*Storage: {[sel_prStorage]}
*Shipping: {[sel_prShipping]}
The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
2-(4-Hydroxyphenyl)ethanol is a natural product isolated and purified from the leaves of Canarium album, which significantly protects dopaminergic neurons from MPP(+)-induced degradation, and reveals potential neuroprotective mechanism of tyrosol.
Synonyms: NSC 59876; 4-Hydroxyphenylethanol; NSC 59876, p-HPEA, Tyrosol
4.5
*For Research Use Only !
Change View
Size | Price | VIP Price | US Stock |
Global Stock |
In Stock | ||
{[ item.pr_size ]} |
Inquiry
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.discount_usd) ]} {[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} |
Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]} | Inquiry {[ item.pr_usastock ]} In Stock Inquiry - | {[ item.pr_chinastock ]} {[ item.pr_remark ]} In Stock 1-2 weeks - Inquiry - | Login | - + | Inquiry |
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days
1-2weeks
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price, item.pr_usd) ]}
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
In Stock
- +
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 501-94-0 |
Formula : | C8H10O2 |
M.W : | 138.16 |
SMILES Code : | C1=CC(=CC=C1CCO)O |
Synonyms : |
NSC 59876; 4-Hydroxyphenylethanol; NSC 59876, p-HPEA, Tyrosol
|
MDL No. : | MFCD00002902 |
InChI Key : | YCCILVSKPBXVIP-UHFFFAOYSA-N |
Pubchem ID : | 10393 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
6.7% | With β-glucosidase from Aspergillus niger In water at 37℃; for 3 h; Enzymatic reaction | Reaction mixture (100 mL) comprising of 2.0725 g (1.5 mmol) tyrosol, 15.4 g cellobiose and Novozyme 188 (735 U of β-glucosidase) in distilled water was incubated at 37 °C. The reaction was stopped after 3 h by boiling in water bath for 5 min, centrifuged for 10 min at 4500 rpm and filtered through 0.22 m filter (25 mm diameter). The filtrate was applied on column of Sephadex LH-20 (75 cm long, 3.2 mm i.d.) equilibrated and eluted with distilled water. Tyrosol was regenerated by gradient of ethanol. The process of purification was monitored by TLC. Fractions containing salidroside were collected and concentrated in vacuo. To remove coloured substances originating from the enzyme, the material was further subjected to flash chromatography with gradient of methanol in chloroform. Fractions containing pure salidroside were concentrated and crystallised from mixture of methanol and chloroform (1:5, v/v). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
24.3% | With β-glycosidase from black plum seeds; 1-octyl-3-methylimidazolium hexafluorophosphate In 1,4-dioxane; aq. phosphate buffer at 50℃; for 72 h; Enzymatic reaction | General procedure: The different seed meals were prepared as described by Yuet al. [10]. The reaction was performed in a 10 ml Erlenmeyershaking flask capped with a septum containing 1.6 ml dioxane, 0.4 ml phosphate buffer (pH 6.8, 100 mmol/L), 0.5 mmolD-glucose, 5 mmol tyrosol, and different fruit seed meal at 50°C and 200 r/min. Aliquots were withdrawn at specified timeintervals from the reaction mixture, and then diluted 50 timeswith the corresponding mobile phase prior to HPLC analysis.One unit of -glycosidase activity (U) was defined as theamount of enzyme required to produce 1 μmol salidroside inthe first hour under the above conditions. The specific activitiesof the black plum seed meal, apple seed meal, peach seed meal,bitter almond seed meal, and prune seed meal were 27.6, 23.4,25.9, 13.5, and 19.7 U/g. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
97% | To a solution of 2-(4-hydroxyphenyl) ethanol, 8 (5.0 g,36.23 mmol) in anhydrous DMF (20 mL), K2CO3 (15.0 g,108.7 mmol) was added and the reaction mixture was stirred atroom temperature for 30 min. Benzyl bromide (6.24 g, 36.5 mmol)was added to the reaction mixture and stirred for 4 h at roomtemperature. The TLC examination (EtOAc/hexane, 1:3) showed thecompletion of the reaction. The reaction mixture was quenchedwith water (200 mL) and EtOAc (200 mL) was added. The organiclayer was separated and the aqueous layer was once again extractedwith EtOAc (100 mL). The combined EtOAc layer was washedwith water (3 100 mL), brine (1 100 mL), and dried over anhydrousNa2SO4. The drying agent was filtered off and the solvent wasevaporated under low pressure to obtain the compound 9 asa white solid (8.0 g, 97%). The proton and 13C NMR data matchedwell with those reported in literature. 1H NMR (CDCl3) d 2.78 (t, 2H,J¼6.4 Hz), 3.78 (t, 2H, J¼6.4 Hz), 5.03 (s, 2H), 6.92 (d, 2H, J¼8.4 Hz),7.12 (d, 2H, J¼8.4 Hz), 7.35e7.45 (m, 5H); 13C NMR d 38.7, 64.2, 70.5,115.4 (2C), 127.9 (2C), 128.4, 129.0 (2C), 130.5 (2C), 131.2, 137.5, 157.9and MS (ESth) m/z 227 (M H). | |
95% | With potassium carbonate; In ethanol; at 20℃;Product distribution / selectivity; | Example 4; ((R/S)-4-{2-[o4-(6-Fluoro-hexyloxy)-phenyl]-ethyl}-2-methyl-4,5-dihydro-oxazol-4- yl)-methanol a) To a solution of 4- (2-hydroxy-ethyl)-phenol (50g, 0. 36mol) in ethanol (400ml) is added potassium carbonate (75g, 0. 54MOL, 1.5eq) and benzyl bromide (47. 2MOI, 0. 39MOL, 1. 1EQ), the reaction mixture is stirred at RT overnight. The reaction mixture is then filtered off through celite and concentrated under vacuum. 2- (4-Benzyloxy-phenyl)-ethanol is isolated after crystallization with diethyl ether; Example 9: Phosphoric acid mono-((R)-2-amino-4-{4-[2-(3-fluoro-phenoxy)-ethoxy]-phenyl}- 2-hydroxymethyl-butyl) ester; To a solution of 4- (2-HYDROXY-ETHYL)-PHENOL (50g, 0. 36MOL) in ethanol (400ml) is added potassium carbonate (75g, 0. 54MOL, 1.5eq) and benzyl bromide (47. 2ml, 0. 39MOL, 1. 1EQ), the reaction mixture is stirred at room temperature overnight. The reaction mixture is then filtered off trough celite and concentrated under vacuum. 2- (4-BENZYLOXY-PHENYL)-ETHANOL is isolated after crystallization with diethyl ether (82. 6G, 95%). |
93% | With potassium carbonate; at 20℃; for 16h;Heating / reflux; | 2- (4-HYDROXYPHENYL) ethyl alcohol (30.5g, 0. 22MOL), benzyl bromide (39.6g, 0. 23MOL) and potassium carbonate (33.5g, 0. 24MOL) were mixed and boiled under reflux for 4 hours. The reaction was left at room temperature for 12 hours. The solvent was evaporated and the residue was dissolved in water and chloroform The phases were separated and the water phase was extracted one more time. The organic phases were pooled, dried (MGS04) and evaporated to give 47g of the desired product (93% yield) |
93.8% | With potassium carbonate; In acetone; for 10h;Reflux; Inert atmosphere; | General procedure: To a stirred solution of compound 8b or 9b inacetone, K2CO3 (2.50 eq for each phenolic hydroxyl) and BnBr(1.05 eq for each phenolic hydroxyl) were added. The resultingmixture was heated to reflux under N2 for 10 h. The mixturewas then filtered and the filtrate was concentrated to form aresidue, which was dissolved with EtOAc, washed with 2.0 MHCl, saturated NaHCO3 and brine. The organic layer wasdried over Na2SO4, and concentrated in vacuo to form a yellowoil that was purified by column chromatography on silicagel to generate compound 8c or 9c. |
90% | This example describes the preparation of 4-benzyloxy-(2-phenethyl ethanol) of formula (6). In a 250 ml reaction flask 2-(4-Hydroxyphenyl)-ethanol of formula, (5) (10 g, 0.07246 mol), potassium hydroxide (6.1 g, 0.1087 mol) and catalytic amount of phase transfer catalyst tetrabutyl ammonium bromide (0.150 g) was dissolved in 65 ml of THF. Stirred it for 1.5 hr. Benzyl bromide (8.6 ml, 0.07246 mol), was added to the reaction mixture dropwise. Stirred the reaction mixture at room temperature for 4 hrs. The progress of reaction was checked by TLC. Filtered the reaction mixture and concentrated the filtrate on rota-vapour. The crude product was recrystalised from petroleum ether to afford 4-benzyloxy-(2-phenethyl ethanol) of formula (7,), 14.9 g (90%) mp 85-86 C. | |
90% | With potassium carbonate; In N,N-dimethyl-formamide; at 25℃; for 12h;Inert atmosphere; | General procedure: The compounds were prepared following a literature procedure.48To a solution of hydroxyaryl substrate (1.0 equiv., 1 mmol) in DMF(0.05 M) was added K2CO3 (1.5 equiv., 1.5 mmol), followed by the dropwise addition of benzyl bromide (1.2 equiv., 1.2 mmol) at RT, and the mixture was stirred at RT for 12 h. After completion monitored byTLC, the solvent was removed under reduced pressure, and the residue was washed with H2O (30 mL) and extracted with ethyl acetate(3×20 mL), the organic layers were dried over MgSO4 and concentratedin vacuo. |
89% | With sodium hydride; In DMF (N,N-dimethyl-formamide); at 20 - 50℃; | To a stirred solution of 4-hydroxyphenethyl alcohol (3.0 g, 22.16 mmol) in anhydrous DMF (50 mL) at ice/water temperature was added sodium hydride (60% in mineral oil, 886 mg, 22.16 mmol). After stirring at room temperature for 10 min, benzyl bromide (3.86 g, 22.16 mmol) was added and the reaction mixture was heated at 50 C. for 30 min. Upon cooling to room temperature, ethyl acetate (250 mL) was added and the organic layer that separated was washed with brine (500 mL, 4*100 mL), dried (MgSO4) and evaporated to give a white residue (6.05 g). The crude was first dissolved in hot isopropanol (10 mL) and hexane (10 mL) was then added dropwise. Upon cooling, 2-(4-benzyloxyphenyl)ethanol was isolated as soft white crystals (2.45 g, 10.73 mmol). A second crop of the product (2.04 g, 8.936 mmol, total yield: 89%) was obtained from the residue of the mother liquor upon recrystallisation from hot hexane (ca. 150 mL); Rf 0.71 (neat ethyl acetate), 0.63 (S.M.); deltaH (400 MHz, DMSO-d6) 2.64 (2H, t, J=7.2 Hz, CH2CH2OH), 3.54 (2H, m, reduced to t after D2O exchange, CH2CH2OH), 4.59 (1H, t, J=5.2 Hz, exchanged with D2O, OH), 5.06 (2H, S, CH2O), 6.90 (2H, AA'BB'), 7.11 (2H, AA'BB') and 7.28-7.46 (5H, m, Bn); LRMS (FAB+): 228.0[94, M+], 91.0[100, Bn+]. |
With potassium tert-butylate; In N-methyl-acetamide; | A. 1-Benzyloxy-4-(2-hydroxyethyl)benzene To a solution of 4-hydroxyphenethyl alcohol (33 g, 0.24 mol) in dry dimethylformamide (200 ml), cooled to 0 C., was added potassium tert-butoxide (29 g, 0.26 mol) by portions. After 10 minutes, benzyl bromide (41 g, 0.28 mol) was added slowly. The reaction mixture was stirred for 15 minutes at 0 C., then for 3 hours at room temperature and was quenched with water (200 ml). The precipitate was collected, dried and recrystallized from isopropyl ether/hexanes (34 g). | |
With potassium carbonate; In acetone; | Step 1: A mixture of 4-hydroxyphenethyl alcohol (15.02 g), benzyl bromide (13.6 ml), and potassium carbonate (75.1 g) in acetone (250 ml) is heated at reflux for about 4 hours. The mixture is cooled and poured into ether and water. The organic layer is washed with water, 1N sodium hydroxide solution, brine, dried over magnesium sulfate, filtered and concentrated in vacuo to give 4-benzyloxyphenethyl alcohol. | |
With NaH; In tetrahydrofuran; hexane; | PREPARATION O 2-(4-Benzyloxyphenyl)ethanol NaH (1.42 g of 60% in oil, 0.036 mol) was washed 2*5 ml hexane and then suspended in tetrahydrofuran (20 ml). 4-Hydroxyphenethyl alcohol (5.0 g, 0.036 mol) was added portionwise and the mixture stirred for 20 minutes to assure complete conversion to the sodium salt. Benzyl bromide (4.2 ml, 1 equivalent) was added and the resulting mixture refluxed for 4 hours, then poured into 50 ml H2 O and extracted 3*50 ml ether. The organic layers were combined, extracted 2*20 ml 1N NaOH and then 2*20 ml H2 O, dried (MgSO4), stripped, and the solid residue recrystallized from ethyl acetate and cyclohexane to yield title product 4.4 g. | |
With potassium carbonate; In ethanol; at 20℃; | To a solution of [4- (2-HYDROXY-ETHYL)-PHENOL] (50 g, 0.36 mol) in ethanol (400 ml) is added potassium carbonate (75 g, 0.54 mol, 1.5 eq) and benzyl bromide (47.2 ml, 0.39 mol, 1.1 eq), the reaction mixture is stirred at room temperature overnight. The reaction mixture is then filtered off through celite and concentrated under vacuum. [2- (4-BENZYLOXY-PHENYL)-] ethanol is isolated after crystallization with diethyl ether. To a solution of [2- (4-BENZYLOXY-PHENYL)-ETHANOL] (78.72 g, 0.34 mol) in methylene chloride (400 [ML)] is added triethylamine (67.3 [MI,] 0.44 mol, 1.4 eq), then at [0C] is added mesylchloride (34.8 ml, 0.44 mol, 1.3 eq). The reaction mixture is stirred at [0C] for 30 minutes and allowed to rise to room temperature. The reaction mixture is extracted with methylene chloride (2 x 300 [ML),] the combined organic layers are then washed with brine (2 x 300 [MI)] and concentrated under vacuum. To the crude product in solution in AcOEt (600 ml) is added sodium iodide (67.2 g, 0.44 mol, 1.3 eq) and the reaction mixture is stirred under reflux for 6 hours. After filtration, the organic layer is washed with brine (3 x 400 [ML),] dried with [NA2SO4,] filtered and concentrated under vacuum. [1-BENZYLOXY-4- (2-IODO-ETHYL)-] benzene is isolated after crystallization with diethyl ether. To a solution of [ACETAMIDOMALONATE] (59.4 g, 0.27 mol, 2 eq) in dry dimethylformamide (400 ml) is added at [0C] under inert atmosphere sodium hydride (60% in oil) (9.94 g, 0.49 mol, 1.8 eq), the reaction mixture is stirred for 3 hours at [0C.] [1-BENZYLOXY-4- (2-IODO-ETHYL)-] benzene (46.8 g, 0.13 mol, 1 eq) in solution in dry DMF (250 ml) is then slowly added at [0C] and the reaction mixture is stirred at room temperature overnight. The reaction mixture is quenched with few drops of methanol and concentrated almost to dryness under vacuum, then extracted with AcOEt and washed subsequently with [1N HCI] (2 x 500 [ML),] saturated solution of [NAHCO3] (2 x 500 mi) and brine (2 x 500 [ML),] dried with [NA2SO4,] filtered and concentrated under vacuum. [2-ACETYLAMINO-2- [2- (4-BENZYLOXY-PHENYL)-ETHYL]-MALONIC] acid diethyl ester is isolated after multiple crystallization using diethyl ether. To a solution of [2-ACETYLAMINO-2- [2- (4-BENZYLOXY-PHENYL)-ETHYL]-MALONIC] acid diethyl ester (44.1 g, 0.1 mol) in ethanol water (2/1) (285 [ML/285 ML)] is added [CAC12] (28.5 g, 0.26 mol, 2.5 eq) and NaBH4 by portion (19.4 g, 0.52 mol, 5.0 eq), the reaction mixture is stirred overnight at room temperature. At [0C] the reaction mixture is carefully quenched with drop wise methanol (10 [ML)] and concentrated to almost dryness under vacuum. The crude mixture is extracted with AcOEt (4 x 500 [ML)] and washed subsequently with 1 N HCI (2 x 300 [ML),] saturated solution of NaHCO3 (2 x 300 [ML)] and brine (2 x 300 [ML).] The combined organic layers are then dried with [NA2SO4,] filtered and concentrated under vacuum. N- [3- (4- benzyloxy-phenyl)-1, 1-bis-hydroxymethyl-propyl]-acetamide is carried on without further purification. To a solution of crude [N- [3- (4-BENZYLOXY-PHENYL)-1, 1-BIS-HYDROXYMETHYL-PROPYL]-ACETAMIDE] in a mixture of tetrahydrofuran, methanol, water [(1/2/2)] (450 [ML/900] [MI/900 M))] is added at room temperature lithium hydroxide (32.7 g, 1.36 mol, 8.0 eq). The reaction mixture is stirred at [55C] for 5 hours, then extracted with AcOEt (500 ml) and washed with brine (2 x 300 [MI),] the combined organic layers are then dried with [NA2S04,] filtered and concentrated under vacuum. [2-AMINO-2- [2- (4-BENZYLOXY-PHENYL)-ETHYL]-PROPANE-1, 3-DIOL] is isolated after crystalli- zation using AcOEt. To a solution of [2-AMINO-2- [2- (4-BENZYLOXY-PHENYL)-ETHYL]-PROPANE-1, 3-DIOL] (31.1 g, 0.10 mol) in acetonitrile (2. 38 l) is added triethylortho acetate (17.1 [ML,] 0.12 mol, 1.2 eq) and acetic acid (5.48 [MI,] 0.11 mol, 1.1 eq), the reaction mixture is then stirred at [80C] for 5 hours. The reaction mixture is then concentrated under vacuum, [{4-[2-(4-BENZYLOXY-PHENYL)-ETHYL]-2-] [METHYL-4,] [5-DIHYDRO-OXAZOL-4-YL}-METHANOL] is isolated after crystallization with AcOEt. To a solution of [{4- [2- (4-BENZYLOXY-PHENYL)-ETHYL]-2-METHYL-4, 5-DIHYDRO-OXAZOL-4-YL}-METHANOL] (26.1 g, 0.08 mol) in methanol (800 ml) is added palladium on charcoal (2.6 [G,] 10% wt), and the reaction mixture is stirred under hydrogen atmosphere at room temperature for 5 hours. The reaction mixture is then filtered through celite and concentrated under vacuum. [4- [2- (4-] Hydroxymethyl-2-methyl-4, [5-DIHYDRO-OXAZOL-4-YL)-ETHYL]-PHENOL] is isolated after crystallization with AcOEt and hexanes. | |
24 g | With potassium carbonate; In N,N-dimethyl-formamide; at -25℃; for 20h; | Potassium carbonate (40 g, 0.289 mol) and benzyl bromide (22.5 mL, 0.188 mol) were added to a solution of 4-(2-hydroxyethyl)phenol (20 g, 0.144 mol) in N,N-dimethylformamide (434 mL) at room temperature and this was stirred at -25 C. conditions for about 20 hours. After completion of reaction, the reaction mixture was extracted in ethyl acetate and washed with water and saturated brine solution. The crude compound was purified on silica gel column chromatograph with 20% ethyl acetate in hexane as elutent to give the title compound. Yield: 24 g Mass: 246.55 (M+18) |
2-[4-(Benzyloxy)phenyl]ethanol (0271) (0272) 4-(2-Hydroxyethyl)phenol (7.0 g, 50.7 mmol) was dissolved in acetone (75 mL) and cooled to 0 C. Potassium carbonate (9.1 g, 65.9 mmol) was added portionwise and the resulting white suspension was vigorously stirred for 10 min at room temperature and cooled again to 0 C. Benzyl bromide was added dropwise (7.2 mL, 60.8 mmol) and the reaction mixture was refluxed for 22 h. The suspension was then cooled to room temperature, filtered and evaporated to dryness. The resulting white solid was dissolved in Et2O and successively washed with 2% aqueous solution of NaOH (3×), brine (3×), dried over anhydrous MgSO4 and evaporated to dryness to afford 11.4 g of a white solid which was used in the following step without further purification. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate; In diethyl ether; [(2)H6]acetone; | 2-[4-(Benzyloxy)phenyl]ethanol 4-(2-Hydroxyethyl)phenol (7.0 g, 50.7 mmol) was dissolved in acetone (75 mL) and cooled to 0 °C. Potassium carbonate (9.1 g, 65.9 mmol) was added portionwise and the resulting white suspension was vigorously stirred for 10 min at room temperature and cooled again to 0 °C. Benzyl bromide was added dropwise (7.2 mL, 60.8 mmol) and the reaction mixture was refluxed for 22 h. The suspension was then cooled to room temperature, filtered and evaporated to dryness. The resulting white solid was dissolved in Et2O and successively washed with 2percent aqueous solution of NaOH (3x), brine (3x), dried over anhydrous MgSO4 and evaporated to dryness to afford 11.4 g of a white solid which was used in the following step without further purification. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
17.7 g | With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 5 - 20℃; for 5h;Inert atmosphere; Cooling with ice; | (Second step) Stirrer,And a reaction vessel equipped with a thermometer,20 g (55 mmol) of the compound represented by formula (S-1),Sodium hydroxide 5.3 g (132 mmol), ethanol 200 ml,Add 50 ml of pure water,Hydrolysis was performed by stirring at 60 C. for 2 hours.After the reaction is completeA 10% aqueous hydrochloric acid solution was added to neutralize the reaction solution.After cooling the reaction solution, the precipitated crystals are filtered,The crystals were washed with water and ethanol and dried.Further, 18 g (53 mmol) of <strong>[1570-05-4]3,4-dibenzyloxybenzoic acid</strong> obtained was added to a stirrer,Charge into a reaction vessel equipped with a cooler and thermometer,Furthermore, 3.7 g (27 mmol) of 2- (4-hydroxyphenyl) ethanol,610 mg of dimethylaminopyridine,200 ml of methylene chloride was charged.Keep the reaction vessel at 5 C or below with an ice-cooled bath.In an atmosphere of nitrogen gas, 8 g (63 mmol) of diisopropylcarbodiimide was slowly added dropwise. After completion of dropping, the reaction vessel was returned to room temperature and reacted for 5 hours. After the reaction solution was filtered, 200 ml of methylene chloride was added to the filtrate, washed with a 10% aqueous hydrochloric acid solution, further washed with saturated brine, and the organic layer was dried over anhydrous sodium sulfate. After distilling off the solvent,Purification was performed with a double amount (weight ratio) silica gel column, and recrystallization with methylene chloride / methanol gave 17.7 g of the compound represented by the formula (S-3). |
Tags: Tyrosol | NSC 59876 | Benzene Compounds | Alcohols | Plant Standard | Organic Building Blocks | Drug Analysis | 501-94-0
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :
Total Compounds: mg
The concentration of the dissolution solution you need to prepare is mg/mL