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Chemical Structure| 24674-39-3 Chemical Structure| 24674-39-3
Chemical Structure| 24674-39-3

*Storage: Inert atmosphere,2-8°C.

2-Methoxy-5-vinylpyridine

CAS No.: 24674-39-3

4.5 *For Research Use Only !

Cat. No.: A143091 Purity: 95%

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Product Citations

Product Citations

William F. Tracy ; Geraint H. M. Davies ; Lauren N. Grant , et al.

Abstract: Immunomodulatory imide drugs form the core of many pharmaceutically relevant structures, but Csp2–Csp2 bond formation via metal-catalyzed cross coupling is difficult due to the sensitivity of the glutarimide ring ubiquitous in these structures. We report that replacement of the traditional alkali base with a fluoride source enhances a previously challenging Suzuki–Miyaura coupling on glutarimide-containing compounds with trifluoroborates. These enabling conditions are reactive enough to generate these derivatives in high yields but mild enough to preserve both the glutarimide and its sensitive stereocenter. Experimental and computational data suggest a mechanistically distinct process of π-coordination of the trifluoroborate enabled by these conditions.

Product Details of [ 24674-39-3 ]

CAS No. :24674-39-3
Formula : C8H9NO
M.W : 135.16
SMILES Code : COC1=NC=C(C=C)C=C1
MDL No. :MFCD13175951

Safety of [ 24674-39-3 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H332-H351-H412-H317-H314
Precautionary Statements:P201-P202-P260-P264-P270-P271-P272-P273-P280-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P308+P313-P310-P333+P313-P363-P405-P501
Class:8
UN#:1759
Packing Group:
 

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