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Chemical Structure| 63612-50-0 Chemical Structure| 63612-50-0

Structure of Nilutamide
CAS No.: 63612-50-0

Chemical Structure| 63612-50-0

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Nilutamide is a non-steroidal androgen receptor antagonist and also inhibits androgen biosynthesis in vitro.

Synonyms: RU 23908; Nilandron; NILANDRON 55dimethyl34nitro3(trifluoromethyl)phenyl24imidazolidinedione

4.5 *For Research Use Only !

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Product Citations

Product Citations

Andressa Santana Santos ; Vinícius Alexandre Fiaia Costa ; Vivianny Aparecida Queiroz Freitas ; Laura Raniere Borges dos Anjos ; Eder Soares de Almeida Santos ; Thales Domingos Arantes , et al.

Abstract: Sporotrichosis is recognized as the predominant subcutaneous mycosis in South America, attributed to pathogenic species within the Sporothrix genus. Notably, in Brazil, Sporothrix brasiliensis emerges as the principal species, exhibiting significant sapronotic, zoonotic and enzootic epidemic potential. Consequently, the discovery of novel therapeutic agents for the treatment of sporotrichosis is imperative. The present study is dedicated to the repositioning of pharmaceuticals for sporotrichosis therapy. To achieve this goal, we designed a pipeline with the following steps: (a) compilation and preparation of Sporothrix genome data; (b) identification of orthologous proteins among the species; (c) identification of homologous proteins in publicly available drug-target databases; (d) selection of Sporothrix essential targets using validated genes from Saccharomyces cerevisiae; (e) molecular modeling studies; and (f) experimental validation of selected candidates. Based on this approach, we were able to prioritize eight drugs for in vitro experimental validation. Among the evaluated compounds, everolimus and bifonazole demonstrated minimum inhibitory concentration (MIC) values of 0.5 µg/mL and 4.0 µg/mL, respectively. Subsequently, molecular docking studies suggest that bifonazole and everolimus may target specific proteins within S. brasiliensis– namely, sterol 14-α-demethylase and serine/threonine-protein kinase TOR, respectively. These findings shed light on the potential binding affinities and binding modes of bifonazole and everolimus with their probable targets, providing a preliminary understanding of the antifungal mechanism of action of these compounds. In conclusion, our research advances the understanding of the therapeutic potential of bifonazole and everolimus, supporting their further investigation as antifungal agents for sporotrichosis in prospective hit-to-lead and preclinical investigations.

Keywords: Sporotrichosis ; Sporothrix brasiliensis ; Drug repurposing ; Structural bioinformatics ; Everolimus

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Alternative Products

Product Details of Nilutamide

CAS No. :63612-50-0
Formula : C12H10F3N3O4
M.W : 317.22
SMILES Code : O=C1N(C2=CC=C([N+]([O-])=O)C(C(F)(F)F)=C2)C(C(C)(C)N1)=O
Synonyms :
RU 23908; Nilandron; NILANDRON 55dimethyl34nitro3(trifluoromethyl)phenyl24imidazolidinedione
MDL No. :MFCD00864670
InChI Key :XWXYUMMDTVBTOU-UHFFFAOYSA-N
Pubchem ID :4493

Safety of Nilutamide

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H360
Precautionary Statements:P201-P301+P310+P330
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Biological Activity

Description
Nilutamide (Nilandron) is an orally active, nonsteroidal androgen receptor antagonist that binds to androgen receptors without affinity for progestogen, estrogen, or glucocorticoid receptors. Nilutamide is used in prostate cancer research and possesses antischistosomal properties[1][4].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.15mL

0.63mL

0.32mL

15.76mL

3.15mL

1.58mL

31.52mL

6.30mL

3.15mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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