Structure of 1211534-25-6
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CAS No. : | 1211534-25-6 |
Formula : | C6H5BrClNO |
M.W : | 222.47 |
SMILES Code : | COC1=NC=C(Cl)C(Br)=C1 |
MDL No. : | MFCD16609882 |
InChI Key : | RSSHUQXUQXYECT-UHFFFAOYSA-N |
Pubchem ID : | 70700260 |
GHS Pictogram: | ![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H332-H335 |
Precautionary Statements: | P261-P280-P305+P351+P338 |
Num. heavy atoms | 10 |
Num. arom. heavy atoms | 6 |
Fraction Csp3 | 0.17 |
Num. rotatable bonds | 1 |
Num. H-bond acceptors | 2.0 |
Num. H-bond donors | 0.0 |
Molar Refractivity | 43.44 |
TPSA ? Topological Polar Surface Area: Calculated from | 22.12 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from | 2.32 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by | 2.48 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from | 2.51 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from | 1.92 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by | 2.67 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions | 2.38 |
Log S (ESOL):? ESOL: Topological method implemented from | -3.16 |
Solubility | 0.154 mg/ml ; 0.000692 mol/l |
Class? Solubility class: Log S scale | Soluble |
Log S (Ali)? Ali: Topological method implemented from | -2.59 |
Solubility | 0.573 mg/ml ; 0.00258 mol/l |
Class? Solubility class: Log S scale | Soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by | -3.63 |
Solubility | 0.0524 mg/ml ; 0.000236 mol/l |
Class? Solubility class: Log S scale | Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg | High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg | Yes |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) | No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) | Yes |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) | No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) | No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) | No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) | No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from | -5.9 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from | 0.0 |
Ghose? Ghose filter: implemented from | None |
Veber? Veber (GSK) filter: implemented from | 0.0 |
Egan? Egan (Pharmacia) filter: implemented from | 0.0 |
Muegge? Muegge (Bayer) filter: implemented from | 0.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat | 0.55 |
PAINS? Pan Assay Interference Structures: implemented from | 0.0 alert |
Brenk? Structural Alert: implemented from | 0.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from | No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) | 1.89 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84% | [00253j 27B. 4-Bromo-5-chloro-2-methoxypyridine: To MeOH (390 mL) at 0 °C was added TMS-C1 (49.0 mL, 386 mmol). The reaction mixture was warmed to rt and stirred for 30 mm. To this solution was added 27A (20.0 g, 96.0 mmol). The reaction mixturewas stirred for 15 mill and then NaNO2 (2.74 g, 39.8 mmol) was added to the mixture at rt. The reaction mixture was stirred at 50 °C for 3 h. The reaction mixture was concentrated. The residue was diluted with EtOAc and then basified to pH = 11-13 with 1 N aq. NaOH and extracted with EtOAc (3x). The combined organic layers wereconcentrated. Purification by recrystallization from MeOH and water afforded 27B as white needles (18.0 g, 81.0 mmol, 84percent yield). LC-MS Anal. Calc?d for C6H5BrC1NO:220.92, found [M+H] 223.9. | |
84% | 81B. 4-Bromo-5-chloro-2-methoxypyridine To MeOH (390 mL) was added chlorotrimethylsilane (49 mL, 386 mmol) at 0° C., and the solution was warmed to rt and stirred for 30 min. To the resulting solution was added 4-bromo-5-chloropyridin-2-amine (20 g, 96 mmol), and the mixture was stirred for 15 min. To the reaction mixture was added sodium nitrite (2.7 g, 40 mmol) and the solution was stirred at 50° C. for 3 h. The reaction mixture was evaporated in vacuo, and the residue was diluted with EtOAc. The pH of the aqueous layer was adjusted to pH=?12 via addition of 1 N NaOH, and the solution was extracted 3* with EtOAc. The combined organic layers were concentrated, and the residue was purified via recrystallization from MeOH and H2O to give 4-bromo-5-chloro-2-methoxypyridine as white crystalline needles (18 g, 81 mmol, 84percent yield). LC-MS Anal. Calc'd for C6H5BrClNO 222.92. found [M+H] 223.9. 1H NMR (400 MHz, CDCl3) delta 8.18 (s, 1H), 7.08 (s, 1H), 3.94 (s, 4H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | With potassium carbonate; In dimethyl sulfoxide; at 110℃; | [00257j 27F. 4-((3 ,4-cis)-4-((tert-Butyldimethylsilyl)oxy)-3 -methylpiperidin- l-yl)-5 - chloro-2-methoxypyridine: A mixture of 27B (9.70 g, 43.6 mmol), 27E (10.0 g, 43.6mmol), and K2C03 (12.0 g, 87.0 mmol) in DMSO (14.5 mL) was vigorously stirred at110 °C overnight. The reaction mixture was diluted with water and extracted with EtOAc. The organic layer was washed with water and brine, dried (MgSO4), and concentrated. Purification via silica chromatography gave 27F as an oil (14.3 g, 77percent yield). LC-MS Anal. Calc?d for C18H31C1N2O2Si: 370.18, found [M+H] 371.2. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
58% | With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; lithium hexamethyldisilazane; In tetrahydrofuran; at 70℃; for 2h;Inert atmosphere; | [00266j 28F. 4-(4-(Qert-Butyldimethylsilyl)oxy)-3 -fluoropiperidin- 1 -yl)-5 -chloro-2- methoxypyridine: A mixture of 28E (194 mg, 0.830 mmol), 27B (185 mg, 0.830 mmol) and SPhos precatalyst (6.0 mg, 8.3 jimol) in THF (1.7 mL) was purged with argon and a 1 M solution of LHMDS in THF (1.0 mL, 1.0 mmol) was added. The reaction mixturewas heated to 70 °C for 2 h and then cooled to rt. Sat. aq. NaHCO3 (10 mL) was added slowly to the reaction mixture. The mixture was then extracted with EtOAc (2 x 10 mL) and the combined organic extracts were washed with water (20 mL) and brine (20 mL), dried (Na2504), filtered, and concentrated. Purification by silica chromatography gave 28F (182 mg, 0.490 mmol, 58percent yield). LC-MS Anal. Calc?d for C17H28C1FN2O2Si:374.16,found[M+H] 374.9. |
58% | With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; lithium hexamethyldisilazane; In tetrahydrofuran; at 70℃; for 2h;Inert atmosphere; | A mixture of 4-((tert-butyldimethylsilyl)oxy)-3-fluoropiperidine (194 mg, 0.83 mmol), <strong>[1211534-25-6]4-bromo-5-chloro-2-methoxypyridine</strong> (185 mg, 0.83 mmol) and Sphos pre.cat. (6 mg, 8 mumol) in THF (1.7 mL) was purged with argon and lithium bis(trimethylsilyl)amide (1 mL, 1.0 mmol) was added. The reaction mixture was heated at 70° C. for 2 h. Sat. aqueous NaHCO3 (10 mL) was added slowly to the reaction mixture. The mixture was extracted with EtOAc (2*10 mL), and the combined organic extracts were washed with water (20 mL) and brine (20 mL), and dried (Na2SO4), filtered, and concentrated. Purification via silica gel chromatography gave 4-(4-((tert-butyldimethylsflyl)oxy)-3-fluoropiperidin-1-yl)-5-chloro-2-methoxypyridine (182 mg, 0.49 mmol, 58percent yield). LC-MS Anal. Calc'd for C17H28ClFN2O2Si 374.16. found [M+H] 374.9. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate; In dimethyl sulfoxide; at 110℃; | [003811 84D. 2-((2S,4R)- 1 -(4-(((3 ,4-trans)- 1 -(5 -Chloro-2-methoxypyridin-4-yl)-3 - methylpiperidin-4-yl)oxy)phenyl)-4-methoxypyrrolidin-2-yl)acetonitrile, Isomer 1 andIsomer 2: To a solution of 84C (100 mg, 0.273 mmol) in DMSO (91 jiL), K2C03 (189 mg, 1.37 mmol) was added followed by 27B (60.8 mg, 0.273 mmol). The reaction mixture was heated to 110 °C overnight. The reaction mixture was diluted with EtOAc and washed with water and brine, dried (Na2SO4), and concentrated. The crude productwas purified by RP-Prep. HPLC followed by chiral SFC to recover 84D, Isomer 1 and Isomer 2 as single isomers. 84D, Isomer 1 (22 mg, 0.047 mmol, 17percent yield) was isolated as a pale yellow oil. LC-MS Anal. Calc?d for C25H31C1N403: 470.99, found [M+H]471.0. 1H NMR (400 MHz, CDC13) oe 7.96 (s, 1H), 6.89 - 6.91 (m, 2H), 6.50 - 6.54 (m,2H), 6.26 (s, 1H), 4.05 - 4.13 (m, 2H), 3.88 (s, 3H), 3.80 (td, J=8.66, 4.08 Hz, 1H), 3.58 -3.65 (m, 2H), 3.51 (d, J10.60 Hz, 1H), 3.36 - 3.41 (m, 4H), 2.88 - 2.96 (m, 1H), 2.68 -2.79 (m, 3H), 2.31 - 2.37 (m, 1H), 2.15 - 2.25 (m, 1H), 2.01 - 2.15 (m, 2H), 1.69 - 1.80 (m, 1H), 1.12 (d, J=6.71 Hz, 3H). 84D, Isomer 2 (24 mg, 0.05 1 mmol, 19percent yield) pale yellow oil. LC-MS Anal. Calc?d for C25H31C1N403: 470.99, found [M+H] 471.0. 1H NMR (400 MHz, CDC13) oe 7.96 (s, 1H), 6.89 - 6.91 (m, 2H), 6.50 - 6.54 (m, 2H), 6.26 (s,1H),4.06 - 4.13 (m, 2H), 3.87 (s, 3H), 3.80 (td, J=8.64, 4.17 Hz, 1H), 3.58 - 3.65 (m, 2H),3.48 - 3.53 (m, 1H), 3.35 - 3.41 (m, 4H), 2.89 - 2.96 (m, 1H), 2.68 - 2.79 (m, 3H), 2.31 -2.37 (m, 1H), 2.02 - 2.25 (m, 3H), 1.70 - 1.80 (m, 1H), 1.12 (d, J=6.71 Hz, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
58% | With potassium carbonate; In dimethyl sulfoxide; at 110℃; for 16h; | [00401j 93E. (3,4-cis)-1-(5-Chloro-2-methoxypyridin-4-yl)-3- (hydroxymethyl)piperidin-4-ol: To a solution of 93D (1.55 g, 4.32 mmol) and K2C03(2.69 g, 19.4 mmol) in DMSO (14.4 mL) was added 27B (1.01 g, 4.54 mmol). The reaction mixture was stirred at 110 °C for 16 h. The reaction mixture was diluted with EtOAc and the organic layer was washed with water and brine, dried over Na2SO4, and concentrated. The crude product was purified by silica chromatography to provide 93E (0.680 g, 2.49 mmol, 58percent yield) as a colorless oil. LC-MS Anal. Calc?d forC12H17C1N203: 272.1, found: [M+H] 273.1. 1H NMR (400 MHz, CDC13) oe 7.95 (s,1H), 6.30 (s, 1H), 4.28 - 4.20 (m, 1H), 3.93 (d, J=4.8 Hz, 2H), 3.87 (s, 3H), 3.23 - 3.14 (m, 4H), 2.97 (d, J=6.6 Hz, 1H), 2.71 (br. s, 1H), 2.13 - 2.06 (m, 1H), 1.98 - 1.88 (m, 2H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
37% | With potassium carbonate; In dimethyl sulfoxide; at 90℃; | [00425j 1 02D. Methyl 2-((2R,4R)- 1 -(4-(( 1 -(5 -chloro-2-methoxypyridin-4-yl)piperidin- 4-yl)methyl)phenyl)-4-methoxypyrrolidin-2-yl)acetate: A solution of 102C (48 mg, 0.14 mmol), 27B (37 mg, 0.17 mmol), and K2C03 (57.4 mg, 0.416 mmol) in DMSO (1.5 mL) was heated to 90 °C overnight. The reaction was quenched with sat. aq. NaHCO3 andextracted with EtOAc (2x). The combined organic extracts were washed with brine, dried (Na2SO4), and concentrated. The crude product was purified by silica chromatography to provide 102D (25 mg, 0.051 mmol, 37percent yield) as yellow oil. LC-MS Anal. Calc?d for C26H34C1N304: 487.1, found [M+H] 488.2. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
88% | With potassium carbonate; In dimethyl sulfoxide; at 110℃; for 14h; | [00443j 1 12A. 1-(5-Chloro-2-methoxypyridin-4-yl)piperidin-4-ol: To a round bottom flask was added 27B (2.8 g, 13 mmol), piperidin-4-ol (1.40 g, 13.8 mmol), K2C03 (8.70g, 62.9 mmol) and DMSO (30 mL). The reaction mixture was stirred at 110 °C for 14 h. The reaction mixture was partitioned between water (150 mL) and EtOAc (150 mL). The organic layer was separated, washed with water (2 x 100 mL) and brine (100 mL), dried over Mg504, filtered, and concentrated. The residue was purified by silica chromatography to give 1 12A (2.7 g, 11 mmol, 88percent yield) as a colorless oil. LC-MSAnal. Calc?d for C11H15C1N202: 242.70, found [M+H] 243.1, 245.0. ?HNMR(400 MHz, CDC13) oe 7.97 (s, 1H), 6.27 (s, 1H), 3.94 - 3.84 (m, 4H), 3.51 - 3.37 (m, 2H), 2.90 (ddd,J=12.3, 9.2, 3.0 Hz, 2H), 2.07- 1.95 (m, 2H), 1.84- 1.66 (m, 2H). |
88% | With potassium carbonate; In dimethyl sulfoxide; at 110℃; for 14h; | solution of 1 J (2.80 g, 12.6 mmol), piperidin-4-ol (1.40 g, 13.8 mmol), and K2C03 (8.70 g, 62.9 mmol) in DMSO (30 mL) was stirred at 110 °C for 14 h. The reaction mixture was partitioned between water (150 mL) and EtOAc (150 mL). The organic layer was separated, washed with water (2 x 100 mL) and brine (100 mL), dried over MgS04, filtered, and concentrated. The residue was purified by silica chromatography to give 4A (2.70 g, 11.1 mmol, 88percent yield) as a colorless oil. LC-MS Anal. Calc'd for CnHi5CiN202: 242.70 found [M+H] 243.0. 1H NMR (400 MHz, CDC13) delta 7.97 (s, IH), 6.27 (s, IH), 3.94 - 3.84 (m, 4H), 3.51 - 3.37 (m, 2H), 2.90 (ddd, J=12.3, 9.2, 3.0 Hz, 2H), 2.07 - 1.95 (m, 2H), 1.84 - 1.66 (m, 2H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | With potassium carbonate; In dimethyl sulfoxide; at 110℃; | 81F. Rac-4-(cis-4-((tert-butyldimethylsilyl)oxy)-3-methylpiperidin-1-yl)-5-chloro-2-methoxypyridine A mixture of <strong>[1211534-25-6]4-bromo-5-chloro-2-methoxypyridine</strong> (9.7 g, 44 mmol), rac-4-cis-((tert-butyldimethylsilyl)oxy)-3-methylpiperidine (10 g, 44 mmol), and K2CO3 (12 g, 87 mmol) in DMSO (15 mL) was vigorously stirred at 110° C. overnight. The reaction mixture was diluted with water and the mixture was extracted with EtOAc. The organic extract was washed successively with H2O and brine, and the resulting organic layer was dried (MgSO4) and concentrated. Purification via silica gel chromatography gave rac-4-(cis-4-((tert-butyldimethylsilyl)oxy)-3-methylpiperidin-1-yl)-5-chloro-2-methoxypyridine as an oil (14.3 g, 77percent yield). LC-MS Anal. Calc'd for C18H31ClN2O2Si: 370.18. found [M+H] 371.2. 1H NMR (400 MHz, CDCl3) delta 7.88 (s, 1H), 6.21 (s, 1H), 3.83-3.79 (m, 4H), 3.19 (dtd, J=11.7, 3.9, 1.8 Hz, 1H), 3.07-2.99 (m, 2H), 2.78 (t, J=11.0 Hz, 1H), 1.93-1.81 (m, 1H), 1.81-1.74 (m, 1H), 1.73-1.63 (m, 1H), 0.89-0.82 (m, 12H), 0.00 (s, 6H). |
77% | With potassium carbonate; In dimethyl sulfoxide; at 110℃; | A mixture of 1J (9.70 g, 43.6 mmol), 1M (10.0 g, 43.6 mmol), and K2C03 (12.0 g, 87.0 mmol) in DMSO (14.5 mL) was vigorously stirred at 110 °C overnight. The reaction mixture was diluted with water and extracted with EtOAc. The organic layer was washed with water and brine, dried (MgS04), and concentrated. (0552) Purification via silica chromatography gave IN as an oil (14.3 g, 38.6 mmol, 77percent yield). LC-MS Anal. Calc'd for Ci8H3iClN202Si: 370.18, found [M+H] 371.2. 1H NMR (400 MHz, CDCls) delta 7.94 (s, IH), 6.27 (s, IH), 3.90 - 3.85 (m, 4H), 3.25 (dtd, J=11.7, 3.9, 1.8 Hz, IH), 3.14 - 3.02 (m, 2H), 2.84 (t, J=11.0 Hz, IH), 2.00 - 1.88 (m, IH), 1.88 - 1.81 (m, IH), 1.80 - 1.71 (m, IH), 0.94 - 0.89 (m, 12H), 0.06 (s, 6H). |
Tags: 1211534-25-6 synthesis path| 1211534-25-6 SDS| 1211534-25-6 COA| 1211534-25-6 purity| 1211534-25-6 application| 1211534-25-6 NMR| 1211534-25-6 COA| 1211534-25-6 structure
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P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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