Structure of 106-37-6
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CAS No. : | 106-37-6 |
Formula : | C6H4Br2 |
M.W : | 235.90 |
SMILES Code : | BrC1=CC=C(Br)C=C1 |
MDL No. : | MFCD00000089 |
InChI Key : | SWJPEBQEEAHIGZ-UHFFFAOYSA-N |
Pubchem ID : | 7804 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H315-H319-H412 |
Precautionary Statements: | P501-P273-P264-P280-P337+P313-P305+P351+P338-P302+P352-P332+P313-P362 |
Num. heavy atoms | 8 |
Num. arom. heavy atoms | 6 |
Fraction Csp3 | 0.0 |
Num. rotatable bonds | 0 |
Num. H-bond acceptors | 0.0 |
Num. H-bond donors | 0.0 |
Molar Refractivity | 41.84 |
TPSA ? Topological Polar Surface Area: Calculated from |
0.0 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
2.36 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
3.79 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
3.21 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
3.79 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
3.25 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
3.28 |
Log S (ESOL):? ESOL: Topological method implemented from |
-4.25 |
Solubility | 0.0134 mg/ml ; 0.0000568 mol/l |
Class? Solubility class: Log S scale |
Moderately soluble |
Log S (Ali)? Ali: Topological method implemented from |
-3.48 |
Solubility | 0.0774 mg/ml ; 0.000328 mol/l |
Class? Solubility class: Log S scale |
Soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
-4.11 |
Solubility | 0.0184 mg/ml ; 0.000078 mol/l |
Class? Solubility class: Log S scale |
Moderately soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
Low |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
Yes |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
Yes |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
Yes |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-5.05 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from |
0.0 |
Ghose? Ghose filter: implemented from |
None |
Veber? Veber (GSK) filter: implemented from |
0.0 |
Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
Muegge? Muegge (Bayer) filter: implemented from |
1.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
Brenk? Structural Alert: implemented from |
0.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<2.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
1.45 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
68% | With aluminum (III) chloride In dichloromethane at -20℃; for 3 h; | 1,4-dibromobenzene (20 mmol), CH2Cl2 (50 mL) and CH3COCl (1.5 eq., 30 mmol) were added to a 250 mL round-bottom flask. After cooled to -20 oC, AlCl3 (3 eq., 8.0 g) was added to the mixture slowly. The reaction was stirred vigorously for 3 h at -20 oC. 80 mL ice water was added to the flask and the mixture was extracted with CH2Cl2 (30 mL x 3), dried by anhydrous Na2SO4. Evaporation of the solvent followed by purification on silica gel provided 1-(2,4-dibromophenyl)ethanone, yield 68percent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
60% | Step 1: (0135) (0136) 47.2 g (0.2 mol) p-dibromobenzene was dissolved in 280 ml tetrahydrofuran, and cooled to -70 C. under nitrogen atmosphere, during which the reaction solution became sticky. 84 ml (0.21 mol, 2.5M) n-butyl lithium was added dropwise for exchanging bromine with lithium, and stirred for an additional 15 min after addition. 14 g (0.2 mol) cyclobutanone was added at this temperature to perform the addition reaction with the lithium reagent, during which the reaction system gradually became thin and completely clear after addition. The reaction solution was heated to 0 C. and poured into 300 ml water. The organic layer is separated, extracted, washed with water, evaporated to completely remove the solvent, and recrystallized in ethanol, to obtain 25 g of a white crystal (1-a). Yield: 60%. | |
54% | l-(4-Bromo-phe?yl)-cycIobutanol (3-1).; n-Butyllithium (1.2 mL 1.92 mmol, 1.6 M/hexanes) was added to a -78 C solution of 1 ,4-dibromobenzene (489 mg, 2.07 mmol) in THF (4.2 mL). After 30 min., a solution of cyclobutanone EPO <DP n="40"/>(141 mg, 2.01 mmol) in 1 inL THF was added by cannula, rinsing with 0.5 mL THF. The reaction was allowed to warm to room temperature and after 2 h, saturated NH4Cl solution was added. The resulting mixture was extracted with ethyl acetate (3 x 30 mL) and the combined ethyl acetate solution was washed with brine. The solution was then dried (Na2SO4), filtered and evaporated. Purification by flash chromatography on silica gel (5% -> 10% ethyl acetate/hexanes) gave 3-1 (235 mg, 54%). | |
34% | To a solution of 1,4-dibromobenzene (1.00 g, 4.24 mmol) at -78 C. in ether (20 ml) was added n-BuLi (2.65 ml, 1.6 M solution in hexane, 4.24 mmol) and the reaction mixture was stirred at -78 C. for 30 min. Cyclobutanone (348 mul, 4.66 mmol) was then added and the reaction mixture was stirred at -78 C. for 15 min. The reaction mixture was then slowly (over 2 h) warmed to 0 C. and stirred for a further 1 h. Water was added followed by sat. NH4Cl and the reaction mixture was extracted with ether. The organic layer was washed with brine, dried (MgSO4), filtered and concentrated in vacuo to give a residue which was purified by flash column chromatography (1:4 ether/pentane) to give 1-(4-bromophenyl)-cyclobutanol (330 mg, 34%) as a colorless oil. 1H NMR (CDCl3, 300 MHz): delta 7.50 (d, J=8.5 Hz, 2H), 7.38 (d, J=8.5 Hz, 2H), 2.57-2.48 (m, 2H), 2.41-2.31 (m, 2H), 2.02 (m, 1H), 1.69 (m, 1H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
93% | 6.12. Preparation of 4-(4'-Chloro-biphenyl-4-yl)-1-pyrimidin-2-yl-piperidin-4-ol To a solution of 1,4-dibromobenzene (213.3 mg, 0.904 mmol) in THF (4 ml), was added n-BuLi (2.5 M in hexanes, 0.362 ml, 0.904 mmol) at -78 C. After being stirred for 30 minutes at the same temperature, a solution of <strong>[116247-92-8]1-pyrimidin-2-yl-piperidin-4-one</strong> (80 mg, 0.452 mmol) in THF (3 ml) was added. The mixture was allowed to warm to room temperature and stirred for 1 hour. The reaction was quenched with addition of water (10 ml) and EtOAc (50 ml). The organic layer was washed with brine (5 ml), dried (MgSO4), filtered, and concentrated under reduced pressure to furnish the crude product. This material was purified by column chromatography (40% EtOAc/hexanes) to give 4-(4-Bromo-phenyl)-1-pyrimidin-2-yl-piperidin-4-ol as a colorless oil (140 mg, 93%): 1H NMR (CDCl3, 400 MHz) delta 8.33 (d, J=6.4 Hz, 2 H), 7.47 (d, J=12.0 Hz, 2 H), 7.41 (d, J=12.0 Hz, 2 H), 6.49 (t, J=6.4 Hz, 1 H), 4.72 (m, 2 H), 3.40 (m, 2 H), 2.05 (m, 2 H), 1.78 (m, 2 H); MS calc'd for C15H17BrN3O [M+H]+: 335; Found: 335. | |
6.12. Preparation of 4-(4'-Chloro-biphenyl-4-yl)-l-pyrimidin-2-yl-piperidin- 4-ol; To a solution of 1 ,4-dibromobenzene (213.3 mg, 0.904 mmol) in THF (4 ml), was added /?-BuLi (2.5 M in hexanes, 0.362 ml, 0.904 mmol) at -780C. After being stirred for 30 minutes at the same temperature, a solution of l-pyrimidin-2-yl-piperidin-4-one (80 mg, 0.452 mmol) in THF (3 ml) was added. The mixture was allowed to warm to room temperature and stirred for 1 hour. The reaction was quenched with addition of water (10 ml) and EtOAc (50 ml). The organic layer was washed with brine (5 ml), dried (MgSO4), filtered, and concentrated under reduced pressure to furnish the crude product. This material was purified by column chromatography (40% EtOAc/hexanes) to give 4-(4- Bromo-phenyl)-l-pyrimidin-2-yl-piperidin-4-ol as a colorless oil (140 mg, 93%): 1H NMR (CDCl3, 400 MHz) delta 8.33 (d, J= 6.4 Hz, 2 H), 7.47 (d, J= 12.0 Hz, 2 H), 7.41 (d, J = 12.0 Hz, 2 H), 6.49 (t, J= 6.4 Hz, 1 H), 4.72 (m, 2 H), 3.40 (m, 2 H), 2.05 (m, 2 H), 1.78 (m, 2 H); MS calc'd for Ci5Hi7BrN3O [M+H]+: 335; Found: 335. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; for 8h;Inert atmosphere; | General procedure: A round-bottomed flask was charged with Pd2(dba)3 (5 mol percent ), ligand (10 molpercent), aryl halide (1mmol), appropriate isoquinolinamine (1 mmol), base (1.5 mmol) and dry solvent (5 mL). Theflask was flushed with argon for 5 min. The mixture was heated at reflux under magnetic stirring.After cooling down to room temperature, the reaction mixture was concentrated and the residuewas purified by flash column chromatography on silica gel. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
61% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In toluene; at 110℃; for 48h;Inert atmosphere; | In the Ar gas protection,Using the intermediate H as a starting material (620 mg; 5 mmol)Were charged into a 50 ml two-necked flask,1,4-dibromobenzene(1.2 g; 5 mmol), 10 mg of Pd (pph3) 4, anhydrous potassium carbonate (1.38 g, 5 mmol)5ml distilled oxygen,40ml anhydrous oxygen-free toluene,110 ° C reflux reaction 48h.Saturated ammonium chloride solution was quenched and extracted with ethyl acetate.The solvent was removed by rotary evaporator,The crude product was then purified by column chromatography to give the substituent (11) as a white solid 700mg(61percent). |
26.26% | A 500 mL sealed tube was charged with pyridin-4-ylboronic acid (1.6 g, 13.0 mmol) 1,4-dibromobenzene (3.07 g, 13.0 mmol), sodium carbonate (5 mL, 2M solution) and mixture of toluene (10 mL) and water (10 mL). The reaction mixture was purged with argon for 30 mm. Then, Pd(PPh3)4 (0.75 g, 0.05 eq) was added to the reactionmixture and the said mixture was heated at 90 00 for about 12 h. After cooling, the reaction mixture was extracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous Na2SO4. The organic layer was concentrated under vacuo to yield crude product, which was purified by column chromatography to yield title compound (0.8 g, 26.26percent) as a white solid. LCMS: (M+2) = 236.0; 1H NMR:(DMSO-d6, 300MHz) 68.64-8.66 (d, 2H), 7.71- 7.80 (m, 6H). | |
26.26% | A 500 mL sealed tube was charged with pyridin-4-ylboronic acid (1.6 g, 13.0 mmol)1 ,4-dibromobenzene (3.07 g, 13.0 mmol), sodium carbonate (5 mL, 2M solution) andmixture of toluene (10 mL) and water (10 mL). The reaction mixture was purged withargon for 30 mm. Then, Pd(PPh3)4 (0.75 g, 0.05 eq) was added to the reactionmixture and heated at 90 00 about 12 h. After cooling, the reaction mixture wasextracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous Na2SO4. The organic layer was concentrated under vacuo to yield crude product, which was purified by column chromatography to yield title compound (0.8 g, 26.26percent) as a white solid. LCMS: (M+2) = 236.0; 1H NMR: (DMSO-d6, 300MHz ) 68.64-8.66 (d, 2H), 7.71- 7.80 (m, 6H). |
With potassium carbonate; palladium; In toluene; at 80℃; for 16h;Inert atmosphere; | Under N2 gas purification system, Compound A, 0.9 equivalents of compound B, 0.05 equivalents of Pd (0) and 4.0 equivalents of potassium carbonate into toluene, the mixture at a temperature of 80 deg. C oil bath with stirring. After 16 hours, water was added to the mixture, was extracted, the product was eluted with methylene chloride and hexane (2: 1) through the column to obtain a white solid compound C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate; palladium; In toluene; at 80℃; for 16h;Inert atmosphere; | Under N2 gas purification system, Compound A, 0.9 equivalents of compound B, 0.05 equivalents of Pd (0) and 4.0 equivalents of potassium carbonate into toluene, and the mixture was stirred in an oil bath at 80 deg. C. After 16 hours, water was added to the mixture, was extracted and the resultant with hexane and ethylene glycol diacetate (8: 2) developing solvent through the column to obtain a white solid compound C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; water; at 80℃; for 3h;Inert atmosphere; | Into a 250-mL round-bottom flask purged and maintained with an inert atmosphere of nitrogen was placed 1-methyl-4-(tetramethyl-1 ,3,2- dioxaborolan-2-yl)-1 H-pyrazole (2.00 g, 9.61 mmol), 1 ,4-dibromobenzene (2.30 g, 9.75 mmol), Pd(PPh3)4 (550 mg, 0.48 mmol), potassium carbonate (2.60 g, 18.8 mmol), dioxane (40 ml_) and water (10 ml_). The resulting solution was stirred for 3 h at 80C. The resulting mixture was evaporated to dryness. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1/10). This resulted in 1.70 g (75%) of 4-(4- bromophenyl)-1-methyl-1 H-pyrazole as a yellow solid. |
47% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; water; at 80℃; for 18h;Inert atmosphere; Sealed tube; | 1-methylpyrazole-4-boronic acid pinacol ester (300 mg, 1.44 mmol) 1,4-dibromobenzene (0.2 mL, 1.6 mmol) and potassium carbonate (399 mg, 20 2.9 mmol) were mixed in water (1 mL) and 1,4-dioxane (4 mL) and the mixture degassed with N2. tetrakis(triphenylphosphine)palladium(0) (167 mg, 0.14 mmol) was added and the tube sealed and heated at 80 C for 18h. The reaction mixture was reduced in vacuo directly onto silica and purified by silica column chromatography, eluting with 5-40% EtOAc in Pet. Ether to afford 4-(4-bromophenyl)-1-methyl-pyrazole (160 mg, 0.67 mmol, 47% yield) as a white solid. LC-MS (ES+, 25 Method A): 1.66 min, m/z 237.1 [M+H]+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; water; for 12h;Inert atmosphere; Reflux; | In 500 ml three-necked flask, 1,4-dibromobenzene 34.7g (0.147mol), triphenylene-2-yl boronicacid 20.0 g (73.5mmol) and tetrakis(triphenylphosphine) palladium 1.7g (0.08mmol) were charged, potassium carbonate (K2CO3) 15.2g (0.110mmol) and 250 mLof 1,4-dioxane was added under nitrogen gas stream, and the mixture was stirred under reflux for 12 hours with 25mL purified water. After completion of the reaction, the reaction solution was slowly cooled to room temperature and filtered. The filtered solids were washed with methanol and purified water, and recrystallized with dichloromethane and methanol to obtain intermediate compound [1-1] 25.0 g (89%) as white solid. |
77% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; at 65℃; for 18h; | 1,4-Dibromobenzene (2.4 g, 0.010 mol) in triphenylen-2-ylboronic acid (3.3 g, 0.012mol), Pd (pph3) 4 (0.6 g, 0.0005 mol), potassium carbonate (2.8 g, 0.020 mol) in THFadd 100 mL was reacted with stirring for 18 hours at 65 C. After the reaction cooledto H20: After layer separation the MC column purification (n-Hexane: MC) to yield theintermediate 1-1 2.9 g (yield 77%) |
70% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; at 65℃; for 18h; | 1,4-dibromobenzene (2.4g, 0.010mol) into the triphenylen-2-ylboronic acid (3.3g, 0.012mol) in synthesis by the same method used in Preparation Example 1-7 to Intermediate 25-2> to give the 2.7g (70% yield). |
70% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; at 65℃; for 18h; | 1,4-dibromobenzene (2.4 g, 0.010 mol) and Pd (PPh3) 4 (0.6 g, 0.012 mol) were added to triphenylen-2-ylboronic acidG, 0.0005 mol) and potassium carbonate (2.8 g, 0.020 mol) in THF (100 mL), and the mixture was reacted at 65 DEG C for 18 hours with stirring. After completion of the reaction, the reaction mixture was cooled, separated into H 2 O: MC and subjected to column purification (N-HEXANE: MC) to obtain 2.7 g (yield 70%) of Intermediate 1-3. |
69% | With bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate; In toluene; at 95℃; for 4h; | 3-bromo-1H-indole (2.0 g, 0.010 mol) in bromobenzene (1.6 g, 0.010 mol), Pd (dba) 2 (0.5 g, 0.0005 mol), sodium-tert-butoxide (1.9 g, 0.020 mol) in TOL into a 70 mL was reacted with stirring for 4 hours at 95 . After the end of the reaction H20: After layer separation the MC column purification (n-HEXANE: MC) to yield the intermediate 1-1 2.1 g (79%). 1,4-dibromobenzene (1.9 g, 0.008 mol) in triphenylen-2-ylboronic acid (2.7 g, 0.010 mol) into the Example 1-Preparation Example 4 in the same manner used in the synthesis <intermediate 6-1> 2.1 g (yield 69%) of the target compound. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
34% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; | Step 2: 3-(4-bromophenyl)-5-chloropyridin-4-amine A mixture of 3-bromo-5-chloropyridin-4-amine (5 g, 24.10 mmol), bis(pinacolato)diboron (12 g, 48320 mmol), potassium acetate (4.7 g, 48.20 mmol) and 1,1'-bis(diphenylphosphino)ferrocene palladium(II)dichloride (3.5 g, 4.82 mmol) in dioxane (100 ml) was stirred at 90° C. overnight under nitrogen. TLC showed the reaction was complete. To this mixture solution was added 1,4-dibromobenzene (11.4 g, 48.20 mmol), potassium carbonate (6.7 g, 48.20 mmol) and water (30 ml). tetrakis(triphenylphosphine)palladium (1.4 g, 1.21 mmol) was added and the mixture was stirred at 90° C. overnight under nitrogen. The reaction mixture was filtered and the filtrate was partitioned between ethyl acetate (100 ml) and water (100 ml), the organic layer was washed with brine (20 ml*2), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a crude residue which was purified by silica gel flash chromatography (eluted with 20-50percent ethyl acetate in hexane) to afford 3-(4-bromophenyl)-5-chloropyridin-4-amine (2.3 g, yield 34percent) as yellow solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75% | (1) After replacing nitrogen with a three-port reaction flask equipped with mechanical stirring, thermometer, and constant pressure dropping funnel,Add the raw materials 1a-1 (200mmol) and 500.0ml THF in sequence, start stirring, and lower the temperature to -85 -90 ,Add 2mol / L n-butyllithium (210mmol) dropwise, keep the temperature at -85 -90 during the dropwise addition, keep the temperature for 1h after the dropwise addition,A solution of the raw material <strong>[102645-33-0]2,5-dichloropyridine-4-aldehyde</strong> (200 mmol) + 140.0 ml of THF was added dropwise.After the dropwise addition, the temperature was kept for 0.5h, and the temperature was naturally raised to room temperature for 3h.The reaction solution was poured into a 10% ammonium chloride aqueous solution, extracted with 320.0 ml of toluene, and the solution was separated.The aqueous phase was extracted once with 320.0 ml of toluene, the organic phases were combined, and washed twice with 260.0 ml of water.Separate the liquid, add 12g of anhydrous sodium sulfate to the organic phase, dry, filter, and concentrate the organic phase (-0.08 -0.09MPa, 55 65 ) until150.0 ml of petroleum ether was added and stirred for 0.5 h, filtered, and the filter cake was rinsed with petroleum ether to obtain intermediate 1a-2 (150 mmol) with a yield of 75%. |
Tags: 106-37-6 synthesis path| 106-37-6 SDS| 106-37-6 COA| 106-37-6 purity| 106-37-6 application| 106-37-6 NMR| 106-37-6 COA| 106-37-6 structure
A1971339 [201595-52-0]
1,4-Dibromobenzene-1,2,3,4,5,6-13C6
Reason: Stable Isotope
A232124 [18869-30-2]
(E)-1,2-Bis(4-bromophenyl)ethene
Similarity: 0.73
A232124 [18869-30-2]
(E)-1,2-Bis(4-bromophenyl)ethene
Similarity: 0.73
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P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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