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Chemical Structure| 1414573-63-9 Chemical Structure| 1414573-63-9

Structure of 1414573-63-9

Chemical Structure| 1414573-63-9

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Product Details of [ 1414573-63-9 ]

CAS No. :1414573-63-9
Formula : C8H9NO3
M.W : 167.16
SMILES Code : O=C(OCC)/C=C/C1=CN=CO1
MDL No. :N/A

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Application In Synthesis of [ 1414573-63-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1414573-63-9 ]

[ 1414573-63-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 867-13-0 ]
  • [ 118994-86-8 ]
  • [ 1414573-63-9 ]
YieldReaction ConditionsOperation in experiment
41.1% Preparation of (E)-ethyl 3-(oxazol-5-yl)acrylate: To a suspension of NaH(60%) in mineral oil, 227 mg, 5.67 mmol) in THF (40 mL) under N2 at 0 C was added dropwise ethyl 2-(diethoxyphosphoryl)acetate (1.12 mL, 5.67 mmol). The mixture was stirred at 0 C for 30 minutes, and then a solution of <strong>[118994-86-8]oxazole-5-carbaldehyde</strong> (500 mg, 5.15 mmol) in THF (5 mL) was added. The ice bath was removed, and the reaction was stirred at ambient temperature for 18 hours. The reaction was diluted with H20 (30 mL) and extracted with EtOAc (50 mL). The organic phase was washed with brine (50 mL), dried with MgS04, filtered and concentrated in vacuo. The crude product was purified by silica column chromatography, eluting with 0 to 1%> MeOH/DCM to yield the product as a pale yellow oil (354 mg, 41.1% yield). 1H NMR (CDC13) delta 7.92 (s, 1H), 7.48 (d, 1H), 7.29 (s, 1H), 6.40(d, 1H), 4.27 (q, 2H), 1.29 (t, 3H).
 

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