Products Cited in Publications Worldwide Sustainable radical approaches for cross electrophile coupling to synthesize trifluoromethyl- and allyl-substituted tert-alcohols

Sustainable radical approaches for cross electrophile coupling to synthesize trifluoromethyl- and allyl-substituted tert-alcohols

Ashraf, Muhammad Awais; Lee, Yunjeong; Iqbal, Naila; Iqbal, Naeem; Cho, Eun Jin

DOI: PMID:

Abstract

Trifluoromethylated mols. have gained privileged recognition among the medicinal and pharmaceutical chemists. Sustainable photoredox- and electrochem. processes were employed to facilitate the relatively less explored radical cross-electrophile coupling to access trifluoromethyl- and allyl-substituted tert-alcs. I (Ar = Ph, 2-ClC6H4, 2-naphthyl, etc.). Reactions proceed through trifluoromethyl ketyl radical and allyl radical intermediates, which underwent challenging radical-radical cross-coupling. The developed transformations are mild and chemo-selective to give cross-coupled products and deliver a wide range of valuable trifluoromethyl- and allyl-containing tertiary alcs. Both processes can also be applied for the synthesis of amine variant containing trifluoromethyl and allyl moiety, which is considered as amide bioisostere.

Purchased from AmBeed