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Chemical Structure| 81-13-0 Chemical Structure| 81-13-0
Chemical Structure| 81-13-0

D-Panthenol

CAS No.: 81-13-0

D panthenol is an alcoholic analogue of D-pantothenic acid and cholinergic agent.

Synonyms: Dexpanthenol; D-Pantothenyl alcohol; Bepantol

4.5 *For Research Use Only !

99%98%
Cat. No.: A208721 Purity: 99%

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Product Details of D-Panthenol

CAS No. :81-13-0
Formula : C9H19NO4
M.W : 205.25
SMILES Code : O=C(NCCCO)[C@H](O)C(C)(C)CO
Synonyms :
Dexpanthenol; D-Pantothenyl alcohol; Bepantol
MDL No. :MFCD00065006

Safety of D-Panthenol

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of D-Panthenol

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 81-13-0 ]

[ 81-13-0 ] Synthesis Path-Downstream   1~35

  • 1
  • [ 81-13-0 ]
  • [ 79-83-4 ]
  • 2
  • [ 156-87-6 ]
  • [ 599-04-2 ]
  • [ 81-13-0 ]
YieldReaction ConditionsOperation in experiment
95% With triethylamine; In ethanol; at 160℃; for 3.0h;Microwave irradiation; Step 1 : (R)-2, 4-Dihydroxy-N-(3-hydroxy-propyl)-3, 3-dimethyl-butyramideTo a solution of D-pantolactone (0.5 g, 1 eq) in dry EtOH (5 mL) in a microwave vial were added 3-amino-propan-1-ol (0.53 mL, 1.5 eq), Et3N (0.54 mL, 1 eq) and irradiated with MW radiation at 160C for 3 h. After this time, the reaction mixture wasconcentrated and purified by silica gel column chromatography to afford the product as a white solid (800 mg, 95%).1H NMR (400 MHz, DMSO d6): delta 7.70 (t, J = 4.0 Hz, 1 H), 5.32 (d, J = 4.0 Hz, H), 4.48-4.42 (m, 2H), 3.68 (d, J = 8.0 Hz, 1 H), 3.40 (dd, J = 4.0, 8.0 Hz, 2H), 3.31-3.26 (m, 1 H), 3.19-3.07 (m, 3H), 2.56-2.52 (m, 2H), 0.78 (s, 3H), 0.76 (s, 3H).
at 60℃; for 5.0h; Preparation of Panthenol:A 1 l four-neck flask was initially charged with 150 g of 3-aminopropanol. While stirring, 260 g of D-pantolactone were added slowly at room temperature. After the addition had ended, the reaction mixture was heated to 60 C. and stirred for a further 5 hours. The D-pantolactone used was washed twice beforehand with methyl tert-butyl ether (MTBE) and then dried.The crude panthenol obtained by the reaction of 3-aminopropanol and D-pantolactone was subsequently degassed and distilled.The degassing was performed in a thin-film evaporator at a pressure of 0.027 mbar, a bottom temperature of 80 C. and a lamellar speed of 280 rpm. After the degassing, the apparatus was cleaned by repeatedly purging with demineralized water and 2-propanol with subsequent drying under reduced pressure.Subsequently, the degassed panthenol was distilled. The distillation was performed in the same apparatus in which the degassing had already been undertaken. The bottom temperature was 120 C., the pressure 0.027 mbar and the lamellar speed 800 rpm.In the internal condenser, at a cooling coil temperature of 60 C., panthenol was obtained.
  • 3
  • [ 81-13-0 ]
  • [ 112-67-4 ]
  • [ 17097-25-5 ]
  • 4
  • [ 38757-64-1 ]
  • [ 81-13-0 ]
  • (E)-4,8-Dimethyl-nona-3,7-dienoic acid (R)-3-((E)-4,8-dimethyl-nona-3,7-dienoyloxy)-1-[3-((E)-4,8-dimethyl-nona-3,7-dienoyloxy)-propylcarbamoyl]-2,2-dimethyl-propyl ester [ No CAS ]
  • 5
  • [ 81-13-0 ]
  • [ 36392-06-0 ]
  • 3,7-Dimethyl-oct-6-enoic acid (R)-3-(3,7-dimethyl-oct-6-enoyloxy)-1-[3-(3,7-dimethyl-oct-6-enoyloxy)-propylcarbamoyl]-2,2-dimethyl-propyl ester [ No CAS ]
  • 6
  • [ 81-13-0 ]
  • [ 61899-99-8 ]
  • C29H47NO6 [ No CAS ]
  • 7
  • [ 81-13-0 ]
  • [ 58558-13-7 ]
  • (E)-3,7-Dimethyl-octa-2,6-dienoic acid (R)-3-((E)-3,7-dimethyl-octa-2,6-dienoyloxy)-1-[3-((E)-3,7-dimethyl-octa-2,6-dienoyloxy)-propylcarbamoyl]-2,2-dimethyl-propyl ester [ No CAS ]
  • 8
  • [ 81-13-0 ]
  • [ 76936-45-3 ]
  • (4E,8E)-5,9,13-Trimethyl-tetradeca-4,8,12-trienoic acid (R)-3-hydroxy-2,2-dimethyl-3-[3-((4E,8E)-5,9,13-trimethyl-tetradeca-4,8,12-trienoyloxy)-propylcarbamoyl]-propyl ester [ No CAS ]
  • 9
  • [ 81-13-0 ]
  • [ 76936-45-3 ]
  • (4E,8E)-5,9,13-Trimethyl-tetradeca-4,8,12-trienoic acid (R)-2,2-dimethyl-3-((4E,8E)-5,9,13-trimethyl-tetradeca-4,8,12-trienoyloxy)-1-[3-((4E,8E)-5,9,13-trimethyl-tetradeca-4,8,12-trienoyloxy)-propylcarbamoyl]-propyl ester [ No CAS ]
  • 10
  • [ 81-13-0 ]
  • [ 81790-45-6 ]
  • (E)-5,9-Dimethyl-deca-4,8-dienoic acid (R)-3-((E)-5,9-dimethyl-deca-4,8-dienoyloxy)-1-[3-((E)-5,9-dimethyl-deca-4,8-dienoyloxy)-propylcarbamoyl]-2,2-dimethyl-propyl ester [ No CAS ]
  • 11
  • [ 81-13-0 ]
  • [ 73427-31-3 ]
  • (2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trienoic acid (R)-3-hydroxy-2,2-dimethyl-3-[3-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienoyloxy)-propylcarbamoyl]-propyl ester [ No CAS ]
  • 12
  • [ 81-13-0 ]
  • [ 73427-31-3 ]
  • (2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trienoic acid (R)-2,2-dimethyl-3-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienoyloxy)-1-[3-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienoyloxy)-propylcarbamoyl]-propyl ester [ No CAS ]
  • 13
  • [ 81-13-0 ]
  • (3E,7E)-4,8,12-Trimethyl-trideca-3,7,11-trienoyl chloride [ No CAS ]
  • (3E,7E)-4,8,12-Trimethyl-trideca-3,7,11-trienoic acid (R)-3-hydroxy-2,2-dimethyl-3-[3-((3E,7E)-4,8,12-trimethyl-trideca-3,7,11-trienoyloxy)-propylcarbamoyl]-propyl ester [ No CAS ]
  • 14
  • [ 81-13-0 ]
  • (3E,7E)-4,8,12-Trimethyl-trideca-3,7,11-trienoyl chloride [ No CAS ]
  • (3E,7E)-4,8,12-Trimethyl-trideca-3,7,11-trienoic acid (R)-2,2-dimethyl-3-((3E,7E)-4,8,12-trimethyl-trideca-3,7,11-trienoyloxy)-1-[3-((3E,7E)-4,8,12-trimethyl-trideca-3,7,11-trienoyloxy)-propylcarbamoyl]-propyl ester [ No CAS ]
  • 15
  • [ 81-13-0 ]
  • [ 2212-88-6 ]
  • 2-Hydroxy-4-phosphoryloxy-3,3-dimethyl-N-<3-phosphoryloxy-propyl>-butyramid [ No CAS ]
  • 16
  • [ 81-13-0 ]
  • [ 371-27-7 ]
  • N-(3'-Butanoyloxy)propyl-3,3-dimethyl-2,4-dihydroxybutanamide [ No CAS ]
  • 18
  • [ 81-13-0 ]
  • [ 7664-93-9 ]
  • Ba(MnO4)2 [ No CAS ]
  • [ 79-83-4 ]
  • 19
  • [ 81-13-0 ]
  • [ 25561-30-2 ]
  • TMS-panthenol [ No CAS ]
  • 20
  • [ 81-13-0 ]
  • [ 108-24-7 ]
  • D-panthenyl triacetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
~ 78 - 80% EXAMPLE I; D-panthenol (88 grams, 0.424 moles) and polymer bound dimethylaminopyridine (2 grams) were added to a flask. Acetic anhydride (144.4 grams, 3.3 moles) was slowly added to the stirring mixture, and the resultant exotherm was controlled when the temperature reached 80 C. The mixture was heated at 80 C. and stirred for 9 hours. The flask was then fitted for vacuum distillation, and the acetic acid was removed under reduced pressure to a concentration of about 4% w/w. The catalyst (P-DMAP) was filtered out from the reaction mixture. The solution was treated with a 50% w/w solution of sodium hydroxide in a volume sufficient to neutralize the residual acetic acid, and the resultant solids of sodium acetate were removed by filtration. The residual water was then removed under vacuum to afford about 80% of the desired product, D-panthenyl triacetate. EXAMPLE II; D-panthenol (177 grams, 0.572 moles) and polymer bound dimethylaminopyridine (2.7 grams) were added to a flask. Acetic anhydride (192.5 grams, 4.4 moles) was slowly added to the stirring mixture, and the resultant exotherm was controlled when the temperature reached 80 C. The mixture was heated at 80 C. and stirred for 9 hours. The flask was then fitted for vacuum distillation, and the acetic acid was removed under reduced pressure to a concentration of about 4% w/w. The catalyst (P-DMAP) was filtered out from the reaction mixture. The solution was treated with a 50% w/w solution of sodium hydroxide in a volume sufficient to neutralize the residual acetic acid, and the resultant solids of sodium acetate were removed by filtration. The residual water was then removed under vacuum to afford about 78% of the desired product, D-panthenyl triacetate.
  • 21
  • [ 81-13-0 ]
  • [ 100-99-2 ]
  • Aluminium panthenolate [ No CAS ]
YieldReaction ConditionsOperation in experiment
In dichloromethane; toluene; EXAMPLE 1 72.8 g (354.7 mmol) of D-panthenol and 400 ml of absolute dichloromethane are added at room temperature under an inert gas to a 1 liter four-necked flask provided with a powerful stirrer, 250 ml dropping funnel with pressure balance and reflux condenser, as well as an apparatus for working under a protective gas. Since the D-panthenol dissolves poorly in dichloromethane, the mixture is stirred very vigorously and cooled to 50 C. in an ice-bath. To this emulsion there are added dropwise within 1 hour 23.46 g (30.0 ml, 118.2 mmol) of tri-isobutylaluminium dissolved in 150 ml of absolute toluene. A white stirrable mass is thereby obtained. After completion of the addition, the mixture is left to warm to room temperature, then warmed to 60 C. (bath temperature) and the dichloromethane is distilled off. The mixture is then heated for 2 hours at the reflux temperature of the toluene. After cooling to about 50 C., the toluene is removed under a water-jet vacuum and the residue is dried up to constant weight under an oil pump vacuum. The residue is dried for 24 hours at 50 C. in a vacuum drying oven under an oil pump vacuum, the product thereby gradually becoming solid. After cooling, the colourless amorphous mass can be pulverized in a mortar to a white powder which is slightly hydgroscopic. There are obtained 73.24 g of aluminium D-panthenolate having a melting interval of 78-82 C. and a specific rotation of [alpha]D20 =+47.8 (c=1 in dimethyl sulphoxide).
  • 22
  • [ 81-13-0 ]
  • [ 67-64-1 ]
  • [ 934244-35-6 ]
YieldReaction ConditionsOperation in experiment
93% To a solution of D-Panthenol (20.5 g, 100.0 mmol, 1.0 eq.) in dry acetone (400 ml.) were added sodium sulphate anhydrous (50.0 g) and p-TsOH monohydrate (1.0 g, 4.0 mmol, 0.04 eq.). The reaction mixture was stirred at room temperature overnight. p-TsOH monohydrate (500 mg, 2.63 mmol, 0.03 eq.) was added again and the reaction mixture stirred at room temperature for 6 days until the reaction showed nearly no starting material and no further conversion anymore. Most of the acetone was removed under low pressure and the residue was suspended in a saturated aqueous solution of NaHCO3 (150 ml.) and extracted five times with ethyl acetate (200 ml_). The organic layers were combined and washed with brine (100 ml_) once. The organic layer was dried over Na2SO4, filtered and the solvent was removed under low pressure. The colourless and oily residue was dried under high-vacuum at room temperature to yield 22.7 g (93 %) of the product as a white solid. 1H NMR (CDCI3) delta = 1.01 (s 3H), 1.05 (s, 3H), 1.44 (s, 3H), 1.47 (s, 3H), 1.70-1.73 (m, 2H), 3.27-3.71 (m, 9H), 4.11 (s, 1H), 6.85 (s, 1H). 13C NMR (CDCI3) <5 = 18.7, 18.9, 22.1 , 29.4, 32.4, 33.0, 35.3, 59.1 , 71.5, 76.6, 99.1 , 171.0.
59% With toluene-4-sulfonic acid; sodium sulfate; at 20℃; for 4.0h; (4R)-N-(3-hydroxypropyl)-2,2,5,5-tetramethyl-1,3-dioxane-4-carboxamide (E-14) D-panthenol (10 mmol), anhydrous Na2SO4 (35.20 mmol) and PTSA monohydrate (0.99 mmol) was stirred in anhydrous acetone (40 mL) at room temperature during 4 hours. The reaction mixture was filtered and the filtrate concentrated under reduced pressure. The crude was purified by chromatography on a silica gel column (eluent: CH2Cl2/CH3OH 0 to 10%) to give the expected compound as a white crystallized solid in 59% yield. 1H NMR (DMSO-d6, 400 MHz) delta (ppm) 0.89 (s, 3H), 0.91 (s, 3H), 1.37 (s, 6H), 1.55 (quintuplet, J=6.52 Hz, 2H), 3.03-3.11 (m, 1H), 3.17-3.25 (m, 2H), 3.38-3.43 (m, 2H), 3.63 (d, J=11.48 Hz, 1H), 4.02 (s, 1H), 4.49 (t, J=5.18 Hz, 1H), 7.45-7.48 (m, 1H).
54% Example 1 : Synthesis of the panthenyl docosahexaenoate of formula A1. Synthesis of intermediate compound I derived from panthenol (protection of the alcohol functional groups on the left side of panthenol)D-panthenol (CAS 81 -13-0) Compound IA 2000 ml three-neck flask, purged and maintained under a nitrogen atmosphere, is used to synthesize this compound.120 ml of trimethylchlorosilane (TMCS) was added drop wise with stirring at a temperature of 10-15 C to a solution of (2R)-2,4-dihydroxy-N- (3-hydroxypropyl)-3,3-dimethylbutanamide (D-panthenol, 100 g, 0.488 mol, 1 .00 eq) in acetone (1 I). The solution obtained was then stirred for 3 hours at room temperature, and the pH of the solution was adjusted to 7 with triethylamine. The resulting solution was then concentrated under vacuum, and the residue was applied to a silica gel column with a mixture of petroleum ether and acetone (5.5: 1 ).65 g (54%) of (4R)-N-(3-hydroxypropyl)-2,2,5,5-tetramethyl-1 ,3- dioxane-4-carboxamide (compound I) was obtained as a white solid.LC-MS of compound I: (ES, m/z):268 [M+Na]+, 513 [2M+Na]+
With toluene-4-sulfonic acid; at 0 - 20℃; for 72.0h;Molecular sieve; Step 2: (R)-2,2,5,5-Tetramethyl-[1,3]dioxane-4-carboxylic acid (3-hydroxy-propyl)-amideTo a solution of (R)-2,4-dihydroxy-A/-(3-hydroxy-propyl)-3,3-dimethyl-butyramide ( eq) in dry acetone (20 vol) was added 4A molecular sieves (200 wt%) followed by a slow addition of PTSA (0.05 eq) at 0C after which it was stirred at RT for 3 days. After completion of the reaction, the solvent was removed under vacuum and the crude product was purified by flash silica gel column chromatography (CHCI3/MeOH) to afford the title compound which was taken forward for the next step.LCMS (Method A, ELSD): 246.2 (M+H)

  • 23
  • [ 81-13-0 ]
  • [ 2186-92-7 ]
  • [ 1196055-91-0 ]
  • 24
  • [ 81-13-0 ]
  • [ 558-43-0 ]
  • [ 1211493-82-1 ]
  • 25
  • [ 81-13-0 ]
  • [ 1267597-07-8 ]
  • 26
  • [ 81-13-0 ]
  • [ 1359819-72-9 ]
  • 27
  • [ 81-13-0 ]
  • C25H39N6O10P [ No CAS ]
  • 28
  • [ 81-13-0 ]
  • C24H50N3O4P [ No CAS ]
  • 29
  • [ 81-13-0 ]
  • C22H35N6O10P [ No CAS ]
  • 30
  • [ 81-13-0 ]
  • [ 108-24-7 ]
  • 3-[[(2R)-2,4-diacetoxy-3,3-dimethylbutanoyl]amino]propyl acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
93.2% Fetch-panthenol D 90g in added in the reaction bottle, heated to 60 C, then adding 4-dimethyl aminopyridine 2.7 g. the agitation treats 4-dimethyl aminopyridine is dissolved, slowly instillment second grade anhydried 147.7g, reaction a sharp rise of the temperature a large amount of heat, control drop of acceleration the temperature is not higher than 90 C, after the completion of the dropping, maintaining the reaction temperature is 80 C, reaction to go on 2h; then after the reaction in addition to distil mixed solution of acetic acid, the temperature is 110 C, pressure is 0.01atm; then cooling to 80 C by adding 180 ml ethyl acetate, then using m/m concentration is 25% NaOH aqueous solution of the washing, and removing the excessive second grade acid anhydride evaporation of acetic acid, the pH value until the aqueous phase 7-8, reuse m/m concentration is 2% aqueous solution of HCl of washing, removing 4-dimethylaminopyridine of a step and NaOH, until the aqueous phase pH value to 6.5-7, the final washing with de-ionized water, until the aqueous phase is neutral; for the water phase after 30g water-free Na2SO4drying 24h, to suction filtering after the end of the drying of the desiccant, then distilled under reduced pressure to remove ethyl acetate, temperature is 85 C, pressure is 0.01atm, the finally obtained three acetates D-panthenol 135.4g, yield of 93.2%.
62% With pyridine; at 25℃; for 12.0h;Inert atmosphere; To a solution of (2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-butanamide (0.2 g) inpyridine (10 mL) was added Ac20 (0.497 g) at 25 00 under N2 and the mixture was stirred for 12 h at 25 00. The mixture was concentrated under reduced pressure and the residue was purified by columnchromatography (Si02, petroleum ether / ethyl acetate, 75:1 to 1:1) to give 3-[[(2R)-2,4-diacetoxy-3,3- dimethyl-butanoyl] amino]propyl acetate (0.21g, 62%) as a colorless oil. 1H NMR (400 MHz, CDCI3): O 6.426 (br s, 1 H), 5.007 (s, 1 H), 4.145 - 4.048 (m, 4H), 3.857 (m, 1 H), 3.322 - 3.278 (m, 2H), 2.176 (s, 3H), 2.077 (s, 3H), 2.071 (s, 3H), 1 .879 - 1 .798 (m, 2H), 1 .087 (s, 3H), 1 .037 (s, 3H) ppm
  • 31
  • [ 32986-56-4 ]
  • [ 81-13-0 ]
  • tobramycin penta-dexpanthenol [ No CAS ]
YieldReaction ConditionsOperation in experiment
In methanol; Example 7 Preparation of Tobramycin Penta-Dexpanthenol (0079) 2.2 g dexpanthenol were dissolved in 75 mL methanol and then 1 g of tobramycin (see Example 5 as the free base) was added to the solution. Subsequently, the solution was evaporated to dryness
  • 32
  • [ 81-13-0 ]
  • [ 60-54-8 ]
  • tetracycline-mono-dexpanthenol [ No CAS ]
YieldReaction ConditionsOperation in experiment
In methanol; Example 33 Preparation Oftetracycline-Mono-Dexpanthenol (0129) 2.2 g dexpanthenol were dissolved in 75 mL methanol and subsequently 1 g tetracyclin (see example 31 as free base) was added to the solution. Then the solution was evaporated to dryness.
  • 33
  • [ 81-13-0 ]
  • [ 564-25-0 ]
  • doxycycline-mono-dexpanthenol [ No CAS ]
YieldReaction ConditionsOperation in experiment
In methanol; Example 34 Preparation of Doxycycline-Mono-Dexpanthenol (0130) 2.2 g dexpanthenol were dissolved in 75 mL methanol and subsequently 1 g doxycycline (see example 32 as free base) was added to the solution. Then the solution was evaporated to dryness.
  • 34
  • [ 81-13-0 ]
  • [ 359700-09-7 ]
  • tert-butyl 3-[(E)-3-[3-[[(2R)-2,4-bis[[(E)-3-(1-tert-butoxycarbonylindol-3-yl)prop-2-enoyl]oxy]-3,3-dimethylbutanoyl]amino]propoxy]-3-oxoprop-1-enyl]indole-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
69% With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 15℃; for 12.0h; To a solution of (2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-butanamide (0.300 g), N,Ndicyclohexylcarbodiimide (1 .06 g) and 4-dimethylaminopyridine (0.089 g), in THE (15 mL) was added (E)-3-(1 -tertbutoxycarbonylindol- 3-yl)prop-2-enoic acid (1 .47 g) and the mixture was stirred at 15C for 12 h. The mixture reaction was filtered and concentrated and the residue was purified by columnchromatography (5i02, petroleum ether / ethyl acetate gradient) to give tert-butyl 3-[(E)-3-[3-[[(2R)-2,4-bis[[(E)-3-(1 -tert-butoxycarbonyli ndol-3-yl)prop-2-enoyl]oxy]-3,3-dimethylbutanoyl] am ino]propoxy]-3-oxo- prop-i -enyl]indole-i -carboxylate (1 .2 g, 69% yield) as a yellow solid.
  • 35
  • [ 830-96-6 ]
  • [ 81-13-0 ]
  • 3-[[(2R)-2,4-bis[3-(1H-indol-3-yl)propanoyloxy]-3,3-dimethylbutanoyl]amino]propyl 3-(1H-indol-3-yl)propanoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
43% With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 25℃; for 12.0h; To a solution of (2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-butanamide (0.2 g), N,N?dicyclohexylcarbodiimide (0.70 g) and 4-dimethylaminopyridine (0.060 g) in THE (4 mL) was added 3- (1 H-indol-3-yl) propanoic acid (0.645 g) and the mixture was stirred at 25 00 for 12 h. The reaction mixture was filtered and concentrated under reduced pressure. The residue was purified by reverse phase prep-HPLC (018, water (10 mM NH4HCO3)-acetonitrile gradient) to give 3-[[(2R)-2,4-bis[3-(1 Hindol-3-yl)propanoyloxy]-3,3-dimethyl-butanoyl]amino]propyl 3-(1 H-indol-3-yl)propanoate (0.307 g, 43%) as an off-white solid. LOMS: 719.2 (M÷H) 1H NMR (400 MHz, DMSO-d6): O 10.797(br s, 3H), 7.981 (m,1 H), 7.485 (m, 3H), 7.208 (m, 3H), 7.107 - 6.942 (m, 9H), 4.718 (s, 1 H), 4.005 - 3.837 (m, 3H), 2.950 (m,2H), 2.937 (m, 6H), 2.781 (m, 2H), 2.693 - 2.639 (m, 4H), 1 .687 (m, 2 H), 0.892 (m, 6H) ppm
 

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