Structure of 118994-86-8
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CAS No. : | 118994-86-8 |
Formula : | C4H3NO2 |
M.W : | 97.07 |
SMILES Code : | O=CC1=CN=CO1 |
MDL No. : | MFCD02179513 |
InChI Key : | YOFJBRZKRZUDGB-UHFFFAOYSA-N |
Pubchem ID : | 11829372 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H317-H319 |
Precautionary Statements: | P280-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With Dess-Martin periodane; In dichloromethane; at 0℃; for 0.5h; | Example A.21General procedure for 5-oxazolyl derivativesSTEP a ) Preparation of ct-ctminonitrilesMethod a)The appropriate oxazole alcohol intermediate (11) or intermediate (12) (0.85 8 mmol, 1 eq) was dissolved in DCM (1.5 mL) and the solution was cooled to 0C. DessMartin periodinane (0.943 mmol, 1.1 eq) was added and the mixture was left stirring at the same temperature. After a few minutes a white suspension formed and after 30 mm. the conversion was complete by TLC (95/5 DCM/MeOH). The aldehyde intermediatewas not isolated. Glacial AcOH (5 mL), AcONa (1.93 mmol, 2.25 eq) and the appropriate amine (1.54 mi-no 1, 1.8 eq) were sequentially added to the suspension and the mixture was allowed to warm to rt. After 1.5 hrs TMSCN (2.57 mmol, 3eq) was added and the mixture was left under stirring at the same temperature overnight. The volatiles were then evaporated and a saturated solution of NaHCO3 (40 mL) was added to the residue. Themixture was extracted with EtOAc (20 mLx3) and the combined organic phases were dried (anh. Na2SO4) and concentrated under reduced pressure. The crude was purified by flash chromatography (Si02) using a mixture of petroleum ether and AcOEt varyng between 9/1 and 4/6. The pure ct-aminonitrile was obtained as a colourless oil (average yield 53%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With 1-hydroxy-7-aza-benzotriazole; Ph3SnH; azobisisobutyronitrile; ammonium chloride; 4-pyrrolidin-1-ylpyridine; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; triethanolamine; hexane; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; ethyl acetate; toluene; | EXAMPLE 24 (4R)-N-[(2-chloro-6-methylphenyl)methyl]-3-[(2S,4S)-5-[((3S,4S)-3,4-dihydro-3-hydroxy-2H-1-benzopyran-4-yl)amino]-2-hydroxy-4-(5-oxazolylmethyl)-1,5-dioxopentyl]-5,5-dimethyl-4-thiazolidinecarboxamide (S)-(+)-5-oxo-2-tetrahydrofurancarboxylic acid (290 mg; 2.2 mmol) was suspended in anhydrous DCM (10 mL) and the TFA salt of amine from Example 23 Step C (769 mg; 1.86 mmol) was added; dissolution occurred. The solution was cooled to 0 C., and DIEA (1.3 mL; 7.44 mmol) added followed by HOAt (229 mg; 2.2 mmol) and then PyBop (1.14 g; 2.2 mmol). The next morning, the reaction mixture was poured into ethyl acetate and washed with water and brine. Drying (MgSO4), filtration and removal of the solvent in vacuo followed by flash column chromatography (75% EtOAc/hexane) provided the desired compound. To a solution of the intermediate obtained in Step A above (150 mg; 0.37 mmol) in 2.5 mL anhydrous THF at -78 C. under nitrogen was added dropwise LHMDS (0.77 mmol; 0.77 mL). After 1 hr 20 min, a solution of <strong>[118994-86-8]5-oxazolecarboxaldehyde</strong> (39 mg; 0.40 mmol) in 0.5 mL anhydrous THF was added dropwise. After 1.25 hr, the reaction was quenched with saturated ammonium chloride. The mixture was poured into EtOAc and washed with 50% brine and brine. Drying (MgSO4), filtration, and removal of the solvent in vacuo followed by flash column chromatography (gradient elution 75% EtOAc/hexane to 100% EtOAc) provided the desired compound. To a solution of the material from Step B (67 mg; 0.13 mmol) in 0.75 mL anhydrous THF cooled to 0 C. was added TEA (20 muL; 0.143 mmol) and 4-pyrrolidinopyridine (cat.); methyl oxalyl chloride (13 muL; 0.143 mmol) was then added dropwise. After 2.25 hours, the reaction mixture was diluted with EtOAc (40 mL) and washed with NaHCO3 solution and brine. Drying (MgSO4), filtration, and removal of the solvent in vacuo followed by flash column chromatography (75% EtOAc/hexane) provided the desired compound. To a solution of the intermediate from Step C (50 mg; 0.084 mmol) in anhydrous toluene (1.0 mL) was added AIBN (cat.) followed by Ph3SnH (43 muL; 0.168 mmol). Twenty minutes at reflux was followed by 1.5 hours at 100 C. Removal of solvent in vacuo was followed by flash column chromatography (75% EtOAc/hexane) to provide the desired compound. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With trifluoroacetic acid; In hexane; toluene; | C. 5-Oxazolecarboxaldehyde A flask was charged with 5-((diethoxy)methyl)oxazole (1.02 g, 0.00596 mol) and cooled to 0 C. A solution of trifluoroacetic acid/CH2 Cl2 (1:1 (v/v), 6.7 mL) and H2 O (0.39 mL) was added and the solution stirred at 0 C. for 10 min. The solvent was removed in vacuo, and the residue was treated with toluene and concentrated. Chromatography on a 100 g SiO2 flash column with a gradient of EtOAc/hexane (20%, 30%, 40%) afforded the desired compound as a colorless liquid (0.344 g, 0.00354 mol, 59%): 1 H NMR (CDCl3) d 7.89 (s, 1H), 8.12 (s, 1H), 9.87 (s, 1H). Mass spectrum: (M+H)+ =98. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium tetrahydroborate; In methanol; | D. 5-(Hydroxymethyl)oxazole A solution of <strong>[118994-86-8]5-oxazolecarboxaldehyde</strong> (0.627 g, 0.00646 mol) in MeOH (10 mL) under argon at 0 C. was treated with NaBH4 (0.247 g, 0.00646 mol). After 5 mins the reaction was quenched with acetone and the solvent removed by rotary evaporation in vacuo. Chromatography on a 100 g SiO2 flash column with a gradient of MeOH/CH2 Cl2 (5%, 10%) afforded the desired compound as a colorless oil (0.408 g, 0.00412 mol, 64%): 1 H NMR (CDCl3)delta2.03 (t, J=6.0 Hz, 1H), 4.70 (d, J=6.0 Hz, 2H), 7.04 (s, 1H), 7.87 (s, 1H). MS (Cl/NH3) m/e 117 (m+NH4), 100 (m+H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium acetate; In methanol; water; at 20℃; | (R)-2-(2-Fluoro-phenyl)-thiazolidine-4-carboxylic acid To a solution of L-cysteine hydrochloride (400 mg, 2.54 mmol) in distilled water (4 mL), potassium acetate (274 mg, 2.79 mmol) was added. Once the solids went into solution, methanol (4 mL) was added followed by 2-fluoro-benzaldehyde (325 muL, 3.06 mmol). The reaction was stirred at ambient temperature overnight. The solvent was removed, and no further purification steps were taken. (R)-2-(2-Fluoro-phenyl)-thiazolidine-3,4-dicarboxylic acid 3-benzyl ester |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium acetate; In methanol; water; at 20℃; for 4h; | (R)-2-Oxazol-5-yl-thiazolidine-4-carboxylic acidTo a solution of L-cysteine hydrochloride (446.9 mg, 2.84 mmol) in distilled water (4.3 mL), potassium acetate (319.8 mg, 3.26 mmol) was added. Once the solids went into solution, methanol (4.3 mL) was added followed by <strong>[118994-86-8]oxazole-5-carbaldehyde</strong> (339.0 mg, 3.49 mmol). The reaction was stirred at ambient temperature for 4 hours. The solvent was removed, and no further purification steps were taken. (R)-2-Oxazol-5-yl-thiazolidine-3,4-dicarboxylic acid 3-benzyl ester |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
58.7% | With titanium(IV) tetraethanolate; In tetrahydrofuran; at 65℃; for 12h; | step 1 : Oxazole-5-carbaldehyde (1.0 g, 10.30 mmol), 2-methylpropane-2-sulfinamide (2.247 g, 18.54 mmol; CASRN 146374-27-8), and tetraethoxytitanium (8.460 g, 37.09 mmol) were placed in THF (15 mL) and heated to 65 C for 12 h. The reaction was cooled and poured onto water. The solids were filtered off and the filtrate was extracted with EtOAc. The layers were separated and the organic layer was concentrated. The resulting residue was purified by Si02 chromatography (20-25% EtOAc/hexane) to afford (E)-2-methyl-N-(oxazol-5- ylmethylene)propane-2-sulfinamide (20, 1.211 g, 6.047 mmol, 58.70 % yield). |
58.7% | With titanium(IV) tetraethanolate; In tetrahydrofuran; at 65℃; for 12h;Inert atmosphere; | [001851 step 1 : Oxazole-5-carbaldehyde (1.0 g, 10.30 mmol), 2-methylpropane-2-sulfinamide (2.247 g, 18.54 mmol; CASRN 146374-27-8), and tetraethoxytitanium (8.460 g, 37.09 mmol) were stirred in THF (15 mL) and heated to 65 C for 12 h under nitrogen. The reaction was cooled and poured onto water. The solids were filtered off and the filtrate was extracted with EtOAc. The layers were separated and the organic layer was dried (MgS04), filtered and concentrated. The resulting residue was purified by Si02 chromatography eluting with an EtOAc hexane gradient (20 to 25% EtOAc) to afford 1.21 1 g (58.7%) of (E)-2-methyl-N-(oxazol-5-ylmethylene)propane-2- sulfinamide (20). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
41.1% | Preparation of (E)-ethyl 3-(oxazol-5-yl)acrylate: To a suspension of NaH(60%) in mineral oil, 227 mg, 5.67 mmol) in THF (40 mL) under N2 at 0 C was added dropwise ethyl 2-(diethoxyphosphoryl)acetate (1.12 mL, 5.67 mmol). The mixture was stirred at 0 C for 30 minutes, and then a solution of <strong>[118994-86-8]oxazole-5-carbaldehyde</strong> (500 mg, 5.15 mmol) in THF (5 mL) was added. The ice bath was removed, and the reaction was stirred at ambient temperature for 18 hours. The reaction was diluted with H20 (30 mL) and extracted with EtOAc (50 mL). The organic phase was washed with brine (50 mL), dried with MgS04, filtered and concentrated in vacuo. The crude product was purified by silica column chromatography, eluting with 0 to 1%> MeOH/DCM to yield the product as a pale yellow oil (354 mg, 41.1% yield). 1H NMR (CDC13) delta 7.92 (s, 1H), 7.48 (d, 1H), 7.29 (s, 1H), 6.40(d, 1H), 4.27 (q, 2H), 1.29 (t, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydrogensulfite; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 100℃; | Step C 5-[6, 8-bis(trifluoromethyl)-3H-imidazo[4, 5-h]quinolin-2-yl]-1 ,3-oxazole [00251] A solution of 2,4-bis(trifluoromethyl)quinoline-7,8-diamine hydrochloride (.150 g, 0.452 mmol) in NMP (1 .822 ml) was treated by the addition of DIEA (0.197 ml, 1.131 mmol). The mixture was then treated by the addition of <strong>[118994-86-8]oxazole-5-carbaldehyde</strong> (0.044 g, 0.452 mmol) and sodium bisulfite (0.047 g, 0.452 mmol) and heated to 100 C overnight. The reaction was treated with water and the solid was filtered. The solid was partially dissolved in DCM, the solids were filtered, rinsing with MeOH, and set aside. The filtrate was concentrated onto celite and purified by silica gel chromatography (0-3% MeOH/DCM). The fractions that contained the product were concentrated, taken up in DMSO and purified by reverse phase chromatography (10-90% ACN/H20 + formic acid). Isolation and lyophilization give 55-[6,8-bis(trifluoromethyl)- 3H-imidazo[4,5-h]quinolin-2-yl]-1 ,3-oxazole. 1H NMR (400 MHz, DMSO-d6) delta ppm 8.76 (s, 1 H), 8.33 (s, 2 H), 8.16 (s, 1 H), 8.02 - 8.09 (m, 1 H), ES LC-MS m/z =373.1 (M+H)+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
86% | In tetrahydrofuran; at 0 - 20℃; for 0.5h;Inert atmosphere; | [003781 Step A: (4-Chloro-3-fluorophenyl)magnesium bromide (40.6 mL, 20.3 mmol; 0.5M in THF) was added dropwise by syringe to a stirred solution of <strong>[118994-86-8]oxazole-5-carbaldehyde</strong> (1.97 g, 20.3 mmol) in THF (40 mL) at 0C under nitrogen. The reaction was allowed to warm to room temperature and then stirred for 30 minutes at room temperature. TLC in 1/1 ethyl acetate/hexanes showed near complete consumption of starting material, and a new slightly lower rf spot as major. The reaction was quenched by careful addition of saturated ammonium chloride solution by pipet with stirring. An ammonium chloride (50 mL) solution was added. The majority of the THF was then removed by rotovap. The residual aqueous suspension was diluted with ethyl acetate (100 mL) and water (50 mL), transferred to a separatory funnel and shaken. The layers were separated, and the organics were isolated and washed with brine (100 mL), dried (MgSO4), filtered and concentrated to an oil. The crude product was loaded onto a Biotage 40M column with 2/3 ethyl acetate/hexanes and eluted. Product containing fractions were pooled and concentrated to a solid, (4-chloro-3- fluorophenyl)(oxazol-5-yl)methanol (4 g, 86%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
General procedure: by Wittigreaction: To a stirred solution of diphosphonium salt of ,?-o-xylenedibromide (4.6 g, 6 mmol) inabsolute ethanol (100 ml, kept on 3 A sieves) simultaneously was added dropwise a solution ofoxazole-4/5-carbaldehyde (3, 4) (0.58 g, 6 mmol) in 4 mL of ethanol and half of a solution ofsodium ethoxide (0.31 g Na, 13 mmol, 2.2 equiv in 30 mL of ethanol) in strictly anhydrous conditions under nitrogen. Reaction mixture was left to stir for 20 minutes. Under the stream of drynitrogen, gaseous formaldehyde (obtained by decomposition of paraformaldehyde taken in excess,1.0 g) was introduced together with the second quantity of sodium ethoxide that was addeddropwise. Reaction mixture was left to stir for 2 more hours. After removal of the solvent theresidue was worked up with ice-water, and extracted with benzene (6 × 20 mL). Benzene extractswere dried over anhydrous MgSO4. Evaporation of solvent under reduced pressure afforded thecrude product. Column chromatography on silica gel using petroleum ether/ether (variable ratio) aseluent afforded a mixture of cis and trans isomers, cis/trans-1 and cis/trans-2, respectively. Theisomers were separated by repeated column chromatography on silica gel. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
45% | Example A.21General procedure for 5-oxazolyl derivativesSTEP a ) Preparation of ct-ctminonitrilesMethod a)The appropriate oxazole alcohol intermediate (11) or intermediate (12) (0.85 8 mmol, 1 eq) was dissolved in DCM (1.5 mL) and the solution was cooled to 0C. DessMartin periodinane (0.943 mmol, 1.1 eq) was added and the mixture was left stirring at the same temperature. After a few minutes a white suspension formed and after 30 mm. the conversion was complete by TLC (95/5 DCM/MeOH). The aldehyde intermediatewas not isolated. Glacial AcOH (5 mL), AcONa (1.93 mmol, 2.25 eq) and the appropriate amine (1.54 mi-no 1, 1.8 eq) were sequentially added to the suspension and the mixture was allowed to warm to rt. After 1.5 hrs TMSCN (2.57 mmol, 3eq) was added and the mixture was left under stirring at the same temperature overnight. The volatiles were then evaporated and a saturated solution of NaHCO3 (40 mL) was added to the residue. Themixture was extracted with EtOAc (20 mLx3) and the combined organic phases were dried (anh. Na2SO4) and concentrated under reduced pressure. The crude was purified by flash chromatography (Si02) using a mixture of petroleum ether and AcOEt varyng between 9/1 and 4/6. The pure ct-aminonitrile was obtained as a colourless oil (average yield 53%). Using an analogous procedure intermediates A0015 60 01 (yield 45%), A0015 64 01 (yield 5 1%), A0015 65 01 (yield 40%) and A0017 43 01 (yield 37%) were prepared starting from intermediate (11); using morpholine, 4,4-difluoropiperidine hydrochloride, 1,2,3 ,4-tetrahydroisoquino line or intermediate (10) respectively; intermediate A0016 31 01 (yield 45%), A0016 29 01, (yield 67%) and A0016 30 01(yield 71%) were prepared starting from intermediate (12) using morpholine, 4,4- difluoropiperidine hydrochloride or 1,2,3 ,4-tetrahydroisoquino line respectively. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
To a solution of <strong>[118994-86-8]oxazole-5-carbaldehyde</strong> (2 g, 20.60 mmol) and nitromethane (3.33 mL, 61.8 mmol) in DCM (4 mL) was added 1 , 1 ,3,3-tetramethylguanidine (0.258 mL, 2.060 mmol) at 25C, and stirred for 10 min. The reaction was then cooled to 0C, and methanesulfonyl chloride (3.21 mL, 41.2 mmol) was added to the reaction mixture. The reaction was stirred at 0C for 10 min and then at 25 C for 20 min. At 0C, triethylamine (5.74 mL, 41.2 mmol) was added and the mixture was stirred at 25C for 1.5 h. The reaction was quenched with saturated NaHC03 (aq), layers were separated and the aqueous layer was extracted with DCM 100 mL (x2). The combined organic layers were washed with brine, dried over MgS04, filtered and concentrated. The residue was triturated with DCM:heptane 1 :9, and filtered. NMR (499 MHz, Acetone): delta 8.47 (s, 1 H); 8.12 (d, J = 13.4 Hz, 1 H); 7.84 (s, 1 H); 7.76 (d, J = 13.4 Hz, 1 H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
45 mg | 2-((3,5-Dicyano-4-ethyl-6-(piper ide 2,2,2- trifluoroacetate (synthesis described in example 176 step 2, 215 mg, 0.413 mmol) was dissolved in dichloromethane (15 mL) and DIEA (0.144 mL, 0.826 mmol). Acetic acid (0.047 mL, 0.826 mmol) was added followed by <strong>[118994-86-8]oxazole-5-carbaldehyde</strong> (80 mg, 0.826 mmol). The reaction was stirred for 30 minutes and sodium triacetoxyborohydride (350 mg, 1.652 mmol) was added. The reaction was stirred at 25 C for 18 hours. The DCM solution was washed with water, dried with sodium sulfate and evaporated. It was loaded on a 12 g silica column with 15 mL of DCM and eluted with ethyl acetate/ethanol (4-25% ethanol) then 25% ethanol in ethyl acetate containing 1% ammonium hydroxide. The purified product was purified further on a Gilson reverse phase HPLC eluting with 0.1% ammonium hydroxide in water and acetonitrile (10-90%) gradient to afford 2-((3,5-dicyano-4-ethyl-6-(4-(oxazol-5- ylmethyl)piperazin-1-yl)pyridin-2-yl)thio)-2-phenylacetamide (45 mg, 0.092 mmol). LCMS m/z = 488.2 [M+H]+. 1H NMR (400 MHz, DMSO-d6) delta ppm 1.20 (t, J=7.60Hz, 4H) 2.75 (d, J=7.60Hz, 2H) 3.32 (s, 1H) 3.68 (s, 2H) 3.88 (br. s., 5H) 5.52 (s, 1H) 7.12 (s, 1H) 7.30 - 7.43 (m, 5H) 7.44 - 7.57 (m, 2H) 7.91 (s, 1H) 8.35 (s, 1H) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
43% | With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20℃; | The N-[(lS)-3-[(3R)-3-[[4-(l,3-dioxoisoindolin-2-yl)butyl-[(8S)-5,6,7,8-tetrahydroquinolin-8- yl]amino]methyl]piperazin-l-yl]-l-phenyl-propyl]-4,4-difluoro-cyclohexanecarboxamide 62 (0.250 g, 0.34 mmol) was dissolved in DCM (5ml) and added <strong>[118994-86-8]oxazole-5-carbaldehyde</strong> (0.070 g, 0.69 mmol), acetic acid (0.02ml, 0.3400mmol) and then sodium triacetoxyborohydride (0.150 g, 0.69 mmol) and stirred overnight at room temperature. The reaction mixture was quenched with 1N NaOH solution and aqueous phase was extracted with DCM three times. Combined organic layer was dried over anhydrous MgSCE, filtered off and evaporated. The desired product 64 was purified with column chromatography using 0-20% MeOH in EtOAc to get 0.l20g (43% yield). |
Tags: 118994-86-8 synthesis path| 118994-86-8 SDS| 118994-86-8 COA| 118994-86-8 purity| 118994-86-8 application| 118994-86-8 NMR| 118994-86-8 COA| 118994-86-8 structure
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P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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