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Chemical Structure| 531-81-7 Chemical Structure| 531-81-7
Chemical Structure| 531-81-7

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Coumarin-3-carboxylic acid can be used as a detector of hydroxyl radicals in aqueous solution.

Synonyms: 2-Oxochromene-3-carboxylic acid

4.5 *For Research Use Only !

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Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

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Product Details of Coumarin-3-carboxylic Acid

CAS No. :531-81-7
Formula : C10H6O4
M.W : 190.15
SMILES Code : O=C1OC2=C(C=CC=C2)C=C1C(O)=O
Synonyms :
2-Oxochromene-3-carboxylic acid
MDL No. :MFCD00006852
InChI Key :ACMLKANOGIVEPB-UHFFFAOYSA-N
Pubchem ID :10752

Safety of Coumarin-3-carboxylic Acid

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301
Precautionary Statements:P264-P270-P301+P310+P330-P405-P501
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of Coumarin-3-carboxylic Acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 531-81-7 ]

[ 531-81-7 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 941-91-3 ]
  • [ 531-81-7 ]
  • 1-methyl-3-(2-oxo-2H-chromen-3-yl)quinolin-2(1H)-one [ No CAS ]
  • 2
  • [ 138907-68-3 ]
  • [ 531-81-7 ]
  • ethyl 1-(4-fluorophenyl)-5-(2-oxo-2H-chromene-3-carboxamido)-1H-pyrazole-4 carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
65% With pyridine; trichlorophosphate; General procedure: Intermediate 4 (0.001mol) and 5 (0.001mol) were dissolved in pyridine, phosphorus oxychloride is slowly added dropwise under ice bath conditions, then at 40-60C reacted for 5-8h. Finally, the mixture was poured into 30mL saturated Na2CO3 solution and stirred well. After the mixture was acidified, the saturated CuSO4 solution was used to remove pyridine, which greatly improved the purity and yield of the product. The data for compounds 8I-8VI are provided in the supporting information.
  • 3
  • [ 531-81-7 ]
  • [ 15001-11-3 ]
  • ethyl 5-(2-oxo-2H-chromene-3-carboxamido)-1-(p-tolyl)-1H-pyrazole-4-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
71% With pyridine; trichlorophosphate; General procedure: Intermediate 4 (0.001mol) and 5 (0.001mol) were dissolved in pyridine, phosphorus oxychloride is slowly added dropwise under ice bath conditions, then at 40-60C reacted for 5-8h. Finally, the mixture was poured into 30mL saturated Na2CO3 solution and stirred well. After the mixture was acidified, the saturated CuSO4 solution was used to remove pyridine, which greatly improved the purity and yield of the product. The data for compounds 8I-8VI are provided in the supporting information.
  • 4
  • [ 531-81-7 ]
  • [ 51516-70-2 ]
  • N-(4-cyano-1-(4-fluorophenyl)-1H-pyrazol-5-yl)-2-oxo-2H-chromene-3-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With pyridine; trichlorophosphate; General procedure: Intermediate 4 (0.001mol) and 5 (0.001mol) were dissolved in pyridine, phosphorus oxychloride is slowly added dropwise under ice bath conditions, then at 40-60C reacted for 5-8h. Finally, the mixture was poured into 30mL saturated Na2CO3 solution and stirred well. After the mixture was acidified, the saturated CuSO4 solution was used to remove pyridine, which greatly improved the purity and yield of the product. The data for compounds 8I-8VI are provided in the supporting information.
  • 5
  • [ 531-81-7 ]
  • [ 103646-82-8 ]
  • N-(4-cyano-1-(p-tolyl)-1H-pyrazol-5-yl)-2-oxo-2H-chromene-3-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With pyridine; trichlorophosphate; General procedure: Intermediate 4 (0.001mol) and 5 (0.001mol) were dissolved in pyridine, phosphorus oxychloride is slowly added dropwise under ice bath conditions, then at 40?60°C reacted for 5?8h. Finally, the mixture was poured into 30mL saturated Na2CO3 solution and stirred well. After the mixture was acidified, the saturated CuSO4 solution was used to remove pyridine, which greatly improved the purity and yield of the product. The data for compounds 8I-8VI are provided in the supporting information.
 

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