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Chemical Structure| 33243-33-3 Chemical Structure| 33243-33-3

Structure of 33243-33-3

Chemical Structure| 33243-33-3

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Product Details of [ 33243-33-3 ]

CAS No. :33243-33-3
Formula : C8H6Br2O
M.W : 277.94
SMILES Code : CC(C1=CC=C(Br)C=C1Br)=O
MDL No. :MFCD00152057
Boiling Point : No data available
InChI Key :PFNFQYGPUFVXPB-UHFFFAOYSA-N
Pubchem ID :2303036

Safety of [ 33243-33-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 33243-33-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 33243-33-3 ]
  • Downstream synthetic route of [ 33243-33-3 ]

[ 33243-33-3 ] Synthesis Path-Upstream   1~6

  • 1
  • [ 108-36-1 ]
  • [ 75-36-5 ]
  • [ 33243-33-3 ]
YieldReaction ConditionsOperation in experiment
93% at 100℃; for 1.5 h; Inert atmosphere Argon under the protection,A solution of 1,3-dibromobenzene (4.1 g, 17.5 mmol)And AlCl3 (5.6 g, 42 mmol) were placed in a 50 ml two-necked flask,At room temperature,Acetyl chloride (2.0 ml, 28 mmol) was slowly added dropwise,Dripping finished system slowly heated to 100 , a large number of HCl gas release,High temperature reaction for 1.5 hours.System down to room temperature,Slowly pour into crushed ice and concentrated hydrochloric acid.The organic phase was washed with water, washed with Na2CO3 solution and brine, dried over anhydrous MgSO4, and the solvent was evaporated under reduced pressure. The compound 16a (4.5 g, 93percent yield) was isolated by column chromatography.
References: [1] Advanced Synthesis and Catalysis, 2016, vol. 358, # 6, p. 926 - 939.
[2] Patent: CN106316958, 2017, A, . Location in patent: Paragraph 0145; 0146; 0152; 0153.
[3] Journal of the Chemical Society, 1949, p. 1133,1136.
[4] Roczniki Chemii, 1973, vol. 47, p. 2333 - 2337.
  • 2
  • [ 106-37-6 ]
  • [ 75-36-5 ]
  • [ 33243-33-3 ]
YieldReaction ConditionsOperation in experiment
68% With aluminum (III) chloride In dichloromethane at -20℃; for 3 h; 1,4-dibromobenzene (20 mmol), CH2Cl2 (50 mL) and CH3COCl (1.5 eq., 30 mmol) were added to a 250 mL round-bottom flask. After cooled to -20 oC, AlCl3 (3 eq., 8.0 g) was added to the mixture slowly. The reaction was stirred vigorously for 3 h at -20 oC. 80 mL ice water was added to the flask and the mixture was extracted with CH2Cl2 (30 mL x 3), dried by anhydrous Na2SO4. Evaporation of the solvent followed by purification on silica gel provided 1-(2,4-dibromophenyl)ethanone, yield 68percent.
References: [1] Chinese Chemical Letters, 2015, vol. 26, # 10, p. 1231 - 1235.
  • 3
  • [ 106-37-6 ]
  • [ 75-36-5 ]
  • [ 33243-33-3 ]
  • [ 99-90-1 ]
References: [1] Molecules, 2010, vol. 15, # 8, p. 5561 - 5580.
  • 4
  • [ 585-79-5 ]
  • [ 33243-33-3 ]
References: [1] Journal of the Chemical Society, 1949, p. 1133,1136.
  • 5
  • [ 591-19-5 ]
  • [ 33243-33-3 ]
References: [1] Journal of the Chemical Society, 1949, p. 1133,1136.
  • 6
  • [ 75-15-0 ]
  • [ 7446-70-0 ]
  • [ 108-36-1 ]
  • [ 75-36-5 ]
  • [ 33243-33-3 ]
References: [1] Journal of the Chemical Society, 1949, p. 1133,1136.
 

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