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Chemical Structure| 3057-74-7 Chemical Structure| 3057-74-7
Chemical Structure| 3057-74-7

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H-Asp(OtBu)-OH is a derivative of aspartic acid, widely used in peptide synthesis. Aspartic acid plays a crucial role in energy metabolism, protein synthesis, and neurotransmitter regulation. This compound can be used for research in neurological diseases, metabolic regulation, and protein engineering.

Synonyms: L-Aspartic acid 4-tert-butyl ester; L-Aspartic acid β-tert-butyl ester; β-tert-Butyl L-aspartate

4.5 *For Research Use Only !

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Product Details of H-Asp(OtBu)-OH

CAS No. :3057-74-7
Formula : C8H15NO4
M.W : 189.21
SMILES Code : O=C(O)[C@@H](N)CC(OC(C)(C)C)=O
Synonyms :
L-Aspartic acid 4-tert-butyl ester; L-Aspartic acid β-tert-butyl ester; β-tert-Butyl L-aspartate
MDL No. :MFCD00038577
InChI Key :MXWMFBYWXMXRPD-YFKPBYRVSA-N
Pubchem ID :7010570

Safety of H-Asp(OtBu)-OH

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of H-Asp(OtBu)-OH

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3057-74-7 ]

[ 3057-74-7 ] Synthesis Path-Downstream   1~4

  • 2
  • [ 1791-13-5 ]
  • [ 3057-74-7 ]
  • 3
  • [ 108-24-7 ]
  • [ 3057-74-7 ]
  • [ 117833-18-8 ]
  • 4
  • L-Lys(Dde)-OH [ No CAS ]
  • [ 133-32-4 ]
  • Fmoc-Cys(Trt)(Wang Resin LL)-resin [ No CAS ]
  • [ 2418-95-3 ]
  • [ 2799-07-7 ]
  • [ 1173-43-9 ]
  • [ 3057-74-7 ]
  • [ 56-40-6 ]
  • amino-PEG(2u)-acid [ No CAS ]
  • [ 147-85-3 ]
  • (S)-2-amino-5-(3-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-ylsulfonyl)guanidino)pentanoic acid [ No CAS ]
  • C94H129N21O28S3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
40% The IBA-iRGD molecule was synthesized using standard solid phase synthesis protocols on a Fmoc-Cys(Trt)Wang Resin and Fmoc chemistry as described above. The following residues were coupled in order: Asp(OtBu), Pro, Gly, Lys(Boc), Asp(OtBu), Gly, Arg(Pbf), Cys(Trt), N-amido-dPEG2-acid, Lys(ivDde), N-amido-dPEG2-acid, Lys(Boc), mBA. The ivDde protecting group was removed by 2percent hydrazine in DMF. FITC was allowed to react for 3 h in DMF. The molecule was then cleaved from the resin in 92.5percent TFA, 2.5percent TIS, 2.5percent EDT and 2.5percent DI. water, purified via RP-HPLC on a Zorbax C18 column, and characterized using MALDI-TOF MS (FIG. 13). The peptide was cyclized overnight in DMF with DIEA and cyclization was verified via MALDI-TOF MS. The yield was 40percent, and product purity was confirmed using RP-HPLC on an analytical Zorbax C18 colunm to be >95percent.
 

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