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Chemical Structure| 98-32-8 Chemical Structure| 98-32-8
Chemical Structure| 98-32-8

3-Amino-4-hydroxybenzenesulfonamide

CAS No.: 98-32-8

4.5 *For Research Use Only !

Cat. No.: A166067 Purity: 98%

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Product Details of [ 98-32-8 ]

CAS No. :98-32-8
Formula : C6H8N2O3S
M.W : 188.20
SMILES Code : C1=C(C(=CC=C1[S](N)(=O)=O)O)N
MDL No. :MFCD00035782
Boiling Point : No data available
InChI Key :AVQFHKYAVVQYQO-UHFFFAOYSA-N
Pubchem ID :66814

Safety of [ 98-32-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 98-32-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 98-32-8 ]

[ 98-32-8 ] Synthesis Path-Downstream   1~27

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  • 2-(2-Benzylsulfanyl-ethyl)-benzooxazole-5-sulfonic acid amide [ No CAS ]
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  • 3-nitro-4-hydroxy-benzenesulfonamide-(1) [ No CAS ]
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  • 2-mercaptobenzooxazole-5-sulfonic acid amide [ No CAS ]
YieldReaction ConditionsOperation in experiment
92% In tetrahydrofuran; at 20℃; for 5h; To a solution of 3-amino-4-hydroxy-benzenesulfonamide (5.00 g, 26.6 mmol, 1.0 equiv) in anhydrous THF (250 mL) was added slowly thiophosgene (3.67 g, 2.43 mL, 31.9 mmol, 1.2 equiv) via syringe pump over a time period of 1 h. After stirring for 4 h at rt, excess thiophosgene was quenched by addition of a conc. solution of ammonium chloride (100 mL) and the majority of solvent removed by evaporation under reduced pressure. The residue was extracted with ethyl acetate (3.x.100 mL) and the combined organic phases dried over MgSO4 yielding 6.1 g (92percent) of crude product, which was used in the subsequent reaction step without further purification. 1H NMR (300 MHz, DMSO): delta 7.51 (br s, 2H), 7.68 (s, 1H), 7.70 (d, J=7.7 Hz, 1H), 7.78 (d, J=7.7 Hz, 1H), 14.21 (br s, 1H). 13C NMR (75 MHz, DMSO): delta 106.29, 108.47, 120.06, 129.91, 139.54, 148.16, 179.38. MS (ISP): 230.9 [M+H]+.
 

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