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Chemical Structure| 1783-96-6 Chemical Structure| 1783-96-6
Chemical Structure| 1783-96-6

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(-)-Aspartic acid is an endogenous NMDA receptor agonist.

Synonyms: (R)-Aspartic acid; (-)-Aspartic acid; NSC 97922

4.5 *For Research Use Only !

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Product Details of H-D-Asp-OH

CAS No. :1783-96-6
Formula : C4H7NO4
M.W : 133.10
SMILES Code : N[C@H](CC(O)=O)C(O)=O
Synonyms :
(R)-Aspartic acid; (-)-Aspartic acid; NSC 97922
MDL No. :MFCD00063081
InChI Key :CKLJMWTZIZZHCS-UWTATZPHSA-N
Pubchem ID :83887

Safety of H-D-Asp-OH

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of H-D-Asp-OH

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1783-96-6 ]

[ 1783-96-6 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 1783-96-6 ]
  • [ 77-78-1 ]
  • [ 6384-92-5 ]
  • 2
  • [ 1783-96-6 ]
  • [ 74-88-4 ]
  • [ 6384-92-5 ]
  • 3
  • [ 1783-96-6 ]
  • [ 2369-29-1 ]
  • C2H4O2*C10H9F2N3O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
57% Compound 57:; Chiral To a 5.5 N HCI solution (7.2 mL) of 1 ,2-diamino-3,5-difluorobenzene (1.04 g, 7.19 mmol) was added D-aspartic acid (1.44 g, 10.8 mmol). The mixture was refluxed for overnight. The reaction crude was purified by prep. HPLC to give the title compound as an acetic acid salt in 57% yield. 1H NMR (DMSO- d6): delta 7.22 (1 H, dd, J=8.6, 2Hz), 7.02 (1 H, td, J=10.6, 2Hz), 4.21 (1 H, t, J=6.3Hz), 3.44 (1 H, dd, J=16.2, 5.6Hz), 3.29 (1 H, dd, J=16.4, 7Hz). LCMS (API-ES): 242.1 (M+H+).
  • 4
  • (SR)-{Ni(O2CCH(CH2CO2C2H5)NC(C6H5)C6H4COC4H7N(CH2C6H5))} [ No CAS ]
  • [ 1783-96-6 ]
  • [ 96293-17-3 ]
  • 5
  • [ 1783-96-6 ]
  • [ 1119-34-2 ]
  • palladium dichloride [ No CAS ]
  • [Pd(OOCCH(NH2)CH2COO)(OOCCH(NH2)(CH2)3NHC(NH2)NH2)]*0.5H2O [ No CAS ]
  • 6
  • [ 64-17-5 ]
  • [ 1783-96-6 ]
  • [ 112018-26-5 ]
YieldReaction ConditionsOperation in experiment
99% [00222] Acetyl chloride (54.6 mL, 0.75 mol) was added drop- wise into ethanol (316 mL) at 0-5 0C. When the addition was completed, the ice bath was removed and the solution allowed to stir while warming to room temperature for another 30 min. D-aspartic acid 19.1 (25 g, 0.188 <n="77"/>mol) was then added. The reaction mixture was refluxed for 2 hours. The reaction solution was then concentrated in vacuo and placed under high vacuum (0.4 mm Hg) overnight. Compound 19.2 was obtained as a white solid (42 g, 99%) and used directly in the next step.
  • 7
  • [ 22929-52-8 ]
  • [ 1783-96-6 ]
  • N-[(S/R)-3-tetrahydrofuranyl]-D-aspartic acid [ No CAS ]
 

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