Home Cart Sign in  
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 27311-65-5 Chemical Structure| 27311-65-5
Chemical Structure| 27311-65-5

1-(Chloromethyl)isoquinoline

CAS No.: 27311-65-5

4.5 *For Research Use Only !

Cat. No.: A375154 Purity: 95%

Change View

Size Price

US Stock

Global Stock

In Stock
100mg łòǶÊÊ Inquiry Inquiry
250mg łÇËó¶ÊÊ Inquiry Inquiry
1g ł§Çď¶ÊÊ Inquiry Inquiry

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 100mg

    łòǶÊÊ

  • 250mg

    łÇËó¶ÊÊ

  • 1g

    ł§Çď¶ÊÊ

In Stock

- +

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support Online Technical Q&A
Product Citations

Alternative Products

Product Details of [ 27311-65-5 ]

CAS No. :27311-65-5
Formula : C10H8ClN
M.W : 177.63
SMILES Code : ClCC1=NC=CC2=C1C=CC=C2
MDL No. :MFCD09701302
InChI Key :LSNWNTHKHQTQMT-UHFFFAOYSA-N
Pubchem ID :13221031

Safety of [ 27311-65-5 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H314-H331
Precautionary Statements:P260-P264-P270-P271-P280-P301+P310-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P310-P311-P312-P321-P322-P330-P361-P363-P403+P233-P405-P501
Class:6.1(8)
UN#:2928
Packing Group:

Application In Synthesis of [ 27311-65-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 27311-65-5 ]

[ 27311-65-5 ] Synthesis Path-Downstream   1~30

  • 1
  • [ 1721-93-3 ]
  • [ 27311-65-5 ]
  • [ 88237-16-5 ]
  • 2
  • [ 533-75-5 ]
  • [ 27311-65-5 ]
  • 2-(isoquinolin-1-ylmethoxy)-cyclohepta-2,4,6-trienone [ No CAS ]
  • 4
  • [ 27311-65-5 ]
  • [ 202931-74-6 ]
  • 3-phenyl-6-(isoquinolin-1-yl)methyloxy-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazine [ No CAS ]
  • 5
  • [ 7283-41-2 ]
  • [ 27311-65-5 ]
  • S-(1-isoquinolyl-methyl)-2-mercapto-benzoic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
EXAMPLE 17 Following the procedure described in Example 16 but starting from 1.8 g. of <strong>[27311-65-5]1-chloromethyl-isoquinoline</strong> and 1.54 g. of thiosalicylic acid, 1.1 g. of S-(1-isoquinolyl-methyl)-2-mercapto-benzoic acid are obtained, melting at 170 to 172 C. Analysis for C17 H13 NO2 S (295.35): calculated: S, 10.86%. found: S, 10.50%.
  • 6
  • [ 27311-63-3 ]
  • [ 27311-65-5 ]
YieldReaction ConditionsOperation in experiment
90% Preparation of 1-chloromethyl-isoquinoline 1g; An excess of thionyl chloride (1.8 mL; 25 mmol) was dropwise added to a stirred ice-cold solution of 1-hydroxymethyl-isoquinoline 1f (2.0 g; 12.6 mmol) in CHCl3 during 30 min. The reaction medium was poured into an ice (100 g)-water (50 mL)-NH4OH (10 mL) mixture and then stirred during 20 min. The organic layer was collected, dried over anhydrous MgSO4 and evaporated under reduced pressure. The resulting oil was purified by flash chromatography (Me2CO) to afford a white solid (2 g); yield, 90%1H-NMR (CDCl3) δ 5.18 (s, 2H), 7.68-7.76 (m, 3H), 7.88 (d, 1H, J=8.1 Hz), 8.27 (d, 1H, J=7.8 Hz), 8.49 (d, 1H, J=5.7 Hz)
  • 7
  • [ 27311-63-3 ]
  • [ 27311-65-5 ]
  • [ 950853-47-1 ]
YieldReaction ConditionsOperation in experiment
68% With sodium hydride; In N,N-dimethyl-formamide; at 20℃; for 2h; Preparation of 1,1'-bis(1-isoquinolyl)-dimethylether 2v; A solution of 1-hydroxymethyl-isoquinoline 1f (0.62 g; 3.9 mmol) and <strong>[27311-65-5]1-chloromethyl-isoquinoline</strong> 1 g (0.7 g; 3.9 mmol) in DMF (15 mL) was added dropwise to a stirred suspension of sodium hydride (0.16 g; 3.9 mmol) in DMF (15 mL) at room temperature. The reaction medium was stirred for 2 h and poured into water (200 mL). The aqueous solution was extracted with CHCl2 (3×50 ml). The organic layers were dried over anhydrous MgSO4 and evaporated under reduced pressure to afford oil. This oil was purified by flash chromatography (Me2CO) to afford a cream solid (0.8 g); yield 68%1H-NMR (CDCl3) δ 5.40 (s, 4H), 7.58 (t, 2H, J=7.6 Hz), 7.68 (d, 2H, J=5.8 Hz), 7.72 (t, 2H, J=7.6 Hz), 7.85 (d, 2H, J=8.2 Hz), 8.33 (d, 2H, J=8.4 Hz), 8.50 (d, 2H, J=5.8 Hz)
  • 8
  • [ 27311-65-5 ]
  • [ 1355450-12-2 ]
  • 9
  • [ 27311-65-5 ]
  • [ 40615-08-5 ]
  • 10
  • [ 27311-65-5 ]
  • [ 40615-08-5 ]
  • [ 1355450-12-2 ]
  • 11
  • [ 27311-65-5 ]
  • [ 1074-82-4 ]
  • [ 1355450-11-1 ]
  • 12
  • [ 27311-65-5 ]
  • [ 616-29-5 ]
  • [ 1453102-44-7 ]
  • 13
  • trans-1,2-Diaminocyclohexane [ No CAS ]
  • [ 27311-65-5 ]
  • N,N,N′,N′-tetrakis(1-isoquinolylmethyl)-trans-1,2-cyclohexanediamine [ No CAS ]
  • 14
  • [ 67-66-3 ]
  • [ 27311-65-5 ]
  • [ 4730-54-5 ]
  • N,N′,N″-Tris(1-isoquinolylmethyl)-1,4,7-triazacyclononane*0.4CHCl3 [ No CAS ]
  • 15
  • [ 27311-65-5 ]
  • N,N′,N″-tris(1-isoquinolylmethyl)-1,4,7-triazacyclononanezinc(II) perchlorate [ No CAS ]
  • 16
  • [ 57260-73-8 ]
  • [ 27311-65-5 ]
  • [ 1615717-14-0 ]
  • 17
  • [ 27311-65-5 ]
  • [ 1615717-19-5 ]
  • 18
  • [ 27311-65-5 ]
  • [ 1615717-06-0 ]
  • 19
  • [ 27311-65-5 ]
  • [ 1615717-51-5 ]
  • 20
  • [ 27311-65-5 ]
  • [ 1615717-15-1 ]
  • 21
  • [ 3731-51-9 ]
  • [ 27311-65-5 ]
  • [ 1618652-36-0 ]
  • 22
  • [ 2706-56-1 ]
  • [ 27311-65-5 ]
  • [ 1618652-37-1 ]
  • 23
  • [ 27311-65-5 ]
  • [ 20947-95-9 ]
  • N,N,N′-tris(1-isoquinolylmethyl)-N′-(2-pyridylmethyl)-ethylenediamine [ No CAS ]
  • 24
  • [ 27311-65-5 ]
  • [ 189440-33-3 ]
  • N,N-bis(1-isoquinolylmethyl)-N′,N′-bis(2-pyridylmethyl)ethylenediamine [ No CAS ]
  • 25
  • [ 27311-65-5 ]
  • [ 4608-34-8 ]
  • N,N′-bis(1-isoquinolylmethyl)-N,N′-bis(2-pyridylmethyl)-ethylenediamine [ No CAS ]
  • 26
  • [ 98-10-2 ]
  • [ 27311-65-5 ]
  • C26H21N3O2S [ No CAS ]
  • 27
  • [ 34984-16-2 ]
  • [ 27311-65-5 ]
  • N,N,N’,N’-tetrakis(1-isoquinolylmethyl)-2,6-lutidylenediamine [ No CAS ]
  • 28
  • [ 1477-55-0 ]
  • [ 27311-65-5 ]
  • N,N,N’,N’-tetrakis(1-isoquinolylmethyl)-1,3-bis(aminomethyl)benzene [ No CAS ]
  • 29
  • (2R,6S)-2,6-di(pyridin-2-yl)piperidine [ No CAS ]
  • [ 27311-65-5 ]
  • 1-(((2R,6S)-2,6-di(pyridin-2-yl)piperidin-1-yl)-methyl)isoquinoline [ No CAS ]
  • 30
  • [ 50-00-0 ]
  • [ 867-13-0 ]
  • [ 27311-65-5 ]
  • C15H15NO2 [ No CAS ]
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 27311-65-5 ]

Chlorides

Chemical Structure| 1263378-97-7

A415265 [1263378-97-7]

1-(Chloromethyl)isoquinoline hydrochloride

Similarity: 1.00

Chemical Structure| 147937-36-8

A320617 [147937-36-8]

3-(Chloromethyl)isoquinoline

Similarity: 0.97

Chemical Structure| 76884-33-8

A314312 [76884-33-8]

3-(Chloromethyl)isoquinoline hydrochloride

Similarity: 0.97

Chemical Structure| 40484-36-4

A791685 [40484-36-4]

6-(Chloromethyl)phenanthridine

Similarity: 0.92

Chemical Structure| 88237-16-5

A478070 [88237-16-5]

1-(Dichloromethyl)isoquinoline

Similarity: 0.90

Related Parent Nucleus of
[ 27311-65-5 ]

Isoquinolines

Chemical Structure| 1263378-97-7

A415265 [1263378-97-7]

1-(Chloromethyl)isoquinoline hydrochloride

Similarity: 1.00

Chemical Structure| 147937-36-8

A320617 [147937-36-8]

3-(Chloromethyl)isoquinoline

Similarity: 0.97

Chemical Structure| 76884-33-8

A314312 [76884-33-8]

3-(Chloromethyl)isoquinoline hydrochloride

Similarity: 0.97

Chemical Structure| 88237-16-5

A478070 [88237-16-5]

1-(Dichloromethyl)isoquinoline

Similarity: 0.90

Chemical Structure| 1079652-68-8

A444259 [1079652-68-8]

7-Chloro-3-(chloromethyl)isoquinoline

Similarity: 0.87