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Chemical Structure| 2093536-12-8 Chemical Structure| 2093536-12-8

Structure of SY2-062
CAS No.: 2093536-12-8

Chemical Structure| 2093536-12-8

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SY2-062 is a bromo substituted E3 Ligand for CRBN, structurally similar to Pomalidomide.

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Product Citations

Product Citations

William F. Tracy ; Geraint H. M. Davies ; Lauren N. Grant ; Jacob M. Ganley ; Jesus Moreno ; Emily C. Cherney , et al.

Abstract: Immunomodulatory imide drugs form the core of many pharmaceutically relevant structures, but Csp2–Csp2 bond formation via metal-catalyzed cross coupling is difficult due to the sensitivity of the glutarimide ring ubiquitous in these structures. We report that replacement of the traditional alkali base with a fluoride source enhances a previously challenging Suzuki–Miyaura coupling on glutarimide-containing compounds with trifluoroborates. These enabling conditions are reactive enough to generate these derivatives in high yields but mild enough to preserve both the glutarimide and its sensitive stereocenter. Experimental and computational data suggest a mechanistically distinct process of π-coordination of the trifluoroborate enabled by these conditions.

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Product Details of SY2-062

CAS No. :2093536-12-8
Formula : C13H9BrN2O4
M.W : 337.13
SMILES Code : O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3Br)=O
MDL No. :MFCD31730866
InChI Key :NUICQRZENMKDBW-UHFFFAOYSA-N
Pubchem ID :131999631

Safety of SY2-062

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.97mL

0.59mL

0.30mL

14.83mL

2.97mL

1.48mL

29.66mL

5.93mL

2.97mL

 

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