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Chemical Structure| 13343-63-0 Chemical Structure| 13343-63-0
Chemical Structure| 13343-63-0

Benzyl 2-Acetamido-4,6-O-benzylidene-2-deoxy-alpha-D-glucopyranoside

CAS No.: 13343-63-0

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Cat. No.: A340930 Purity: 95%

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Zhichang Zhang ; Weicheng Wang ; Peng Xu , et al.

Abstract: N-acetyl glucosamine (NAG) is a natural amino sugar found in various human tissues with previously described anti-inflammatory effects. Various chemical modifications of NAG have been made to promote its biomedical applications. In this study, we synthesized two bi-deoxygenated NAG, BNAG1 and BNAG2 and investigated their anti-inflammatory properties, using an in vivo and in vitro inflammation mouse model induced by lipopolysaccharide (LPS). Among the parent molecule NAG, BNAG1 and BNAG2, BNAG1 showed the highest inhibition against serum levels of IL-6 and TNF α and the leukocyte migration to lungs and peritoneal cavity in LPS challenged mice, as well as IL-6 and TNF α production in LPS-stimulated primary peritoneal macrophages. BNAG2 displayed an anti-inflammatory effect which was comparable to NAG. These findings implied potential application of these novel NAG derivatives, especially BNAG1, in treatment of certain inflammation-related diseases.

Keywords: N-acetyl glucosamine ; Bi-deoxygenation ; Infammation ; Macrophages

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Product Details of [ 13343-63-0 ]

CAS No. :13343-63-0
Formula : C22H25NO6
M.W : 399.44
SMILES Code : CC(N[C@@H]1[C@@H](O)[C@]2([H])OC(C3=CC=CC=C3)OC[C@@]2([H])O[C@@H]1OCC4=CC=CC=C4)=O
MDL No. :MFCD00143679
InChI Key :NXGXFAKJUWEFEC-NVZUTRPHSA-N
Pubchem ID :2735220

Safety of [ 13343-63-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338
 

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