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Chemical Structure| 962-39-0 Chemical Structure| 962-39-0

Structure of 962-39-0

Chemical Structure| 962-39-0

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Product Details of [ 962-39-0 ]

CAS No. :962-39-0
Formula : C16H17NO2
M.W : 255.31
SMILES Code : N[C@@H](CC1=CC=CC=C1)C(OCC2=CC=CC=C2)=O
MDL No. :MFCD00801039

Safety of [ 962-39-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 962-39-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 962-39-0 ]

[ 962-39-0 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 962-39-0 ]
  • [ 59969-65-2 ]
  • Z-(2S,3R)-AHPA-(S)-Phe-OBzl [ No CAS ]
  • 2
  • [ 6624-49-3 ]
  • [ 962-39-0 ]
  • [ 1184612-38-1 ]
YieldReaction ConditionsOperation in experiment
87% With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20℃; for 14h;Inert atmosphere; General procedure: At 0 °C and with stirring to the solution of 865 mg (5.0 mmol) of <strong>[6624-49-3]isoquinoline-3-carboxylic acid</strong> in 10 ml of anhydrous THF 675 mg (5.0 mmol) of HOBt was added to form reaction mixture A. The solution of 5.5 mmol of l-amino acid benzylester in 5 ml of anhydrous THF was adjusted pH 9 with triethylamine and stirred for 30 min to form mixture B. At 0 °C the mixtures A and B were mixed and then 1339 mg (6.5 mmol) of DCC was added. The reaction mixture was stirred at 0 °C for 2 h, at room temperature for12 h and TLC (ethyl acetate/petroleum ether, 1:2) indicated the complete disappearance of <strong>[6624-49-3]isoquinoline-3-carboxylic acid</strong>. The formed precipitates of DCU were removed by filtration and the filtrate was evaporated under vacumm. The residue was dissolved in 50 ml of ethyl acetate and the formed solution was washed successively with saturated aqueous solution of NaHCO3 (30 ml .x. 3), 5percent aqueous solution of KHSO4 (30 ml .x. 3) and saturated aqueous solution of NaCl (30 ml .x. 3) and dried over anhydrous Na2SO4. After filtration the filtrate was evaporated under vacumm and the residure was purified on silica gel chromatography (CHCl3:MeOH, 20:1) to give the title compounds.
  • 3
  • [ 28170-07-2 ]
  • [ 962-39-0 ]
  • 4
  • [ 962-39-0 ]
  • [ 59969-65-2 ]
  • (2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl-(S)-phenylalanin [ No CAS ]
 

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