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Chemical Structure| 941-91-3 Chemical Structure| 941-91-3
Chemical Structure| 941-91-3

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3-Bromo-1-methylquinolin-2(1H)-one

CAS No.: 941-91-3

4.5 *For Research Use Only !

Cat. No.: A830344 Purity: 98%

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Product Details of [ 941-91-3 ]

CAS No. :941-91-3
Formula : C10H8BrNO
M.W : 238.08
SMILES Code : O=C1N(C)C2=C(C=CC=C2)C=C1Br
MDL No. :MFCD00234612

Safety of [ 941-91-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis [ 941-91-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 941-91-3 ]

[ 941-91-3 ] Synthesis Path-Downstream   1~24

  • 1
  • [ 110-00-9 ]
  • [ 941-91-3 ]
  • [ 138073-20-8 ]
  • 2
  • [ 188290-36-0 ]
  • [ 941-91-3 ]
  • [ 138037-47-5 ]
  • 3
  • [ 109-97-7 ]
  • [ 941-91-3 ]
  • [ 138037-46-4 ]
  • 4
  • [ 941-91-3 ]
  • [ 85-01-8 ]
  • [ 138037-43-1 ]
  • 5
  • [ 941-91-3 ]
  • [ 138037-45-3 ]
  • 6
  • 1,2-dihydro-2-tert-butoxy-3-bromo-1-methylquinoline [ No CAS ]
  • [ 941-91-3 ]
  • 7
  • [ 941-91-3 ]
  • [ 146140-95-6 ]
  • [ 197524-35-9 ]
  • 8
  • [ 939-16-2 ]
  • [ 74-88-4 ]
  • [ 941-91-3 ]
YieldReaction ConditionsOperation in experiment
82% With potassium carbonate; In N,N-dimethyl-formamide; at 60℃; for 16.0h; To a mixture of 3-bromoquinolin-2(1H)-one (224 mg, 1.0 mmol) in DMF (4 mL) was added CH3I (210 mg, 1.5 mmol), K2CO3 (273 mg, 2.0 mmol) at r.t.. The reaction was stirred at 60 oC for 16 h. The mixture was concentrated in vacuum. The residue was purified by column chromatography on silica gel (PE : EA =5:1 to 1:1) to 3-bromo-1-methylquinolin-2(1H)-one (132 mg, yield 82%) as a white solid.1H NMR (400 MHz, DMSO-d6) delta 8.54 (s, 1H), 7.75 (dd, J = 7.8, 1.2 Hz, 1H), 7.70-7.66 (m, 1H), 7.57 (d, J = 8.5 Hz, 1H), 7.36- 7.24 (m, 1H), 3.71 (s, 3H).
  • 11
  • 3-bromo-quinoline iodomethylate [ No CAS ]
  • [ 941-91-3 ]
  • 12
  • [ 74-88-4 ]
  • 3-bromo-carbostyril sodium [ No CAS ]
  • [ 941-91-3 ]
  • 13
  • [ 941-91-3 ]
  • [ 106473-33-0 ]
  • C24H20N2SO5 [ No CAS ]
  • 14
  • [ 941-91-3 ]
  • [ 70-55-3 ]
  • C17H16N2O3S [ No CAS ]
  • 15
  • [ 941-91-3 ]
  • [ 3144-09-0 ]
  • C11H12N2O3S [ No CAS ]
  • 16
  • [ 941-91-3 ]
  • [ 57-13-6 ]
  • C33H26N4O3 [ No CAS ]
  • 17
  • [ 941-91-3 ]
  • [ 954416-51-4 ]
  • 18
  • [ 941-91-3 ]
  • [ 1201-74-7 ]
  • C22H20N2O [ No CAS ]
  • 19
  • [ 941-91-3 ]
  • [ 765-30-0 ]
  • C13H14N2O [ No CAS ]
  • 20
  • [ 941-91-3 ]
  • [ 3424-93-9 ]
  • 4-methoxy-N-(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100℃; for 10.0h;Inert atmosphere; Sealed tube; General procedure: A flame-dried resealable Schlenk tube was charged with Pd(OAc)2 (7.5 mg, 0.05 mmol, 5 mol%), Xantphos (29 mg, 0.05 mmol, 5 mol%), the solid reactant(s) (1.0 mmol of the bromoquinolin-2(1H)-one 6, 1.5 mmol of appropriate amine or amide) and Cs2CO3 (651 mg, 2 mmol). The Schlenk tube was capped with a rubber septum, evacuated and backfilled with argon; this evacuation/backfill sequence was repeated one additional time. The liquid reactant(s) and 1,4-dioxane (2 mL) were added through the septum. The septum was replaced with a teflon screwcap. The Schlenk tube was sealed, and the mixture was stirred at 100 C for 10 h. The resulting suspension was cooled to room temperature and filtred through celite eluting with ethyl acetate, and the inorganic salts were removed. The filtrate was concentrated and purification of the residue through a silica gel column chromatography gave the expected product 7.
  • 21
  • [ 60-35-5 ]
  • [ 941-91-3 ]
  • C12H12N2O2 [ No CAS ]
  • 22
  • [ 616-45-5 ]
  • [ 941-91-3 ]
  • C14H14N2O2 [ No CAS ]
  • 23
  • [ 941-91-3 ]
  • [ 598-81-2 ]
  • C13H14N2O3 [ No CAS ]
  • 24
  • [ 941-91-3 ]
  • [ 62-53-3 ]
  • C16H14N2O [ No CAS ]
 

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