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CAS No. : | 67104-97-6 |
Formula : | C3H8N2O2S |
M.W : | 136.17 |
SMILES Code : | CN1CCNS1(=O)=O |
MDL No. : | MFCD04037145 |
InChI Key : | SYFJRHFWDDLSJF-UHFFFAOYSA-N |
Pubchem ID : | 10393280 |
GHS Pictogram: | ![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H320-H335 |
Precautionary Statements: | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
Num. heavy atoms | 8 |
Num. arom. heavy atoms | 0 |
Fraction Csp3 | 1.0 |
Num. rotatable bonds | 0 |
Num. H-bond acceptors | 4.0 |
Num. H-bond donors | 1.0 |
Molar Refractivity | 36.91 |
TPSA ? Topological Polar Surface Area: Calculated from | 57.79 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from | 0.28 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by | -0.99 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from | -0.91 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from | -0.98 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by | -0.67 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions | -0.66 |
Log S (ESOL):? ESOL: Topological method implemented from | -0.06 |
Solubility | 118.0 mg/ml ; 0.87 mol/l |
Class? Solubility class: Log S scale | Very soluble |
Log S (Ali)? Ali: Topological method implemented from | 0.26 |
Solubility | 249.0 mg/ml ; 1.83 mol/l |
Class? Solubility class: Log S scale | Highly soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by | -0.1 |
Solubility | 108.0 mg/ml ; 0.793 mol/l |
Class? Solubility class: Log S scale | Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg | High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg | No |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) | No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) | No |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) | No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) | No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) | No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) | No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from | -7.83 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from | 0.0 |
Ghose? Ghose filter: implemented from | None |
Veber? Veber (GSK) filter: implemented from | 0.0 |
Egan? Egan (Pharmacia) filter: implemented from | 0.0 |
Muegge? Muegge (Bayer) filter: implemented from | 2.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat | 0.55 |
PAINS? Pan Assay Interference Structures: implemented from | 0.0 alert |
Brenk? Structural Alert: implemented from | 0.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from | No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) | 2.48 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
52.3% | With pyridine; imidosulfonic acid; for 3h;Reflux; | N-methylethylendiamine (1.5 g, 20.8 mmol) and sulfuric diimide (2.0 g, 20.8 mmol) were added to a pyridinesolvent (20 mL), and refluxed, stirred, and heated for 3 hours. After the reaction was completed, toluene (5 mL) wasadded to the reactant, followed by concentration and extraction with ethyl acetate. An organic solvent layer was driedover MgSO4 and filtered to remove the solvent. A residue was purified by column chromatography (EtOAc) to obtain acompound 6a. White solid (52.3 %). Mp 80 to 82 C; 1H-NMR (CDCl3, 300 MHz) delta7.27 (s, 1H), 3.53-3.19 (m, 2H), 3.42-3.37 (m, 2H), 2.75 (s, 1H); 13C NMR (CDCl3, 75 MHz) delta 32.67, 39.64, 46.94; LC-MS: Predicted value calculated with respect to C3H8N2O2S m/z: 136. Measured value: 137(M+1)+. |
28% | With pyridine; SULFAMIDE; at 120℃; for 16h; | Preparation 98 2-Methyl-1,2,5-thiadiazolidine-1,1-dioxide To a stirred mixture of N-methylethylenediamine (1.200 g, 16.2 mmol) in pyridine (20 mL) was added sulfamide (1.867 g, 19.4 mmol). The mixture was heated in an oil bath at 120 C. for 16 hrs. After cooling to room temperature, the mixture was concentrated and the residue was partitioned between ethyl acetate and saturated aqueous sodium chloride. The organic layer was washed with 1 N aqueous hydrochloric acid, saturated aqueous sodium chloride, dried (anhydrous sodium sulfate), filtered, and concentrated to afford a colorless oil (0.61 g, 28%). 1H NMR (300 MHz, CDCl3) delta 4.30 (br s, 1H), 3.53 (m, 2H), 3.40 (m, 2H), 2.76 (s, 3H). |
16% | With SULFAMIDE; In 1,4-dioxane; for 20h;Reflux; | Step a) 2-Methyl-?.2.51thiadiazolidine 1.1 -dioxide (Acid-12a); N-Methylethylene diamine (1.02 ml, 11.6 mmol) in dioxane (4 ml) was added dropwise to sulphamide (1.12 g, 11.6 mmol) in dioxane (10 ml) over 2 h. The mixture was refluxed for 18 h, solvent evaporated and residue purified by flash chromatography using 3% MeOH in DCM as eluent which gave the title compound (259 mg, 16%) as a semisolid. |
799.4 mg | With pyridine; SULFAMIDE; at 120℃; for 24h;Inert atmosphere; | To a solution of N1-methylethane-1,2-diamine (2.0 g, 27 mmol) in pyridine (30 mL) was added sulfuric diamide (3.10 g, 32.4 mmol). The reaction was heated at 120 C under nitrogen for 24 h. All solvents were removed in vacuo. The residue was partitioned between saturated NaCl (aq, 25 mL) and EtOAc (125 mL) and organic component was washed with IN HC1 (aq, 50 mL) and saturated NaCl (aq, 25 mL). The organic component was dried over MgS04, filtered, and concentrated in vacuo to afford the title compound as a yellow viscous oil (799.4 mg). The product was used without further purification. NMR (400 MHz, CDCh) delta 4.48 (br s, 1H), 3.59 - 3.45 (m, 2H), 3.44 - 3.33 (m, 2H), 2.75 (s, 3H). |
2.7 g | With pyridine; SULFAMIDE; at 100℃; for 16h; | To a mixture of sulfamide (5 g, 52.1 mmol) in pyridine (120 mL) was added a solution of n-methylethylenediamine (3.85 g, 52.1 mmol) in pyridine (30 mL) at 100 C. The mixture was stirred at 100 C for 16 hours, and then concentrated under reduced pressure. The residue was purified by column chromatography to give intermediate 1-17 (2.7 g) as a colorless oil. 1H NMR (400 MHz, CDC13) delta 4.37 (brs, 1 H), 4.45-4.58 (m, 2 H), 3.34-3.42 (m, 2H), 2.76 (s, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
2.61 g (68.7%) | In N-methyl-acetamide; water; | 1. 4-(1,1-dioxo-5-methyl-1,2,5-thiadiazolidine-2-yl)nitrobenzene To a solution of <strong>[67104-97-6]2-methyl-1,2,5-thiadiazolidine-1,1-dioxide</strong> (2.02 g, 14.8 mmol) in anhydrous dimethylformamide (30 ml) was added sodium hydride (60% dispersion in oil; 0.59 g) and the mixture was stirred at room temperature under nitrogen for 40 minutes. A solution of 1-fluoro-4-nitrobenzene (2.09 g, 14.8 mmol) in anhydrous dimethylformamide (15 ml) was added to the above solution and the mixture was refluxed for 1 hour. Water (200 ml) was added and products were extracted with ethyl acetate (2*150 ml), dried (MgSO4) and concentrated to an orange solid. Crystallisation from ethyl acetate (150 ml) afforded 2.61 g (68.7%) of the title compound as a pale orange solid; mp 155-163 C.; deltaH (250 MHz, DMSO-d6) 8.29 (2H, d, J=9.3 Hz, Ar--H), 7.34 (2H, d, J=9.3 Hz, Ar--H), 4.00 (2H, t, J=6.4 Hz, --CH2 --), 3.57 (2H, t, J=6.4 Hz, --CH2 --), 2.78 (3H, s, --CH3); m/z (EI) 257 (M+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate; In N-methyl-acetamide; | 1. 5-Methyl- 2-(4-nitrobenzyl)-1,2,5-thiadiazolidine-1,1-dioxide To a stirred suspension of anhydrous potassium carbonate (14.49 g, 104.8 mmol) in anhydrous dimethylformamide (80 ml) was added dropwise over 4 minutes a solution of <strong>[67104-97-6]2-methyl-1,2,5-thiadiazolidine-1,1-dioxide</strong> (14 g, 102.8 mmol) in anhydrous dimethylformamide (40 ml), under nitrogen. After 5 minutes, solid 4-nitrobenzyl bromide (22.43 g, 103.8 mmol) was added in one portion and stirring was continued at room temperature for 5 hours. Water (200 ml) was added and products were extracted into ethyl acetate (3*150 ml). The combined organic phases were washed with brine (1*50 ml), dried (Na2 SO4) and concentrated. The crude residue was crystallized from ethyl acetate-hexane (70:30) to give 18.31 g (67%) of the title compound as pale yellow crystals. Purification of the mother liquors by flash chromatography (silica gel, hexane-ethyl acetate, 30:70) afforded a further 5.1 g (18.2%) of required product; mp 105-107 C.; deltaH (250 MHz, CDCl3) 8.22 (2H, d, J=8.7 Hz, Ar--H), 7.57 (2H, d, J=8.7 Hz, Ar--H), 4.32 (2H, s, Ar--CH2 --), 3.36--3.21 (4H, m, N--CH2 CH2 --N), 2.80 (3H, s, --NMe); m/z (CI) 270 (M+ -1). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol; chloroform; dimethyl sulfoxide; mineral oil; | EXAMPLE 25 To a solution of <strong>[67104-97-6]1,1-dioxo-2-methyl-1,2,5-thiadiazolidine</strong> (0.89 g) in dimethyl sulfoxide 22 ml) was added 60% sodium hydride (0.26 g) in mineral oil portionwise under water-cooling. The reaction mixture was stirred at ambient temperature for 30 minutes and thereto was added 3,4-dihydro-2,2-dimethyl-3,4-epoxy-2H-1-benzopyran-6-carbonitrile (0.88 g). The reaction mixture was stirred at ambient temperature for 2 days, poured into ice-water (65 g), extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate, and evaporated in vacuo. The residue was subjected to column chromatography on silica gel (45 g) and eluted with a mixture of methanol and chloroform (1:50). The fractions containing object compound were combined and concentrated under reduced pressure. The residue was recrystallized from ethanol to give white crystal of trans-2,2-dimethyl-4-[1,1-dioxo-5-methyl-1,2,5-thiadiazolidin-2-yl)-3-hydroxy-2H-1-benzopyran-6-carbonitrile (0.28 g). mp: 213 to 214 C. IR (Nujol): 3520, 2220, 1607, 1275 cm-1. NMR (DMSO-d6, delta): 1.17 (3H, s), 1.43 (3H, s), 2.67 (3H, s), 2.83-3.50 (4H, m), 3.64 (1H, dd, J=6, 10Hz), 4.44 (1H, d, J=10Hz), 5.80 (1H, d, J=6Hz), 6.92 (1H, d J=8Hz), 7.61 (1H, dd, J=2, 8Hz), 7.70 (1H, d, J=2Hz). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
48% | With potassium carbonate;tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100℃; for 9h; | A high pressure reaction vessel containing 2-bromo-4-fluorobenzonitrile (0.250 g, 1.25 mmol), 2-(methyl)-1,2,5-thiadiazolidine 1,1-dioxide (0.204 g, 1.5 mmol), K2CO3 (0.242 g, 1.4 mmol) and xantphos (0.058 g, 0.1 mmol) in dioxane (6 mL) was degassed with argon for 15 min. Pd2dba3 (0.034 g, 0.08 mmol) was introduced and the reaction mixture was heated at 100 C. for 9 h. The mixture was cooled, diluted with dioxane, and then filtered through Celite. The resulting mixture was concentrated in vacuo and the residue was purified with a Biotage column chromatography system on silica gel with hexanes:ethyl acetate (7:3) gradient as the eluent to afford the title compound as a white solid (0.152 g, 48%): 1H NMR (400 MHz, CDCl3) delta 7.69 (2 H, dd, J=8.6, 5.8 Hz), 7.52 (2 H, dd, J=9.5, 2.4 Hz), 7.09 (2 H, ddd, J=8.7, 7.4, 2.4 Hz), 4.06 (3 H, t, J=6.4 Hz), 3.56 (3 H, t, J=6.6 Hz), 2.90 (3 H, s); LCMS (+ESI, M+H+) m/z 256. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Sodium hydride (0.128g, 60% disp. in oil) was added to a stirred solution of 2-methyl- 1,2, 5-thiadiazolidine 1, 1-dioxide (0.433g) in THF (10ml). DMF (10ml) was added and the mixture heated at 80C for 5min then a solution of the product from step (i) (0.8g) in DMF (SML) was added. The mixture was heated at 60C for 10MIN, poured into water (100ml), acidified with citric acid and extracted with ethylacetate. The organics were evaporated under reduced pressure and the residue purified by chromatography on silica eluting with diethylether, yield 0.58g. 1H NMR CDC13 : 8 8.50 (s, 1H), 4.05 (t, 2H), 3.45 (t, 2H), 2.87 (s, 3H), 2.58 (s, 3H). MS: APCI (+ve) 307/9 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75% | With caesium carbonate;tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; at 105℃; for 2h;Inert atmosphere; | Step b) 5-(5-Methyl-l,l-dioxo-llambda*6*-ri,2,51thiadiazolidin-2-yl)-isophthalic acid dimethyl ester (Acid- 12b^; Tris(dibenzylideneacetone)palladium (27 mg, 0.029 mmol) was added to a degassed mixture of 5-bromo-isophthalic acid dimethyl ester (159 mg, 0.583 mmol), 2-methyl-[l,2,5]thiadiazolidine 1,1 -dioxide (Acid- 12a) (79 mg, 0.583 mmol), Cs2CO3 (474 mg, 1.46 mmol) and Xantphos (50.6 mg, 0.0874 mmol) in dioxane (5 ml). The mixture was heated at 105 0C under N2 for 2 h, the solvent was evaporated and the residue purified by flash chromatography using 2% MeOH in DCM as eluent, which gave the title compound (143 mg, 75%) as a yellow solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
61% | With caesium carbonate;tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; at 80℃; for 6h; | Compound prepared as set out in step 1 of the scheme for example 3.1H NMR (300 MHz, CDC13) delta 2.89 (s, 3H), 3.57(t, J= 6.6Hz, 2H), 3.89 (s, 3H), 4.37 (t, J = 6.3 Hz, 2H,), 5.34 (s, 2H), 7.32-7.42 (m, 3H), 7.48 (dd, J - 8.4,1.8 Hz, 2H), 7.97(d, J= 2.3 Hz, 1H), 8.98 (d, J= 1.8Hz, 1H)MS (ESI+) m/z 523 (M[Br79]+l), 525 (M[Br81]+l) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
42.9% | Under nitrogen atmosphere, the compound 6a (0.856 g, 6.26 mmol) was dissolved in 5 mL of anhydrous DMSO,and 60% NaH (0.282 g, 11.8 mmol) was slowly added dropwise at 0C. The temperature was raised to room temperature,and then the solution was stirred for 1 hour. 2-(((benzyloxy)carbonyl)amino)ethyl methane sulfonate (1.5 g, 5.83 mmol)was slowly added dropwise at 0 C, and then stirred at room temperature for 5 hours. After the reaction was completed,extraction was performed with ethyl acetate, and an organic solvent layer was dried over MgSO4. Filtration was performedto remove the solvent, and a residue was purified by column chromatography (EtOAc) to obtain a compound 7a (0.82 g). Sticky oil (42.9%). 1H-NMR (CDCl3, 300MHz) delta7.36-7.30 (m, 5H), 5.19 (bs, 1H), 5.10 (s, 2H), 3.46 (q, 2H, J = 5.9 Hz), 3.36-3.26 (m, 4H), 3.20 (t, 2H, J = 6.0 Hz). LC-MS: Predicted value calculated with respect to C13H19N3O4S m/z: 313. Measured value: 314(M+1)+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; at 50℃; for 2h; | Part 1 - Synthesis of (R)-tert-butyl (2-((5-methyl-l,l-dioxido-l,2,5-thiadiazolidin-2- yl)methyl)-3,4-dihydro-2H-benzo 6] [l,4]oxazin-6-yl)carbamate [0241 ] To a solution of (R)-ierf-butyl (2-(hydroxymethyl)-3 ,4-dihydro-2H- benzo[£][l ,4]oxazin-6-yl)carbamate (200 mg, 0.713 mmol), triphenylphosphine (187 mg, 0.713 mmol), 2-methyl-l ,2,5-thiadiazolidine 1 ,1 -dioxide (97 mg, 0.713 mmol), and toluene (3567 mu) was added diisopropyldiazodicarboxylate (146 mu, 0.749 mmol). The reaction was stirred at 50 C for two hours. The mixture was partitioned between ethyl acetate and saturated NaHC03. The organic layer was washed with brine, dried (MgS04), and concentrated. The residue was purified by MPLC eluting with a gradient of 0-100% ethyl acetate in hexanes to afford the title compound: LCMS (ESI) calculated for Ci7H27N405S (M+H)+: 399, Found: 399. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
9.3 mg | With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 25℃; for 3h; | To a mixture of Intermediate VN-29 (0.050 g, 0.11 mmol) and Intermediate VN-28.1 (0.016 g, 0.118 mmol) in acetonitrile (1 mL) was added DBU (0.018 mL, 0.12 mmol). The reaction mixture was stirred at -25 C for 3 h. The reaction was diluted with acetonitrile (1 mL) and purified via preparative HPLC (AcCN/water/NH40Ac) to afford the tittle compound (9.3 mg). LC-MS retention time = 1.579 min; m/z = 510.0 [M+H]+. (Column: Waters Acquity UPLC BEH CI 8, 2.1 x 50 mm, 1.7 muiotaeta particles; Mobile Phase A: 5:95 acetonitrile:water with 10 mM ammonium acetate; Mobile Phase B: 95:5 acetonitrile: water with 10 mM ammonium acetate; Temperature: 50 C; Gradient: 0- 100% B over 3 minutes, then a 0.75 minute hold at 100% B; Flow: 1.0 mL/min; Detection: UV at 220 nm). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
15% | With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine; In acetonitrile; at 80℃; for 40h; | To a solution of tert-butyl (3S)-3- [[4- [2- [(5 -iodo-2-methyl- 1 -naphthyl)oxy]-3 - pyridyl]pyrimidin-2-yl]amino]piperidine-1-carboxylate (150 mg, 0.24 mmol) in acetonitrile (2 mL) was added <strong>[67104-97-6]2-methyl-1,2,5-thiadiazolidine 1,1-dioxide</strong> (64.1 mg, 0.47 mmol), copper (I) iodide (22.4 mg, 0.12 mmol), N,N?-dimethyl-1,2-ethanediamine (20.7 mg, 0.24 mmol) and potassium carbonate (97.6 mg, 0.71 mmol) followed by stirring at 80 C for 40 h. After cooling, the mixture was filtered, concentrated and dissolved in ethyl acetate (50 mL) and subsequently washed with H20 (40 mL x 2). The organic phase was dried over anhydrous sodium sulfate and filtered and the filtrate was concentrated in vacuo and purified by prep-TLC (50% ethyl acetate in petroleum ether, Rf= 0.1) to yield 22 mg (15% yield) of the title compound as a white solid. LCMS (ESI) [M+Na]= 646.1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With caesium carbonate; In N,N-dimethyl-formamide; at 20℃; | General procedure: To the mixture of the precursor 10(2.26 g, 10.1 mmol, 1.5 equiv) and tert-butyl 1,2,5-thiadiazolidine-2-carboxylate 1,1-dioxide (1.50 g, 6.75 mmol, 1.0 equiv) in dry DMF(10 mL), was added Cs2CO3 (6.60 g, 20.25 mmol, 3.0 equiv). Themixture was stirred at room temperature overnight, and thenextracted with ethyl acetate. The organic phase was washed withsaturated NaHCO3 and brine, dried over anhydrous Na2SO4, filteredand concentrated. The resulting residue was purified via silica gelchromatography to give 11a as colorless oil (1.96 g, 79%). |
Tags: 67104-97-6 synthesis path| 67104-97-6 SDS| 67104-97-6 COA| 67104-97-6 purity| 67104-97-6 application| 67104-97-6 NMR| 67104-97-6 COA| 67104-97-6 structure
A183771 [137830-77-4]
2-Methyl-1,2,6-thiadiazinane 1,1-dioxide
Similarity: 0.79
A163184 [5823-51-8]
1,2,5-Thiadiazolidine 1,1-dioxide
Similarity: 0.79
A163184 [5823-51-8]
1,2,5-Thiadiazolidine 1,1-dioxide
Similarity: 0.79
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P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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