, with an eluent solution (dichloromethane:methanol=20/1-5/1) to obtain 0.63 g of the target product 24-4 as a pale yellow liquid, yield 47%. LC-MS: m/z=134[M+H]+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
25% | Weigh 0.6mmol 2,3- dimethyl maleic anhydride to a three neck round bottom flask, and dissolved in 10ml of acetone, 0.5mmol the propanolamine is dissolved by acetone 10ml was slowly dropped into a constant pressure funnel neck flask , magnetic stirring, at room temperature IH after the reaction, the acetone solvent was removed by rotary evaporation, 15ml of toluene as a solvent instead, 0.02g of anhydrous sodium acetate were added to the reaction system, 0.2ml of triethylamine, 0.05 g of hydroquinone was slowly 115 deg.] C the reaction was warmed to reflux for 2.5h, the reaction is tracked by thin layer chromatography on silica gel.After the reaction was cooled to room temperature, the solvent was removed by rotary evaporation, to obtain a concentrate, the concentrate was subjected to silica gel column chromatography (eluent: VPetroleum ether: VEthyl acetate= 12: 1), and collecting the target fluid, the rotation solvent in vacuo to give the desired product.Yield 20percent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78% | With potassium carbonate; In N,N-dimethyl-formamide; at 20℃; | General procedure: A mixture of the corresponding benzyl chloride/bromide (2.1 eq.), 3-aminopropanol (1.0 eq.) and K2CO3 (5.0 eq.) in acetone, dichloromethane or dimethylformamide was stirred at room temperature. After completion of the reaction (12-16h) monitored by TLC, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography to afford the corresponding aminoalcohol. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | at 110℃; for 1.5h; | 4-Chloro-8-(trifluoromethyl)quinoline (20.49 g, 88.5 mmol) and 3-amino-1-propanol(43.0 mL, 562 mmol) were allowed to heat at 110C for 1.5 hours, at the end of whichtime TLC indicated that reaction was complete. The hot reaction mixture was pouredinto 500 mL deionized water, agitating vigorously with a stirring rod, and the resultingprecipitate was recovered by vacuum filtration. Upon drying, the desired product wasobtained as an off-white powder (21.53 g, 90%, mp = 162.6-163.7C). |
Tags: 156-87-6 synthesis path| 156-87-6 SDS| 156-87-6 COA| 156-87-6 purity| 156-87-6 application| 156-87-6 NMR| 156-87-6 COA| 156-87-6 structure
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
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P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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