Structure of 3-Bromo-9-phenyl-9H-carbazole
CAS No.: 1153-85-1
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CAS No. : | 1153-85-1 |
Formula : | C18H12BrN |
M.W : | 322.20 |
SMILES Code : | BrC1=CC2=C(C=C1)[N](C3=CC=CC=C23)C4=CC=CC=C4 |
MDL No. : | MFCD11977305 |
InChI Key : | KUBSCXXKQGDPPD-UHFFFAOYSA-N |
Pubchem ID : | 18942624 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Num. heavy atoms | 20 |
Num. arom. heavy atoms | 19 |
Fraction Csp3 | 0.0 |
Num. rotatable bonds | 1 |
Num. H-bond acceptors | 0.0 |
Num. H-bond donors | 0.0 |
Molar Refractivity | 88.48 |
TPSA ? Topological Polar Surface Area: Calculated from |
4.93 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
3.3 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
5.69 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
5.55 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
5.01 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
4.74 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
4.86 |
Log S (ESOL):? ESOL: Topological method implemented from |
-6.06 |
Solubility | 0.000281 mg/ml ; 0.000000872 mol/l |
Class? Solubility class: Log S scale |
Poorly soluble |
Log S (Ali)? Ali: Topological method implemented from |
-5.56 |
Solubility | 0.000889 mg/ml ; 0.00000276 mol/l |
Class? Solubility class: Log S scale |
Moderately soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
-7.48 |
Solubility | 0.0000107 mg/ml ; 0.0000000331 mol/l |
Class? Solubility class: Log S scale |
Poorly soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
Low |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
No |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
Yes |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
Yes |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
Yes |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-4.23 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from |
1.0 |
Ghose? Ghose filter: implemented from |
None |
Veber? Veber (GSK) filter: implemented from |
0.0 |
Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
Muegge? Muegge (Bayer) filter: implemented from |
2.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
Brenk? Structural Alert: implemented from |
0.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
1.81 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; water; toluene; for 6h;Inert atmosphere; Reflux; | 3-BrPCz (6.44g, 0.02mol) was added to a three-necked flask, BnImBA (6.91g, 0.022mol), aqueous potassium carbonate (38.3g, 0.06mol), 100ml of toluene, 50ml of ethanol; under nitrogen with stirring was added Pd (PPh3)4(0.23g, 0.2mmol), after the replacement with nitrogen, the reaction was refluxed for 6 hours; after completion of the reaction, was cooled to room temperature, the layers were separated and the organic phase was washed with saturated aqueous sodium chloride solution until neutral, dried over anhydrous sodium sulfate and filtered to give a brown liquid; The solvent was removed by rotary evaporation, silica gel column, eluent VPetroleum ether: VEthyl acetate= 1: 1 was purified to obtain the white solid in 80% yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | With potassium carbonate;palladium diacetate; tris-(o-tolyl)phosphine; In ethanol; water; toluene; at 85℃; for 9h;Inert atmosphere; | Synthesis Example 1; In a 200-mL three-neck flask, a mixture of 5.0 g (15.5 mmol) of 3-bromo-9-phenyl-9H-carbazole, 4.2 g (17.1 mmol) of 4-(1-naphthyl)-phenylboronic acid, 38.4 mg (0.2 mmol) of palladium(II) acetate, 104 mg (0.3 mmol) of tris(2-methylphenyl)phosphine, 50 mL of toluene, 5 mL of ethanol, and 30 mL of a potassium carbonate aqueous solution (2 mol/L) was deaerated while being stirred under reduced pressure, and then heated and stirred in a nitrogen atmosphere at 85 C. for 9 hours to be reacted.After the reaction, 500 mL of toluene was added to the reaction mixture solution, and an organic layer of the mixture solution was filtrated through Florisil (Catalog No. 540-00135, produced by Wako Pure Chemical Industries, Ltd.), alumina (neutral, produced by Merck Ltd), and Celite (Catalog No. 531-16855, produced by Wako Pure Chemical Industries, Ltd.). The obtained filtrate was washed with water, and magnesium sulfate was added thereto so that moisture was adsorbed. This suspension was filtrated to obtain a filtrate. The obtained filtrate was concentrated and purified by silica gel column chromatography. At this time, a mixed solvent of toluene and hexane (toluene:hexane=1:4) was used as a developing solvent for the chromatography. The obtained fraction was concentrated, and methanol was added thereto. The mixture was irradiated with ultrasonic waves and then recrystallized to give 6.24 g of white powder that was an objective substance in a yield of 90%. The reaction scheme of Synthesis Example 1 above is shown in (F1-1). The Rf values of the objective substance and 3-bromo-9-phenyl-9H-carbazole were respectively 0.42 and 0.58, which were obtained by silica gel thin layer chromatography (TLC) (with a developing solvent of ethyl acetate and hexane in a 1:10 ratio).The compound obtained in Synthesis Example 1 was examined by a nuclear magnetic resonance (NMR) method. The measurement data are shown below.1H NMR (CDCl3, 300 MHz): delta (ppm)=7.30-7.35 (m, 1H), 7.44-7.67 (m, 14H), 7.76 (dd, J=8.7 Hz, 1.8 Hz, 1H), 7.84-7.95 (m, 4H), 8.04 (d, J=7.8, 1H), 8.23 (d, J=7.8, 1H), 8.46 (d, J=1.5, 1H).FIGS. 7A and 7B are 1H NMR charts. Note that FIG. 7B is a chart showing an enlarged part of FIG. 7A in the range of 7.0 ppm to 9.0 ppm. The measurement results confirmed that 3-[4-(1-naphthyl)-phenyl]-9-phenyl-9H-carbazole (abbreviation: PCPN) that was the objective substance was able to be obtained. |
90% | With palladium diacetate; potassium carbonate; tris-(o-tolyl)phosphine; In ethanol; water; toluene; at 85℃; for 9h;Inert atmosphere; | In a 200 mL three-neck flask, a mixture of 5.0 g (15.5 mmol) of 3-bromo-9-phenyl-9H-carbazole, 4.2 g (17.1 mmol) of 4-(1-naphthyl)-phenylboronic acid, 38.4 mg (0.2 mmol) of palladium(II) acetate, 104 mg (0.3 mmol) of tri(ortho-tolyl)phosphine, 50 mL of toluene, 5 mL of ethanol, and 30 mL of a 2 mol/L aqueous potassium carbonate solution was degassed while being stirred under reduced pressure, and reacted by being stirred and heated at 85 C. for 9 hours under a nitrogen atmosphere. (0523) After the reaction, 500 mL of toluene was added to this reaction mixture solution, and the organic layer of this mixture solution was filtered through Florisil (produced by Wako Pure Chemical Industries, Ltd., Catalog No. 540-00135), alumina, and Celite (produced by Wako Pure Chemical Industries, Ltd., Catalog No. 531-16855). The obtained filtrate was washed with water, and magnesium sulfate was added thereto so that moisture was adsorbed. This suspension was filtered to obtain a filtrate. The obtained filtrate was concentrated and purified by silica gel column chromatography. At this time, a mixed solvent of toluene and hexane (toluene:hexane=1:4) was used as a developing solvent for the chromatography. The obtained fraction was concentrated, and methanol was added thereto. The mixture was irradiated with ultrasonic waves and then recrystallized to give 6.24 g of a white powder in a yield of 90%, which was the object of the synthesis. (0524) This compound was identified as 3-[4-(1-naphthyl)-phenyl]-9-phenyl-9H-carbazole (abbreviation: PCPN), which was the object of the synthesis, by nuclear magnetic resonance (1H-NMR) spectroscopy. (0525) 1H NMR data of the obtained substance are as follows: 1H NMR (CDCl3, 300 MHz): delta (ppm)=7.30-7.35 (m, 1H), 7.44-7.67 (m, 14H), 7.76 (dd, J=8.7 Hz, 1.8 Hz, 1H), 7.84-7.95 (m, 4H), 8.04 (d, J=7.8, 1H), 8.23 (d, J=7.8, 1H), 8.46 (d, J=1.5, 1H). |
90% | With palladium diacetate; potassium carbonate; tris-(o-tolyl)phosphine; In ethanol; water; toluene; at 85℃; for 9h;Inert atmosphere; | In a 200 mL three-necked flask3-bromo-9-phenyl-9H-carbazole(11.5 mmol) of 4- (1-naphthalene) phenylboronic acid, 38.4 mg (0.2 mmol) of palladium (II) acetate, 104 mg (0.3 mmol) of tris (o-tolyl) , 50 mL of toluene, 5 mL of ethanol and 2 ml of a 20 mol / L aqueous solution of potassium carbonate were degassed with stirring under reduced pressure, and then stirred at 85 C for 9 hours under nitrogen atmosphere to cause reaction.After the reaction, 500 mL of toluene was added to the reaction mixture, and the organic layer of the mixed solution was treated with magnesium silicate (Japan Wako Pure Chemical Industries, Ltd., catalog number: 540-00135), alumina and diatomaceous earth (Manufactured by Wako Pure Chemical Industries, Ltd., catalog number: 531-16855). The resulting filtrate was washed with water and magnesium sulfate was added to adsorb moisture. The suspension was filtered to obtain a filtrate. The resulting filtrate was concentrated and then purified by silica gel column chromatography. In this case, as a developing solvent for silica gel column chromatography, a mixed solvent of toluene and hexane (toluene: hexane = 1: 4) was used. The resulting rinsing was concentrated, and methanol was added and ultrasonic waves were applied, followed by recrystallization, and a white powder of the desired product was obtained at a yield of 6.24 g and a yield of 90%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
60% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; toluene; for 12h;Inert atmosphere; Reflux; | 10.00 g (31.04 mmol) of 3-bromo-N-phenylcarbazole, 10.99 g (31.04 mmol) of 2-triphenylene boronic ester, 150 mL of a mixture of tetrahydrofuran (THF) and toluene (1:1), and 75 mL of an aqueous solution of 2 M potassium carbonate were mixed in a 500-mL round-bottom flask equipped with a stirrer in a nitrogen atmosphere, and 1.79 g (1.55 mmol) of tetrakis(triphenylphosphine)palladium(0) was added thereto, and heated under reflux in a nitrogen atmosphere for about 12 hours. After completion of the reaction, the reaction product was added to methanol to obtain a solid by filtering. This solid was thoroughly washed with water and methanol, and then dried. The resulting product was dissolved in 400 mL of chlorobenzene by heating, followed by filtration using silica gel and removing the solvent. The resulting product was dissolved in 300 mL of toluene by heating, followed by recrystallization to obtain Compound A15 (8.74 g, Yield: 60%). calcd. C36H23N: C, 92.08; H, 4.94; N, 2.98; found: C, 92.43; H, 4.63; N, 2.84 |
60% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; toluene; for 12h;Inert atmosphere; Reflux; | A 500 mL round bottom flask equipped with a stirrer in a nitrogen atmosphere 3-Bromo-phenyl carbazole -N- 10.00 g (31.04 mmol), 2-With triphenyl renbo Nick ester 10.99 g (31.04 mmol) and tetrahydrofuran: toluene (1: 1) of potassium carbonate and 150 mL accommodate 2M-After mixing the solution 75mL, put tetrakistriphenylphosphine palladium (0) 1.79 g (1.55mmol) copper 12 hours under a nitrogen gas streamNot heated to reflux. After the end of reaction the reaction was poured in methanol, filtered solids, the solids water obtained therefromAnd it was sufficiently washed with methanol and dried. Is the result obtained therefrom is then dissolved by heating in chlorobenzene in 400mLSilica gel filter that the solution and remove the solvent completely, and then recrystallized by heating to dissolve granulation to 300mL of tolueneCompounds A15 8.74 g (yield: 60%). |
60% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; toluene; for 12h;Inert atmosphere; Reflux; | Nitrogen atmosphere equipped with a stirrer a 500 mL round bottom flask was charged with 3-bromo-N-phenyl carbazole 10.00 g (31.04 mmol), 2-triphenyleneboronicesters 10.99 g (31.04 mmol) and tetrahydrofuran: toluene (1: 1) 150 mL and 2M- into the aqueous solution of potassium carbonate were mixed 75mL, tetrakistriphenylphosphine palladium (0) 1.79 g (1.55mmol) was heated to reflux for 12 hours under a nitrogen flow. After the end of reaction the reaction was poured in methanol, filtered, the solid was sufficiently washed with a solid obtained therefrom with water and methanol and dried. The results obtained therefrom is then dissolved by heating in chlorobenzene, and then a solution of 400mL silica gel filter, and remove the solvent completely, and then recrystallization is then dissolved by heating in 300mL of toluene to afford A15 8.74 g (yield 60%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
60% | 3-bromo-9-phenyl-9H-carbazole 50.0 g (155 mmol) and 500 mL THF and then dissolved, and then cooled to -78 C, n- butyl lithium (n-butyllithium) 97.0 mL (155.0 mmol, 1.6 M solution in n-hexane) for 30 minutes slowly added and the reaction mixture was stirred at -78 C for one hour. <strong>[6843-66-9]dimethoxydiphenylsilane</strong> 45.5 g (186 mmol) dissolve in 250 mL of THF was slowly added to the resulting mixture for 30 minutes. The reaction temperature was raised slowly to room temperature for one hour, and the reaction mixture was additionally stirred at room temperature for 15 hours. After completion of the reaction, it was added to a saturated ammonium chloride (NH4Cl) aqueous solution to separate the organic layer was extracted and then, by using anhydrous magnesium sulfate (MgSO4) and concentrated to remove the water after filtration. Separating the product obtained there from by a silica gel column chromatography (dichloromethane (DCM): n- hexane (n-hexane) = 1: 10 ) to the desired compound of intermediate (A) 42.4 g (yield: 60%) was obtained. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
63% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,2-dimethoxyethane; water; for 14h;Inert atmosphere; Reflux; | In a nitrogen flushed 250 mL two-necked round-bottomed flask 3-bromo-9-phenyl-9H-carbazole (2.62 g, 8.12 mmol), <strong>[870119-58-7]9-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-9H-carbazole</strong> (3 g, 8.12 mmol), Pd(PPh3)4 (0.094 g, 0.081 mmol) and potassium carbonate (2.246 g, 16.25 mmol) were dissolved in a DME (100 ml)/Water (20 ml) mixture under nitrogen to give a yellow suspension. The reaction mixture was refluxed under nitrogen for 14 h. After cooling to room temperature, the organic phase was separated and the solvent was evaporated. The residue was purified by column chromatography on silica gel with heptane/DCM (1/1,v/v) as the eluent and recrystallized from heptane to yield compound cc-1 (2.5 g, 63%) as a white solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
4.5 g | With tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine; sodium t-butanolate; In toluene; at 20℃; for 12h;Reflux; Inert atmosphere; | To the reaction flask3-Bromo-9-phenyl-9H-carbazole6.24 g (18.78 mmol), <strong>[56525-79-2]3,6-diphenyl-9H-carbazole</strong>5 g (15.65 mmol),TertButoxy sodium 2.25 g (23.48 mmol),Add 150 ml of toluene and stir at room temperature.Tris(Dibenzylideneacetone)Dipalladium (0)0.43 g (0.47 mmol),0.16 mL (0.47 mmol) of tri-tert-butylphosphine (50 wtpercent)And the mixture was refluxed under nitrogen flow for 12 hours.After completion of the reaction, the reaction mixture was slowly cooled to room temperature, and then the reaction solution was poured into a saturated aqueous solution of ammonium chloride and extracted with ethyl acetate.The organic layer was separated, dried over anhydrous magnesium sulfate and filtered.The filtrate was concentrated under reduced pressure and purified by column chromatography to obtain 4.5 g (51percent by weight) of the target compound [31] as a white solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84% | With n-butyllithium; In tetrahydrofuran; hexane; at -78℃; | The compound (A-1) (10.3 g, 32 mmol) prepared in the above step (1) was dissolved in 50 mL of tetrahydrofuran (THF)n- butyl lithium (n-BuLi) at -78 1.1eq. The mixture was stirred into a (2.5M in HEX, 14.1 mL, 35.2 mmol), was added dropwise an anhydrous dimethylformamide (DMF) 10mL. After the reaction was stirred at the same temperature for 1 hour, distilled water was added to the reaction solution, and the organic layer was extracted. The reaction solution was concentrated and recrystallized with ethyl alcohol (EtOH) to obtain the compound of formula B-1 (9.5 g, yield 84%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
82% | (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) -9-phenylcarbazole,One equivalent (20 g, 40.49 mmol),3-Bromo-9-phenylcarbazole, 2Equivalent (26 g, 81 mmol), 33.5 g of K2CO3, 800 ml of toluene,And 200 ml of water was added to a 2-L 2-neck round bottom flask. The mixture was stirred at room temperature for 30 minutes,Pd (PPh3) 4 (1.4 g, 1.21 mmol) was added and refluxed for 24 hours.After the reaction was completed, the reaction mixture was extracted with methylene chloride, added with MgSO 4 and filtered.After removing the solvent of the obtained organic layer, it was purified by column chromatography to obtain intermediate compound 1 (24.80 g, yield 82%). |
Tags: 1153-85-1 synthesis path| 1153-85-1 SDS| 1153-85-1 COA| 1153-85-1 purity| 1153-85-1 application| 1153-85-1 NMR| 1153-85-1 COA| 1153-85-1 structure
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P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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