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Chemical Structure| 958230-19-8 Chemical Structure| 958230-19-8

Structure of 958230-19-8

Chemical Structure| 958230-19-8

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Product Details of [ 958230-19-8 ]

CAS No. :958230-19-8
Formula : C8H5ClN2O
M.W : 180.59
SMILES Code : O=CC1=CN=C(NC=C2)C2=C1Cl
MDL No. :MFCD09859124
InChI Key :SVRMXFJXIGCKII-UHFFFAOYSA-N
Pubchem ID :24229274

Safety of [ 958230-19-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H319
Precautionary Statements:P305+P351+P338

Application In Synthesis of [ 958230-19-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 958230-19-8 ]

[ 958230-19-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 958230-19-8 ]
  • [ 1175298-09-5 ]
  • tert-butyl (3-(5-formyl-1H-pyrrolo[2,3-b]pyridin-4-yl)cyclohex-3-en-1-yl)carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
91% With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In 1,4-dioxane; water; at 100℃; for 14h; [0302] 1,4-Dioxane (20 mL), a 2 M aqueous solution of sodium carbonate (6 mL) and Pd(PPh3)4 (318 mg) were addedto 4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde (1.00 g) and the compound of Reference Example 1(2a) (1.96 g),and the temperature of the obtained mixture was then increased to 100C, followed by stirring for 14 hours. Thereafter,water was added to the reaction mixture for dilution, and the obtained mixture was then extracted with chloroform. Thegathered organic layer was washed with a saturated saline, dried over anhydrous sodium sulfate, and then concentratedunder a reduced pressure. The obtained residue was purified by silica gel chromatography (chloroform : methanol) toobtain a product of interest (1.70 g, yield: 91%).ESI-MS m/z 342(MH+)
 

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