Structure of 106-39-8
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CAS No. : | 106-39-8 |
Formula : | C6H4BrCl |
M.W : | 191.45 |
SMILES Code : | ClC1=CC=C(Br)C=C1 |
MDL No. : | MFCD00000600 |
InChI Key : | NHDODQWIKUYWMW-UHFFFAOYSA-N |
Pubchem ID : | 7806 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Num. heavy atoms | 8 |
Num. arom. heavy atoms | 6 |
Fraction Csp3 | 0.0 |
Num. rotatable bonds | 0 |
Num. H-bond acceptors | 0.0 |
Num. H-bond donors | 0.0 |
Molar Refractivity | 39.15 |
TPSA ? Topological Polar Surface Area: Calculated from |
0.0 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
2.25 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
3.54 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
3.1 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
3.64 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
3.22 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
3.15 |
Log S (ESOL):? ESOL: Topological method implemented from |
-3.81 |
Solubility | 0.0295 mg/ml ; 0.000154 mol/l |
Class? Solubility class: Log S scale |
Soluble |
Log S (Ali)? Ali: Topological method implemented from |
-3.22 |
Solubility | 0.114 mg/ml ; 0.000596 mol/l |
Class? Solubility class: Log S scale |
Soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
-3.87 |
Solubility | 0.0259 mg/ml ; 0.000136 mol/l |
Class? Solubility class: Log S scale |
Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
Low |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
Yes |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
Yes |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
Yes |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-4.95 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from |
0.0 |
Ghose? Ghose filter: implemented from |
None |
Veber? Veber (GSK) filter: implemented from |
0.0 |
Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
Muegge? Muegge (Bayer) filter: implemented from |
2.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
Brenk? Structural Alert: implemented from |
0.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<2.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
1.43 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | With caesium carbonate In N,N-dimethyl-formamide at 80℃; for 25 h; | EXAMPLE 6 Coupling of 4-chlorobromobenzene with diethyl malonate to give diethyl 2-(4-chlorophenyl) malonate 191.5 mg of 4-chlorobromobenzene (1 mmol) and 160 mg of diethyl malonate (1 mmol) were dissolved in 5 ml of N,N-dimethylformamide under protective gas, admixed with 652 mg of cesium carbonate (2 mmol) and stirred for 1 h. 17.9 mg (4 mol percent) of the HBPNS ligand and 9.0 mg of palladium(II) acetate (4 mol percent) were then added, and the mixture was heated to 80° C. for 24 h. For workup, 5 ml of water and 10 ml of toluene were added, the mixture was shaken, and the lower water phase was discharged and washed once again with 5 ml of water to remove residual dimethylformamide. After removal of the toluene on a rotary evaporator, 230 mg (0.85 mmol, 85percent) of the product were obtained. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75% | To a stirred suspension of magnesium (5.37 g, 223.75 mmol, 3 equiv) in dry THF (60 mL) under argon atmosphere was added iodine (2 crystals), 1,2-dibromo ethane (2 drops). 1-bromo-4-chlorobenzene (25.76 g, 134.39 mmol, 1.8 equiv) was then added dropwise for 1 h at room temperature. The reaction mixture was stirred at room temperature for 1 h. A solution of picolinaldehyde (8 g, 74.68 mmol) in dry THF (19 mL) was added drop wise at room temperature and stirred for 2 h. After completion of reaction, the reaction mixture was quenched with saturated ammonium chloride solution and extracted with EtOAc. The combined organic extract was washed with water, brine, dried over sodium sulfate, filteredand concentrated under reduced pressure. Purification using silica gel column chromatography (40percent EtOAc/hexanes as eluent) afforded 12.26 g of (4-chlorophenyl) (pyridin-2-yl) methanol (yield = 75percent). ESI + MS: m/z 220 ([M + Hj). | |
The compounds of the present invention were synthesized according to the procedure, which is illustrated schematically in FIG. 1 for three MPH alkyl analogs. Referring to FIG. 1, para-bromochlorobenzene 1 was converted into a Grignard reagent with Mg/THF which was then reacted with the pyridine-2-carboxaldehyde 2 to produce the alcohol 3. The alcohol 3 was oxidized with pyridinium chlorochromate in CH2Cl2 to produce the ketone 4. The ketone 4 was then reacted with a Grignard reagent that contains the required R group to produce the alcohol 5. After dehydration with refluxing HCl, the resulting Z and E olefin mixture 6 was hydrogenated with 10percent Pt/C in HOAc containing 3percent CF3COOH to produce the final compounds 7 with a ratio of about 40:60 of the R,R/S,S and R,S/S,R racemates for the ethyl compound. The racemates were separated by column chromatography and their relative configurations were determined by x-ray crystallography. | ||
170 g | Into a 3 lit RB Flask, 22.28 gm of Magnesium turnings was added. 200 ml of Tetrahydrofuran and 400 ml of Toluene were added which was then heated to 65°C and reaction was initiated and added 214.4 gm of 4-Bromochlorobenzene solution in 440 ml of Toluene. After careful addition and maintenance of reaction at 75-90°C for 1 hr 30 min, cooled the contents of the reaction to 45°C. A solution of 100 gm of Pyridine-2-carbaldehyde dissolved in 200 ml Toluene was added at 48-52°C and maintained the reaction mass for 1 hr at 45-55°C, the reaction was decomposed by the addition of above reaction mass to 1 lit of 33percent Ammonium chloride solution, followed by extraction with Toluene. The Toluene layer was distilled under vacuum and the product was isolated by Hexane. Yield: 160-170 gm |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With ammonium chloride; iodine; magnesium; In tetrahydrofuran; | a) 4.53 mg of magnesium shavings and a granule of iodine were treated with 150 ml of tetrahydrofuran while stirring and gassing with nitrogen. Subsequently, the mixture was treated dropwise within 20 minutes with a solution of 38.4 g of 4-bromo-1-chlorobenzene in 150 ml of tetrahydrofuran and boiled at reflux for 1.25 hours. Thereafter, the reaction mixture was cooled to 0° C. and treated dropwise within 30 minutes at 0°-5° C. with a solution of 35.7 g of 8-(4-oxocyclohexyl)-1,4-dioxaspiro-[4.5]decane in 240 ml of tetrahydrofuran. The reaction mixture was stirred for a further 4 hours without cooling, then treated within 10 minutes with 240 ml of 10 percent ammonium chloride solution and extracted with diethyl ether. The ether phases were washed twice with water, dried over sodium sulfate, filtered and concentrated. There were thus obtained 54.7 g of 1-(4-chlorophenyl)-4-(1,4-dioxa-8-spiro[4,5]decyl)cyclohexanol as beige crystals. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With ammonium chloride; In diethyl ether; benzene; | EXAMPLE 13 4',5-Dichloro-2-hydroxymethylbenzophenone Magnesium turnings (2.5 g.) are suspended in 20 ml. of ethyl ether and 19 g. of 4-chlorobromobenzol in 35 ml. of ethyl ether is added to the mixture which is then refluxed for two hours. After cooling to room temperature, 16.8 g. of <strong>[19641-29-3]6-chlorophthalide</strong> in 100 ml. of anhydrous benzene is added and the solution is heated at 50-60 C. for about 1 hour. The reaction mixture is cooled and stirred with 50 ml. of aqueous 20% ammonium chloride. The organic phase is separated and washed with aqueous sodium bicarbonate, then with water. Evaporation yields 24 g. of crude titular product which is hydrogenated according to the procedure of the foregoing example to give the corresponding benzhydrol. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With n-butyllithium; chloro-trimethyl-silane; triethylamine; In tetrahydrofuran; hexane; dichloromethane; ammonium chloride; toluene; | EXAMPLE XVIII Preparation of alpha,alpha-bis(p-chlorophenyl)-<strong>[20075-26-7]1-methoxymethylimidazole</strong>-2-methanol. To a solution of 22.4 g. (0.2 mol) of <strong>[20075-26-7]1-(methoxymethyl)imidazole</strong> in 150 ml. of anhydrous tetrahydrofuran 92 ml. (0.2 mol) of butyllithium solution (20% in hexane) was added drop-wise with stirring under a nitrogen atmosphere at -60 C. The reaction mixture was stirred for 2 hours, after which anhydrous carbon dioxide gas was introduced. After being stirred for one hour, the mixture was poured onto solid carbon dioxide. The lithium salt of <strong>[20075-26-7]1-(methoxymethyl)imidazole</strong>-2-carboxylic acid precipitated. The salt was filtered off and washed with diethyl ether. To a suspension of 16.2 g. (0.1 mol) of the lithium salt and 35 g. (0.35 mol) of triethylamine in 150 ml. of anhydrous dichloromethane 48.8 g. (0.45 mol) of chlorotrimethylsilane was added drop-wise with stirring under a nitrogen atmosphere. The mixture was stirred for 20 hours, then 300 ml. of anhydrous toluene was added and stirring was continued for another hour. The lithium salts formed were filtered off and the filtrate was concentrated by evaporation of the solvents. The residue, containing the trimethylsilyl ester of <strong>[20075-26-7]1-(methoxymethyl)imidazole</strong>-2-carboxylic acid, was dissolved in 100 ml. of anhydrous tetrahydrofuran and added dropwise to a refluxing solution of a Grignard compound prepared from 8.1 g. (0.3 g. at.) of magnesium and 57.5 g. (0.3 mol) of 4-bromo-1-chlorobenzene in 150 ml. of anhydrous tetrahydrofuran. The mixture was refluxed for one hour and then decomposed in an ammonium chloride solution. The precipitate was filtered off and the filtrate was extracted with diethyl ether. The ethereal phase was extracted with 2 N hydrochloric acid and the acid extract was made alkaline with ammonia and extracted with diethyl ether. The ethereal extract was dried over sodium sulphate and the solvent was distilled off. The residue was twice crystallized from isopropyl alcohol. alpha,alpha-Bis-(p-chlorophenyl)-<strong>[20075-26-7]1-(methoxymethyl)imidazole</strong>-2-methanol was obtained. Melting point 145-146 C. The compound was converted into alpha,alpha-bis(p-chlorophenyl)imidazole-2-methanol as described in Example VII B. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
51% | [Li(TMP)Zn(tBu)2] 1 was made according to the literature procedure2 on a 0.4 mmol scale in THF solution. To this 1-methyl-1,2,3-triazole (0.015 mL, 0.2 mmol) was added and the resultant light yellow solution was allowed to stir at room temperature for 2 hours. This solution was then transferred to a THF (1 mL) solution of Pd[P(tBu)3]2 (10.2 mg, 2.5 mol percent) and 1-bromo-4-chlorobenzene (38.3 mg, 0.2 mmol) to give a heterogeneous orange solution. The reaction mixture was then reacted in the microwave at 100°C for 10 minutes. The reaction was then quenched with saturated NH4Cl solution (2 mL) and extracted with DCM (3 x 1 mL). The organic fractions were combined and dried by passing through a phase separator cartridge with a hydrophobic frit and the solvent removed under reduced pressure. The residue was purified by column chromatography using a 4 g silica cartridge and eluent EtOAc:Heptane (50:50 to 60:50) to give 14b as a light yellow oil 40 mg (51percent yield) 1H NMR (400 MHz, CDCl3) delta ppm 4.00 (s, 3 H) 7.48 - 7.55 (m, 2 H) 7.61 - 7.69 (m, 2 H) 7.94 (s, 1 H) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; for 6h;Inert atmosphere; | General procedure: A round-bottomed flask was charged with Pd2(dba)3 (5 mol percent ), ligand (10 molpercent), aryl halide (1mmol), appropriate isoquinolinamine (1 mmol), base (1.5 mmol) and dry solvent (5 mL). Theflask was flushed with argon for 5 min. The mixture was heated at reflux under magnetic stirring.After cooling down to room temperature, the reaction mixture was concentrated and the residuewas purified by flash column chromatography on silica gel. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
50% | With copper(l) iodide; potassium carbonate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; at 140℃; for 3h; | A 50 mL of flask was charged with 2.87 g of 4-chlorobenzenebromide (15 mmol), 1.40 g of ethyl 1-H-pyrazole-3-carboxylate (10 mmol), 400 mg of CuI (2.0 mmol), 4.5 g of K2CO3 (3.3 mmol) and 0.9 mL of trans-N,N'-dimethylcyclohexayldiamine (2.0 mmol). The resulting mixture was stirred at 140° C. for 3 h. After the mixture was cooled down to room temperature, it was diluted with 200 mL EtOAc and then was washed with water (2*50 mL) and brine (2*50 mL). The organics were dried over MgSO4 and concentrated under reduced pressure. The residued was purified via flash column chromatography on silica gel (0-25percent EtOAc in hexanes) to get the desired product (1.25 g, 50percent). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | With sodium hydroxide; In toluene; at 30 - 113℃; for 4.5h; | After reducing the solution containing pyrazol in step (2) to 30 ° C, adding 45.18 g of toluene, stirring for 0.5 h, increasing the temperature of the mixture and refluxing the water to a moisture content of 0.08percent in the mixture. The temperature of the mixture was lowered to 40 ° C, 58.01 g (99percent, 0.3 mol) of p-bromochlorobenzene and 16.16 g (99percent, 0.4 mol) of sodium hydroxide were added, and the temperature of the mixture was raised to 110 ° C. After refluxing for 4 hours, the mixture was detected by liquid phase method multiple times. When the pyrazole peak disappeared, the reaction was stopped. After the temperature of the mixed solution was lowered to 40 ° C, 50 g of water was added to the mixture, and the mixture was dropped. Add hydrochloric acid to the pH of the mixture = 3, then raise the temperature of the mixture to 95 ° C, distill off the toluene, finally reduce the temperature of the mixture to 30 ° C, and suction to obtain 1-(4-chlorophenyl)-3-pyrazolol.Using this method, 31.96 g of 1-(4-chlorophenyl)-3-pyrazol was obtained in content of 97percent, yield 80percent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
71.3% | With tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine; sodium t-butanolate; In toluene; for 24h;Inert atmosphere; Reflux; | (1) In a 250 ml three-necked flask, 0.02 mol of raw material B2 was added under nitrogen protection.0.024 mol of p-chlorobromobenzene, 0.04 mol of sodium tert-butoxide, 1 x 10-4 mol of Pd2 (dba) 3,1×10-4 mol of tri-tert-butylphosphine, 150 ml of toluene, and heating under reflux for 24 hours.Sampling the plate, the reaction is complete; naturally cooled, filtered, and the filtrate is steamed.Column chromatography gave Intermediate A1, HPLC purity 99.4%, yield 71.3%; |
71.3% | With tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine; sodium t-butanolate; In toluene; for 24h;Inert atmosphere; Reflux; | (1) In a 250 ml three-necked flask, 0.02 mol of raw material B2 was added under nitrogen protection.0.024 mol of p-chlorobromobenzene, 0.04 mol of sodium tert-butoxide, 1 x 10-4 mol of Pd2 (dba) 3,1×10-4 mol of tri-tert-butylphosphine, 150 ml of toluene, and heating under reflux for 24 hours.Sampling the plate, the reaction is complete; natural cooling, filtration, rotary distillation of the filtrate, column chromatography to obtain the intermediate A1,HPLC purity 99.4%, yield 71.3%; |
71.3% | With tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine; sodium t-butanolate; In toluene; for 24h;Reflux; | (1) In a 250 ml three-opening in the bottle, through under the protection of nitrogen, adding 0.02 µM raw material B2, 0.024mol P-bromophenylacetic, 0.04 µM tert [...], 1 × 10-4Mol Pd2(Dba)3, 1 × 10-4Mol tri-butyl phosphate, 150 ml toluene, heating reflux for 24 hours, the sampling [...], the reaction is complete; natural cooling, filtration, filtrate and steaming and, column chromatography on the intermediate A1, HPLC purity 99.4%, yield 71.3% |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92.8% | With potassium carbonate; In N,N-dimethyl-formamide; at 110 - 115℃; for 5h; | Add 100 g of DMF to a 250 ml four-necked flask equipped with a stirring, thermometer, and reflux condenser.11.8 g (0.05 mol) of 1-amino-4-(pyridin-4-yl)methylpyridazine (IV),15.0 g (0.08 mol) of 4-bromochlorobenzene, 10.0 g of potassium carbonate, and the reaction was stirred at 110 to 115 C for 5 hours.After cooling to 20 to 25 C, the reaction liquid was poured into 200 g of water, filtered, and the filter cake was washed successively with 30 g of water and 20 g of isopropyl alcohol, and dried.The yield of 16.1 g of vatalanib was 92.8%, and the liquid phase purity was 99.6%. |
Tags: 106-39-8 synthesis path| 106-39-8 SDS| 106-39-8 COA| 106-39-8 purity| 106-39-8 application| 106-39-8 NMR| 106-39-8 COA| 106-39-8 structure
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P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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